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FAK和FAKpY397在喉癌中的表达及意义高尚;董频;李大伟;沈斌【摘要】Objective To detect the expression and clinicopathological significance of focal adhesion kinase (FAK) and phosphorylation of focal adhesion kinase tyrosine 397 (FAKpY397) in human squamous cell carcinoma of larynx.Methods The expression of FAK and FAKpY397 in tissues of squamous cell carcinoma of larynx ( n = 57) and normal laryngeal tissues ( n = 10) was detected by immunohistochemistry.Results The positive expression of FAK and FAKpY397 was 66.7％ and 84.4％, respectively in tissues of squamous cell carcinoma of larynx, and was significantly different from that of normal laryngeal tissues (P ＜0.01).The expression of FAK and FAKpY397 was correlated with the clinical stage and lymph node metastasis ( P ＜ 0.05), but was not related to the age of patients, tumor size and degree of differentiation of carcinomacells.Conclusion There is high expression of FAK and FAKpY397 in tissues of squamous cell carcinoma of larynx, which may be related to the invasion and metastasis of squamous cell carcinoma of larynx.%目的检测黏着斑激酶(FAK)及磷酸化黏着斑激酶(FAKpY397)在喉鳞状细胞癌中的表达及临床病理意义.方法采用免疫组织化学方法检测57例喉鳞状细胞癌和10例正常喉部组织中FAK 及FAKpY397的表达.结果 57例喉鳞状细胞癌中FAK与FAKpY397阳性表达率分别为66.7%和84.4%,与正常喉组织相比差异有统计学意义(P<0.01).FAK、FAKpY397与肿瘤的临床分期和淋巴结转移有关(P<0.05),与患者年龄、肿瘤大小及分化程度无明显相关.结论 FAK和FAKpY397在喉癌中有高表达,推测与喉癌的侵袭及转移相关.【期刊名称】《上海交通大学学报（医学版）》【年(卷),期】2011(031)002【总页数】4页(P212-215)【关键词】黏着斑激酶;磷酸化黏着斑激酶;喉癌;免疫组织化学【作者】高尚;董频;李大伟;沈斌【作者单位】上海交通大学附属第一人民医院耳鼻喉头颈外科,上海,200080;上海交通大学附属第一人民医院耳鼻喉头颈外科,上海,200080;上海交通大学附属第一人民医院耳鼻喉头颈外科,上海,200080;上海交通大学附属第一人民医院耳鼻喉头颈外科,上海,200080【正文语种】中文【中图分类】R739.65黏着斑激酶(focal adhesion kinase,FAK)是一种细胞内酪氨酸激酶,在正常细胞和肿瘤细胞中都是整合素及其他受体诱导的信号通路的重要中介。
【毕业论文】恶意代码分析实例恶意代码实例分析2011 年 5 月1目录1虚拟环境及所用软件介绍 (1)1.1虚拟环境介绍 ..................................................................... (1)1.1.1 Vmware Workstation7.1.4 .................................................................. (1)1.1.2 Gost XP SP3 装机版YN9.9................................................................... .. 11.2 检查软件介绍 ..................................................................... .. (1)1.2.1 ATool1.0.1.0 ................................................................ .. (1)1.2.2 Regmon 7.04 汉化版...................................................................... . (1)1.2.3 FileMon 7.04 汉化版 ..................................................................... .. (2)1.2.4 TCPView3.04.................................................................... .. (2)1.2.5procexp.exe ............................................................ . (2)1.2.6 IceSword 1.22 中文版 ..................................................................... (2)2 木马冰河分析与检测 ......................................................................32.1 木马冰河V2.2介绍 ..................................................................... ....................... 3 2.2 样本分析 ..................................................................... (3)2.2.1 进程监测 ..................................................................... .. (3)2.2.2 文件监测 ..................................................................... .. (3)2.2.3 注册表监测...................................................................... . (4)2.2.4系统通信端口监测 ..................................................................... ................ 5 2.3 样本外部特征总结 ..................................................................... ......................... 5 2.4 木马清除方法 ..................................................................... .. (5)3 xueranwyt.exe木马分析与监测 (7)3.1 木马xueranwyt.exe介绍...................................................................... .............. 7 3.2 样本分析 ..................................................................... (7)3.2.1进程监测 ..................................................................... (7)3.2.2 文件监测 ..................................................................... .. (7)3.2.3 注册表监控...................................................................... . (8)3.2.4 端口监测 ..................................................................... ............................. 