Adults 65 Years Old and Older Have Reduced Numbers of Functional
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2023-2024学年全国九年级上英语月考试卷考试总分:45 分考试时间: 120 分钟学校:__________ 班级:__________ 姓名:__________ 考号:__________注意事项:1.答题前填写好自己的姓名、班级、考号等信息;2.请将答案正确填写在答题卡上;卷II(非选择题)一、完形填空(本题共计 2 小题,每题 5 分,共计10分)1.All the friends were a little (1)________, when Ben asked us to have a meal at his house. "Itmust(2)________ a delicious supper, because Ben is a good (3)________. What will he bring for his friends this time?" I said to Marina. As usual, Ben said(4)________ to us at the door and we went into his dinning room happily. There was a new table waiting for us. After a while, Ben brought four bowls of hot soup(5)________ carrots, potatoes and tomatoes. The soup smelled very(6)________. Andwe didn't(7)________ what it was. As we ate, Marina asked, "Was there a recipe(食谱)for this?" Ben put down his fork and(8)________(回答), "Supermarkets usually throw away 5% of their food every day. I have just taken some throw-away vegetables from there. But many poor people(9)________ got their supper yet this evening!"Ben's decent(不错的)meal has really(10)________ us a lesson.(1)A.happyB.sadC.worriedD.angry(2)A.will beB.beC.wasD.were(3)A.workB.cookC.doctorD.teacher(4)A.helloB.goodbyeC.good nightD.thank you(5)A.someB.haveC.aboutD.with(6)A.goodB.badC.hotD.delicious(7)A.thinkB.seeC.knowD.hear(8)A.has repliedB.repliedC.replyingD.reply(9)A.didn'tB.haven'tC.don'tD.won't(10)A.teachesB.teachingC.to teachD.taught2.What will life be like in 2050? Will life be better,(1)________ or the same as now? I oftenthink about the(2)________. I believe life will probably be very(3)________ in 2050.First, I think there will be(4)________ televisions in 2050. People will watch(5)________ programs on the Internet,(6)________ they won't need TVs. I believe(7)________ will be as cheap as telephones. Most people will have(8)________ money to own their personal computers. For transportation, cars will run on clean fuels, so there will be less(9)________. By 2050, cars will have computers to control how(10)________ they run. Computers will(11)________ cars to any place you want to go. There will be(12)________ accidents. We won't need so many(13)________. Now you can see robots in many factories. Factories(14)________ robots, because they do not ask for money.(15)________ 2050, robots will work everywhere in schools, offices and homes.(1)A.worseB.worstC.goodD.best(2)B.predictionC.pictureD.future(3)A.similarB.easyC.differentD.difficult(4)A.noB.enoughC.manyD.more(5)A.kind ofB.a kind ofC.all kinds ofD.kind(6)A.butB.soC.orD.until(7)C.emailsputers(8)A.lessB.enoughC.moreD.foreign(9)A.workB.waterC.spaceD.pollution(10)A.quicklyB.soonC.longD.often(11)A.driveB.askC.findD.hope(12)C.manyD.few(13)A.teachersB.policemenC.carsD.fuels(14)A.knowB.heareD.sell(15)A.ByB.BeforeC.AfterD.For二、阅读理解(本题共计 5 小题,每题 5 分,共计25分)3.PainkillerUses: tablet(药片)to treat(治疗)headaches, or the common cold.Warnings(警告)Keep at room temperature. If you are pregnant(怀孕的), ask a doctor before using. If more than two tablets are taken at one time, get a doctor's help at once.How to take it:For adults(成人)and children of 12 years old and older: take 1 tablet every 4 to 6 hours. If pain is not better, 2 tablets may be taken. Do not take more than 5 tablets in 24 hours. For children under 12 years old, ask a doctor.Antibiotic CreamUses: cream to treat pain from small cuts and burns on skin(皮肤). WarningsUse on skin only. Do not eat. Do not use in eyes or over large parts of body. Visit a doctor if you have serious cuts or burns. Stop using and visit a doctor if you still have the problem after one week or if the pain is worse. Keep at room temperature. How to take it:Only use on adults and children aged 2 or older.Clean the cut or burn. Put the cream on the cut or burn up to three times a day. If you are pregnant, ask a doctor before using.(1)Who can't take Painkiller before asking a doctor?A.An old man.B.A pregnant woman.C.A 13-year-old child.D.A 20-year-old young woman.(2)What can Antibiotic Cream treat?A.A cold.B.Headaches.C.Stomachaches.D.Pain from small cuts.(3)What do Painkiller and Antibiotic Cream have in common?A.People should keep them cold.B.They are useful for 1-year-old children.C.They are useful for people with something wrong.D.People can use both of them on skin.4.A father had three sons who were always arguing(争吵)among themselves. Nothing he said wouldstop them, and so one day he decided to show them something that would make them think."Go into the forest," he said, "and bring me back some sticks."The sons did as he asked and soon came back with some sticks. He took the sticks from them andtied(捆)them together."Try to break(折断)these sticks in two," he said.Each of his sons tried to break the sticks in two, but they could not."Now try to break the sticks one at a time," he told them.The sons each took a stick out of the bundle and broke it easily."If you all work together and do not quarrel," the father said, "you will be strong. If each of you go your own way, you will be weak."(1)The sons went into the forest to ________.A.bring back some sticksB.sell some sticksC.borrow some sticksD.buy some sticks(2)What did the father do to the sticks?A.He broke the sticks.B.He gave the sticks away.C.He tied the sticks together.D.He planted the sticks.(3)It was difficult for each son to ________.A.find sticks in the forestB.take a stick out of the bundleC.break the sticks one at a timeD.break the sticks in two at a time(4)We can learn from the passage that ________.A.we should always ask for help from othersB.we need to be careful when we're in the forestC.it is good to go your own way in your lifeD.working together will make us strong6. 阅读下面的短文,然后根据短文内容回答问题。
Different Age Groups and Their CharacteristicsIn today's diverse society, people of different age groups have distinct characteristics and perspectives. These differences arise from various factors, including life experiences, cultural influences, and generational gaps. Understanding these differences can help foster better communication and collaboration among individuals of different age groups. In this article, we will explore the characteristics of different age groups and how they contribute to the overall dynamics of society.1. Children (0-12 years old):Children are full of curiosity and energy. They are in the process of discovering the world around them and developing their cognitive, emotional, and social skills. Their innocence and imagination make them open-minded and receptive to new experiences. Children often express their thoughts and emotions freely, without much inhibition. They rely heavily on their parents or caregivers for guidance and support.2. Teenagers (13-19 years old):Teenagers are going through a period of rapid physical, emotional, and cognitive changes. They are exploring their identities and seeking independence from their parents. Teenagers often exhibit a rebellious nature as they challenge authority and societal norms. They are highly influenced by their peers and strive to fit in with their social groups. Teenagers are also known for their idealism and passion for causes they believe in.3. Young Adults (20-35 years old):Young adults are transitioning from adolescence to adulthood. They are often focused on building their careers, establishing relationships, and finding their place in the world. This age group is characterized by a sense of optimism and enthusiasm. Young adults are more likely to take risks and embrace new opportunities. They are also more adaptable to change and open to learning from their experiences.4. Middle-aged Adults (36-55 years old):Middle-aged adults are typically at the peak of their careers and family responsibilities. They have gained significant life experience and have a better understanding of their strengths and limitations. This age group is often focused on stability and security. Middle-aged adults may face challenges such as balancing work and family life, as well as dealing with aging parents. They are more likely to prioritize their health and well-being.5. Older Adults (56 years old and above):Older adults have accumulated a wealth of knowledge and wisdom over the years. They have experienced various life events and have a broader perspective on life. Older adults often prioritize family and relationships. They may face challenges related to retirement, health issues, and loss of loved ones. However, they also have more time for leisure activities and pursuing their passions. Older adults are often respected for their wisdom and are seen as mentors in society.It is important to note that these age group characteristics are generalizations and may not apply to every individual. People are unique, and their experiences and personalities can vary greatly within each age group. However, understanding these general characteristics can help foster empathy, respect, and effective communication among individuals of different age groups. By appreciating the diversity of perspectives and experiences, we can build a more inclusive and harmonious society.不同年龄段人群英文表达。
在校大学生到了法定年龄可以结婚英语作文全文共6篇示例,供读者参考篇1Marriage at College Age? I Don't Get It!Hello friends! Today I want to talk about something that seems really weird to me - college students getting married! I overheard my older brother discussing it with his friends, and I just don't understand why someone would want to get married so young. Let me explain my confusion.First of all, aren't college students still basically kids themselves? I'm only 10 years old, but even I know that college is just an upgraded version of school. The students there still have to listen to teachers, do homework, take tests, and follow lots of rules. They can't even stay out as late as adults or go wherever they want. So how can they be ready for such a huge responsibility like marriage?When I think about marriage, I picture two full-grown adults with jobs, their own house, and maybe even kids of their own. The married couples I know are always busy working, cleaning, cooking, and taking care of their families. It seems like a ton ofwork that I'm nowhere near ready for! I can barely remember to make my bed in the morning. How could a college student handle all those adult duties on top of tough classes, papers, and exams? It boggles my mind.Besides, aren't you supposed to be really mature and know yourself super well before you get married? My parents are always lecturing me about how I need to work on my maturity level. They say I'm still impulsive, irresponsible, and have no clue what I'll want to do with my future yet. If that's true for a10-year-old, imagine how much more true it must be for college-aged kids! Aren't the college years supposed to be a time when you discover who you really are, what you believe in, and what path you want to take in life? How can you pick a lifelong partner before you've even figured yourself out?Then there's the financial side of things. From what I understand, weddings are hugely expensive! Like, thousands and thousands of dollars for just one day. And that's not even including the costs of an apartment, furniture, a car, and all the other adult things you need to get started in life as a married couple. My smart older cousin once told me that most college grads today have enormous loans to pay back and can barely afford theirrent, let alone a wedding and married life! Wherewould the money come from? It seems way too risky for kids who haven't even landed a real full-time job yet.At the end of the day, college should be a time for fun, freedom, self-discovery, and pursuing your wildest dreams. Adding the massive responsibility of marriage on top of that seems like way too much unnecessary stress! If I were a college student, I'd want to focus all my energy on my studies, enjoying my friends, and figuring out my future career. Marriage can always come later, once you're financially stable with a good job and have experienced everything the world has to offer. At least, that's how I see it through my 10-year-old eyes!What do you guys think about college kids getting married? Is it a totally crazy idea like I'm picturing, or could you maybe see some logic behind it? Let me know your thoughts, because this grown-up concept is really baffling me! Thanks for listening to my rambling. Now it's time for me to head outside and just be a kid for a while. No marriage weighing me down for at least 10 more years!篇2When I Grow Up I Can Get Married!Wow, did you know that when people go to university they are adults? That means they can get married if they want to! My big brother just started university last year and he is 18 years old now. Mom and Dad said once kids turn 18, they are grown-ups in the eyes of the law. That seems so old to me! I'm only 8 years old.I can't even imagine being a grown-up yet.But my brother says some of the students at his university are already married or getting married soon. Can you believe that? Getting married when you're just starting university? That seems crazy to me. Isn't university supposed to be a time for fun, making friends, and learning? Why would you want to get married so young?I asked my parents about it and they said that in our culture, it's not that unusual for people to get married right after finishing high school or in their early years of university. They said marriage is an important commitment that many people want to make once they become adults. Some people even get arranged marriages set up by their families!I can't wrap my head around that. Arranging for someone to get married just doesn't make sense to me. Shouldn't you marry someone because you love them and want to spend your whole life with them? How can your family just pick someone for you tomarry? That seems like it would be weird and uncomfortable. What if you don't even like the person your parents choose? That's just bizarre if you ask me.Then again, I'm just a kid. I don't really understand love or marriage or any of that grown-up stuff yet. All I know is that I'm perfectly happy being single and a kid for as long as possible! I like playing with my friends, watching cartoons, and not having any serious responsibilities. I can't imagine getting married anytime soon. My mom says I need to at least finish elementary school first before I can start thinking about that!Still, the idea of university students getting married is fascinating to me in a way. They are so young, just finally becoming adults. Yet they are already making huge life decisions about settling down and starting a family. A part of me thinks that's way too young to get married. You're just barely an adult, still figuring out who you are and what you want in life. Shouldn't you have more experience and be more established in your career before making that commitment? Plenty of adults in their 20s and even 30s are still single and taking their time to find the right person.But then another part of me understands why some people do want to get married young. If you've found your soulmateand you're serious about your religious and cultural traditions, then why wait? My parents had an arranged marriage when they were just 20 years old and they are still blissfully happy together over 25 years later. As hard as it is for me to comprehend, I know arranged marriages can work out beautifully when the couple treasures commitment and partnership above all else.Maybe I'll understand it better when I'm older and experiencing my first crush or my first serious relationship. For now though, my plan is just to be a kid for as long as possible! I'm going to enjoy playing video games, riding my bicycle, and hanging out with my friends. Marriage can wait until after I've finished university, started my dream career, gone on adventures, and lived on my own for awhile. Then maybe I'll be ready to find my soulmate too.But I'm glad university students have the freedom to make that choice for themselves once they become legal adults. From what I've seen, marriage is a hugely important decision that you can't fully appreciate until you've actually experienced it. So I respect that some students know what they want and are ready to commit even at a young age. As long as they are happy and have thought it through, more power to them!I guess growing up and becoming an adult happens gradually. You don't just wake up one morning magically "grown up" and ready for marriage on your 18th birthday. It's a process of learning, soul-searching, and figuring out your values. Some university students surprisingly are at a stage where marriage feels right. Many others want to wait and keep exploring. Either way, at least they get to make that crucial decision for themselves once they are of legal age.Me? I'm just going to keep being a kid for now. But who knows, maybe I'll shock everyone and be a happily married university student myself one day too! For this second grader though, that's still light years away. I've got building forts and chasing butterflies on my agenda first. Let me enjoy my childhood a while longer before I start stressing over篇3When I'm Older and in College, I Can Get Married!Hi there! My name is Jamie and I'm 9 years old. I'm in the 4th grade and I love learning about new things every day. My teacher Mrs. Henderson always has us write essays on different topics so we can practice our writing skills. Today she gave us a really interesting writing prompt - what do we think aboutcollege students being able to get married once they reach the legal age?At first I was a little confused. College seems SO far away for