基因多态性与药物不良反应相关性研究进展
周婷;王春江;粟群芳
【期刊名称】《药物不良反应杂志》
【年(卷),期】2015(017)001
【摘要】PubMed,Nature database,ScienceDirect database and China National Knowledge Infrastructure (from year 2009 to 2013) were searched.The journal articles on correlation between gene polymorphism and adverse drug reactions were collected and analyzed.This article reviews the articles on correlation between adverse drug reactions and pleomorphic gene of metabolic enzymes,transporters,immune molecule and receptors.The metabolic enzymes mainly included cytochrome P450 2C9,N-acetyltransferase 2,uridine diphosphate glucuronosyl transferase 1A6,methylenetetrahydrofolate reductase,matrix metalloproteinase-9 and dihydropyrimidine dehydrogenase.The transporters mainly included solute carrier family 22 member 2,calcium channel,voltage-dependent,gamma subunit 6,solute carrier family 6 member 12,and ATP-binding cassette B1.The immune molecules mainly included human lymphocyte antigen (HLA) for instance HLA-B,HLA-A and HLA-C.The receptors mainly included dopamine 2 receptors/ankyrin repeat and kinase domain containing 1 Taq IA,chemokine receptor 3,orphan nuclear receptor NR4A1,pregnane X receptor and interleukin-4-receptor