8 3.3 样本外部特征总结 ..................................................................... ......................... 8 3.4 解决方案 ..................................................................... (9)4 2.exe木马分析与监测 (10)4.1 木马样本2.exe介绍...................................................................... ................... 10 4.2 样本分析 ..................................................................... . (10)4.2.1 进程监控 ..................................................................... (10)4.2.2 文件监控 ..................................................................... (10)4.2.3 注册表监控...................................................................... .. (11)4.2.4 端口检测 ..................................................................... ........................... 11 4.3 样本外部特征总结 ..................................................................... ....................... 12 4.4 解决方案 ..................................................................... . (12)25 红蜘蛛样本分析与检测 (13)5.1 样本介绍 ..................................................................... ..................................... 13 5.2 样本分析 ..................................................................... . (13)5.2.1 进程检测 ..................................................................... (13)5.2.2 文件检测 ..................................................................... (13)5.2.3 注册表监控...................................................................... .. (14)5.2.4 端口监控 ..................................................................... ........................... 14 5.3 样本外部特征总结 ..................................................................... ....................... 14 5.4 解决方案 ..................................................................... . (15)6 031gangsir.ch.exe样本分析 (16)6.1 样本介绍 ..................................................................... ..................................... 16 6.2 样本分析 ..................................................................... . (16)6.2.1 进程监控 ..................................................................... (16)6.2.2 文件监控 ..................................................................... (16)6.2.3 注册表监控...................................................................... .. (17)6.2.4 端口监控 ..................................................................... ........................... 17 6.3 样本特征总结 ..................................................................... .............................. 17 6.4 解决方案 ..................................................................... . (18)7 .exe样本监测与分析 (19)7.1 样本简介 ..................................................................... ..................................... 19 7.2 样本分析 ..................................................................... . (19)7.2.1 进程监控 ..................................................................... (19)7.2.2 文件监控 ..................................................................... (19)7.2.3 注册表监控...................................................................... .. (20)7.2.4 端口监控 ..................................................................... ........................... 20 7.3 样本外部特征总结 ..................................................................... ....................... 20 7.4 解决方案 ..................................................................... . (21)8 .exe样本监测与分析 (22)8.1 样本信息介绍 ..................................................................... .............................. 22 8.2 样本分析 ..................................................................... . (22)8.2.1进程监控 ..................................................................... . (22)8.2.2 文件监控 ..................................................................... (22)8.2.3 注册表监控...................................................................... .. (22)8.2.4 端口监控 ..................................................................... ........................... 