me. I can barely imagine being a teenager, let alone being in college and old enough to get married! But the more I thought about it, the more intrigued I became. Marriage is a big step that grown-ups take when they find their true love and want to spend the rest of their lives together. I've been to a few weddings with my parents and they always look so happy and glamorous.My aunt Jessica just got married last summer to her boyfriend Marcus who she met in college. They had been dating for 5 years before he finally proposed! The wedding was beautiful. My aunt wore a big white princess dress and Marcus dressed up in a sharp tuxedo. The ceremony was in a lovely garden with flowers everywhere. Afterwards there was a huge party with tons of food, music, and dancing. I got to be the flower girl and walk down the aisle sprinkling rose petals. It was so much fun!Aunt Jessica told me that she knew Marcus was "the one" pretty early on when they were in college together. They took a lot of the same classes, joined the same clubs, and had so many of the same interests and values. As their relationship grew moreserious over the years, they realized they had found their perfect match. Once they both graduated and got settled into their dream jobs, they felt ready to take that next big step into marriage.I can understand why being a college student and reaching that pivotal age of 18 or 21 (depending on where you live) could make you feel prepared for such a huge commitment. You're finally an adult, independent, and starting to figure out your path in life. If you've also found your soulmate during those incredibly formative college years, it could feel like the ideal time to get married before you dive into "real" adulthood with careers and maybe a family down the the road.At the same time, the idea of getting married so young seems a little scary to me! Aren't you supposed to live on your own first, go a little crazy, and experience the world? That's what a lot of movies and TV shows seem to say. Plus, what if you pick the wrong person and have to get divorced? Divorce seems really sad, stressful, and hard, especially if you have kids involved. No thanks!My parents have been happily married for 12 years and they always tell me not to rush into anything too quickly. They were both in their late 20s when they finally met, allowing them tohave lots of fun adventures apart and together before deciding to share their lives forever. My dad says they "played the field" and dated around a lot after college until they each knew exactly what they wanted in a spouse. Then one fateful night at a mutual friend's dinner party, they locked eyes across the room and knew their soulmate search was finally over!I'm glad my parents waited and were patient to find "The One" instead of just marrying their college girlfriend or boyfriend. What if they had missed out on their perfect partner because they settled too young? That would be so sad. Although I guess if you meet your true love in college and you just know, then it's okay to get married earlier. You have to follow your heart! Still, making that decision as a young 20-something with your whole future ahead of you seems like a lot of pressure.Marriage is a enormous responsibility and commitment, after all. It's not something to enter into lightly from what I've seen and been told. Once you say those vows and sign that certificate, your lives are legally bound together through the good times and bad. If it's a loving, healthy relationship then that sounds beautiful! But if it's toxic or the spark fades, being stuck in an unhappy marriage could be a real nightmare from the divorce stories I've heard.I think that's why it's better to wait until you're a bit older and have lived more of life first before making that forever promise. Use your free 20s to explore the world, focus on your blossoming career, and just datearound until you finally meet the person you know with 100% certainty is your perfect partner to walk through all of life's ups and downs together. Then, when the time is right and you're truly ready, you can plan that magical wedding and start your happy marriage!For now though, I'm in no rush to grow up. I'm having way too much fun being a carefree kid! Marriage can wait at least 20 more years as far as I'm concerned. I have bigger issues to worry about at this age anyway, like making sure I still have time for riding my bike and eating pizza after finishing all my homework. Being a grown-up with those kinds of huge lifetime decisions can hold off until I'm very old...like maybe 25! Just kidding, Mom and Dad. Don't have a heart attack!篇4大学生可以结婚啦!嘿,大家好!我是一名小学生,今天我要告诉大家一个很有趣的事情——在校大学生也可以结婚啦!是不是很惊讶?让我来给你们讲讲为什么大学生可以结婚,以及这对他们有什么好处。
四川省遂宁市第一中学2023-2024学年高二下学期4月期中考试英语试题一、阅读理解Babysitter(保姆) WantedI am seeking a babysitter for my 6-month-old son. A few hours on Saturdays and Sundays to help me and then other times as needed. He or she should be over 18, responsible, loving, warm, and have some experience in caring for babies. This position also suits a college student with experience looking for a part-time job. The pay is $10 an hour.Ifthissoundslikeagoodjobtoyou,***************************************-4964.Office Manager WantedOur company is looking for a full-time experienced manager to run the business. Strong skills in organization and business management are required for this position. The office manager will be responsible for keeping financial (财务的) records, so he or she should be familiar with computers.************************************************-6978 to apply.Waiter/ Waitress WantedA restaurant is looking for an experienced waiter / waitress. Knowledge of wines and experience in dining are necessary. Must work well under pressure and understand the basics (基本要素) of fine dining and customer service.If you’re interested, please contact us at job-tkupe-********************************.This is a part-time job.Office Cleaner WantedLooking for a Part-time job? A position in the Mississauga area needs an office cleaner! Part-time 4 hours a day from 10:00 am - 2:00 pm.Duties include:●Cleaning the washrooms●Cleaning the furniture●Sweeping the floors●Other general cleaning experience is necessary. Pay: $15 per hourReply to:job-p3b7u-**********************************-8197.1.Which of the following position is a full-time job?A.Babysitter.B.Office manager.C.Waiter / waitress.D.Office cleaner.2.If a college girl with some experience caring for children wants to apply for a job, where should she send an email?A.job-p3b7u-*************************B.job-tkupe-*************************C.**************************D.*****************3.Which of the following is necessary for a waiter / waitress?A.Being familiar with computers.B.Having knowledge of wines.C.Knowing more about menus.D.Working well with others.Sitting in the classroom I felt confused, for I couldn’t read the blackboard. Then Mum took me to the hospital. Within a few days, I was diagnosed (诊断) with a severe visual impairment (视力障碍). In fact, I was practically blind. Amazingly, I’d managed to reach the age of 13 without anyone realizing, not even me! “It all makes sense now,” Mum said. As a kid living on a farm, I was forever falling over things. I was known as the clumsy (笨拙) one to my parents and four sisters. But now, I was being told that I saw the world differently — I could only make out the outlines of things. I was given reading glasses but they didn’t help much.Refusing to let my diagnosis hold me back, I continued doing everything I loved. As long as everything was in its place, I could feel my way around.Later I got married to Lance and had amazing kids. I could change nappies (尿布) and dress the kids fine — it just took a little longer as I relied on touch to work out where things were. Cooking, on the other hand, was not my forte. I was terrible — always mixing up sugar and salt!Nowadays, my grandkids have all been brought up not to leave toys on the floor or movechairs away from the table. “We don’t want Grandma tripping,” Lance will say.Over the year, I’ve enjoyed lovely family holidays, but sometimes felt like Lance or the kids were too protective of me. So I was thrilled when I booked myself on a trip to the Gold Coast with people who were just like me in a travel company. I’m not missing out — my life is beautiful. I’m so lucky to have a wonderful family and lots of experiences.Life is precious — you don’t need to “see” that.4.What can we know from the first paragraph?A.The reading glasses got the problem fixed.B.She always tripped because she was awkward.C.She got severe visual impairment at the age of 13.D.Nobody realized her sight was poor until she was 13.5.What does the underlined word “forte” in Paragraph 3 mean?A.Weakness.B.Favourite.C.Strength.D.Business.6.What can we know about the author?A.She is able to see things clearly now.B.She led a lonely and hopeless life.C.She could help care for the kids.D.She went to the Gold Coast all by herself.7.What can we learn from the author’s story?A.We need to go to travel frequently on our own.B.We should always turn to the family for help.C.Everyone should pay special attention to the blind people.D.Everyone can enjoy the beauty of life with a positive mind.Dog owners walked about 23minues longer each day than non-dog owners In a new study, dog owners took 2,760 additional seps—compared to people who didn’t have a dog at home. Bu here’s the real good news: That extra exercise was done at a moderate(适度的)pace, which means it could help adults meet their recommended weekly totals for physical activity.The research, published in BMC Public Health, focused on adults 65 and older, who tend to be less active than younger people. The study included 43 dog owners and 43 non-dog owners, allof whom were monitored continuously for three week-long periods. When they compared the two groups, the researchers found that dog ownership was associated with a large, potentially health-improving effect.Dog owners walked about 23 minutes longer each day than non-dog owners, 119 minutes versus 96 minutes on average. They also took an additional 2,760 steps, and had eight fewer continuous periods of sitting down. Most of that extra walking was done at moderate pace, defined as 100 or more steps a minute. Dog owners walked at this pace for 32 minutes a day, versus just 11 minutes a day for non-dog owners.The World Health Organization(WHO)recommends that adults get at least 150 minutes of physical activity a week. This increased walking time alone could just about satisfy that requirement, say the researchers—so it makes total sense that 87 percent of dog owners in the study met these guidelines, versus just 47 percent of non-dog owners.Co-author Nancy Gee says that pet ownership may help older adults get more activity or maintain their current activity level for a longer period of time. “This could improve their chances of a better quality of life, improved or maintained cognition(认知), and perhaps, even overall longevity(寿命),”she said.Here at Health, we’ ll add that caring for pets has been shown to have plenty of other physical and mental health benefits, as well. As animal lovers ourselves, we’ re happy to add one more to the list.8.What can we learn about the research?A.It was targeted on old people.B.It was sponsored by the WHO.C.It had an undesirable effect on dog owners.D.It took the mental health of dog owners into consideration.9.What does the author intend to do in Paragraph 3?A.To present the results of the research.B.To show the guidelines of the research.C.To describe the process of doing the research.D.To explain the reasons for conducting the research.10.What does Nancy Gee think of owning a dog?A.It is too expensive.B.It is time-consuming.C.It enables older adults to live a healthy life.D.It helps young adults to keep a healthy routine.11.What is the best title for the text?A.Non-pet owners enjoy more pleasureB.Animal lovers are more generousC.Young people walk less todayD.Dog owners walk way moreThe Amazon rainforest is as undisturbed a place as most people can imagine, but even there, the effects of a changing climate are playing out. Now, research suggests that many of the region’s most sensitive bird species are starting to evolve in response to warming.Birds are often considered sentinel (哨兵) species — meaning that they indicate the overall health of an ecosystem — so scientists are particularly interested in how they’re responding to climate change. In general, the news has not been good. For instance, a 2019 report by the National Audubon Society found that more than two-thirds of North America’s bird species will be in danger of extinction by 2100 if warming trends continue on their current course.For the new study, researchers collected the biggest database so far on the Amazon’s resident birds, representing 77 non-migratory species and lasting the 40 years from 1979 to 2019. During the study period, the average temperature in the region rose, while the amount of rainfall declined, making for a hotter, dryer climate overall. According to the report on November 12 in the journal Science Advances, 36 species have lost substantial weight, as much as 2 percent of their body weight per decade since 1980. Meanwhile, all the species showed some decrease in average body mass, while a third grew longer wings.Because of the study’s long time series and large sample sizes, the authors were able to show the morphological (形态学的) effects of climate change on resident birds. However, the researchers themselves are unsure and wonder what advantage the wing length changes give the birds, but suppose smaller birds may have an easier time keeping cool. In general, smaller animals have a larger rate of surface area to body size, so they dissipate more heat faster than a biggeranimal. Less available food, such as fruit or insects, in dryer weather might lead to smaller body size.12.Why are scientists fond of doing research on birds?A.They have small body sizes.B.They are sensitive to hot weather.C.They are ecological balance indicators.D.They live in an undisturbed rainforest. 13.What can we learn from the new study?A.Two-thirds of species showed a considerable decrease in weight.B.About 26 species responded to climate change with longer wings.C.36 species lost 2% of their body weight every year from 1979 to 2019.D.A third of species have been extinct for a decade due to the hotter climate.14.What does the underlined word “dissipate” in the last paragraph mean?A.Put off.B.Give off.C.Put away.D.Give away. 15.What would probably the researchers further study?A.Why it is easier for smaller animals to keep cool.B.Why the Amazonian birds have lost substantial weight.C.Whether bird species in Amazon will be extinct in 2100.D.What effects the wing length changes have on birds.In the modern busy life, there are a large number of immigrants (移民) who have been willing to have a comfortable life in other nations. Many advocate that people should follow the local customs and traditions when they settle in a new country. 16 People will face problems and enjoy benefits from local customs.There are two important reasons why new comers should bring themselves into the local culture in the host country. Firstly, the refusal to adapt to host environment would create a cultural barrier for immigrants. 17 The loneliness in turn has negative influences on people’s life.Secondly, it is true that limited knowledge of local customs may result in some illegal actions in the host country and make local people unpleased. For instance, Singapore is one of the cleanest countries in Asia. 1819 One is that if immigrants behave in agreement with the local norms (规范), they will be accepted easily by local people. As a result, they can easily gain respect as well as helpfrom the local. For example, when a company wants to expand its production in a new country, it must be aware of business practices there, which provides it with useful information to maximize profits. Another benefit is that newcomers might gain the richness of knowledge through the local customs and traditions. 20 In many festivals, people are able to join freely and feel harmonious like their own country.A.It also creates social loneliness.B.Visitors are asked to clean the street.C.Personally, I strongly agree with this idea.D.They will be appreciated and offered a good job.E.It enables them to join in the activities of the community.F.Anyone who leaves rubbish in public is considered ill-mannered.G.Newcomers can gain some benefits if they adopt the customs of a new country.二、完形填空I’ve been having a really hard time lately with the very recent loss of my father and work-related stress. I went back to 21 after taking one day off and was having a very 22 , tear-filled day.My job took me around the city. As I was 23 a busy street, I saw a homeless man who 24 himself with a blanket(毛毯). His feet were sticking out with no shoes. A 25 wind was sweeping through the street. I rushed to a shop without thinking, and bought him some 26 and gloves. I left them beside him to find when he woke up. Then he could at least be a little warmer.The next day I came back to the street, still feeling sad, still 27 , when two ladies 28 me to ask if I was the girl who left socks and gloves to that homeless man yesterday. I said yes and they 29 told me how they 30 to buy him a big warm jacket after seeing me and then another person give him some warm and 31 clothes. One of the ladies said I was a 32 . Now as she meets with me in that 33 , she greets(问候)me “Hey, my hero!”I think what I did meant nothing, but I hope it made that man’s day a little better and a little34 . At least, he could stay warm. Those ladies really filled my heart with 35 on the winter day.21.A.school B.work C.hospital D.sleep 22.A.common B.boring C.difficult D.funny 23.A.walking down B.looking for C.thinking of D.coming across 24.A.shared B.covered C.provided D.filled25.A.hot B.cool C.calm D.cold 26.A.socks B.shoes C.jackets D.trousers 27.A.wondering B.improving C.struggling D.pretending 28.A.cheated B.stopped C.pushed D.punished 29.A.shyly B.painfully C.secretly D.excitedly 30.A.failed B.needed C.offered D.refused 31.A.comfortable B.big C.formal D.old 32.A.buyer B.guest C.teacher D.hero 33.A.way B.street C.shop D.year 34.A.longer B.safer C.easier D.harder 35.A.wealth B.credit C.spirit D.warmth三、语法填空阅读下面短文,在空白处填入1个适当的单词或括号内单词的正确形式。
