当前位置：文档之家 › SKF-86002_72873-74-6_DataSheet_MedChemExpress

SKF-86002_72873-74-6_DataSheet_MedChemExpress

  • 格式：pdf
  • 大小：120.95 KB
  • 文档页数：1

Product Name:SKF-86002CAS No.: 72873-74-6Cat. No.:HY-12511MWt:297.35Formula:C16H12FN3SPurity :>98%

Solubility:

Mechanisms:

Biological Activity:

References:

Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com[1]. Griswold DE, et al. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase-and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.[2]. Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem. 1998 Apr 3;273(14):8389-97.[3]. Nick JA, et al. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest. 1997 Mar 1;99(5):975-86.SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). IC50 value: Target: p38 MAPK inhibitorin vitro: SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well asprostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation ofdihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speedsupernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophilphenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition offormylmethionylleucylphenylalanine-stimulatable and stress-inducible p3... Pathways:MAPK; Target:p38 MAPKProduct Data Sheet

DMSO

11 Deer Park Drive, Suite 102D Monmouth Junction, NJ 08852,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com

合集下载

kobe2602_COA_12064_MedChemExpress

kobe2602_COA_12064_MedChemExpress

Inhibitors, Agonists, Screening Certificate of Analysis

PHYSICAL AND CHEMICAL PROPERTIES Molecular Formula:C14H9F4N5O4SMolecular Weight:419.31Storage:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthChemical Structure:

ANALYTICAL DATA Appearance:Light brown to brown (Solid)1 H NMR Spectrum:Consistent with structureLCMS:Consistent with structurePurity (LCMS):96.97%Conclusion:The product has been tested and complies with the given specifications.Product Name:kobe2602Cat. No.:HY-15717CAS No.:454453-49-7Batch No.:12064Chemical Name:Hydrazinecarbothioamide, 2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)-

Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852,

派克精密流体微型泵说明书

派克精密流体微型泵说明书

微型泵精密流体

/precisionfluidics 1 603 595-1500您与运动和控制技术领域的先行者合作，就是希望促进您的业务发展和全球的发展。从微型电磁阀到高集成型自动化系统，我们的产品对于用于药物研发和病原体检测的救生医疗设备和科学仪器至关重要。并且对于缩短上市时间和降低总体拥有成本也十分关键。因此，请与派克合作，准备改变这一切吧！目录页

T2-05Helix

124

高效和紧凑型 13.5mm 宽泵 – 高达 800 mLPM高压泵 – 超过5.5 LPM和高达100 PSI的压力

T2-0320高性能与尺寸比率泵 – 高达 2.5 LPM

LTC 系列76液体系列传送泵 – 高达 650 mLPM

EZ 底座92振动隔离安装系统小型活塞泵（空气）

微型泵（空气/气体）

微型泵（液体）T2-0494超紧凑型、高效泵 – 高达

7.5LPMBTC-IIS 系列62应用广泛的多功能双头泵系列产品 – 高达

11 LPMBTC 系列52应用广泛的多功能泵系列产品 – 高达 6 LPM

LTC-IIS 系列84液体系列双头传送泵 – 高达

1.5 LPMCTS 系列

BTX-Connect 2836高性能紧凑型 20 mm 宽泵 – 高达 2.5 LPM

多功能双头和单头泵系列，适合多种应用-高达10 LPM

TTC 系列74紧凑、高效、低压泵 – 高达 6 LPM

TTC-IIS 系列84紧凑、高效、低压双头泵 - 高达 11 LPM附件4Helix 微型高压泵

高达100 PSI (6.9 bar)压力

Parker Helix是一款紧凑型高压泵，旨在实现小型即时临床护理仪器。Helix

可在挑战性的高海拔环境和无法使用外部压缩空气的应用中实现高压操作。 Helix泵可提供5.5 LPM以上的流量和高达100 PSI (6.9 bar)的压力，为性能至关

