Presence of Bacterial Infection in Bleeding
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PresenceofBacterialInfectioninBleeding
CirrhoticPatientsIsIndependently
AssociatedwithEarlyMortalityandFailure
toControlBleeding
SANTIAGOVIVAS,MD,MANUELRODRIGUEZ,MD,M.ANTONIAPALACIO,MD,
ANTONIOLINARES,MD,JOSELUISALONSO,MD,andLUISRODRIGO,MD
Bacterialinfectionisstronglyassociatedwithgastrointestinalbleedingincirrhoticpatients
andseemstoberelatedwiththefailuretocontrolbleeding.Theaimsofthisstudywereto
assesstheinfluenceofinfectionsonthefailuretocontrolbleedinganddeathincirrhotic
patientswithoutantibioticprophylaxis.Ninety-oneconsecutivebleedingcirrhoticpatients
wereanalyzed.Bleedingwasmanagedusingsomatostatinwithsclerotherapyforactive
bleeding.Screeningforbacterialinfection(analysisandcultureofblood,urine,asciticand
otherfluids,togetherwithchestradiography)wasmadeattime0andwhenclinicalsigns
suggestedinfection.Thecauseofbleedingwasvaricealin72(79%)patients.Failureto
controlbleedingoccurredin24(26%)patients,and10(11%)ofthepatientsdied.Compared
withthegroupwithoutinfection,failuretocontrolbleeding(65%vs15%;PϽ0.001)and
mortality(40%vs3%;PϽ0.001),wereobservedmorefrequentlyinpatientswithinfection.
Multivariateanalysisshowedthatbacterialinfection(ORϭ9.7;PϽ0.001)andthepresence
ofshock(ORϭ3.5;PϽ0.05)wereindependentlyassociatedwithfailuretocontrolbleeding.
Bacterialinfection(ORϭ12.6;PϽ0.01),encephalopathy(ORϭ6.9;PϽ0.05),andshock
(ORϭ5.8;PϽ0.05)wereidentifiedaspredictiveofdeath.Inconclusion,inbleeding
cirrhoticpatientsbacterialinfectionisassociatedwithfailuretocontrolbleedingaswellasmortality.
KEYWORDS:bacterialinfection;cirrhosis;varicealbleeding;portalhypertension.
Bacterialinfectionisfrequentlydiagnosedinpatients
withcirrhosisandgastrointestinalbleeding.Prospec-
tivestudieshaveshownthatbacterialinfectionsde-
velopinupto66%ofcases(1),about20%withinthe
first48hr(2,3),and35–66%withinthesecondweek
(1,4).Ithasbeenreportedthattheshort-termmortality
rateofinfectedpatientsisabout30–40%(9,10).One
studyhasshownthatbacterialinfectionsincreasethe
riskofearlyrebleedingininfectedcirrhoticpatients
butthatmortalityisrelatedtotheseverityofcirrhosis
(4).Arecentstudyshowedthatbacterialinfection
andtheuseofempiricalantibiotictreatmentare
independentlyassociatedwithfailuretocontrol
varicealbleedingduringthefirstfivedays(11).
Althoughshort-termantibioticprophylaxisiseffec-
tiveinthepreventionofbacterialinfectionsinthese
patients,noneofthefiverecentlyreported
random-ManuscriptreceivedFebruary5,2001;acceptedJune15,2001.FromtheGastroenterologyService,HospitalCentraldeAstu-rias,Oviedo,Spain.Addressforreprintrequests:Dr.ManuelRodriguez,Gastroen-terologyService,HospitalCentraldeAsturias,CelestinoVillamils/n33006Oviedo,Spain.DigestiveDiseasesandSciences,Vol.46,No.12(December2001),pp.2752–2757(©2001)
2752DigestiveDiseasesandSciences,Vol.46,No.12(December2001)
0163-2116/01/1200-2752/0©2001PlenumPublishingCorporationizedcontrolledtrialshaveshownasignificantdiffer-
enceformortalityduringthetotalperiodofhospital-
ization(1,5–8).Onlyarecentmeta-analysishas
shownthatshort-termantibioticprophylaxissignifi-
cantlyincreasesthesurvivalrateat19daysincir-
rhoticpatientswithgastrointestinalhemorrhage(12).
Theaimofthisprospectivestudywastoinvestigate
theprognosticinfluenceofbacterialinfectiononthe
failuretocontrolbleedinganddeathincirrhotic
patientsadmittedforuppergastrointestinalbleeding,
withoutantibioticprophylaxis.
MATERIALSANDMETHODS
Patients.Threehundredthirty-fourconsecutiveadmis-sionsin233patientswithcirrhosiswereevaluatedbetween
October1995andJanuary1997.Uppergastrointestinal
bleedingwaspresentin100patients.Ninepatientswere
excludedfromtheanalysis(twoduetodeathwithinthefirst
12hr,sixbecausetheywerereceivingantibiotics,onedueto
transfertoanothermedicalcenter).Ninety-onepatients
werefinallyevaluated.
Definitions.Cirrhosishadbeendiagnosedbyliverbiopsyoracombinationofclinical,biochemicalfindings,andim-
agingdata.Uppergastrointestinalbleedingwasdefinedas
gastrointestinalbleeding:melena,hematemesis,redblood
perrectum,orredbloodingastriclavage.Bleedingwas
attributedtoruptureofesophagealvaricesifactive,orifa
whiteplugwasidentifiedonavarixintheabsenceofother
lesions,orwhenthecauseofbleedingwasanotportal
hypertensionlesion,thatis,endoscopyrevealedalesion
withrecentsignsofbleeding—eitherclotorvisiblevessel.
Thepresenceofhemodynamicshockwasdefinedas
systolicpressurebelow90mmHgoradecreaseofmore
than20mmHgfromtheinitialvalueduringthebleeding
episode.
Time0wasdefinedasthedevelopmentofmelenaor
hematemesisatthetimeofadmissionorwhenitdeveloped
inahospitalizedpatient.Patientsweredividedintotwo
groups.Group1patientswerethosewithfailuretocontrol
bleeding—thosewithpersistentbleedingduring24hrinthe
first48hraftertime0,orthosewithearlyrebleedingafter
24hrsfromtime0orwithinfivedays.Group2patients