英国互联网各年龄阶段使用的英语作文全文共6篇示例,供读者参考篇1Internet Usage by Age in the UKBy Claude the AI AssistantHi there, friends! Today I'm going to tell you all about how people of different ages use the internet in the United Kingdom. The internet is super cool and can do so many awesome things, but different people tend to use it in different ways. Let's dive in!Little Kids (Under 10 Years Old)The youngest kids don't use the internet all that much, at least not on their own. Most of their internet time is watching videos on sites like YouTube Kids or playing simple online games. Their favorite videos are often nursery rhymes, cartoons, or toys being unboxed. For games, they tend to like educational games that teach numbers, letters, colors and shapes. Little kids mostly use tablets or their parents' smartphones to access the internet.Bigger Kids (10-14 Years Old)As kids get a bit older, their internet usage really picks up! At this age, gaming is massive. Lots of bigger kids are really into multiplayer games like Roblox, Minecraft or Fortnite where they can play with friends online. Social media also starts becoming popular, with apps like TikTok being a major hit. Bigger kids love watching YouTubers, especially ones who post gaming videos or funny skits. They use the internet a ton for homework too, looking up information for school projects and essays.Teens (15-19 Years Old)Teenagers definitely spend the most time on the internet of any age group! Social media is their biggest thing - they're constantly posting selfies, sharing memes, and chatting with their friends on apps like Snapchat, Instagram and WhatsApp. Gaming is still huge for teen boys, but teen girls tend to use the internet more for stuff like fashion blogging, shopping, streaming music and shows. Teens also use the internet a lot for schoolwork, searching for info, writing papers and even taking online classes sometimes.Young Adults (20-34 Years Old)Young adults were the first generation to grow up with modern internet, so they're pretty tech savvy. They use the internet for a bit of everything - social media, gaming, streamingentertainment, reading news, shopping online, and lots of stuff for work too like video calls, cloud storage, productivity apps and more. This age group was also really into early internet phenomenons like memes, viral videos and online dating apps. Overall, the internet is deeply woven into young adults' everyday lives.Middle-Aged Adults (35-54 Years Old)For middle-aged adults, the internet plays a pretty practical role. They don't tend to use it for gaming or spending hours on social media as much as younger people do. Instead, their internet usage revolves more around work, shopping, booking travel, banking, reading news and researching topics of interest. Lots of people in this age range had to learn to use the internet as adults when it became so essential for jobs and everyday tasks. Some struggle with the technology a bit more than digital natives.Older Adults (55+ Years Old)Older adults were the last generation to fully adopt the internet, but nowadays the vast majority are online to some degree. Their usage tends to be fairly minimal and basic though. Common activities for older adults include sending emails (maybe with the help of grandkids!), light internet browsing,looking up health info, and using social media to keep up with friends and family. Many older adults are still just not super comfortable or familiar with technology. But some elderly folks have totally embraced the internet too!So there you have it - a quick overview of how folks of all ages engage with the internet these days here in the UK. The internet has evolved into a huge part of everyday life for people young and old. But it's crazy to think that not so many years ago, none of this existed at all! I wonder what new technologies will take the internet's place years from now? I guess only time will tell. Thanks for reading, friends!篇2The Internet is Really Cool and Everyone Uses It!Hi friends! Today I want to tell you all about how people in the UK use the internet. The internet is this amazing thing that lets you talk to people anywhere in the world, play games, watch videos, and learn about any topic you can think of. It's really neat!Even little kids use the internet these days. Babies don't use it of course, but kids as young as 2 or 3 years old might usekid-friendly websites and apps to watch shows, play simplegames, and look at pictures and videos their parents show them. By age 5-7, a lot of kids are using tablets and computers to play more complex games, watch YouTube videos about their interests, and start learning to use search engines like Google to find information for school projects.Once kids get to be 8-11 years old, their internet use really takes off. At this age, having a smartphone, tablet or laptop becomes really important for keeping up with friends through messaging apps, playing online multiplayer games together, and sharing memes and TikTok videos. Kids this age spend a lot of time watching YouTube gamers, unboxing videos, and other entertainment content. They also start using internet resources more for schoolwork like researching topics and finding examples. But they still mainly use the internet for fun!Then we get to teenagers from 12-18 years old. Teens live on the internet, seriously! All their friends use social media like Instagram, Snapchat and TikTok constantly. They spend hours every day checking updates, reacting to posts, and staying in group chats. Teens also play a ton of online multiplayer games, both on games consoles and their phones/laptops. School assignments often involve online research, and some classes even take place online these days. Teens use the internet forpractically everything - finding directions, shopping, listening to music, checking movie times, and more. They're real experts!Once people get to be adults from 19-65, their internet use becomes a mix of work and personal. For their jobs, adults spend a lot of time sending emails, video calling, giving presentations, making spreadsheets, and writing reports - all using online tools. But they also do loads of personal stuff online like online banking, buying stuff from stores, booking travel, reading news sites, using social media, and streaming TV shows. The time adults spend online for work versus fun depends on their job.Older adults over 65 tend to go online a bit less than younger ages. But a lot of grandmas and grandpas do use the internet for things like video calling their families, getting neighborhood news and announcements from community websites, finding health information, reading e-books, and getting assistance from online resources. As time goes on, more and more older people get comfortable using the internet.No matter what age you are, the internet connects you to a huge world of information and people. From little kids watching nursery rhyme videos to grandparents reading the latest news, the internet is a big part of everyday life in the UK these days. It lets you learn new things, communicate easily, and have funexperiences you couldn't have any other way. While too much internet isn't good for you, using it in balance can really expand your world. What's your favorite way to use the internet?篇3The Internet is Awesome for Everyone!Hi friends! Today I want to tell you all about how people in the UK use the internet. It's really neat to see the different ways kids, teens, adults, and even grandparents go online. The internet connects us all!First up, let's talk about little kids like me. We use the internet mostly for fun and games. Our favorite websites have cool videos, puzzles, coloring pages and other activities. YouTube is hugely popular for watching toy unboxing videos and episodes of our favorite shows. Games like Roblox and Minecraft are a blast to play online with friends too.Older kids and teenagers are all about social media. Apps like TikTok, Snapchat and Instagram are where it's at. They use these apps to post videos and pics, chat with their friends, and hop on the latest trends. Teens spend hours every day scrolling and sharing memes or whatever silly stuff is viral at the moment. Their socials are their life!Of course, we have to use the internet for schoolwork and learning too. There are lots of educational websites and apps for doing research, reading books, watching video lessons and more. Personally, I like doing coding activities on and exploring virtual worlds on Google Earth. The internet opens up so many opportunities to learn in fun, interactive ways.Adults, especially those in their 20s and 30s, use the internet for pretty much everything - working, shopping, banking, finding info on hobbies and interests, you name it. A lot of them are really into online communities and forums for connecting with people who share niche interests like certain sports, types of music, or hobbies. Sites like Reddit, Facebook groups and specialized message boards are perfect for geeking out over that kind of stuff.Working adults depend on internet a ton for doing their jobs, especially if they work remotely from home. They use online productivity tools for video meetings, collaborating on documents and presentations, tracking projects and more. Some even have online stores or do freelance work through websites. The internet makes working flexible which is awesome.Then there are parents who couldn't survive without the internet! They use it for buying stuff their family needs likeclothes and groceries. They can read parenting tips and advice. And they can entertain restless kids by streaming shows and movies on services like Netflix, Hulu and Disney+. The internet is a lifesaver for moms and dads!My favorite internet users might be grandparents though. Seeing older people video chatting with their grandkids or great-grandkids who live far away is the cutest. Some grandpas and grandmas have really gotten good at social media too. They share old-timey memes, inspirational quotes and updates about gardening or latest cruise they went on. It's so fun seeing them embrace the online life.There are some downsides to the internet that we have to be aware of at any age though. We have to be careful about online predators trying to scam or mislead us, especially kids. Spending too much time staring at screens isn't healthy. And there's a lot of false information and inappropriate content out there that we need to verify and filter out.But overall, isn't the internet amazing? There's truly something for everyone online! I can't even imagine life without being able to connect to the world, learn about any topic, have services at my fingertips and be entertained endlessly. I'm so thankful for the internet and all the awesome ways we use it.What about you? How do you and your family use the internet? I'd love to hear all about it. Just log into our class message board and leave me a comment. Catch you online!篇4The Internet is Super Cool!Hi there! My name is Jamie and I'm 10 years old. I love using the internet - it's so much fun and you can do tons of awesome stuff online. Today I'm going to tell you all about how kids, teenagers, adults and even grandparents use the internet here in the UK. Get ready to be amazed!For little kids like my 6-year-old sister Katie, the internet is mostly for playing games and watching videos. She's obsessed with this YouTube channel called Little Baby Bum that has nursey rhymes and simple songs. It's pretty baby-ish if you ask me, but she thinks the cartoon characters are hilarious. She'll sit for hours watching the same videos over and over again. I have to admit some of the songs get stuck in my head too!Katie also loves playing games on websites like CBeebies and BBC Bitesize. The games teach you numbers, letters, colors and all that preschool stuff but in a really fun and interactive way.Using the internet helps little kids learn without even realizing it. Sneaky, huh?For bigger kids like me, we use the internet for games too but more advanced ones. I'm currently playing through an epic adventure game called Prodigy Math Game that's all about battling math monsters. You have to answer math questions correctly to win fights and go on quests. It makes practicing math way more fun than just doing boring worksheets.We also use the internet for school projects, looking up information on sites like Wikipedia and KidInfo. My best friend Lucas is a massive dinosaur nerd so he's always googling facts about different species. I'm more into science experiments - you can find so many awesome videos on YouTube showing you how to make a volcanic eruption with baking soda or grow colourful crystals. Who knew learning could be so cool?YouTubers are super popular too - people our age are obsessed with gamers like DanTDM, professionals players who live stream themselves playing games like Minecraft or Roblox. I'll admit I've watched a few too many YouTuber videos when I was supposed to be doing homework. Whoops!Teenagers are all about social media these days. Apps like Instagram, Snapchat and TikTok are a huge deal - you'rebasically a nobody at school if you don't have an account. Teens use socials to post selfies, share memes and stay up-to-date on the latest trends. They can spend literal hours scrolling through their feeds or making the perfect IG post. I don't get it myself, but apparently looking good online is super important when you're a teen.I've got an older sister in high school and she's always on her phone texting friends or scrolling on Twitter. She complains that I'm an annoying little bro but I think she's just addicted to her phone! Her generation is all about connecting through social apps and finding a sense of community online, even if actual human interaction suffers. It's a different world.Adults in their 20s, 30s and 40s seem to be more practical with the internet. They use it for work a lot - sending emails, updating spreadsheets, video conferencing and stuff like that. My dad is a financial consultant so he's always taking work calls over Zoom. It looks pretty boring to me but I guess it's important for his job.Online banking and shopping are major things for adults too. Instead of going to a physical store, they can just order everything from clothes to groceries to electronics with a few clicks. Amazon Prime is super popular - my parents get like 3packages delivered every week. It's so convenient but I can't imagine internet life without actually visiting real stores.Adults also use the internet to stream TV shows and movies on apps like Netflix and Hulu. My parents love binge watching intense dramas or true crime documentaries on the weekends. They can get through an entire season in just a day or two!As for grandparents and really old people, the internet is more of a novelty to them. A lot of seniors struggle with technology and computers in general. But some embrace it as a way to keep in touch with family through things like Facebook, FaceTime and WhatsApp.My Grandpa Frank is 78 and he is constantly messaging our family group chat with dad jokes and funny animal videos. He also uses Google to settle family arguments over trivia - he always has to be right about everything. Surfing the internet gives older people a way to stay connected to the world and continue learning as they age.The internet is such a huge part of modern life in the UK - it's wild how differently people of various ages use it. For the younger generation, it's all about entertainment, education and connecting with friends. For adults, it's about working remotely,shopping conveniently and accessing entertainment. And for seniors, it provides a social lifeline and way to satisfy curiosity.There are downsides too, like internet addiction or trustingbad information from dodgy websites. But overall, having the world at your fingertips through the internet is an amazing thing! I can't even imagine life without it. Who knows what awesome new ways we'll all be using the internet in the future? I can't wait to see!