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无创正压通气治疗慢性阻塞性肺疾病并Ⅱ型呼吸衰竭临床分析（作者:___________单位: ___________邮编: ___________）【摘要】目的研究无创正压通气（NIPPV）治疗慢性阻塞性肺疾病（COPD）急性加重并Ⅱ型呼吸衰竭的临床疗效。
方法自2003年12月—2006年3月我们取COPD并Ⅱ型呼吸衰竭患者62例，随机分成两组，对照组给予抗感染、平喘、祛痰、兴奋呼吸中枢、抗凝等传统治疗，治疗组在此基础上加用无创正压通气，观察两组治疗前后的心率、呼吸频率、血气变化、插管率、病死率的变化。
结果31例治疗组患者心率、呼吸频率及血气指标明显改善（P＜0.01），插管率、病死率明显降低。
结论无创正压通气是治疗慢性阻塞性肺疾病并Ⅱ型呼吸衰竭的一种非常有效方法。
【关键词】无创正压通气；慢性阻塞性肺疾病；Ⅱ型呼吸衰竭【Abstract】Objective To study the clinical effect of noninvasive positive pressure ventilation on the treatment of chronic obstructive pulmonary disease(COPD) with type Ⅱrespiratory failure.Methods 62 patients were divided into twogroups randomly,one groups received conventional medical therapy and the other received conventional medical therapy plus noninvasive positive pressure ventilation,to observe the difference of the data in vital sign,arterial blood gas,the rate of endotracheal intubation between two group.Results After treatment,heart rate,respiratory frequency,and arterial blood gas were significantly improved in NIPPV group,the data in trial group were much better than those in control group (P＜0.01）.Conclusion NIPPV was an effective method in the treatment of COPD with type Ⅱrespiratory failure.【Key words】NIPPV，COPD，type Ⅱrespiratory failure慢性阻塞性肺疾病（COPD）急性发作期多由感染等因素所致，致缺氧和二氧化碳潴留加重，出现呼吸衰竭，常规治疗很难有效改善缺氧和二氧化碳潴留状态。
无创通气治疗慢性阻塞性肺疾病急性加重期（AECOPD)合并重度呼吸衰竭患者的疗效汤灵雪，王同（安徽医科大学第二附属医院全科医学科，安徽合肥230032)[摘要]目的：观察无创双水平正压通气治疗慢性阻塞性肺疾病急性加重期（AECOPD)合并重度呼吸衰竭患 者的临床疗效。
方法：选择160例AECO PD合并重度高碳酸血症昏迷患者，其中80例给予无创双水平正压通气，作为 无创通气组;80例给予有创通气，作为有刨通气组。
比较两组治疗前和治疗后72 h及出院前的心率（H R)、呼吸频率 (R R)、动脉血气及检测入院、出院时的降钙素原（PC T)和C-反应蛋白（C R P)水平。
结果：①患者治疗72 h及出院前 H R与R R明显改善，p H值恢复正常，PaCO2降低，PaO2升高，与治疗前相比，差异均有统计学意义（P<0.05);②经无创 双水平正压呼吸机治疗的患者使用N IP P V的平均天数为（9 ±2. 1)d，不良反应并发症低;③患者入院时PCT、C R P升高，经治疗后恢复正常，但C R P与PaCO2高低有关联性，P C T则无关联性。
结论：无创双水平正压通气治疗A EC O PD合并 重度呼吸衰竭患者安全、可靠。
[关键词]无创正压通气;慢性阻塞性肺疾病；呼吸衰竭Effect of noninvasive bi-level positive airway pressure ventilation and invasive ventilation on AECOPD patients with severe respiratory failure TANG Ling-xue，W ANG Tong (General Medicine department of the Second Affiliated Hospital of Anhui Medical University，Hefei230032, China)Abstract：Objective To obser^^e the clinical effect of noninvasive b i-level positive pressure ventilation (BiPA P)in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with severe respiratory failure.Method 160 patients with AECOPD with severe hypercapnia coma admitted to our hospital were selected，of which80 patients were given noninvasive bi-level positive pressure ventilation，as noninvasive ventilation group，and80 patients were given invasive ventilation，as invasive ventilation group.The data of the two groups before and 72 h after treatment and before discharge were compared.Heart rate(H R)，respiratory rate(R R)，arterial blood gas，PCT and CRP at admission and discharge.Results ① heart rate (H R)and respiratory rate (R R)were significantly improved72 hours after treatment and before discharge，pH returned to normal，PaCO2decreased and pared with before treatment，the difference was statistically significant (P<0. 05);②The average days of NIPPV use for patients treated by non-invasive b i-level positive pressure ventilator is (9±2. 1) d，with low adverse reaction complications;③ When the patient was admitted to hospital，the levels of PCT and CRP increased and returned to normal after treatment，but CRP was correlated with the level of PaCO2，while PCT was not correlated.Conclusion Noninvasive bi-level positive pressure ventilation is safe and reliable in the treatment of AECO-PD patients with severe respiratory failure.Key Words:Noninvasive positive pressure ventilation；Chronic obstructive pulmonary disease;Respiratory failure慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Dis-ease，COPD)是一种常见的以持续性气流受限为特征的可以预 防和治疗的疾病，气流受限通常为进展性，呈不完全可逆。