23 8.3 样本外部特征总结 ..................................................................... ....................... 23 8.4解决方案 ..................................................................... .. (24)9 .exe样本分析与监测 (25)9.1 样本简介 ..................................................................... ..................................... 25 9.2 样本分析 ..................................................................... . (25)39.2.1 进程监控 ..................................................................... (25)9.2.2 文件监控 ..................................................................... (25)9.2.3 注册表监控...................................................................... .. (26)9.2.4 端口监控 ..................................................................... ........................... 26 9.3 样本外部特征总结 ..................................................................... ....................... 26 9.4 解决方案 ..................................................................... . (26)10 ................................................................. (27)10.1 样本简介 ..................................................................... ................................... 27 10.2 样本分析 ..................................................................... .. (27)10.2.1 进程监控 ..................................................................... . (27)10.2.2 文件监控 ..................................................................... . (27)10.2.3 注册表监控...................................................................... (28)10.2.4 端口监控 ..................................................................... ......................... 28 10.3 样本外部特征总结 ..................................................................... ..................... 28 10.4 解决方案 ..................................................................... .. (29)11 NetThief12.9样本分析与检测 (30)11.1 样本简介 ..................................................................... ................................... 30 11.2 样本分析 ..................................................................... .. (30)11.2.1 进程监控 ..................................................................... . (30)11.2.2 文件监控 ..................................................................... . (30)11.2.3 注册表监控 ..................................................................... . (30)11.2.4 端口监控 ..................................................................... ......................... 31 11.3 样本外部特征总结 ..................................................................... ..................... 31 11.4 解决方案 ..................................................................... .. (31)41虚拟环境及所用软件介绍1.1虚拟环境介绍1.1.1 Vmware Workstation 7.1.4恶意代码具有很强的破坏性和传播性，为了系统的安全，所以实例的分析均在虚拟机下进行。
【新提醒】AAF“⾼级制作格式”（各种后期软件内⾃由转换的格式）懒版：虽然Adobe公司的两款后期软件PR2.0和AE7已经作到了⽆缝兼容，但在后期制作的过程中，不是所有特效都可⽤他们来合成的。
⼀个部门中也有各类后期软件（Avid、Final Cut Pro、AfterEffects、Premier Pro、Conbustion3 Boris Red、Quantel Q系列）的使⽤者，如何在各软件平台中作到⾃由转换呢？总不能先做成AVI再给下⼀个⼈吧~~，这样⼀来你的原素材有损失不算，也给特效的修改带了很⼤的⿇烦！AFF由此应运⽽⽣。
下⾯我们针对这个看着眼熟，⽤着陌⽣的格式作下详细解释：AAF技术及其在后期制作系统中的应⽤作者：孙春华孙锂在⼴播电视领域，随着计算机和⽹络技术的引⼊，AV和IT技术正⽇益融合，这从根本上改变了电视节⽬的制作流程，⼤⼤降低了节⽬的制作成本，提⾼了⼯作效率。
素材交换格式——AAF、MXF以及元数据的应⽤，是实现AV和IT融合的技术基础。
本⽂重点介绍AAF技术，并探讨AAF技术在后期制作中的应⽤，以及对后期制作流程的影响。
⼀ AAF简介AAF是⼀个协会（），它包括了⽬前世界上主要的电⼦设备供应商、计算机软硬件⼚家和⼀些⼴播机构。
协会主要负责制定⽤于增强的编辑和制作的通⽤AV⽂件格式标准，即Advanced Authoring Format格式。
AAF是Advanced Authoring Format的缩写，意为“⾼级制作格式”，是⼀种⽤于多媒体创作及后期制作、⾯向企业界的开放式标准。
AAF是⾃⾮线性编辑系统之后电视制作领域最重要的新进展之⼀，它解决了多⽤户、跨平台以及多台电脑协同进⾏数字创作的问题，给后期制作带来了极⼤的⽅便。
AAF格式包括实体（Essence）和元数据（Metadata）两⽅⾯内容。
实体即视⾳频素材和节⽬数据（如字幕⽂本）。
实体中的视⾳频素材只有以开放式标准格式存在时，不同软件平台才有可能共享该素材。