篇5The Internet is Awesome!Hey guys and gals! Today I want to tell you all about how people in the UK use the internet. It's really cool and fascinating stuff. The internet connects computers and phones and all sorts of devices together so we can share information, play games, watch videos, and much more. Pretty much everyone uses the internet these days, from little kids to grandmas and grandpas. But how they use it is a bit different depending on their age. Let me break it down for you!Little Kids (0-5 years old)The tiniest humans don't surf the web much themselves since they're just learning to use tablets and smartphones. But their parents definitely use the internet A LOT for them! Moms and dads google things like "best shows for toddlers" and look up nursery rhyme videos on YouTube to keep the little ones entertained. They also use apps to track feedings, nap times, and other baby stuff. My little baby cousin always gets her tablet time watching clay surprise egg videos - she loves those!Kid Kids (6-10 years old)This is where I come in! Kids my age are just starting to really use the internet on our own for schoolwork, games, and fun. We google stuff for research projects, use educational websites and games recommended by our teachers, and watch YouTube videos about our favorite toys and characters. Gaming is also huge for this age group - we can play online games, watch gamers on Twitch and YouTube, buy games on websites, etc. My favorites are Roblox and Minecraft! The internet is an amazing place for kids to learn and play.Teenage Chads (11-18 years old)Teenagers and the internet go together like peanut butter and jelly. Teens are online pretty much constantly - for school, entertainment, socializing with friends, and just looking uprandom stuff they're interested in. They live on social media apps like Instagram, Snapchat, and TikTok. They use tons of streaming sites for shows, movies, music, etc. And of course they play ALL the games - multi-player ones, mobile games, you name it. Teens use the internet way more than any other age group. It's their lifeline!Working Age Adults (19-65 years old)Once people get jobs, their internet usage is a bit different. They still use it for entertainment after work, but they spend most of their internet time doing work stuff. They send lots of emails, make video calls, use company networks and websites, and do all sorts of other professional tasks online. When they're not working, grown-ups also use the internet to pay bills, make appointments, shop for stuff, get news, find directions, and millions of other handy things. Oh and they also use social media to share pics of food and complain about their kids!Senior Citizens (65+ years old)Believe it or not, even really old people use the internet these days! More and more grandmas and grandpas are getting online, especially to keep in touch with family. They love video chatting with their grandkids and great-grandkids. They also google health information, get daily news updates, play mindgames, read e-books, and do plenty of other old person stuff. My own gran learned how to video call during lockdown and she's a total pro now. Some elderly folks are still a bit baffled by tech, but many are embracing the world wide web!So that's the scoop on how people of all ages are surfing the net these days. From babies to seniors, the internet has something for everyone in the UK. Watching videos, socializing, gaming, working, learning - we can do pretty much anything online now. The internet connects the world in the most amazing way and it just keeps evolving every year. I can't wait to see what online crazes and tech trends come next!篇6The Internet is Super Cool!Hi there! My name is Jamie and I'm 10 years old. Today I want to tell you all about how people in the UK use the internet. It's really fascinating stuff!Let's start with little kids like my baby sister Emma who is only 3 years old. You might be surprised to learn that even todddlers use the internet these days! Of course, they don't go surfing websites by themselves. But their parents will put on shows for them to watch on streaming services like Netflix orDisney+. There are also lots of learning apps and games for little ones to play on tablets and smartphones. My sister's favorite is one with singing animal puppets!Once kids get a bit older and start going to school, their internet use changes quite a bit. For primaryschool aged children from around 5 to 11 years old, the internet becomes a cool tool for learning and playing games. At school, we use online educational programs and websites for things like math, reading, science experiments and researching any topic you can imagine. It's so much more fun than just reading from a textbook!At home, we young kids love gaming websites and apps where you can play against friends or random players online. Some popular games are Roblox, Minecraft and Fortnite. We also watch tonnes of videos on YouTube, especially YouTubers who do silly stunts or tell funny stories. When I'm bored, I just hop on the internet and can find endless entertainment!As you get to be a teenager, using the internet becomes even more exciting and important. Teens around 12 to 18 years old use it for schoolwork of course, with online research and learning platforms. But they also spend a huge amount of time on social media apps like Instagram, Snapchat and TikTok. These apps are crazy popular for sharing photos and videos, keepingup with trends, and just chatting with friends online. I can't wait until I'm old enough to get my own accounts!Teens also use the internet for streaming TV shows and movies, downloading music, and even online shopping for clothes from their favorite brands. With all this usage though, parents do have to keep a close eye on what their teenagers are doing online to make sure they stay safe.Once people get to be adults, their time spent on the internet just keeps increasing. Young adults in their 20s and 30s use it for absolutelty everything - work, recreation, socializing, you name it. They are usually very active on social media, sharing updates about their lives, promoting their side hustles or small businesses, and joining interest-based groups.Lots of young adults are also big into online dating apps and meeting new people that way. Other popular uses are looking up information for hobbies, streaming entertainment, online banking, and ordering food or Shopping with just a few taps on a smartphone.In the middle ages of adulthood from 40 to 65 years old, the internet is relied upon even more for certain key purposes. Many in this age range use it heavily for work,videoconferencing, trading stocks or banking online. It's also a main source of news,weather updates, making travel plans, and getting medical information.While social media may drop off a bit compared to young adults, this age group definitely uses it to keep in touch with friends and family by sharing photos and updates. Some get really into special interest websites about hobbies like gardening, sports, or travel blogs. Overall though, adults in this age range treat the internet as a big resource for work, logistics and information.Finally, let's look at the oldest age group of senior citizens over 65 years old. You might assume they don't use the internet much, but you'd be wrong! While total usage does go down for this oldest group, a good percentage are definitely taking advantage of being online these days.Many seniors use video calling services like Skype or FaceTime to visit with kids and grandkids who live far away. They also rely a lot on the internet for things like reading news from trusted sources, getting medical information from serious sites, checking entertainment listings for local events, and even watching TV shows or movies through streaming services.Some savvy seniors have really embraced emailing, sharing photos, using online banking and shopping from big onlinestores. Others spend time in online communities or special interest groups, making new friends with similar hobbies. It does tend to depend on how familiar and comfortable each individual senior is with internet technology though.Well, that's my overview of how the internet is used by different ages here in the UK! From little kids watching learning videos, to teens staying trendy on social media, to adults using it for work and information, to seniors calling their grandchildren - the internet is pretty much everywhere in our lives.I can't even imagine what it will be like when I'm an adult or senior citizen myself with all the new cool websites, apps, and internet possibilities that will exist by then. I just know I'll be taking full advantage of being online no matter how old I am! The internet is amazing and has changed the way we live forever. Isn't technology awesome? Thanks for reading my essay!。
中国六十岁以上人口占比英语作文全文共5篇示例,供读者参考篇1China is a Big Country with Lots of Old PeopleChina has a really really big population. There are over 1.4 billion people living in China! That's way more people than any other country. China is so huge and there are Chinese people all over the place.But did you know that China also has a lot of really old people too? I'm talking about people who are over 60 years old. These are seniors, grandmas and grandpas, elderly folks. In China, we call them "lao ren" which just means "old people" in Chinese.There are around 260 million lao ren living in China right now. That's a absolutely massive number! It's almost as big as the entire population of the United States, which is around 330 million people. Imagine if almost everyone in America was over 60 years old. That's kind of what it's like in China with all the lao ren.260 million lao ren means that around 18.7% of the total population in China is over 60 years old. That's almost one out ofevery five people! It's a really really big percentage compared to other countries.For example, in the United States only around 16% of people are over 65. And in Japan it's around 28% over 65. So China has way more old people percentage-wise than America, but a little less than Japan. Japan is actually the "oldest" country in the world by percentage.But why does China have so many lao ren? Well, there are a few main reasons for it:Life expectancy in China has gone way up over the past few decades as the country has developed and gotten richer. These days, if you're a Chinese person born in the city, you can expect to live over 80 years on average! That's a pretty long life. So more and more Chinese people are living into their 60s, 70s, 80s and even 90s.China had a really strict "one child policy" for a long time where families were only allowed to have one kid. This policy lasted from 1980 to 2015. During those 35 years, way fewer babies were born in China compared to previous generations. Now all those adults who had just one kid are getting older and older with not as many young people to support them.China's birth rates have dropped a lot over the past few decades, even after the one child policy ended. These days, most Chinese families only have one or two kids at the very most. Fewer babies being born means the population is gradually getting older over time.So between longer life expectancy, the effects of the one child policy, and lower birth rates, China is graying very rapidly. It has a huge population of elders.This can create some challenges for China as a country though. With so many lao ren, China has to figure out how to take care of them all with pensions, healthcare, and other services for the elderly. Having lots of older people who are retired and no longer working can also slow down economic growth over time.But lao ren are also very respected in Chinese culture. We have a saying: "Raorendao, shengren dao" which means "where there are elderly people, there is a spiritual road." Grandmas and grandpas are very wise and experienced, so we cherish our time with them. Families look after each other across generations.Plus, elders in China today grew up during really tough times - wars, famines, the Cultural Revolution. But they workedincredibly hard and sacrificed a lot to help build the new China we see today. So we are grateful for everything they did.Having such a large elderly population definitely creates some difficulties. But it's also a sign of progress in many ways that so many Chinese people are living long lives now. I hope that when I'm a lao ren myself in 60 or 70 years, society will be taking good care of me too!Until then, I should practice my respect and appreciation for the millions and millions of lao ren who came before me. They helped get China to where it is today as a strong and prosperous nation. Thank you lao ren! Let's have some lao ren join us in class sometime so we can practice speaking to our elders properly.篇2The Big Old People Problem in ChinaHi! My name is Li Ming and I'm 10 years old. Today my teacher asked us to write about a big problem in China. I decided to write about how China has a lot of really old people now.China used to have a one-child policy for a long time. That means families could only have one kid. The government did this because they thought China had too many people. But now that policy is gone and people can have more babies again.The problem is that because of the one-child policy years ago, there are way more old people than kids being born these days. The people who could only have one baby back then are all grandpas and grandmas now. But they don't have very many grandkids!According to my research, in 2020 there were 264 million people aged 60 or older in China. That's almost 1 out of every 5 people! In some provinces, the percentage is even higher than 20%. Woah!By 2050, it's expected that over a third of Chinese people will be aged 60 and up. That's like if every class at my school only had 2 kids, but 8 grandmas and grandpas! Can you imagine? The chairs wouldn't even fit them!Having so many old people is a big challenge for China. How will we take care of all those grandmas and grandpas when they can't work or take care of themselves anymore? They'll need health care, nursing homes, pension money from the government, and helpers at home. But there won't be enough young people to do those jobs or pay the taxes for the pensions.It's a problem because of something called the "dependency ratio." That's the number of old people compared to the number of working age people. When the ratio is too high, it means thereare too many old folks and not enough workers to support them. Right now, China's dependency ratio is about 19 old people for every 100 workers. But by 2050 it could be 45 to 100! That's crazy!The solution is to have more babies, but Chinese families are still choosing to have fewer kids these days. Maybe it's because everything is so expensive - houses, education, food. Or maybe the young people just want to focus on their careers and personal lives. Whatever the reasons, not enough new babies are being born.If I was the president of China, I would find ways to encourage people to have more children. Like giving big tax breaks or paying money to families with more than one kid. I would also try to improve the day care and kindergarten systems, so it's easier for parents to work while raising multiple children. Building a great economy for the future of China is important, but people are the foundation. We need more young people!Taking care of the huge number of elderly people will be hard work. We'll need to build lots more nursing homes, hospitals, and recreation centers for the aged. Community volunteers of all ages should visit the grandpas and grandmas who are lonely. The government will have to spend tons ofmoney on their health care and living expenses too. Wow, it's a massive challenge!But China's old folks deserve respect and to be taken care of. After all, they are the ones who built modern China through their hard work over many decades. They survived tough times and made sacrifices so that the younger generations could have better lives. We owe them a debt of gratitude. Even if it's expensive and difficult, we have to figure out how to provide for their needs as they get really old.Still, I hope I don't have to be taking care of mygreat-great-grandparents when I'm an adult! By then, the number of elderly people will be absolutely ginormous. Perhaps science will find ways to extend health and lifespan. Or maybe we'll have robot care-takers by that point. Robotics is getting really advanced these days.In conclusion, China's rapidly aging population is a major demographic challenge that will put big pressures on the economy and society in the coming decades. With fewer working age people compared to elderly, it will be a struggle to provide decent living standards for all the gran篇3My Country is Getting Older!Hi there! My name is Xiaoming and I'm 10 years old. Today my teacher asked us to write about an important issue happening in China. I decided to write about how China is getting older because there are more and more old people!You might be wondering - what does that mean, that China is getting older? Well, it means that the percentage of people in China who are 60 years old and up is increasing. Back in 1950, only around 8% of people in China were 60 or older. But now in 2023, that number is almost 19%! That means almost one out of every five people in China is a senior citizen. Wild, right?There are a few big reasons why this is happening. First, people in China are living much longer lives than before. Thanks to better healthcare, nutrition, and living conditions, the average life expectancy in China has gone way up over the last few decades. When my grandparents were young in the 1950s, the average person in China only lived to be around 40 years old. But now, most Chinese people live into their late 70s! Lots of my friends even have great-grandparents who are in their 90s. Getting to be a very old age is becoming much more common.Another reason there are more elderly people in China is because of the one-child policy that was in place for a long time.From 1979 until 2015, most Chinese families were only allowed to have one child. This caused the birth rate to drop a lot for decades. With fewer babies being born each year, it makes sense that the percentage of older people went up over time. My mom was an only child, like many adults her age in China.Finally, China's large population is also a factor. Even though the percentage of seniors may not seem that high at 19%, China has so many people that it works out to a huge total number of elderly citizens. There are currently over 260 million people aged 60 and up living in China! That's almost as many people as the entire population of the United States. Woah!So what does it mean for China to have such a big population of older folks? Well, it creates some challenges for sure. The government has to make sure there are enough medical resources and care facilities for all the senior citizens who will need them as they get more frail. Building affordable nursing homes and training more doctors and nurses is important. China also has to make sure the pension system has enough money to pay out retirement funds to all the people who have finished working.But having a lot of elders in society isn't all bad - it means China also has a lot of experienced wise people! The elderly canshare their knowledge and life lessons with younger generations. Seniors are also revered in Chinese culture, andfilial piety towards one's parents and ancestors is considered very important. I always enjoy visiting my grandparents and hearing their stories about the old days.My grandpa loves telling me about how different life in China was when he was a kid back in the 1950s. He says they were very poor, and his childhood home didn't even have electricity or running water. His family grew all their own food in the fields. Can you imagine?? Grandpa had to walk for miles to get to the nearest school. I'm glad things have improved so much and life is easier for today's children.Even though China is facing the challenge of an aging population, I think it will be okay in the end. We are such an innovative, hard-working, and family-oriented nation. I'm sure we will find ways to take good care of our elders while still being productive and prosperous. Respecting and honoring seniors is a big part of our culture and values.Besides, in a few more decades, it will be my turn to be one of the old folks! I sure hope society treats me well when I'm a grandpa myself someday. Maybe things will be even more futuristic and amazing by then. I can't wait to see what China islike in 50 years. But for now, I better go call my grandparents and say hi! The end!