缺血性脑卒中患者幽门螺杆菌感染与两种血清标志物的关系

幽门螺旋杆菌感染与脑卒中的相关性研究李艳平;张元元【摘要】Objective To study the correlation between helicobacter pylori infection and cerebral apoplexy. Methods 30 patients with cerebral apoplexy who were admitted to our hospital November 2012 to February 2014 and 30 persons who had received physical examination and been proved healthy during the same period were divided into study group and control group.Two groups of subjects were dawn collecting venous blood oral condition, the determination of low density lipoprotein cholesterol (ldl-c), high-density lipoprotein cholesterol (hdl-c), total cholesterol, Hp-IgG and three acyl glycerin, at the same time analysis of helicobacter pylori infection and blood lipid. Results The group of 20 patients with positive Hp - IgG, the proportion was 66.7%, the control group there were 11 cases with positive Hp - IgG, obvious proportion was 36.7%, the difference was statistically significant (P<0.05);For two groups of Hp- IgG positive for total cholesterol, low density lipoprotein cholesterol (hdl-c) and three acyl glycerol were higher than a negative, high-density lipoprotein cholesterol (hdl-c), lower than the negatie clear difference was statistically significant (P<0.05);Through analysis, the team Hp-IgG and low density lipoprotein cholesterol (hdl-c), three acyl glycerin was positive correlation between, and high density lipoprotein was negative correlation. Conclusion The study shows that helicobacter pylori infection has close relation with cerebral apoplexy and it can change the lipid metabolism thus causes thecerebral apoplexy.%目的：研究幽门螺旋杆菌感染和脑卒中的相关性。

幽门螺杆菌感染与不同类型脑梗死患者C-反应蛋白的关系研究张欣;山珊;周楠;侯辰【期刊名称】《脑与神经疾病杂志》【年(卷),期】2018(026)008【摘要】目的研究幽门螺杆菌(Hp)感染与不同类型脑梗死(CI)患者的关系,及Hp-CagA-IgG抗体浓度与血清C-反应蛋白(CRP)水平的关系,探讨Hp感染影响CI患者发病的可能机制.方法通过生物蛋白芯片技术检测Hp-CagA-IgG抗体来评价Hp感染对不同类型CI患者的影响;应用免疫比浊法测定血清CRP水平,观察Hp感染与血清CRP的关系.结果①急性脑梗死(ACI)患者组Hp-CagA-IgG抗体阳性率及抗体浓度较对照组显著升高(P<0.05).其中,动脉粥样硬化性脑梗死组的Hp-CagA-IgG抗体阳性率、抗体浓度高于对照组(P<0.05),而腔隙性脑梗死组与对照组间(P>0.05);②动脉粥样硬化性脑梗死患者组的CRP水平高于对照组(P<0.05),且Hp-CagA-IgG抗体浓度与血清CRP浓度呈正相关(r=0.427,P<0.001).结论 CagA 阳性菌株Hp感染与脑梗死发病存在相关性,且与大动脉粥样硬化性脑梗死关系更为密切,其机制可能是通过直接作用血管内皮及介导全身炎症反应,促使动脉粥样硬化,导致动脉粥样硬化性脑梗死的发生,从而为根除Hp感染预防脑梗死的临床应用提供了实验依据.【总页数】4页(P468-471)【作者】张欣;山珊;周楠;侯辰【作者单位】710068 西安,陕西省人民医院神经内科;710068 西安,陕西省人民医院神经内科;710068 西安,陕西省人民医院药学部;710068 西安,陕西省人民医院神经内科【正文语种】中文【中图分类】R743.32【相关文献】1.不同剂量普伐他汀对脑梗死患者血清C-反应蛋白及血脂的影响 [J], 陈琰;牛国忠;金石2.幽门螺杆菌感染与脑梗死患者颈动脉斑块稳定性、纤维蛋白原、C-反应蛋白的关系 [J], 刘兵荣;肖瑾;陈伟;丁新生3.不同剂量氟伐他汀对急性脑梗死患者超敏C－反应蛋白的影响 [J], 钱监军4.不同剂量阿托伐他汀对急性脑梗死患者高敏C-反应蛋白及基质金属蛋白酶9的影响 [J], 曹云友5.不同剂量氟伐他汀对急性脑梗死患者超敏C-反应蛋白的影响 [J], 钱监军因版权原因，仅展示原文概要，查看原文内容请购买。

幽门螺杆菌感染与中国缺血性脑卒中亚型关系的临床分析目的探讨幽门螺杆菌（Hp）感染与中国缺血性脑卒中亚型的相关性。

方法回顾性分析2014年1～10月在我院住院的215例缺血性脑卒中患者，作为观察组，进行CISS分型，选取同时期156名健康体检人员为对照组，所有受检者行WLD600C-13C尿素呼气试验检测有无Hp感染。

结果观察组Hp阳性133例，占61.86%，为Hp阳性组，Hp阴性82例，占8.14%，为Hp阴性组；对照组Hp阳性79例，占50.64%，Hp阴性77例，占49.36%。

两组Hp阳性率比较差异有统计学意义（χ2=4.647，P=0.031）。

CISS分型中，LAA组的Hp感染例数为106例，和CS、PAD、OE、UE组比较，差异有统计学意义（P＜0.05），其余各组两两比较，差异无统计学意义（P>0.05）。

结论Hp感染与缺血性脑卒中有相关性，尤其与LAA关系密切。

[Abstract] Objective To explore the relation between Helicobacter pylori（Hp）infection and China ischemic stroke subtype. Methods 215 patients with ischemic cerebral stroke who were hospitalized in our hospital from January to October 2014 were retrospectively analyzed.They were assigned to observation group，and were classified according to China ischemic stroke subtype （CISS）.156 healthy subjects received physical examination at the same period were selected as control group.All subjects were given WLD600C-13C urea breath test to test whether Hp infection existed or not. Results 133 patients showed Hp positive in observation group，accounting for 61.86%，and they were assigned to Hp positive group.82 patients showed Hp negative，accouting for 8.14%，and they were assigned to Hp negative group；79 patients showed Hp positive in control group，accounting for 50.64%，and 77 patients showed Hp negative，accouting for 49.36%.There was statistically significant difference of Hp positive rate between two groups（χ2=4.647，P=0.031）.In CISS subtypes，the number of patients infected with Hp in LAA group was 106.There were significant differences compared with CS，PAD，OE and UE groups（P＜0.05），and there was no significant difference in the pair comparison between the other groups（P>0.05）. Conclusion Hp infection is related to ischemic cerebral stroke，and particularly closely related to LAA.[Key words] Helicobacter pylori；Ischemic cerebral stroke；Large-artery atherothrombotic stroke；China Ischemic stroke subtype中国缺血性脑卒中亚型（Chinese ischemic stroke subclassification，CISS）是目前最新的基于病因及发病机制进行的脑卒中分型方法，临床应用较广泛，其将急性缺血性脑卒中分为大动脉粥样硬化性脑卒中（LAA）、心源性脑卒中（CS）、穿支动脉病变性脑卒中（PAD）、其他原因（OE）和原因不明（UE）五类[1]。