本节主要介绍一些植物化学物的防癌抗癌作 用:
一、黄酮类化合物 二、硫化物
三、异硫氰酸盐 四、萜类
五、皂甙类化合物 六、类胡萝卜素
一、黄酮类化合物
•黄酮类化合物(flavonoids)是一类多酚化合物 •存在于水果、蔬菜、干果、种子、花卉、树皮中
•多以甙类形式存在,有许多类型 •具有良好的抗氧化性能和清除自由基的能力
叶酸参与DNA合成和甲基化,影响正常 的细胞周期
过低则影响DNA切除修复功能
•在许多癌症中存在因DNA甲基化引起的基 因表达异常,
•叶酸缺乏的影响
Folate plays an important role in the synthesis and methylation of DNA. Abnormal DNA methylation leading to aberrant gene expression has been demonstrated in several types of cancer. Folate deficiency may produce misincorporation of uracil instead of thymine into DNA. The effects of folate deficiency and supplementation on DNA methylation are gene- and site-specific, and appear to depend on cell type, target organ, stage of transformation, and degree and duration of folate depletion.
endometrium.