篇4The Big Change in China's Older PopulationHi there! My name is Xiaoming and I'm a 10-year-old student in Beijing. Today I want to tell you about a really big change that is happening in my country, China. It's a change that will affect everyone, including kids like me!The change is that China is getting a lot more older people. I'm talking about people who are 60 years old and up. Right now, almost 1 out of every 5 people in China is over 60 years old. That's a huge number! And it's only going to keep growing in the coming years.When my grandparents were young, there weren't nearly as many older people in China. Back then, most people had several kids. So the young people far outnumbered the old people. But things are very different today.Nowadays, most families in China only have one child. Some have two kids, but not many have more than that. So we don't have as many young people being born compared to the past. At the same time, people are living much longer lives thanks tobetter food, health care and living conditions. That means the number of older folks just keeps going up and up!By the year 2050, it's expected that over 1 out of 3 people in China will be 60 or older. That's more than one billion senior citizens! Imagining having that many grandmas and grandpas is kind of mind-boggling for a kid like me.So why is having a huge elderly population such a big deal? Well, there are some good things and some challenging things about it.One good thing is that it means we Chinese really value and respect our elders. In our culture, we have a tradition of honoring and taking care of older family members. With so many seniors around, we'll have lots of wise grandparents to learn from and look after.Another positive is that many of the oldsters these days are staying healthy and active much later in life compared to the past. My own grandpa is 75 but he still goes climbing mountains and playing badminton regularly! With better health, seniors can keep working, volunteering and being productive members of society for longer.However, having such a huge elderly population will also create some big challenges for China. One of the biggest is how we'll be able to provide enough healthcare, retirement funds, nursing homes and other resources for all those seniors. Caring for so many old people will be very expensive!It will also put a lot of strain on the working-age population. There will be fewer young people in the workforce to support all the retirees. My parents已经说过,他们将在未来不得不支付更高的养老金和医疗费用税。
视听说Passage2Unit1In a perfect world, we would all avoid too much credit card debt and would never have to deal with the trouble of being unable to meet our credit card payment obligations. But this is not a perfect world, and unfortunately, these 1) distressing situations are the norm for many people.If you find yourself in this position, or heading there, you should cut your spending now. Don't wait until your situation is so 2) desperate that you have few options available to you.Facing the factors that give you the 3) urge to spend money carelessly can be uncomfortable, but if you don't face them, how will you control your debt and 4) acquire the things you truly want?One negative aspect of using credit cards instead of cash is that you 5) are totally unaware of the fact that you're spending real money. The pleasant feelings you experience when you purchase the item 6) are isolated from the unpleasant feelings of making the payment when you get the credit card statement.Studies 7) affirm that most people are much less likely to buy when paying with cash as opposed to credit cards. So, try leaving your credit cards at home, and pay with cash or check.To really control your spending and your credit card debt, you need to examine what money means to you. Make an effort to notice how you 8) interact with money and what beliefs and attitudes you have about money. Studies also show that people with low self-esteem engage themselves in more 9) impulse spending and buying things they don't need.Remind yourself daily that your worth as a person has nothing to do with how much money you have. Once you 10) are convinced of this, you will break the psychological barriers that were keeping you from handling your money wisely.Unit2Of all the threats to human society, including war, disease and natural disaster, one outranks all others. It is the aging of the human population. The 1) proportion of people aged 60-plus around the world is 2) estimated to more than double in 2050. By 2047, for the first time in human history, the number of old people is projected to exceed that of children on the planet.This change will 3) have profound impacts on human society. One problem concerns the ratio of the number of people of working age to the number of older people, which is known as the "4) potential support ratio". This index has fallen from 12 in 1950 to 8 in 2013 and is expected to drop to 4 in 2050. Its decline means that the burden on the young, 5) economically and socially, will rise accordingly. This is because older people rely on the young, not only for care and support but also for the economic productivity that ensures 6) pensions can be paid and health and social costs met.A variety of issues in other areas such as family composition, the transfer of property, taxation and housing may 7) originate from the population "age-quake", too. For instance, family ties have been weakened by increased mobility and rising divorce, and hence the demand for 8) residential and nursing homes will increase since more older people will need to live in an institution or elder care center.No matter what the future reality will be, the aging of the human population certainly 9) poses a challenge to policy makers, economists and health care specialists around the world. This suggests that the human society will need to 10) be transformed into a structure that has the ability and resources to address the diverse needs of older people.Unit3A solution may be at hand for holidaymakers who are struggling to find quiet, out-of-the-way places to go. For those who really want to get away from the crowded and much-traveled 1) resorts, they now find it possible because a new holiday destination has 2) sprung up –Antarctica. However, this new hotspot, or freezing zone, might only be for those who are fabulously rich if a new policy gets under way. Tourism on Antarctica has been increasing 3) dramatically, from a few thousand people in 1985 to more than 40,000 in 2007. The growing numbers are 4) having an adverse effect on the untouched environment of the South Pole. To 5) combat this, researchers from Holland's Maastricht University have come up with a sensible solution: Limit the number of tourists allowed to visit and hawk the vacations to those who are determined to go and are willing to offer higher amounts of money than others for the trip.Many environmental protection agencies agree that there is a need to protect the frozen 6) wilderness from the damage created by modern tourism. Antarctica is the last 7) unspoiled place on earth. It has a very delicate ecosystem that could be easily upset by 8) streams of tourists landing in airplanes and using skimobiles. A difficulty exists because Antarctica is not a country and therefore has no government to pass laws or 9) guidelines to control the number of visitors. The Maastricht University team's proposal to 10) auction off a fixed number of tourist places seems a workable solution. It would limit the number of visitors and therefore contain the amount of environmental damage, and the money would beused to protect Antarctica's future.Unit4In recent years, doctors have focused on the growing rate of diabetes among children and young people. But the most common kind of diabetes, type II, is more 1) prevalent as people grow older and gain more weight. Before you know it, there is more fat around the waist and hips than you remembered. The statistics are 2) scary enough to make you want to stop eating immediately.The World Health Organization says by 2015, more than two billion adults will be overweight and 700 million will 3) be classified as obese. Being overweight or obese is an expanding problem in many countries. Less physical activity and foods high in fat and sugar are considered as causes for this global 4) epidemic.Some researchers studied how body composition, the 5) ratio of lean tissue to fat, and increased weight affected the risk of diabetes in more than 4,000 adults, aged 65 and older.At the beginning of the study, none of the participants had been 6) diagnosed with diabetes. Researchers assess the relationship between being overweight and the disease through 7) keeping track of their body mass index.According to researchers, even among adults over the age of 75, having a higher body mass index 8) was still associated with a considerably higher risk of diabetes. Men who were obese had a five and a half times higher risk of diabetes than those who were just overweight. For women, the risk was about three and a half times higher.As hard as it might be, making sure your weight stays at a healthy level is the only way to keep the risk of diabetes down. The results 9) affirm the importance of weight control during the middle and later stages of life 10) in terms of reducing diabetes risks. The study has sent a warning signal to those who don't think that there is much connection between their waists and their health.Unit5Each January, the entertainment community and film fans around the world turn their attention to the Academy Awards, which are officially known as the Oscars. Interest and 1) anticipation builds to a fevered pitch leading up to the Oscar telecast in February, when hundreds of millions of film lovers tune in to watch the 2) glamorous ceremony and learn whom the highest honors in filmmaking will 3) be conferred upon.The Oscars reward the greatest cinema achievements of the previous year. There are up to 25 categories of awards for outstanding individual or 4) collective efforts. In each category, there are as many as five nominees determined by members of the relevant Academy branch. For instance, only film editors may 5) nominate for the Achievement in Film Editing Award. There are two categories standing as 6) exceptions to this rule, namely the Best Picture category, for which nominees are selected by the entire membership, and the Best Foreign Language films, which are chosen by a committee of members drawn from all branches.The members of the Academy are some of the world's most 7) accomplished motion picture artists and professionals. There are roughly 6,000 members, who vote for the Oscars using secret ballots. The results of the vote are kept in 8) absolute secrecy until the TV presenters open the envelopes and reveal the 9) recipients on live television. In addition to the regular annual awards presented by the membership, the Board of Governors, which is the governing body of the Academy, 10) is entitled to grant Scientific and Technical Awards, Special Achievement Awards and some other honors.As one of the highest honors in the film industry, the Oscars acknowledge excellence in filmmaking and carry great significance in the world of film.Unit6British tabloids provide their readers with an exciting mixture of gossip, entertainment and news. They 1) differentiate themselves from mainstream broadsheets by giving prominence to celebrities, sports and crime stories.No matter how many people 2) frown upon tabloid newspapers, it is a fact that the tabloids are popular and successful. The public has a demand for 3) concise news dose with minimum text and eye-catching pictures, and the tabloids are giving the readers just that. Here are some of the reasons why the British tabloids continue to enjoy popularity and success.First of all, the British tabloids 4) combat the new media wisely. Print media all over the world is facing 5) severe competition from the new media, be it the Internet or television, and no one 6) is geared up for the competition better than the tabloids. Most of the British tabloids have 7) embraced the new media instead of competing with them and hence have created e-versions or online editions of their daily tabloid editions.Second, the British tabloids are getting the format right. They have maintained a 8) compact format, which is rather convenient for the reader to pick up, read and carry. The text is short and 9) is supplemented with eye-catching pictures.The entire format stresses more on the visual appeal rather than the textual content.The British tabloids are proud of being what they are and accept that they are profit driven and aim for good business. The readers want 10) sensational news, and the tabloids have it. They do not compete with the serious newspapers, but rather carve a special market for themselves. In this way, they have earned a readership segment that is large enough to keep them going in the business.Unit7It is common knowledge that drug abuse leads to harmful consequences. Why then do people, particularly youngsters, continue to use drugs? Psychologists claim that there are three basic 1) motivations that influence people to take drugs: curiosity, stress and environmental factors. First, young people take drugs because they are curious, so they simply want to have a try. But the 2) hazard is that they don't know taking seemingly innocent drugs can 3) develop an appetite for stronger drugs later on. Secondly, young people take drugs because they are frustrated due to problems 4) associated with parents, school or the opposite sex. They want to escape from the stress caused by all these problems. Thirdly, the environment can also 5) contribute to drug-taking. If, for instance, a youngster belongs to a community, school, or peer group where other youngsters take drugs, he or she may soon be tempted to 6) follow suit, for fear of exclusion or non-acceptance.There is a growing 7) consensus among psychologists about the best possible approach to the problem of youngsters' addiction to drugs. They believe that school 8) authorities and social workers should work together to provide young people with much needed education on the dangers of drug abuse. Moreover, parents can do a great job in leading their children away from drugs by showing them attention, concern and love. Parents who always scream at their children and keep talking about their 9) inadequacies are regarded as likely drug pushers. A warm and happy family, where children get maximum encouragement and support, is most powerful against the attack of drugs. It is no 10) exaggeration to say that a happy home is a drug-free home.Unit8Almost forgotten these days, Mollie Panter-Downes' work provides a vivid impression of life in the Second World War.A Londoner by birth, Mollie Panter-Downes wrote for The New Yorker for about 50 years. In the 1930s, she sold the magazine a few poems, some short stories, and a piece about Jewish 1) refugee children coming to England. In 1939, with war approaching, Harold Ross, the editor of the magazine, was 2) desperate to find a London correspondent, and his fiction editor suggested Panter-Downes.Thereafter, she started to write for The New Yorker, specifically for a column 3) entitled "Letter from London" Weekly or fortnightly, Panter-Downes would put together a letter of about 1,500 words and had it cabled to New York. There it needed almost no editing because her writing was always concise.American readers 4) became informed of the war in England through Panter-Downes' letters. They read of the evacuation of pets as well as children, and the difficulties people 5) are confronted with, not just in terms of losses of ships and territory but also in terms of no food and hot-water bottles. The British temper found a splendid 6) spokesperson in Panter-Downes. She also desired to give voice to the people of all classes, and her willingness to 7) seek out working-class Londoners was evident in a report about a dustman's family in 1944.Panter-Downes went on writing "Letter from London" into the 1980s. She wrote reporter pieces and 8) profiles on such subjects as the British Museum and novelist E. M. Forster. Several of her books, for example Ooty Preserved (1967) and At the Pines (1971), largely appeared in The New Yorker. She 9) stayed loyal to the magazine for decades until 1985, not long after it was acquired by Samuel I. Newhouse, Jr. Today Panter-Downes is 10) virtually unknown in Britain. It seems a terrible shame to risk losing a writer who makes accurate yet subtle observations about human beings and how they deal with life.。
