Presence of Bacterial Infection in Bleeding

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PresenceofBacterialInfectioninBleeding

CirrhoticPatientsIsIndependently

AssociatedwithEarlyMortalityandFailure

toControlBleeding

SANTIAGOVIVAS,MD,MANUELRODRIGUEZ,MD,M.ANTONIAPALACIO,MD,

ANTONIOLINARES,MD,JOSELUISALONSO,MD,andLUISRODRIGO,MD

Bacterialinfectionisstronglyassociatedwithgastrointestinalbleedingincirrhoticpatients

andseemstoberelatedwiththefailuretocontrolbleeding.Theaimsofthisstudywereto

assesstheinfluenceofinfectionsonthefailuretocontrolbleedinganddeathincirrhotic

patientswithoutantibioticprophylaxis.Ninety-oneconsecutivebleedingcirrhoticpatients

wereanalyzed.Bleedingwasmanagedusingsomatostatinwithsclerotherapyforactive

bleeding.Screeningforbacterialinfection(analysisandcultureofblood,urine,asciticand

otherfluids,togetherwithchestradiography)wasmadeattime0andwhenclinicalsigns

suggestedinfection.Thecauseofbleedingwasvaricealin72(79%)patients.Failureto

controlbleedingoccurredin24(26%)patients,and10(11%)ofthepatientsdied.Compared

withthegroupwithoutinfection,failuretocontrolbleeding(65%vs15%;PϽ0.001)and

mortality(40%vs3%;PϽ0.001),wereobservedmorefrequentlyinpatientswithinfection.

Multivariateanalysisshowedthatbacterialinfection(ORϭ9.7;PϽ0.001)andthepresence

ofshock(ORϭ3.5;PϽ0.05)wereindependentlyassociatedwithfailuretocontrolbleeding.

Bacterialinfection(ORϭ12.6;PϽ0.01),encephalopathy(ORϭ6.9;PϽ0.05),andshock

(ORϭ5.8;PϽ0.05)wereidentifiedaspredictiveofdeath.Inconclusion,inbleeding

cirrhoticpatientsbacterialinfectionisassociatedwithfailuretocontrolbleedingaswellasmortality.

KEYWORDS:bacterialinfection;cirrhosis;varicealbleeding;portalhypertension.

Bacterialinfectionisfrequentlydiagnosedinpatients

withcirrhosisandgastrointestinalbleeding.Prospec-

tivestudieshaveshownthatbacterialinfectionsde-

velopinupto66%ofcases(1),about20%withinthe

first48hr(2,3),and35–66%withinthesecondweek

(1,4).Ithasbeenreportedthattheshort-termmortality

rateofinfectedpatientsisabout30–40%(9,10).One

studyhasshownthatbacterialinfectionsincreasethe

riskofearlyrebleedingininfectedcirrhoticpatients

butthatmortalityisrelatedtotheseverityofcirrhosis

(4).Arecentstudyshowedthatbacterialinfection

andtheuseofempiricalantibiotictreatmentare

independentlyassociatedwithfailuretocontrol

varicealbleedingduringthefirstfivedays(11).

Althoughshort-termantibioticprophylaxisiseffec-

tiveinthepreventionofbacterialinfectionsinthese

patients,noneofthefiverecentlyreported

random-ManuscriptreceivedFebruary5,2001;acceptedJune15,2001.FromtheGastroenterologyService,HospitalCentraldeAstu-rias,Oviedo,Spain.Addressforreprintrequests:Dr.ManuelRodriguez,Gastroen-terologyService,HospitalCentraldeAsturias,CelestinoVillamils/n33006Oviedo,Spain.DigestiveDiseasesandSciences,Vol.46,No.12(December2001),pp.2752–2757(©2001)

2752DigestiveDiseasesandSciences,Vol.46,No.12(December2001)

0163-2116/01/1200-2752/0©2001PlenumPublishingCorporationizedcontrolledtrialshaveshownasignificantdiffer-

enceformortalityduringthetotalperiodofhospital-

ization(1,5–8).Onlyarecentmeta-analysishas

shownthatshort-termantibioticprophylaxissignifi-

cantlyincreasesthesurvivalrateat19daysincir-

rhoticpatientswithgastrointestinalhemorrhage(12).

Theaimofthisprospectivestudywastoinvestigate

theprognosticinfluenceofbacterialinfectiononthe

failuretocontrolbleedinganddeathincirrhotic

patientsadmittedforuppergastrointestinalbleeding,

withoutantibioticprophylaxis.

MATERIALSANDMETHODS

Patients.Threehundredthirty-fourconsecutiveadmis-sionsin233patientswithcirrhosiswereevaluatedbetween

October1995andJanuary1997.Uppergastrointestinal

bleedingwaspresentin100patients.Ninepatientswere

excludedfromtheanalysis(twoduetodeathwithinthefirst

12hr,sixbecausetheywerereceivingantibiotics,onedueto

transfertoanothermedicalcenter).Ninety-onepatients

werefinallyevaluated.

Definitions.Cirrhosishadbeendiagnosedbyliverbiopsyoracombinationofclinical,biochemicalfindings,andim-

agingdata.Uppergastrointestinalbleedingwasdefinedas

gastrointestinalbleeding:melena,hematemesis,redblood

perrectum,orredbloodingastriclavage.Bleedingwas

attributedtoruptureofesophagealvaricesifactive,orifa

whiteplugwasidentifiedonavarixintheabsenceofother

lesions,orwhenthecauseofbleedingwasanotportal

hypertensionlesion,thatis,endoscopyrevealedalesion

withrecentsignsofbleeding—eitherclotorvisiblevessel.

Thepresenceofhemodynamicshockwasdefinedas

systolicpressurebelow90mmHgoradecreaseofmore

than20mmHgfromtheinitialvalueduringthebleeding

episode.

Time0wasdefinedasthedevelopmentofmelenaor

hematemesisatthetimeofadmissionorwhenitdeveloped

inahospitalizedpatient.Patientsweredividedintotwo

groups.Group1patientswerethosewithfailuretocontrol

bleeding—thosewithpersistentbleedingduring24hrinthe

first48hraftertime0,orthosewithearlyrebleedingafter

24hrsfromtime0orwithinfivedays.Group2patients