LC信用证样本L/C信用证样板评论:0 条查看:2981 次sohoren发表于 2008-09-15 15:35 2006 01/24 09:17 FAXBooking No TXH 33302/06/04-07：46:18 FKPRT4-5188-013668 ORIGINALAuthentication Result: Correct with current keyInstance Type and Transmission----------------------------------------------------------------------------------------------------------------------Original received from SWIFTPriority: NormalMessage Output Reference: 0742 040602NISIJPJTAFKK3377525147Correspondent Input Reference: 1702 040601BKCHCNBJA5001076463736----------------------------------------------Message Header----------------------------------------------------Swift Output: FIN 700 Issue of a documentary creditSender: BKCHCNBJ500BANK OF CHINA(SHANDONG BRANCH)QINGDAO CNReceiver: NISIJPJTFKKNISHI-NIPPON BANK, LTD., THE(INTERNATIONAL DEPT.)FUKUOKA JPMUR: SDXOXE45CSD83801----------------------------------------------Message Text-------------------------------------------------------27: Sequence of Total1/140A: Form of Documentary CreditIRREVOCABLE20: Documentary Credit NumberLC50455031331C: Date of Issue04060131D: Data and Place of Expiry040705JAPAN50: ApplicantSHANDONG CHERRY GROUP CORP 2NANJING ROAD QINGDAO CHINA POSTCODE:266071TEL*************FAX*************59: Beneficiary – Name & AddressTERAMATSU SHOTEN CO., LTD 371-2TSUBUKU IMAMACHI KURUME-SHI FUKUOKA JAPAN TEL: 0942-35-2708 FAX: 0942-35-270932B: Currency Code, AmountCurrency: USD (US DOLLAR)Amount: # 112,000.0039A: Percentage Credit Amt Tolerance10/1041D: Available with … by … - Name & AddrANY BANKBY NEGOTIATION42C: Drafts at…AT 90 DAYS AFTER SIGHT FOR 100PCT OF THE INVOICE VALUE42D: Drawee – Name & AddressBANK OF CHINA SHANDONG BRANCH43P: partial shipmentsALLOWED43T: TranshipmentALLOWED44A: On Board/Disp/Taking charge at/fJAPAN MAIN PORT44B: For transportation to…XINGANG CHINA44C: Latest Date of Shipment04062245A: Descriptn of Goods &/or ServicesDESCRIPTION OF COMMODITY : NO. 3 J-SMP WASTE PAPER, 1000MT, USD112/MT (DTHC PREPAID) CIF XINGANG JAPAN ORIGIN PACKING: IN BALES, SHIPPED IN CONTAINERS 46A: Documents required1. MANUALLY SIGNED COMMERCIAL INVOICE IN 3 COPIES, INDICATING THIS L/C NO. AND CONTRACT NO. 24YSP066 {PHOTO COPY AND CARBON COPY NOT ACCEPTED AS ORIGINAL}.2. 2/3 SET (INCLUDE 2 ORIGINALS AND 3 NON-NEGOTIABLE COPIES) OF CLEAN ON BOARD “FREIGHT PREPAID” OCEA N BILLS OF LADING MADE OUT TO APPLICANT, MARKED “NOTIFYING APPLICANT”.3. FULL SET OF INSURANCE POLICY / CERTIFICATE FOR 110 PCT OF THE INVOICE VALUE, SHOWING CLAIMS PAYABLE IN CHINA, IN CURRENCY OF THE DRAFT, BLANK ENDORCED,COVERING OCEAN MARINE TRANSPORTATION ALL RISKS AND WAR RISKS.4. PACKING LIST/WEIGHT MEMO IN 3 COPIES ISSUED BY BENEFICIARY INDICATING QUANTITY/GROSS AND NET WEIGHTS OF EACH CONTAINER.5. BENEFICIARY’S CERTIFIED COPY OF FAX DISPATCHED TO APPLICANT WITHIN 72 HOURS AFTER SHIPMENT ADVISING NAME OF VESSEL, DATE, QUANTITY, WEIGHT AND VALUE OF SHIPMENT.6. BENEFICIARY’S CERTIFICATE CERTIFYING 1/3 SET OF ORIGINAL B/L AND ORIGINAL J.C.I.C., INVOICE, PACKING LIST AND NON-WOOD PACKING MATERIAL MUST BE SENT TO THE APPLICANT BY COURIER DHL WITHIN THREE DAYS AFTER SHIPMENT.47A: Additional Conditions1. A DISCREPANCT FEE OF USD 54.00 WILL BE DEDUCTED FROM THE PROCEEDS IF DOCUMENTS ARE PRESENTED WITH DISCREPANCY (IES).2. BOTH QUANTITY AND AMOUNT 10PCT MORE OR LESS ARE ALLOWED.71B: Charges1. ALL BANKING CHARGES OUTSIDE THE OPENING BANK ARE FOR BENEFICIARY’S ACCOUNT.48: Period for PresentationDOCUMENTS MUST BE PRESENTED FOR NEGOTIATION WITHIN 10 DAYS AFTER BILL OF LADING DATE, BUT WITHIN THE VALIDITY OF THIS L/C49: Confirmation InstructionsWITHOUT78: Instr to Payg/Accptg/Negotg Bank1. ALL DOCUMENTS ARE TO BE FORWARDED TO BANK OF CHINA, SHANDONG BRANCH NO. 37 HONGKONG MIDDLE ROAD QINDAO IN ONE LOT.2. UPON RECEIPT OF ALL DOCUMENTS IN ORDER, WE WILL DULY HONOUR/ ACCEPT THE DRAFTS AND EFFECT THE PAYMENT AS INSTRUCTED AT MATURITY.72: Sender to Receiver InformationTHIS LC IS SUBJECT TO UCP 1993 ICC PUB. NO.500 THIS IS OPERATIVE INSTRUMENT AND NO CONFIRMATION TO FOLLOW.----------------------------------------Message Trailer -------------------------------------------End of Message本附件为2004年6月2日通知中言及的不可撤销的信用证业务的组成部分，不可分割。
