B3U2P6

甲醛释放型防腐剂，但游离甲醛含量低，应用pH范围2-12
??百杀得CI-14
14%CMIT/MIT
0.02-0.8%
对真菌、细菌、霉菌及酶菌都有很好的抑制能力，用量低，无气味，不产生颜色变化，毒性低，易操作。
使用环境pH＜9，与硫化物和胺类有配伍反应，该产品贮存温度＜40度
?? ??百杀得MIT-20
20%MIT
0.2-1%
?? ??百杀得BIT-20D
BIT分散体（20%）
0.05-0.4%
对胺类化合物稳定，不含甲醛,无VOC。
在碱性条件下十分稳定，耐高温。
?? ??百杀得BIT-20
BIT（20%）
0.05-0.4%
对胺类化合物稳定，不含甲醛。
碱性条件下十分稳定，耐高温。
?? ??百杀得MIT-20
MIT（20%）
?? ??百杀得MIT-S
MIT（99%）
0.03-0.3%
杀菌广谱长效，可用于pH2-12的体系中，不含甲醛
没有局限性，并对氧化、还原剂稳定
?? ??百杀得BBC
BRONOPOL等
0.02-0.1%
具有复合防腐剂的所有优点，杀菌广谱、长效
pH范围2-8有效
?? ??百杀得BBD
BRONOPOL等
0.02-0.1%
具有复合防腐剂的所有优点，杀菌广谱、长效
pH范围2-8有效
?? ??百杀得BQI
IPBCand1227等（35%）
0.05-0.3%
具有复合防腐剂的所有优点，杀菌广谱、长效
pH范围4-10有效
?? ??百杀得DB
DMDM，BIT等
0.05-0.6%
具有复合防腐剂的所有优点，杀菌广谱、长效

Product Data SheetProduct Name:Mirogabalin besylate (DS 5565 besylate)Cat. No.:GC30961Chemical PropertiesCas No.1138245-21-2ChemicalNameN/ACanonicalSMILESO=S(C1=CC=CC=C1)(O)=O.OC(C[C@@]2([C@@]3([H])[C@@](CC(CC)=C3)([H])C2)CN)=O Formula C18H25NO5S M.Wt367.46Solubility DMSO : 125 mg/mL (340.17 mM;Need ultrasonic)Storage Store at -20°CGeneral tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request.StructureBackgroundMirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels,Product Data Sheetwith Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.Mirogabalin besylate is a ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. Mirogabalin shows binding affinity for the gabapentin binding site in rat cortical brain homogenates with the IC50 value of 16.0 nM. Mirogabalin has no effect on any other receptors, channels, transporters, or enzymes at 50 μM[1].Mirogabalin besylate (3 and 10 mg/kg) markedly increases AUC0-8 hours values in a dose-dependent manner in partial sciatic nerve ligation model rats. Mirogabalin (2.5, 5, and 10 mg/kg) causes significant and dose-dependent increase in AUC0-12 hours values and enhances analgesic effects, with estimated ED50 of 4.4, 3.1, and <2.5 mg/kg on day 1, day 3, and day 5, respectively. Moreover, Mirogabalin besylate shows no obvious effect on rota-rod performance and locomotor activity at 3 and 10 mg/kg via oral administration, exhibits significant inhibition on rota-rod performance at 10, 30, and 100 mg/kg, and decreases locomotor activity at 30 and 100 mg/kg in rats[1]. [1]. Domon Y, et al. Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for the α2δ Subunit of Voltage-Gated Calcium Channels. J Pharmacol Exp Ther. 2018 Jun;365(3):573-582.。