如何为老年人弥合数字鸿沟英语作文全文共3篇示例,供读者参考篇1Bridging the Digital Divide for the ElderlyIntroductionIn today's digital age, technology plays an increasingly important role in our daily lives. From online shopping to video calls, the internet has revolutionized the way we communicate, work, and access information. However, not everyone has the same level of access to and comfort with technology, and this is particularly true for the elderly. As a result, there is a growing concern about the digital divide that exists between older and younger generations. In this article, we will explore the reasons behind this gap and discuss some strategies for bridging it.Understanding the Digital DivideThe digital divide refers to the gap between those who have access to and can effectively use digital technologies and those who do not. While this divide can exist for various reasons, such as income level or geographic location, age is a significant factor. According to a report by the Pew Research Center, only 42% ofadults ages 65 and older own a smartphone, compared to 92% of adults ages 18 to 29. Additionally, older adults are less likely to use the internet for activities such as social networking, online banking, or accessing news.There are several reasons why older adults may struggle to embrace technology. Some may feel overwhelmed by the rapid pace of technological advancements and fear making mistakes. Others may lack confidence in their ability to learn new skills or worry about their privacy and security online. Additionally, physical limitations such as poor eyesight or arthritis can make using digital devices challenging.Strategies for Bridging the GapWhile the digital divide presents a significant challenge, there are several strategies that can help bridge the gap for older adults. These include:1. Providing access to technology: One of the first steps in bridging the digital divide is to ensure that older adults have access to the necessary devices and resources. This can include providing affordable internet access, offering computer and smartphone classes, and setting up community centers with technology for older adults to use.2. Making technology user-friendly: Technology companies can help bridge the gap by designing products that are intuitive and easy to use for older adults. Features such as large buttons, simple interfaces, and voice commands can make it easier for older adults to navigate digital devices.3. Offering training and support: Many older adults may benefit from training and support to help them feel more comfortable using technology. This can include one-on-one tutorials, group classes, or online resources. Additionally, providing ongoing technical support can help older adults troubleshoot issues and feel more confident in their abilities.4. Encouraging social connections: Technology can help older adults stay connected with friends and family, especially in today's world where in-person interactions may be limited. Encouraging older adults to use social media, video calls, or messaging apps can help reduce feelings of isolation and improve their overall well-being.5. Promoting online safety: Older adults may be more vulnerable to online scams and fraud due to their lack of experience with technology. Educating older adults about how to protect their personal information, identify phishing emails,and secure their devices can help prevent them from falling victim to online threats.ConclusionBridging the digital divide for older adults is crucial for ensuring that everyone can benefit from the advantages of technology. By providing access to technology, making devices user-friendly, offering training and support, encouraging social connections, and promoting online safety, we can help older adults navigate the digital world with confidence. Ultimately, bridging the digital gap will not only improve the quality of life for older adults but also strengthen intergenerational connections and create a more inclusive society.篇2Bridging the Digital Divide for the ElderlyIntroductionAs technology continues to advance at a rapid pace, the digital divide between generations has become a pressing issue. While younger generations are quick to adapt to new technologies, many older individuals struggle to keep up with the digital world. This divide not only hinders older adults from fully participating in modern society, but also isolates them fromimportant resources and services that are increasingly moving online. In this essay, we will explore the importance of bridging the digital gap for the elderly and provide strategies to help seniors become more tech-savvy.Importance of Bridging the Digital DivideThe digital world plays a crucial role in our daily lives, from communication and information access to online shopping and entertainment. For older adults who may not be familiar with technology, the digital divide can lead to feelings of isolation, exclusion, and disempowerment. Moreover, as more services and resources are being offered online, such as healthcare, banking, and government services, seniors who are not proficient in using technology may be left behind.Bridging the digital gap for the elderly is essential for promoting social inclusion, enhancing quality of life, and ensuring equal access to important resources and services. By empowering older adults to navigate the digital world, we can help them stay connected with their loved ones, access vital information, and take advantage of online services that can improve their well-being.Strategies to Help Seniors Become More Tech-Savvy1. Digital Literacy Training Programs: One of the most effective ways to help seniors bridge the digital gap is by providing digital literacy training programs. These programs should be tailored to the specific needs and interests of older adults, teaching them basic computer skills, internet browsing, email communication, online safety, and how to use popular applications and services.2. One-on-One Support: Many seniors may feel overwhelmed by technology and may be hesitant to ask for help in a group setting. Providing one-on-one support from volunteers or tech-savvy individuals can help older adults feel more comfortable and confident in using technology. These mentors can offer personalized assistance, answer questions, and provide guidance on how to use different devices and applications.3. User-Friendly Devices and Interfaces: Technology companies should design devices and interfaces that areuser-friendly and accessible for older adults. This includes larger fonts, simple layout designs, intuitive navigation, andvoice-activated commands. By making technology moreuser-friendly for seniors, we can help them overcome barriers and feel more empowered to use digital tools.4. Community Centers and Senior Centers: Community centers and senior centers can play a crucial role in bridging the digital gap for the elderly. These centers can offer technology workshops, computer labs, and access to devices and internet connectivity. They can also create a supportive and social environment where seniors can learn from each other, share experiences, and build confidence in using technology.5. Intergenerational Programs: Intergenerational programs that bring together older adults and younger generations can help bridge the digital gap and foster mutual learning and understanding. Younger individuals can share their knowledge and expertise in technology with older adults, while seniors can offer wisdom, experience, and valuable insights. These programs can create meaningful connections across generations and promote digital literacy for all ages.ConclusionBridging the digital divide for the elderly is a crucial step towards promoting social inclusion, enhancing quality of life, and ensuring equal access to important resources and services. By providing digital literacy training programs, one-on-one support, user-friendly devices and interfaces, community resources, and intergenerational programs, we can help seniors become moretech-savvy and empowered in the digital world. It is essential that we work together to create a more inclusive and accessible digital environment for older adults, so that they can fully participate in modern society and enjoy the benefits of technology.篇3Bridging the Digital Divide for the ElderlyIntroductionIn today's digital age, technology is deeply integrated into every aspect of our lives. From communication to shopping, from entertainment to education, technology has transformed the way we live and work. However, there is a growing concern about the digital divide, especially among the elderly population. Many older adults struggle to adapt to the fast-paced changes in technology, leaving them isolated and at a disadvantage in a digitally driven world. In this article, we will explore the ways in which we can bridge the digital gap for the elderly and empower them to navigate the digital landscape with confidence.Understanding the ChallengesBefore we can address the issue of the digital divide, it is important to understand the specific challenges that the elderlyface when it comes to technology. Some common barriers include:1. Lack of Access: Many older adults do not have access to the internet or devices such as smartphones, tablets, or computers.2. Fear of Technology: Older adults may feel overwhelmed or intimidated by new technology, leading to a reluctance to learn how to use it.3. Cognitive Decline: As people age, they may experience cognitive decline, making it more difficult to learn new skills or remember how to use technology.4. Lack of Digital Literacy: Older adults may not have the digital literacy skills needed to navigate the internet, use social media, or online banking.Bridging the DivideFortunately, there are several ways in which we can help older adults bridge the digital divide and become more comfortable with technology:1. Technology Training Programs: Organizations and community centers can offer technology training programs specifically designed for older adults. These programs can coverbasic skills such as how to use a smartphone, send an email, or browse the internet.2. One-on-One Support: Providing one-on-one support to older adults can help them feel more comfortable and confident with technology. Volunteers or family members can offer personalized assistance and guidance.3. Simplifying Technology: Companies can design technology with older adults in mind by making interfaces more user-friendly and intuitive. This can include larger text, clearer icons, and simple navigation.4. Community Engagement: Encouraging older adults to engage with technology in a social setting can help reduce feelings of isolation and build confidence. This can include social media groups, online games, or virtual chats with friends and family.5. Continuous Learning: Technology is constantly evolving, so it is important for older adults to continue learning and adapting to new advancements. Online tutorials, workshops, and classes can help older adults stay up-to-date with the latest technology trends.ConclusionBridging the digital divide for the elderly is essential in today's digital world. By providing access to technology, offering training and support, and creating a more inclusive anduser-friendly digital environment, we can empower older adults to embrace technology and enjoy the many benefits it has to offer. Together, we can ensure that no one is left behind in the digital age.。
2024年江苏省扬州市中考英语考前模拟测试注意事项:1.全卷满分120分。
考试时间为100分钟。
试题包含选择题和非选择题。
考生答题全部答在答题卡上,答在本试卷上无效。
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如需改动,请用橡皮擦干净后,再选涂其他答案。
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第I卷(选择题共60分)一、单项选择(本题共15小题;每题1分,满分15分)在下列各题A、B、C、D四个选项中选择一个能填入题干空白处的最佳答案。
1.—________great progress Li Ming has made during the past few weeks!—Yes.That’s all because of his hard work.A.What a B.How a C.What D.How2.The astronauts of Shenzhou-18manned spaceship entered China’s space station early________April26,2024.A.in B.at C.on D.to3.The course of life never runs smoothly________it is full of ups and downs.A.though B.since C.while D.unless4.—Which of the two books will you take?—I’ll take________,science book interests me while comic book makes me relaxed.A.both B.neither C.all D.none5.What a pity!________,I believe you will succeed someday!A.Instead B.Moreover C.Anyway D.Otherwise6.—What a pity!A4-year-old boy was hit by a truck when playing by the road.—I agree that,to parents,children’s safety________be paid too much attention to.A.mustn’t B.can’t C.needn’t D.shouldn’t7.The novel was so attractive that he read it for hours________he realized it.A.before B.after C.while D.as soon as8.Lucy is not so quick,but she has a good habit of working hard,it is like a hidden________ A.tradition B.treasure C.competition D.influence9.Students should be________to form good working habits through labour education.A.forced B.encouraged C.warned D.promised10.Physical work plays an important role in developing students’view of the world and life.That’s why we need to________labour education at school.A.work on B.work out C.carry on D.carry out11.—Why are you so angry?—Look!Someone has________my parking space.A.put up B.taken up C.stayed up D.turned up12.Nearly________of the task________completed by us.We worked closely.A.three-fifth;was B.three-fifths;wasC.third-fifths;were D.third-fifth;were13.—I’ve just heard that Jackie achieved high grades in the Maths exam.—That’s no surprise.He is________,you know.A.a dark horse B.a green hand C.an early bird D.a wet blanket14.—Come on,Cathy.Just________.Nothing can beat me.—Well,to tell you the truth,you’re laid off(解雇).A.be brave B.take your time C.come to the point D.be confident15.—Paris Olympic Games will take place in July,2024.The organizer has announced________.—Oh,on the River Seine.At least600,000viewers can attend it.A.where will the opening ceremony be heldB.where the opening ceremony will be heldC.when viewers would attend the opening ceremonyD.when viewers will attend the opening ceremony二、完形填空(共15小题:每小题1分,计15分)阅读下面短文,从文后各题所给的A、B、C、D四个选项中选出一个最佳答案。
