介入栓塞治疗肝血管瘤57例临床研究朱海涛;李晓光;马强;李振峰【期刊名称】《中国实用医药》【年(卷),期】2015(000)014【摘要】目的：分析和探讨平阳霉素碘化油乳剂(PLE)超选择肝段动脉栓塞在肝血管瘤介入治疗中的临床疗效。
方法57例肝血管瘤患者进行超选择动脉栓塞治疗,其中41例运用 PLE联合聚乙烯醇颗粒进行栓塞治疗作为B组,16例选用超液态碘化油(LE)、适量造影剂联合聚乙烯醇颗粒制成乳剂进行栓塞作为A组,术后3~12个月观察碘油沉积、肿瘤大小变化及并发症的发生情况。
结果所有患者术前肝动脉造影显示供血动脉轻度增粗,瘤体较大时可有受压移位征象。
动脉早期血窦显影,血窦染色常维持到肝实质后期,持续不退,为“早出晚归”表现。
栓塞后肿瘤内碘油沉积良好,造影复查血管瘤染色缺如,供血血管消失。
两组患者第1次栓塞后12个月复查疗效比较,差异具有统计学意义(P<0.05)。
结论平阳霉素碘化油乳剂联合聚乙烯醇颗粒动脉栓塞治疗肝血管瘤是一种疗效肯定、安全理想的治疗方法。
%Objective To analyze and investigate the clinical effect by Pingyangmycin lipiodol emulsion (PLE) super choice hepatic artery embolization in interventional treatment of hepatic hemangioma.Methods Super choice hepatic artery embolization treatment was applied for 57 hepatic hemangioma patients. 41 case among them as group B received PLE combined with polyvinyl alcohol granule for embolization treatment, and the other 16 cases as group A received LE, contrast medium combined with polyvinyl alcohol granule for mixed emulsion in embolizationtreatment. In 3~12 months after operation, deposition of lipiodol, changes of tumor size and complications condition were observed.Results All the patients had mild thickening in feeding artery shown by preoperative hepatic angiography, and they might have compression displacement signs due to big tumor size. Early artery blood sinus angiography showed that blood sinus dye lasted till late stage of liver parenchyma, with the manifestation of “early leave and late return”. After embolization, deposition of lipiodol in tumor was good. Angiography reexamination showed absence of hemangioma dye and disappearance of feeding artery. Comparison between curative effects between the two groups in 12 months after operation showed a statistically significant difference(P<0.05).Conclusion Combination of Pingyangmycin lipiodol emulsion and polyvinyl alcohol granule is an ideal treatment method with precise effect in treating hepatic hemangioma by embolization.【总页数】2页(P3-4)【作者】朱海涛;李晓光;马强;李振峰【作者单位】273500 山东省邹城市人民医院介入科，影像科;273500 山东省邹城市人民医院介入科，影像科;273500 山东省邹城市人民医院介入科，影像科;273500 山东省邹城市人民医院介入科，影像科【正文语种】中文【相关文献】1.介入栓塞治疗不同体积肝血管瘤的临床疗效及血流动力学特征 [J], 李旭彤;吴宝音;李伟男;王浩;张涛2.腹腔镜手术切除术和介入栓塞治疗肝血管瘤患者的近期和远期疗效 [J], 张崇伦3.微创手术切除与介入栓塞治疗对肝血管瘤患者围术期指标及近期预后的影响 [J], 李思源; 华向东; 傅熙博4.婴幼儿肝血管瘤经动脉介入栓塞治疗的疗效及安全性 [J], 李晓伟;马瑞霞;贺小明;叶志球;梅世伟5.平阳霉素联合超化碘油混悬液经动脉介入栓塞治疗肝血管瘤患者中远期疗效研究[J], 唐文涛;黄会;蔡婵娟因版权原因，仅展示原文概要，查看原文内容请购买。
