胰岛素样生长因子系统与多囊卵巢综合征研究进展

颜琪，张慧霞，张慧英△【摘要】多囊卵巢综合征（PCOS）是最常见的女性内分泌疾病，以慢性无排卵和高雄激素血症为特征，其病因复杂，临床表现高度异质，不仅影响女性生殖和内分泌系统，还常伴随多种代谢异常，包括胰岛素抵抗、高胰岛素血症、肥胖等。

Apelin是脂肪因子家族新成员，是由脂肪细胞分泌的一类活性肽激素，主要参与体液平衡、食物摄入、胰岛素分泌、能量代谢等生理过程。

具有改善胰岛素抵抗，增强胰岛素敏感性的作用。

近年研究发现，PCOS患者血清Apelin浓度升高，尤其在伴有肥胖和胰岛素抵抗的患者中升高更为明显，这可能与其参与PCOS相关的代谢紊乱有关。

因此，Apelin作为一种新的生物学指标，可能参与到PCOS发病及其代谢紊乱过程，因而有望成为治疗PCOS的新靶点。

【关键词】多囊卵巢综合征；Apelin；超重；肥胖症；胰岛素抗药性；综述Research Progress of Apelin in Polycystic Ovary Syndrome YAN Qi,ZHANG Hui-xia,ZHANG Hui-ying.Department of Obstetrics and Gynecology,Tianjin Medical University General Hospital,Tianjin300052,ChinaCorresponding author:ZHANG Hui-ying,E-mail:*********************【Abstract】Polycystic ovary syndrome(PCOS)is the most common female endocrine disease,which ischaracterized by chronic anovulation and hyperandrogenemia,with complex etiology and highly heterogeneousclinical manifestations.PCOS not only affects female reproduction and endocrine system,but also is oftenaccompanied with a variety of metabolic abnormalities,including insulin resistance(IR),hyperinsulinemia,obesityand so on.Apelin,a new member of adipokines family,is a kind of active peptide hormone secreted by adiposity.Apelin is mainly involved in many physiological processes,such as fluid balance,food intake,insulin secretion andenergy metabolism.It can reverse IR and enhance insulin sensitivity.In recent years,it has been observed that theelevated level of serum Apelin in PCOS patients,especially in those patients with obesity and IR,may be relatedto the abnormal proliferation of granulosa cells and the related metabolic disorders.Therefore,Apelin as a novelbiological indicator may be involved in the pathogenesis of PCOS and its metabolic disorders,so it is expected tobecome a potential target for the treatment of PCOS.【Keywords】Polycystic ovary syndrome;Apelin;Overweight;Obesity;Insulin resistance;Review（ＪＩｎｔＲｅｐｒｏｄＨｅａｌｔｈ蛐ＦａｍＰｌａｎ，2021，40：74-78）·综述·基金项目：天津市科技计划项目（18ZXDBSY00220）作者单位：300052天津医科大学总医院妇产科通信作者：张慧英，E-mail:*********************△审校者多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄妇女常见的一种复杂的内分泌及代谢异常所致的疾病，发病率为6%～20%[1]。

多囊卵巢综合征伴胰岛素抵抗的中医药研究现状游芳凝;曹文富【期刊名称】《海南医学》【年(卷),期】2015(000)011【摘要】多囊卵巢综合征是临床常见的生殖内分泌代谢障碍疾病，有出现糖尿病、心血管疾病等并发症的风险。

在多囊卵巢综合征中，胰岛素抵抗、高胰岛素血症起着重要的病理生理作用。

中医辨证论治在改善多囊卵巢综合征患者的生殖功能、调节糖脂代谢及预防并发症方面有良好的疗效。

%Polycystic ovary syndrome (PCOS) is a common clinical disease characterized by reproductive en-docrine and metabolic abnormalities, which even has the risk of developing complications such as diabetes and cardio-vascular diseases. The insulin resistance and hyperinsulinemia play an important role in the pathophysiologic process of polycystic ovary syndrome. Syndrome differentiation and treatment are intended to improve the reproductive func-tion in women with PCOS, and has obtained good curative effect on regulating glucolipid metabolism and preventing complications.【总页数】3页(P1647-1649)【作者】游芳凝;曹文富【作者单位】重庆医科大学附属第一医院中西医结合科，重庆 400016;重庆医科大学附属第一医院中西医结合科，重庆 400016【正文语种】中文【中图分类】R711.5【相关文献】1.伴或不伴胰岛素抵抗的多囊卵巢综合征的超声特征及其与内分泌指标的相关性[J], 陈慧;詹维伟;杨志芳;喇端端;陈晨2.体质量指数正常的多囊卵巢综合征伴胰岛素抵抗患者的临床特征及胰岛素抵抗影响因素分析 [J], 高金金;侯丽辉;李妍;王颖;孟小钰;张春兰;徐芳3.中医药治疗多囊卵巢综合征伴胰岛素抵抗的研究进展 [J], 董娟;刘琼辉4.补肾通脉方对伴胰岛素抵抗的多囊卵巢综合征大鼠胰岛素抵抗及排卵障碍的影响[J], 李琼;黄冬梅;陆付耳;谢阳;徐丽君;邹欣;龚菂5.小檗碱改善多囊卵巢综合征伴胰岛素抵抗大鼠子宫组织局部胰岛素抵抗的作用机制研究 [J], 李慕白;王婷婷;张多加;吴效科;张明明因版权原因，仅展示原文概要，查看原文内容请购买。