年轻与年老优缺点英语作文Here is an English essay on the pros and cons of being young and old, with the content exceeding 1,000 words as requested. The title is not included in the word count.The Pros and Cons of Being Young and OldAs we go through life, we experience different stages, each with its own unique advantages and disadvantages. The contrast between being young and old is particularly stark, with both stages offering distinct benefits and challenges. In this essay, we will explore the pros and cons of being young and old, shedding light on the complexities and nuances of these two pivotal phases of life.The Advantages of Being YoungOne of the primary advantages of being young is the abundance of energy and vitality. Young people often possess a boundless enthusiasm and a zest for life that can be truly inspiring. They are typically brimming with physical strength, endurance, and the ability to recover quickly from illness or injury. This youthful vigor allows them to engage in a wide range of activities, from sports andoutdoor adventures to physically demanding work, with relative ease.Another significant advantage of being young is the flexibility and adaptability that often comes with this stage of life. Young people are generally more open to new experiences, more willing to take risks, and more receptive to learning and personal growth. This adaptability can be particularly valuable in a rapidly changing world, where the ability to embrace change and acquire new skills is increasingly important.Moreover, young people tend to have a greater sense of freedom and independence. They are often unencumbered by the responsibilities and obligations that often come with adulthood, such as mortgages, careers, and family commitments. This freedom can provide young people with the opportunity to explore their passions, pursue their dreams, and discover their true selves without the constraints of heavy responsibilities.The Disadvantages of Being YoungWhile being young offers numerous advantages, it is not without its drawbacks. One of the primary challenges faced by young people is the lack of experience and wisdom that often comes with age. Young individuals may find themselves ill-equipped to navigate the complexities of life, make informed decisions, or handle difficultsituations that require a deeper understanding of the world.Another potential disadvantage of being young is the tendency towards impulsiveness and recklessness. Young people may be more prone to making hasty decisions, taking unnecessary risks, or engaging in behaviors that could have long-term consequences. This lack of foresight and maturity can sometimes lead to regrettable outcomes, both personal and professional.Furthermore, young people may face financial challenges and instability. Many young adults are still in the process of establishing their careers, building their savings, and gaining financial independence. This can create a sense of uncertainty and stress, as they navigate the often-daunting task of managing their finances and securing their economic future.The Advantages of Being OldAs we age, we often gain a wealth of experience, knowledge, and wisdom that can be invaluable. Older individuals have typically navigated a wide range of life experiences, from personal relationships to professional challenges, and have developed a deeper understanding of the world around them. This accumulated wisdom can be a tremendous asset, allowing them to make more informed decisions, provide guidance to younger generations, andnavigate life's complexities with a greater degree of confidence and resilience.Another advantage of being old is the increased sense of emotional maturity and stability. Older individuals often have a better grasp on managing their emotions, dealing with stress, and maintaining a balanced perspective on life's ups and downs. This emotional intelligence can be a valuable resource, not only for the individual but also for those around them who may seek their counsel and support.Additionally, older adults may have more financial stability and security, having had the time to build up savings, investments, and a stable source of income, such as pensions or retirement benefits. This financial security can provide a sense of comfort and the ability to enjoy the later stages of life without the constant worry of financial instability.The Disadvantages of Being OldWhile being old offers many advantages, it is not without its challenges. One of the primary disadvantages of being old is the potential decline in physical health and mobility. As we age, our bodies may become more susceptible to various ailments, chronic conditions, and a gradual loss of physical capabilities. This can limitthe ability to engage in activities that were once taken for granted, potentially leading to a diminished quality of life and a sense of frustration or loss of independence.Another disadvantage of being old is the potential for social isolation and loneliness. As we age, we may lose friends and loved ones, and our social circles may shrink. This can be particularly challenging for older adults who may have difficulty making new connections or maintaining existing relationships due to physical or cognitive limitations. The feeling of isolation and disconnection can have a profound impact on mental health and overall well-being.Furthermore, older adults may face the challenge of adapting to a rapidly changing world. Technology, social norms, and cultural shifts can sometimes outpace the ability of older individuals to keep up, leading to a sense of disconnect and a feeling of being left behind. This can be particularly true in the digital age, where the pace of technological advancement can be dizzying for those who did not grow up with these tools.In conclusion, the pros and cons of being young and old are multifaceted and complex. While being young offers the advantages of energy, adaptability, and freedom, it also presents challenges in terms of inexperience and impulsiveness. Conversely, being old provides the benefits of wisdom, emotional maturity, and financialstability, but also the potential drawbacks of declining physical health and social isolation. Ultimately, each stage of life has its own unique set of advantages and disadvantages, and the key is to embrace the strengths and navigate the challenges of whichever phase of life we find ourselves in.。
Adults65Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion ProteinAnu Cherukuri,a Kathryn Patton,a Robert A.Gasser,Jr.,b Fengrong Zuo,a Jennifer Woo,a Mark T.Esser,c Roderick S.Tang aInfectious Diseases/Vaccines Research,MedImmune,LLC,Mountain View,California,USA a;Clinical Development,MedImmune,LLC,Gaithersburg,Maryland,USA b; Translational Sciences,MedImmune,LLC,Gaithersburg,Maryland,USA cRespiratory syncytial virus(RSV)infects elderly(>65years)adults,causing medically attended illness and hospitalizations. While RSV neutralizing antibody levels correlate inversely with RSV-associated hospitalization in the elderly,the role of RSV-specific T cells in preventing disease in the elderly remains unclear.We examined RSV-specific humoral,mucosal,and cellular immune profiles in healthy elderly(65to85years)and young(20to30years)adults.RSV neutralization antibody titers in the elderly(10.5؎2.2log2)and young(10.5؎2.1log2)were similar.In contrast,levels of RSV F protein-specific gamma interferon (IFN-␥)-producing T cells were lower in elderly(180؎80spot-forming cells[SFC]/106peripheral blood mononuclear cells [PBMC])than in young adults(1,250؎420SFC/106PBMC).Higher levels of interleukin-13(IL-13;3,000؎1,000pg/ml)in cul-tured PBMC supernatants and lower frequency of RSV F-specific CD107a؉CD8؉T cells(3.0%؎1.6%versus5.0%؎1.6%) were measured in PBMC from elderly than young adults.These results suggest that deficient RSV F-specific T cell responses con-tribute to susceptibility to severe RSV disease in elderly adults.R espiratory syncytial virus(RSV)causes annual outbreaks of respiratory disease.In North America and western Europe, these outbreaks are seasonal,occurring in winter and lasting for about4months.While the high global disease burden of RSV in young children and infants is well documented(1–5),the epide-miology of RSV illness in elderly adults is less well defined.Data from a variety of studies(6–14)suggest that in U.S.adults over65 years of age,the overall annual incidence of RSV illness isϳ3to 4%,with an estimated annual RSV-associated hospitalization rate ofϳ0.1to0.4%and an estimated10,000RSV-associated deaths per year(Table1).The immune correlates associated with increased susceptibility to severe RSV illness in the elderly are not well understood.Serum anti-RSV neutralizing antibody titers have been reported to in-versely correlate with an increased risk of RSV-associated hospi-talizations in the elderly(15).Other studies have found that the RSV-specific memory CD8ϩT cells are reduced in the peripheral blood of healthy elderly adults(16,17),and that a switch from a CD4ϩTh1to a Th2functional phenotype occurs with age(17). One report suggested that aging is associated with a defect in T cell responses to RSV,and this defect in cellular immunity is related to RSV disease susceptibility in older adults(18).These studies sug-gest that either waning RSV-specific neutralizing antibodies or declining cell-mediated immunity,or a combination of both,con-tribute to the greater severity of RSV disease in elderly compared to young adults.Our immune profiling studies revealed that plasma from healthy young and elderly adults had comparably high RSV neu-tralizing antibody titers.However,RSV F protein-specific mem-ory CD4ϩand CD8ϩT cell responses were significantly lower in the elderly than young donors,suggesting that deficient RSV F-specific T cell responses contribute to susceptibility to severe RSV disease in this population.Further characterization of RSV-spe-cific immune deficits in the elderly may help elucidate the under-lying mechanisms mediating protection against severe RSV dis-ease,thereby facilitating the design and development of RSV vaccines for the elderly.MATERIALS AND METHODSStudy cohort.Thirty young adults who were20to30years old(median age,26years)and30elderly individuals who were65to85years old (median age,74years)were enrolled.All subjects were healthy and free of respiratory illness and had no hospitalization episodes for a2-month pe-riod prior to sample collection by SeraCare Life Sciences,Inc.(Milford, MA),and Bioreclamation(Hicksville,NY).Informed consents given by all subjects were approved by Bioreclamation’s Independent Institutional Review Board.Since the amount of available peripheral blood mononu-clear cells(PBMC)was insufficient to perform every assay on every donor sample,we used the indicated number of donor samples in each assay to enable reasonable comparisons between the age cohorts.The subjects’demographic characteristics and the number and type of samples assessed in each immunological assay are shown in Table2.Specimen collection and processing.All specimens(whole blood, plasma,and nasal washes)were collected between the months of May and July and transported at ambient temperature to the processing site within 2h of sample draw.PBMC were isolated from fresh whole blood using serum-free medium conditions,and frozen PBMC were placed atϪ80°C overnight before being transferred to liquid nitrogen for storage.Samples were shipped overnight on dry ice to MedImmune within2weeks of freezing and were thawed for enzyme-linked immunosorbent spot (ELISPOT)assay evaluation within3days of arrival.Plasma and nasal wash samples were aliquoted into1-ml cryovials(Thermo Scientific, Rochester,NY)and frozen atϪ80°C at the processing site within2h of collection.Samples were shipped overnight on dry ice to MedImmune within2weeks of freezing and were thawed for evaluation within1week of arrival.RSV antigens.The soluble fusion F protein of RSV A2was expressed in Chinese hamster ovary(CHO)cells and immunoaffinity purified with Received3October2012Returned for modification8November2012Accepted3December2012Published ahead of print12December2012Address correspondence to Anu Cherukuri,PattonK@.Copyright©2013,American Society for Microbiology.All Rights Reserved.doi:10.1128/CVI.00580-12February2013Volume20Number2Clinical and Vaccine Immunology p.239–239an anti-RSV F monoclonal antibody(palivizumab;MedImmune,Gaith-ersburg,MD)toϾ95%purity.The sequence of the soluble RSV F protein lacking the transmembrane and cytoplasmic tail has been previously de-scribed(19).Wild-type(wt)RSV A2and recombinant greenfluorescent protein(GFP)-tagged RSV A2were produced in Vero cells.RSV F-specific CD4ϩand CD8ϩT cell immunodominant peptides described elsewhere (20–23)were custom designed and ordered atϾ90%purity from ProImmune(Oxford,United Kingdom).Although the major histocom-patibility complex(MHC)restriction of some of the peptides in the pools was unknown,we utilized the information available in the published re-ports(20–23)to optimize our RSV F-specific CD4ϩand CD8ϩT cell peptide pools for use in ELISPOT and cytokine multiplex assays.RSV microneutralization assay.Donor plasma samples were heat in-activated at56°C and serially diluted2-fold in growth medium.Equal volumes of the diluted plasma were mixed with GFP-tagged RSV A2virus at a concentration of500PFU/well.Samples were preincubated at33°C for1h to facilitate antibody neutralization of the GFP-tagged RSV A2 virus.Samples were used to infect confluent monolayers of Vero cells (ATCC,Manassas,VA),and the cell plates were incubated at33°C for22 h.Fluorescent viral foci were enumerated using an IsoCyte Reader(Blue-shift Biotechnologies,Sunnyvale,CA),and a50%reduction influorescent viral foci was calculated using a4-parameter curve-fit algorithm.Data were expressed as log2neutralization titers.RSV F-specific IgG by ELISA.RSV F-specific IgG antibody titers in plasma were measured by enzyme-linked immunosorbent assay(ELISA). The plasma samples were serially diluted2-fold and incubated on RSV F-coated plates for1h at37°C.Horseradish peroxidase(HRP)-conju-gated goat anti-human IgG antibody(Jackson ImmunoResearch,West Grove,PA)was diluted1:20,000and incubated with the samples for1h at 37°C.Titers were reported as endpoint titers.RSV F-specific nasal wash IgA.Nasal wash samples were prediluted 1:4in matrix inhibition buffer(MIB),which contains bovine serum albu-min(BSA),polysorbate20,EDTA,3-[(3-cholamidopropyl)-dimethyl-ammonio]-1-propanesulfonate,and NaCl in phosphate-buffered saline (PBS),followed by a1:3serial dilution in MIB into duplicate wells of a 96-well plate coated with0.4g/ml RSV F or0.2g/ml purified goat anti-human IgAϩIgGϩIgM(HϩL)(KPL,Gaithersburg,MD).A pooled human reference plasma standard(AllCells,LLC,Emeryville,CA)was included on each plate for comparison,and all plates were incubated for1 h.A SulfoTag-labeled goat anti-human IgA antibody(Jackson Immu-noResearch,West Grove,PA)was added to the plates at a1:2,000dilution in MIB,and plates were incubated at37°C for1h.After afinal plate wash, the MSD read buffer(Meso Scale Discovery,Gaithersburg,MD)was added,and the plates were imaged using the MSD Sector Imager6000. The RSV F-specific and total IgA endpoint titers were calculated using SoftMax Pro.The total protein concentration in the nasal wash samples was determined using the Pierce BCA(bicinchoninic acid)assay kit (Thermo Scientific,Rockford,IL).Memory B cell expansion and RSV F-specific ELISPOT assay.Pe-ripheral blood mononuclear cells(PBMC)were stimulated using a poly-clonal stimulation cocktail containing pokeweed mitogen(Sigma-Al-drich,St.Louis,MO),S.aureus strain Cowan protein A(Sigma-Aldrich), and CpG oligonucleotide(ODN2006;InvivoGen,San Diego,CA)for5 days at37°C as described previously(24).Unstimulated PBMC served as the negative control.Expanded memory B cells were incubated in ELISPOT plates(Millipore,Billerica,MA)coated with10g/ml RSV F or goat anti-human IgAϩIgGϩIgM antibody(KPL,Gaithersburg,MD)to detect antigen-specific antibody-secreting cells(ASC)or total IgG/IgA-producing ASC,respectively.Spots were enumerated using an Immuno-Spot analyzer(Cellular Technologies Ltd.,Cleveland,OH).RSV-F-specific IFN-␥ELISPOT assay.Human gamma interferon(IFN-␥)ELISPOT kits containing anti-IFN-␥-precoated plates and anti-IFN-␥detection antibodies were purchased from Mabtech,Inc.(Mari-emont,OH),and the assay was carried out per the manufacturer’s instruc-tions.PBMC were incubated for24h at37°C on the ELISPOT platestogether with wt RSV A2virus(1PFU/10cells)or5g/ml of RSV F or2g/ml of RSV F-specific CD4ϩ/CD8ϩT cell peptide pools(ProImmune, Oxford,United Kingdom).The peptide pools were custom designed asdescribed in the review by Olson and Varga to represent12CD8ϩT cellepitopes and21CD4ϩT cell epitopes of RSV F,respectively(21).Cellsincubated with CTL-test medium(Cellular Technology Ltd.,Cleveland,OH)or phorbol12-myristate13-acetate(PMA)and ionomycin(Sigma,St.Louis,MO)served as the negative and positive controls,respectively.Data were expressed as spot-forming cells(SFC)/106PBMC after back-ground subtraction of medium wells to indicate a positive response.Validsamples were defined as those with viabilities ofՆ70%,medium back-ground ofՅ50SFC/106PBMC,and PMA/ionomycin response ofՆ500SFC/106PBMC.Th1/Th2cytokine profiling by Luminex.PBMC were incubated with5g/ml of RSV F for72h.Medium alone or PMA with ionomycin stim-ulation served as the negative and positive control for each sample,respec-tively.Human cytokine multiplex kits were custom designed to includeIFN-␥,interleukin-2(IL-2),IL-4,IL-5,IL-10,IL-12(p70),IL-13,IL-17,IP-10,and tumor necrosis factor alpha(TNF-␣;Millipore,Billerica,MA).The assay was performed per the manufacturer’s instructions.The culturesupernatants were analyzed on a Bio-Rad BioPlex2200(Bio-Rad,Hercu-les,CA),and cytokine concentrations are expressed in pg/ml.CD107a expression on CD8؉T cells.Donor samples that were testedin the IFN-␥ELISPOT assay were also stained for CD107a expressionfollowing RSV F-specific stimulation.Cells were incubated with5g/mlof RSV F or2g/ml of RSV F-specific CD8ϩT cell peptide pool for8h.Phycoerythrin(PE)-labeled CD107a or isotype control(BD Biosciences,San Jose,CA)antibody was added to the wells.Four hours later,0.5g/mlof the Golgi plug,brefeldin A(BD Biosciences,San Jose,CA),was addedfor the last8h of incubation.Medium alone or PMA with ionomycin-treated cells served as the negative and positive controls,respectively.Cellswere surface stained with an antibody cocktail(BD Biosciences)to labelCD3,CD8,CD19,and CD56for30min.Cells werefixed,permeabilized,and incubated with PE-labeled CD107a or isotype control antibody for30min.All antibody incubations were carried out at4°C.Samples were an-alyzed on a FACS Canto(BD Biosciences),and data are expressed aspercent CD107aϩCD8ϩT cells,fold change relative to the medium,andmeanfluorescence intensity(MFI).Statistical analysis.The Pearson’s correlation coefficient was used tomeasure the strength of the correlation between the different serologicaland cellular markers evaluated in the study cohorts.Statistical significanceof the difference in the means between the young and elderly IFN-␥SFC/106PBMC was determined using analysis of variance(ANOVA)and thetwo-sample t test.RESULTSYoung and elderly adults have comparable titers of neutralizing antibodies to RSV.To determine whether the higher incidence of severe RSV disease in the elderly was related to the neutralizing antibody titers against RSV,wefirst examined RSV neutralizing antibody levels in plasma from30healthy young versus30elderly adults.Neutralizing antibody titers to RSV were determined using a microneutralization assay to a GFP-RSV A2virus.The