平阳霉素碘油乳剂动脉栓塞治疗肝血管瘤的中远期疗效评价蒋旭远;徐克【摘要】Objective To evaluate the middle-long term effect of transcatheter arterial embolization (TAE ) with pingyangmycin-lipiodol emulsion ( PLE ) in the treatment of hepatic hemangioma. Methods Collected 116 hepatic hemangioma cases underwent interventional treatment with PLE in our hospital from April 2000 to September 2010. According to WHO solid tumors reference standard, evaluate clinical efficacy by the reduction rate of tumor; the changes of the clinical symptoms and complications were all recorded in the follow-up data. Results 139 lesions of 116 cases were treated successfully. Follow-up 6 months to 10 years, the clinical symptoms disappeared in 79 cases, relieved in 6 cases and no change in 2 cases, effective rate is 97.7%. The size of the lesions reduced in different degrees. The effective rate of 6 months to 1 year, 1 to 3 years, 3 to 5 years and 5 to 10 years were 84.2%, 85.4%, 88.1% and 96.4% respectively. The largest cross-sectional areas of long-term follow-up 28 lesions were ( 30.54 ± 23.98 )cm2,( 24.89 ±19.48 )cm2, ( 20.73 ± 17.78 )cm2, ( 17.30 ± 15.21 )cm2 respectively, compared with preoperative [ ( 89.44 ± 67.93 )cm2 ] respectively with a significant difference (P < 0.05 ). There were no serious complications in all cases. Conclusion TAE with PLE in hepatic hemangioma proves to be effective, safe and little side-effects. It has broad indications and is an ideal method in the treatment of hepatic hemangioma.%目的评价平阳霉素碘油乳剂(PLE)经动脉栓塞治疗肝血管瘤的中远期疗效.方法 2000年4月至2010年9月在沈阳中国医科大学第一附属医院116例肝血管瘤患者接受经动脉PLE栓塞治疗,术后进行定期随访.参照WHO实体瘤疗效评价通用标准,根据肿瘤的缩小率评价其临床疗效,同时观察临床症状的改善和并发症情况.结果对116例患者的139个病灶成功实施了栓塞治疗.随访6个月～ 10年,87例术前有临床症状的患者79例症状完全消失,6例缓解,2例无变化,有效率97.7%.术后复查病灶有不同程度的缩小,术后6个月～ 1年,1 ～ 3年,3 ～ 5年,5 ～ 10年的有效率分别为84.2%、85.4%、88.1%、96.4%.长期随访的28个病灶术后6个月～ 1年、1 ～ 3年、3 ～ 5年、5 ～ 10年瘤体的最大截面积分别为(30.54 ± 23.98)cm2,(24.89 ±19.48)cm2,(20.73 ± 17.78)cm2,(17.30 ± 15.21)cm2,分别与术前[89.44 ±67.93)cm2]相比,差异均有统计学意义(P ＜ 0.05).所有病例均未出现严重的并发症.结论 PLE经动脉栓塞治疗安全、有效、适应证广、并发症少,是治疗肝血管瘤的理想方法.【期刊名称】《介入放射学杂志》【年(卷),期】2012(021)001【总页数】4页(P31-34)【关键词】肝血管瘤;平阳霉素碘油乳剂;栓塞;疗效【作者】蒋旭远;徐克【作者单位】110001,沈阳,中国医科大学第一附属医院放射科;110001,沈阳,中国医科大学第一附属医院放射科【正文语种】中文【中图分类】R735.7肝血管瘤是肝脏最常见的良性肿瘤［1-2］，占肝脏良性肿瘤的41.6%，以女性多见。
肝血管瘤治疗中不同介入栓塞方法的应用及效果对照分析目的分析肝血管瘤治疗中不同介入栓塞方法的应用及效果对照。
方法方便收集山东省菏泽市立医院介入科2015年5月—2017年1月收治的90例肝血管瘤患者并随机分组。
单纯栓塞组用平阳霉素碘化乳剂栓塞，联合栓塞组在单纯栓塞组基础上进行明胶海绵颗粒栓塞。
比较两组患者肝血管瘤疗效；介入栓塞并发症发生率；治疗前和治疗后患者总胆汁酸情况的差异。
结果联合栓塞组患者肝血管瘤疗效95.56%高于单纯栓塞组82.22%（P＜0.05）。
联合栓塞组介入栓塞并发症发生率33.33%低于单纯栓塞组40.00%，但两者之间差异无统计学意义（P>0.05）；治疗前两组总胆汁酸情况比较数据接近（P>0.05）；治疗后联合栓塞组总胆汁酸降低显著优于单纯栓塞组（P＜0.05）。