英文版销售合同样本（分享）8篇篇1SALES CONTRACTThis Sales Contract (hereinafter referred to as the "Contract") is made and executed on [Date] by and between [Seller's Name] (hereinafter referred to as "Seller"), and [Buyer's Name] (hereinafter referred to as "Buyer").1. PartiesThe Seller and Buyer, through their authorized representatives, agree to the terms and conditions stated in this Contract.2. Product DescriptionThe Product to be sold under this Contract is [Description of the product], with specifications as detailed in the Annexure attached hereto.3. Quantity and QualityThe Seller shall sell and the Buyer shall purchase the Quantity of Products specified in this Contract, ensuring that the Products comply with the Quality standards specified in Annexure.4. Price and PaymentThe Price of the Products shall be as stated in this Contract. The terms of payment shall be as follows: [Insert details of payment terms, including mode of payment, timing of payments, etc.]5. DeliveryThe Seller shall ensure timely delivery of the Products to the Buyer, as per the agreed schedule. [Insert details of delivery, including place of delivery, mode of transport, etc.]6. Terms of ShipmentThe Products shall be shipped under the following conditions: [Insert details of terms of shipment, including shipping documents, insurance, etc.]7. Risk and OwnershipRisk of loss or damage to the Products shall pass to the Buyer upon delivery. Ownership of the Products shall be transferred to the Buyer upon full payment by the Buyer.8. Warranty and GuaranteeThe Seller guarantees that the Products are new, comply with all applicable specifications and are free from defects in material and workmanship. The Seller provides a warranty period of [insert period] from the date of delivery. During this period, any defects in the Products shall be rectified by the Seller at no additional cost to the Buyer.9. Intellectual Property RightsBoth parties shall ensure that the sale and purchase of Products under this Contract does not infringe any intellectual property rights of third parties.10. ConfidentialityBoth parties shall maintain confidentiality of all information related to this Contract that is not intended for public disclosure.11. Force MajeureNeither party shall be liable for failure to perform its obligations under this Contract due to events of force majeure, such as war, riots, natural disasters, acts of government, etc.12. TerminationThis Contract may be terminated by either party in the event of breach by the other party. The terminating party shall provide a written notice to the other party specifying the reasons for termination.13. DisputesAny disputes arising out of or in connection with this Contract shall be settled through friendly negotiation. If no settlement can be reached, such disputes may be submitted to [Insert applicable court/arbitration institution] for resolution.14. MiscellaneousThis Contract constitutes the entire agreement between the Seller and Buyer pertaining to the sale of Products specified herein. No modifications or amendments shall be binding unless made in writing and signed by both parties. This Contract is made in duplicate, with each party retaining one copy for record.IN WITNESS WHEREOF, the parties have executed this Contract in their respective presence on the date stated above.Seller:_____________________(Authorized Representative)Buyer:_____________________(Authorized Representative) Date: [Date] Place: [Place] 签名到此表示该合同已得到双方在场人士的认可并在此日期签署。
液相色谱质谱联用仪动物样本要求1.引言1.1 概述概述液相色谱质谱联用仪（LC-MS）作为一种先进的分析技术，已经成为现代生物医学研究、药物代谢动力学和临床分析等领域中不可或缺的分析仪器之一。
其能够将液相色谱（LC）和质谱（MS）两种分析技术的优势相结合，实现对复杂样品的高灵敏度、高选择性的定量和定性分析。
本文将重点讨论液相色谱质谱联用仪在动物样本分析中的应用，并介绍相关的样本要求。
动物样本常常用于药物代谢研究、体内药物分布和代谢产物检测等领域，因此对于液相色谱质谱联用仪而言，合适的样本处理和准备至关重要。
在液相色谱质谱联用仪中，动物样本的要求涉及到多个方面，包括样品的数量、稳定性、纯度以及样品的处理方法等。
对于不同的样品类型，如血液、尿液、组织等，其要求可能会有所不同。
在本文的后续部分，我们将详细探讨各个方面的要求和处理方法，并对未来液相色谱质谱联用仪在动物样本分析中的发展进行展望。
通过充分了解并满足液相色谱质谱联用仪对动物样本的要求，我们可以更好地发挥该仪器在生物医学研究和药物开发中的作用。
相信本文的内容将对液相色谱质谱联用仪用户和相关研究人员有所帮助，促进该技术的进一步发展和应用。
1.2 文章结构文章结构：本文共分为引言、正文和结论三部分。
引言部分主要概述液相色谱质谱联用仪动物样本要求的研究背景和意义，并简要介绍了本文的结构和目的。
正文部分首先介绍了液相色谱质谱联用仪的基本原理和应用范围，包括其在药物、环境、食品、生物分析等领域中的重要性和应用前景。
随后，详细探讨了动物样本在液相色谱质谱联用仪中的应用，包括动物样本的收集与处理、样本制备方法、样本中固有物质的影响因素等内容。
通过对动物样本在液相色谱质谱联用仪中的应用进行全面而深入的探讨，旨在为研究者提供关于动物样本处理和分析的参考依据。
结论部分对液相色谱质谱联用仪动物样本要求进行了总结，并从未来的发展角度对液相色谱质谱联用仪动物样本要求进行了展望。