USP60USP60 (Ubiquitin Specific Peptidase 60) is a deubiquitinating enzyme that plays a crucial role in cellular processes such as protein degradation, DNA repair, and cell cycle regulation. In this document, we will explore the structure, function, and regulatory mechanisms of USP60.Structure of USP60USP60 is a member of the ubiquitin-specific protease family. It consists of several distinct domains that contribute to its enzymatic activity and substrate specificity. The catalytic domain of USP60 contains a conserved cysteine residue that mediates the cleavage of the isopeptide bond between ubiquitin and its target protein. Adjacent to the catalytic domain, there is a ZnF-UBP domain that helps in substrate recognition and binding. The C-terminal domain of USP60 is responsible for its stability and localization within the cell.Function of USP60USP60 primarily functions as a deubiquitinating enzyme, deconjugating ubiquitin molecules from target proteins. By removing ubiquitin chains, USP60 can prevent the degradation of target proteins by the proteasome, thereby stabilizing them. Additionally, USP60 regulates the levels of ubiquitin by recycling ubiquitin molecules back into the cytoplasm for further use.USP60 is also involved in DNA repair processes. It interacts with various DNA repair proteins, such as BRCA1 and RAD51,and helps in the removal of ubiquitin moieties from DNA repair complexes. This activity of USP60 ensures efficient DNA damage repair and maintenance of genomic stability.Furthermore, USP60 has been implicated in cell cycle regulation. It interacts with cell cycle regulators, such as p53 and CDC25C, and modulates their stability and activity. This regulation of cell cycle progression by USP60 is essential for proper cell division and prevention of aberrant cell growth.Regulation of USP60 ActivityThe activity of USP60 is regulated by various mechanisms, including post-translational modifications, protein-protein interactions, and subcellular localization. One of the key regulatory mechanisms is phosphorylation. Phosphorylation of specific residues within USP60 can either enhance or inhibit its enzymatic activity. For example, phosphorylation of USP60 by ATM kinase increases its activity and promotes DNA repair.USP60 can also interact with other proteins, forming complexes that modulate its activity. For instance, interaction with BRCA1 enhances the deubiquitinating activity of USP60 in DNA repair processes. On the other hand, interaction with negative regulators such as UAF1 can inhibit the function of USP60.Subcellular localization of USP60 is crucial for its proper function. It is primarily localized in the nucleus, where it interacts with DNA repair and cell cycle proteins. However, under certain cellular stress conditions, USP60 can translocate to the cytoplasm and participate in other cellular processes.Role of USP60 in DiseaseDysregulation of USP60 function has been associated with various diseases. For example, aberrant expression or activity of USP60 has been observed in certain types of cancer. In some cases, overexpression of USP60 can stabilize oncoproteins and promote tumor growth. In other cases, downregulation of USP60 can impair DNA repair mechanisms, leading to genomic instability and increased cancer susceptibility.Furthermore, mutations in the USP60 gene have been associated with neurodegenerative disorders. These mutations can lead to a loss of USP60 function, resulting in the accumulation of abnormal proteins and neuronal cell death.ConclusionUSP60 is a versatile deubiquitinating enzyme that has important roles in protein degradation, DNA repair, and cell cycle regulation. Its structure, function, and regulatory mechanisms make it an attractive target for therapeutic interventions in various diseases. Further research is required to fully elucidate the complex network of interactions and pathways involving USP60.。

ET63133YBQ2EtekMicroelectronics Ultra-Low I Q 150mA CMOS LDO RegulatorGeneral DescriptionThe ET63133YBQ2 CMOS are designed specifically for portable battery-powered applications which require ultra-low quiescent current as low dropout regulators. The ultra-low consumption of type 0.6uA ensures long battery life and dynamic transient boost feature improves device transient response for wireless communication applications.The device is available in small 1x1mm DFN4 packages.Features● Operating Input V oltage Range: 2.2V to 5.5V ● Ultra-Low Quiescent Current Typical 0.6uA● Low Dropout: 160mV Typ. at 150mA@VOUT=3.3V ● High Output V oltage Accuracy ±1%● Stable with Ceramic Capacitors 1uF ● Over-Current Protection● Thermal Shutdown Protection● Available in Small 1x1 mm DFN4 Packages● These Devices are Pb−F ree, Halogen Free/BFR Free and are RoHS CompliantApplications● Battery Powered Equipments● Portable Communication Equipments ● Cameras, Image Sensors and Camcorders ● Label InformationOutput Voltage ：3.3VET631 XX Y B Q2With auto discharge function at off state DFN4 PackagePIN1 DirectionPin ConfigurationPin FunctionBlock DiagramAbsolute Maximum Ratingsexceeded, device functionality should not be assumed, damage may occur and reliability may be affected.1. Refer to ELECTRICAL CHARACTERISTIS and APPLICATION INFORMATION for Safe Operating Area.2. This device series incorporates ESD protection and is tested by the following methods:ESD Human Body Model tested per EIA/JESD22-A114CDM tested per JESD22-C101Latch up Current Maximum Rating tested per JEDEC78Thermal CharacteristicsRecommended Operating ConditionsElectrical CharacteristicsVOLTAGE VERSION 3.3 VIN IN OUT,IN OUT is safety.4. V DROP FT test method: Test the Vout voltage at Vset+V DROPMAX with 150mA output current.5. Guaranteed by design and characterization. Not a FT item.6. The minimum operating voltage is 2.2V.V DROP=V IN(min)-V OUT。