结论肝血管瘤治疗中在平阳霉素碘化乳剂栓塞基础上进行明胶海绵颗粒栓塞的应用及效果优于单纯采用平阳霉素碘化乳剂栓塞，可提高治疗效果，降低总胆汁酸水平，值得推广。
[Abstract] Objective To analyze the comparison of application effect of different intervention embolization methods in treatment of hepatic hemangioma. Methods Convenient selection 90 cases of patients with hepatic hemangioma admitted and treated in our hospital from May 2015 to January 2017 were selected and randomly divided into two groups，the simple embolization group adopted the embolization with pingyangmycin lipiodol emulsion，while the combined embolization group adopted the embolization with gelatin sponge particles on the basis of the simple group，and the curative effect of hepatic hemangioma，incidence rate of interventional embolization complications and the total bile acid of patients before and after treatment were compared between the two group. Results The curative effect of hepatic hemangioma in the combined group was higher than that in the simple group（95.56% vs 82.22%）（P＜0.05），and the incidence rate of intervention embolization in the combined group was lower than that in the simple group（33.33% vs 40.00%），and there was no obvious difference between the two （P>0.05），before treatment，the total bile acid of the two groups was similar（P>0.05），after treatment，the total bile acid decrease in the combined group was obviously better than that in the simple group（P＜0.05）. Conclusion The application effect of embolization with gelatin sponge particles on the basis of embolization with pingyangmycin lipiodol emulsion in treatment of hepatic hemangioma is better than that of simple embolization with pingyangmycin lipiodol emulsion，which can improve the treatment effect and reduce the total bile acid level，and it is worth promotion.[Key words] Hepatic hemangioma treatment；Different intervention embolization methods；Comparison of application effect肝血管瘤是一種肝脏良性肿瘤，患者没有典型症状，其中以海绵状血管瘤多见。
肝动脉栓塞治疗肝血管瘤的临床研究
许飞;李忱瑞
【期刊名称】《中国临床医生》
【年(卷),期】2017(045)004
【摘要】目的探讨肝血管瘤的肝动脉造影表现、栓塞治疗效果及不良反应.方法对72例肝血管瘤患者使用博来霉素、碘化油注射液、吸收性明胶海绵颗粒或海藻酸钠微球行肝动脉栓塞术,观察造影表现、疗效及不良反应.结果 72例肝血管瘤患者均成功行肝动脉栓塞术,6个月后复查,部分缓解50例,稳定病灶22例,有效率69.4%,肿瘤内碘油沉积较好.不良反应主要为发热、疼痛及呕吐等栓塞后反应,转氨酶一过性增高,2周后恢复正常.无胆道并发症、骨髓抑制、肾功能损伤及肺纤维化.结论肝动脉栓塞术是治疗肝血管瘤的有效治疗手段,且不良反应发生率低,值得在临床上进一步推广和研究.
【总页数】3页(P30-32)
【作者】许飞;李忱瑞
【作者单位】国家癌症中心中国医学科学院北京协和医学院肿瘤医院介入治疗科,北京100021;国家癌症中心中国医学科学院北京协和医学院肿瘤医院介入治疗科,北京100021
【正文语种】中文
【中图分类】R735.7
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