重要且空间有限的台式诊断设备提供了出色的解决方案。

矽力杰产品选型_恒佳兴电子专业电源IC

矽力杰产品选型_恒佳兴电子专业电源IC

Single output step down (Buck) Converter Vin max < 7V

Part Vin (min) Vin (max) Iout (max) Fsw Vout (min) Voltage Quiescent MO SFET (Ron H/L) Power Good

Number (V) (V) (A) (MHz) (V) Acurracy Current (uA) (m? ) Output Feature/ Special Function Package

SY8018A 2.5 5.5 0.45 / 0.6 ±2% 1.5 400/200 √ Ultra Low Quiescent Current DFN2x2-8

SY8030L 2.5 5.5 0.6 2.25 0.6 ±1.5% 50 300/200

DFN2x2-6

SY8078B 1.85 5.5 0.6 3 0.4 ±2% 40 350/250

DFN1.45x1-6

SY8010 2.5 5.5 1 1.5 0.6 ±1.5% 50 200/150

DFN2x2-6

SY8011A 2.5 5.5 1 1.5 0.6 ±2% 40 230/150

DFN1.5x1.5-6

SY8061A 2.5 5.5 1 1.5 0.6 ±2% 60 260/170

Auto Discharge DFN2x2-6

SY8065L 2.5 5.5 1 1.5 0.6 ±2% 90 250/200 √

SOT 23-6

SY8071 2.5 5.5 1 2 0.6 ±2% 40 260/170

SOT 23-5

SY8075 2.5 6.5 1 1.5 0.6 ±2% 40 260/170

DFN2x2-6

SY8077 2.5 6.5 1 1.5 0.6 ±2% 40 260/170

最新贴片缩写对照表

最新贴片缩写对照表

Marking CodeArt.-Bez. im KatalogGehäuseWG im Katalog0PIC10F200T-I/OTSOT23-6Y38432PIC10F202T-I/OTSOT23-6Y38434PIC10F204T-I/OTSOT23-6Y38436PIC10F206T-I/OTSOT23-6Y3843123LM3700XCBP-290BGA9Y769512LSS12LSub-SMAV347513LSS13LSub-SMAV347214LSS14LSub-SMAV34721BBC846BSOT23U12731BTS431BCXSOT23B44751DSMBTA42SOT23U13751DLS1DLSub-SMAV17711EBC847ASOT23U12731F10BQ040PBFSMBV34741FBC847BSOT23U12731GBC847CSOT23U12731GLS1GLSub-SMAV17711J10BQ100PBFSMBV34741KBC848BSOT23U12731LBC848CSOT23U12731MPMBTA13SOT23U17751MLS1MLSub-SMAV17711NPMBTA14SOT23U177522PIC10F222-I/OTSOT23-6Y3843200A1SMA200ZSMAV43792DSMBTA92SOT23U13752F10MQ040NPBFSMAV34742FBC850BSOT23U12732GBC850CSOT23U12732H10MQ060NPBFSMAV34742VPMBTA64SOT23U17753ABC856ASOT23U12733BBC856BSOT23U12733EBC857ASOT23U12733F30BQ040PBFSMCV34743FBC857BSOT23U12733GBC857CSOT23U12733H30BQ060PBFSMCV34743J30BQ100PBFSMCV34743KBC858BSOT23U12733LBC858CSOT23U127343BAS40SOT23V337347BAS70SOT23V33734GBC860CSOT23U12735ABC807-16SOT23U12735BBC807-25SOT23U12735CBC807-40SOT23U12736ABC817-16SOT23U12736BBC817-25SOT23U12736CBC817-40SOT23U1273610NDS0610SOT23U7795sortiert nach Marking Code9APLVA650ASOT23V43729CPLVA656ASOT23V43729FPLVA665ASOT23V4372926A1SMA5926SMAV4775927A1SMA5927SMAV4775929A1SMA5929SMAV4775935A1SMA5935