distribu-tion range of the GFP-RSV A2virus-specific neutralizing antibody titers across donors in the two cohorts demonstrated that the ma-jority of the donors had RSV neutralizing antibody titers between 10and12log2,with the elderly cohort showing slightly higherTABLE1RSV epidemiology in U.S.elderly(Ն65years)Parameter Incidence rate(%)Total no.of cases aRSV illnesses/yearϳ30/1,000(ϳ3)ϳ1,200,000RSV medically attended illnesses/yearϳ10/1,000(ϳ1)ϳ420,000RSV-associated hospitalizations/yearϳ1.5/1,000(ϳ0.15)ϳ45,000–50,000RSV-associated deaths/yearϳ0.25/1,000(ϳ0.025)ϳ10,000a Total cases based on a U.S.population ofϳ40,000,000elderly,i.e.,Ն65years of age.Cherukuri et al. Clinical and Vaccine Immunologynumbers of donors with titers between12and15log2(Fig.1A).An average neutralizing antibody titer of10.5Ϯ2.2log2was ob-served in both cohorts.Since neutralizing antibody titers can include antibodies toboth RSV F and G proteins,we next examined whether therewere measurable differences in the RSV F-specific IgG titersbetween the young and elderly donors.The young and elderlydonors also had equivalent titers of RSV F-specific plasma IgGantibodies(Fig.1B),and there was a strong correlation(r2ϭ0.855)between RSV A2neutralizing antibody and RSV F-spe-cific IgG titers(Fig.1C).Presence of RSV F-specific nasal IgAantibodies has been associated with protection from severeRSV disease in the elderly;therefore,we compared RSV F-spe-cific IgA titers in the nasal washes of the young and elderlydonors(Fig.1D).We also measured the total IgA and proteinconcentration levels(data not shown)in the nasal washes anddid notfind significant differences between the young and el-derly samples.Importantly,the RSV F-specific IgA titers wereequivalent between the young and elderly donors(Fig.1D),suggesting that other deficits in the immune system account forsusceptibility to RSV disease in the elderly.RSV F-specific memory B cell frequencies are comparable in the young and elderly.We next explored the RSV F-specific memory B cell frequency in PBMC to determine if there were quantitative differences between young and elderly donors. Young adults showed an RSV F-specific IgG ASC frequency rang-ing from0.05to0.5%of the total IgG ASC,whereas elderly adults showed an RSV F-specific IgG ASC frequency ranging from0to 0.68%of the total IgG ASC frequency(Fig.2).The difference in the frequency of RSV F-specific IgG ASC between the two cohorts as calculated by the unpaired t test was not statistically significant (Pϭ0.2413).However,an overall trend of reduced RSV F-specific memory B cell frequency in the elderly was noted,except for two donors that possessed relatively high F-specific memory IgG ASC frequency(Fig.2).Taken together,these data indicated that the elderly were not deficient in neutralizing antibody titers or RSV F-specific memory B cell responses.Elderly adults have lower levels of RSV F-specific IFN-␥-pro-ducing cells than young adults.We decided to evaluate whether RSV F-specific memory T cell responses would be significantly different between the young and elderly.Findings on the fre-quency of RSV F-specific T cell immune responses in PBMC fromTABLE2Demographic characteristics of the study cohort and assays performedDemographic or assay parameter Demographic or assay result by ageP value 20–30yr old(young)65–85yr old(elderly)DemographicsAge(yr;medianϮSD)26Ϯ374Ϯ6Ͻ0.0001 Age(yr;range)20–3065–85Gender(no.[%])Male14(46.7)12(40)0.6021 Female16(53.3)18(60)0.6020 Race(no.[%])Caucasian8(26.7)7(23.3)0.3903 Hispanic11(36.7)7(23.3)0.4196 African-American11(36.7)16(53.3)0.2776 Assay parameters[meanϮSD(no.of samples/assay)]SamplePlasmaRSV neutralization(log2titer)10.5Ϯ2.2(30)10.5Ϯ2.1(30)0.7758 RSV F IgG ELISA(ϫ103titer)0.90Ϯ0.31(20)0.93Ϯ0.36(20)0.8821 Nasal washRSV F IgA ELISA(RLU) 1.4ϫ104Ϯ1.2ϫ104(10) 1.0ϫ104Ϯ1.1ϫ104(20)0.7694 PBMCMemory B cell ELISPOT(%F-specific ASC/total IgG ASC)0.22Ϯ0.25(10)0.18Ϯ0.5(20)0.2413 Memory T cell ELISPOT(SFC/106PBMC)RSV A2virus360Ϯ130(12)93Ϯ41(20)0.0262 RSV F protein1,250Ϯ420(20)180Ϯ80(20)Ͻ0.0001 CD4ϩT cell peptides450Ϯ180(12)100Ϯ60(12)Ͻ0.0001 CD8ϩT cell peptides400Ϯ210(12)90Ϯ55(12)Ͻ0.0001 CD107aflow cytometry(%CD107aϩCD8ϩT cells)RSV F protein 5.0Ϯ1.6(14) 3.0Ϯ1.7(14)0.0173 CD8ϩT cell peptides 4.7Ϯ1.9(14) 2.3Ϯ1.8(14)0.0045 Th1-Th2cytokines(pg/ml)7,500Ϯ3,100(10)3,000Ϯ800(10)0.0004 RSV F IFN-␥475Ϯ450(10)5,000Ϯ4,000(10)0.0017 RSV F IL-131,000Ϯ560(10)3,000Ϯ1,000(10)0.0033Reduced RSV F-Specific T Cells in Elderly 241the young and elderly donors are summarized in Table 2.In con-trast to findings for plasma neutralizing antibody titers and mem-ory B cell responses,PBMC from elderly donors had reduced RSV-specific IFN-␥responses to whole virus (Fig.3A ),F antigen (Fig.3B ),and F-specific immunodominant CD4ϩand CD8ϩT cell peptide pools (Fig.3C and D )compared to PBMC from young donors.RSV A2virus-specific IFN-␥-producing memory T cell frequency/106PBMC was 360Ϯ130SFC in the young and 93Ϯ41SFC in the elderly (P ϭ0.0262)(Fig.3A ).Total RSV F-specific IFN-␥-producing cell frequency in the young cohort was 1,250Ϯ420SFC,while that observed in the elderly was only 180Ϯ80SFC (P Ͻ0.0001)(Fig.3B ).Further examination of the RSV F-specific memory T cell responses revealed that the IFN-␥-producing CD4ϩT cell frequency in the young was 450Ϯ180SFC,while that seen in the elderly was 100Ϯ60SFC (P Ͻ0.0001)(Fig.3C ).The CD8ϩT cell frequency in the young was 400Ϯ210SFC and 90Ϯ55SFC in the elderly (P Ͻ0.0001)(Fig.3D ).Finally,there existed a strong correlation (r 2ϭ0.887)between the RSV F-specific IFN-␥-producing CD4ϩand CD8ϩT cell numbers in both of these cohorts (Fig.3E ).Thus,the observed deficit in the numbers of functional memory T cells in the elderly existed in both the CD4ϩand CD8ϩT cell compartments.Taken together,our results sug-gest that the reduced numbers of RSV F-specific IFN-␥-producing T cells contribute to the lack of complete immunity against RSV,predisposing elderly adults to disease.Elderly humans have significantly lower numbers of de-granulating RSV F-specific CD107a ؉CD8؉T cells.The compar-ative cytolytic potential of the RSV F-specific CD8ϩT cells in PBMC from the two cohorts was evaluated by quantifying the number of CD107a-expressing degranulating CD8ϩT cells fol-lowing an in vitro stimulation of PBMC with RSV F or a peptide pool containing RSV F-specific immunodominant CD8ϩT cell peptides.The CD107a or LAMP1(for lysosomalassociated mem-brane protein-1)protein is intracellularly expressed in activated CD8ϩT cells and natural killer T cells and is a marker of activated cytotoxic T cells (25).The gating strategy utilized in the study and acquisition plots for medium,PMA/ionomycin,RSV F protein,or CD8ϩT cell peptide pool stimulation are illustrated for represen-tative young (24years)and elderly (76years)donor PBMCFIG 1Equivalent RSV-specific antibody levels in plasma of young and elderly donors.(A)RSV-specific antibody titers in plasma from young (n ϭ30)and elderly (n ϭ30)donors were compared by microneutralization of GFP-RSV A2virus.(B)F-specific IgG ELISA.(C)Correlation analysis between neutralizing antibody titers and F-specific IgG titers.(D)RSV F-specific and total IgA titers in nasal washes of young (n ϭ10)and elderly (n ϭ20)adults.FIG 2RSV F-specific memory B cells in young and elderly donors.RSV F-specific memory B cells were measured in young (n ϭ10)and elderly (n ϭ20)donor PBMC.PBMC cultures were stimulated ex vivo with a mixture of poke-weed mitogen,S.aureus protein A,and CpG DNA.The expanded RSV F-spe-cific antibody-secreting cells (ASC)were measured in a memory B cell ELISPOT assay.Data are expressed as percent RSV F-specific IgG ASC/total IgG ASC.Cherukuri et al.Clinical and Vaccine Immunology(Fig.4A ).Different degrees of background CD107a expression were observed in all samples (Fig.4B ).However,upon incubation with RSV F protein or CD8ϩT cell peptide pool,this number increased from a baseline of 1.5to 5%of the parent CD8ϩT cell population in the young cohort compared to an increase from 2.0to 3.0%of the parent CD8ϩT cell population following antigen incubation in PBMC from the elderly (P ϭ0.005)(Fig.4B ).The fold change relative to medium in the percentage of CD107a ϩCD8ϩT cells following RSV F or CD8ϩpeptide pool stimulation was calculated and showed an increase of 2-to 22-fold in young and 0-to 2.5-fold in elderly donor PBMC,respectively (P ϭ0.005)(Fig.4C ).The mean fluorescence intensity (MFI)of the RSV F-specific CD107a ϩCD8ϩT cells was equivalent in the elderly and young donor PBMC samples (data not shown),suggesting that the difference between the young and elderly was the frequency of CD8ϩT cells expressing CD107a rather than the number of CD107a molecules expressed on each RSV F-specific CD8ϩT cell.The lower numbers of RSV F-specific CD107a ϩCD8ϩT cells inthe elderly suggests a potential mechanism for the higher suscep-tibility to RSV disease in this population.Elderly donor PBMC secrete relatively high basal levels of IL-13ex vivo .The functional activity of the RSV F-specific T cells was examined ex vivo by measuring cytokine production in PBMC in response to stimulation with RSV F antigen or a peptide pool containing RSV F-specific immunodominant CD4ϩT cell pep-tides.The cytokines that were undetectable in the cell superna-tants of PBMC cultures from either cohort included IL-2,IL-4,IL-5,IL-17,IL-12(p70),and TNF-␣.In contrast,cytokines that were present in measurable quantities in the cell supernatants in-cluded IFN-␥,IP-10,IL-10,and IL-13.Basal levels of the Th1cytokine,IFN-␥,were secreted at low levels in both cohorts.How-ever,upon RSV F stimulation,considerably higher levels of IFN-␥(7,500Ϯ3,100pg/ml)were produced by PBMC from young com-pared to elderly donors (3,000Ϯ1,000pg/ml)(P ϭ0.0004)(Fig.5A ).This finding was consistent with the results obtained in the IFN-␥T cell ELISPOT assay,where significantly highernumbersFIG 3Elderly have significantly lower numbers of RSV F-specific IFN-␥-producing cells.PBMC from young and elderly donors were stimulated ex vivo using (A)wt RSV A2at 1PFU/10cells (n ϭ12young and n ϭ20elderly),(B)5g/ml of RSV F protein (n ϭ20young and n ϭ20elderly),(C)2g/ml of RSV F-specific CD4ϩT cell peptide pools (n ϭ12young and n ϭ12elderly),or (D)2g/ml of RSV F-specific CD8ϩT cell peptide pools (n ϭ12young and n ϭ12elderly).The IFN-␥secreted by T cells was measured by ELISPOT assay,and data are expressed as spot-forming cells (SFC)/106PBMC.(E)Correlation between RSV F-specific CD4ϩand CD8ϩT cell frequencies.Reduced RSV F-Specific T Cells in ElderlyFebruary 2013Volume 20Number 2 243of IFN-␥-producing T cells were observed in PBMC from the young cohort (Fig.3).Interestingly,PBMC from elderly donors secreted relatively high basal levels of the Th2cytokine,IL-13(2,500Ϯ2,000pg/ml),compared to the levels produced by PBMC from young donors (800Ϯ600pg/ml)(Fig.5B ).Stimulation of elderly or young PBMC with RSV F slightly increased IL-13secre-tion;however,the increase above basal levels was not statistically significant in either cohort (Fig.5B ).The inability of elderly PBMC to secrete high levels of IFN-␥upon RSV F stimulation seemed to reflect the inherently weak Th1antigenic responsesobserved in aged individuals.Moreover,the high basal levels of IL-13are consistent with a Th2polarization of the CD4ϩT cell compartment in this population.Both of these factors may con-tribute to the increased susceptibility to RSV disease observed in the elderly.DISCUSSIONIn this study,we explored immunological factors that could con-tribute to the higher susceptibility of elderly adults to severe dis-ease by measuring the RSV F-specific humoral and cellularim-FIG 4Elderly PBMC have lower numbers of RSV F-specific CD107a ϩCD8ϩT cells.PBMC cultures were incubated in medium alone or were stimulated withRSV F protein or an RSV F-specific CD8ϩT cell peptide pool.(A)CD107a gating strategy and acquisition data plots for medium,PMA/ionomycin,RSV F,or CD8ϩT cell peptide pool stimulation of representative young (ME25)and elderly (ME26)donor PBMC.(B)The percentages of CD107a ϩCD8ϩT cells were quantified using multiparameter flow cytometry in young (n ϭ14)and elderly (n ϭ14)donor PBMC.(C)Fold CD107a ϩCD8ϩT cell numbers relative to medium following stimulation of young (n ϭ14)and elderly (n ϭ14)donor PBMC samples with RSV F protein or CD8ϩT cell peptide pool.Cherukuri et al.244Clinical and Vaccine Immunologymune responses in healthy elderly and young pared to the overall U.S.population (26),the African-American and His-panic numbers in both our study cohorts appeared relatively over-represented,while the Caucasian numbers appeared relatively un-derrepresented (Table 2).However,analysis of the RSV F-specific responses obtained in the different assays by race indicated that the results were not influenced by racial or ethnic origin of the donors (data not shown).RSV infection in adults elicits a robust serum antibody re-sponse (27,28).The neutralizing antibody titers to GFP-tagged RSV A2measured in the elderly donors in our study were consis-tent with previous findings (27–30).RSV F-and G-specific IgA antibodies measured in nasal washes of older adults Ն65years of age have been shown to correlate with protection from RSV dis-ease (31).We expect a successful RSV vaccine candidate that pre-vents disease in elderly adults to elicit robust and durable hu-moral,mucosal,and T cell-mediated immunity (31).It has been shown that RSV-specific IgE antibodies can be detected in the nasopharyngeal secretions of patients with acute RSV bronchioli-tis,and interestingly,the levels correlated inversely with the num-ber of circulating RSV-specific CD8ϩT cells (32).Evidence indi-cates that RSV-specific IgE-mediated mast cell degranulation and histamine release in the airway epithelium,along with the induc-tion of Th2-type cytokines in the respiratory tract,potentiates the clinical symptoms of severe RSV disease (33).Our data showed no measurable RSV-specific serologic,mucosal,or memory B cell deficits in elderly adults (Table 2),implying that these immune responses are insufficient to fully protect against RSV disease in this population.We hypothesized that T cell responses to RSV proteins play an important role in clearing RSV infections,and at least one report has suggested that the persistence of RSV-specific memory CD8ϩT cells following primary infection is important in preventing se-vere RSV disease (16).Moreover,RSV-specific CD8ϩT cells have been detected in the peripheral blood of previously infected adults in whom these responses have been associated with decreased clinical symptoms (34,35).The contribution of the different an-tigen-specific T cell subsets to recovery from RSV infection has been extensively studied in mouse models,and long-lived RSV-specific cytotoxic T cell function has been demonstrated to becritical for the accelerated clearance of virus from the lungs of infected animals (36–40).Recently,it was demonstrated that RSV-specific CD8ϩT cells induced upon vaccination protected mice against RSV infection and pathogenesis,and the authors reported that waning protection correlated with reduced CD8ϩT cell cytokine expression (41).To determine if impaired RSV-specific T cell numbers and/or function could account for the susceptibility to severe RSV illness in the elderly,we compared the RSV F-specific CD4ϩand CD8ϩT cells in PBMC from elderly and young adults.We utilized previ-ously published RSV F T cell epitope mapping results (20–23)to custom synthesize T cell peptide pools consisting of 12mers or 9mers to evaluate putative CD4ϩor CD8ϩT cell responses,re-spectively,realizing that the lack of a response in our ELISPOT assay may also be attributed to HLA mismatch between the stim-ulating peptide and the donor PBMC.Notably,the young-adult PBMC produced significantly higher IFN-␥responses to the same peptide pools than elderly PBMC.Furthermore,elderly PBMC appeared to have comparable numbers of total CD3ϩ,CD4ϩ,and CD8ϩT cells and CD19ϩB cells compared to young-adult PBMC based on our flow cytometry studies (data not shown).Future studies will focus on delineating the CD4ϩversus CD8ϩT cell responses in the ELISPOT assay by performing T cell subset de-pletions of whole PBMC or using flow cytometry to identify rele-vant cytokine-producing T cell populations.Cell surface expression of CD107has been correlated with the secretion of cytolytic molecules,such as perforin and granzyme B,following cytotoxic T lymphocyte (CTL)activation (42).In vivo ,CD107a and CD107b are expressed on the surface of CD8ϩT cells following activation with the cognate antigen leading to IFN-␥production and cytolytic activity directed against the target cells (25).Our studies suggest that since the amount of CD107a ex-pressed on CD8ϩT cells of elderly PBMC is relatively similar to that seen in young adults,the elderly may benefit from a vaccine that can boost the numbers of RSV F-specific degranulating cyto-toxic T cells.Aging individuals experience deficits in both innate and adap-tive immune responses to pathogens,reflecting changes at the molecular,cellular,and tissue levels that accumulate over time (21,43,44).As a result,immune responses to vaccination intheFIG 5Elderly PBMC secrete relatively low levels of IFN-␥in conjunction with secreting high basal levels of IL-13ex vivo .PBMC cultures (n ϭ10young and n ϭ10elderly)were incubated in medium alone or with RSV F protein,and the resulting cytokines secreted into the supernatant were measured using a multiplex Th1-Th2cytokine bead array panel (Luminex).(A)IFN-␥.(〉)IL-13.Reduced RSV F-Specific T Cells in ElderlyFebruary 2013Volume 20Number 2 245。