MAIN SYMPOSIUM
- 格式:pdf
- 大小:378.63 KB
- 文档页数:67
《计算机组成与设计》典型思政案例山东大学计算机科学与技术学院《计算机组成与设计》课程团队知识点思政元素计算机的基本组成/计算机发展史山东大学DJL 1集成电路数字通用计算机➢1972年山东大学自主研制成功DJL-1小规模集成电路计算机获全国科学大会奖➢作为新一代山大人为中国计算机发展做出贡献科技报国图片来源于网络,仅用于教学图片来源于网络,仅用于教学知识点思政元素指令集设计龙芯推出自主研发指令集➢当今国际形势下,指令集对芯片的自主研发起到关键性作用➢龙芯推出自主研发指令集LoongArch ,支撑“中国芯”提升行业服务意识科技报国图片来源于网络,仅用于教学知识点思政元素指令流水火神山的“中国速度”➢流水线的思想是火神山速度的支撑➢科技支撑“中国速度”,专业素质支撑科技发展提升行业服务意识2020年1月23日,武汉市委市政府做出建设“火神山”医院的决定2月2日,火神山医院完成交接10天!图片来源于网络,仅用于教学冯·诺依曼架构的性能瓶颈存储器运算器计算机的基本组成/冯·诺依曼体系架构华人学者对计算机架构的前沿研究存内计算架构存储器运算阵列Chi, Ping, et al.. “PRIME: A Novel Processing -in-Memory Architecture for Neural Network Computation in ReRAM-Based Main Memory.”In 2016 ACM/IEEE 43rd Annual International Symposium on Computer Architecture (ISCA).➢基于经典的冯·诺依曼架构,大数据应用中存储器和运算器间有大量数据交换,成为性能瓶颈➢2016年加利福尼亚大学圣塔芭芭拉分校华人教授团队提出“存内计算”这种新架构,有效解决了这一问题了解前沿知识、开拓眼界的同时培养文化自信计算机的工作步骤/计算机的工作步骤计算机国际形势图片来源于网络,仅用于教学➢复杂的国际形势下需要掌握核心技术➢了解计算机工作方式是设计计算机的重要基础夯实基础,科技报国图片来源于网络,仅用于教学知识点思政元素存储介质/DRAM DRAM 国际市场形势➢DRAM 是当今计算机系统内存的主要介质➢目前DRAM 的国际市场,韩国三星、海力士、美国美光占97%的市场份额,处于垄断地位➢关注国际、国内DRAM 行业发展,贡献自己力量提升行业服务意识44%29%24%3%DRAM 国际市场份额三星SK 海力士美光其他知识点思政元素存储器访问/并行访问效率中国银河-1号巨型计算机➢我国研发的银河-I巨型计算机的存储器结构:素数模块、交叉访问,分析其并行性➢1983年研制成功,填补了国内巨型计算机的空白,中国成为继美国、日本之后,第三个能独立设计和制造巨型计算机的国家树立实现中华民族伟大复兴的信心银河-1号巨型计算机图片来源于网络,仅用于教学图片来源于网络,仅用于教学知识点思政元素存储器扩展国产内存模块上市➢2020年,合肥长鑫自主研发内存模块上市,填补国产DRAM 空白➢该内存模块由8个内存颗粒扩展而成,结合本节知识分析其扩展方式树立文化自信,科技报国自主研发的国产长鑫DDR4内存模块知识点思政元素存储器校验/海明校验海明发明校验方法的故事Richard Hamming(1915-1998)图片来源于网络,仅用于教学➢海明为了解决读卡错误,提出改进的校验方法➢鼓励学生养成善于发现问题、解决问题的习惯勤于观察,擅于创新图片来源于网络,仅用于教学知识点思政元素存储器/cache中国互联网的蓬勃发展➢2020年互联网普及率达70.4%,极大便利了人们生活➢PowerCache(缓存)技术是打破网络速度瓶颈的武器培养文化自信网络扶贫:累计帮助超过100万贫困人口脱贫,宽带网络覆盖90%以上的贫困村网络教育互联网医疗电商直播图片来源于网络,仅用于教学知识点思政元素原码中国数学家首次提出正负数概念➢负数是由三国时期中国数学家刘徽在《九章算术》提出的➢为数的表示提供了科学的方法“正算赤,负算黑;否则以斜正为异”---三国∙刘徽培养民族自豪感视频来源于网络,仅用于教学知识点思政元素溢出阿丽亚娜-5空难➢1996年6月4日,阿丽亚娜-5运载火箭首次测试发射,火箭在发射后37秒被迫自行引爆。
Changchun,located northeast of Beijing,is the capital of Jilin Province. In the eyes of a Chinese,it is a Chinese version of a combination of Detroit and Hollywood. It has China's largest motor vehicle plant and its biggest film studio.S cenic spots in Changchun长春电影世纪城,东方好莱坞Changchun Movie WonderlandThe First World-class Movie Theme Amusement Park in China长春雕塑公园Changchun World Sculpture Park长春文化广场Changchun Cultural Square净月潭森林公园Jingyuetan National Forest Parkone of the largest artificial forests in Asiaand a national forest park where the ecological system is well protected伪满皇宫The Puppet Manchurian Imperial Palace Museum (The Puppet Manchukuo Palace) 长春电影制片厂Changchun Film Studio长春第一汽车制造厂Changchun First Automobile Works (FAW)长春国际汽车展览会Changchun International Auto Expo北大湖滑雪场Beidahu Ski Resort长春南湖公园Changchun South Lake ParkMain Exhibition & ConferenceChangchun Film FestivalChina (Changchun) International Auto ExpoChina Jilin-Northeast Asia Investment & Trade ExpoChina (Changchun) International Agriculture-Food Expo (Trade Fair)China Changchun International Education FairChina Changchun International Sculpture SymposiumChangchun Vasaloppet International Cross-country Ski FestivalChina (Changchun) Summer Festival。
制片人, 监制Producer副制片人Junior Producer出品人Executive Producer总策划Associate producer策划Co-Associate producer执行制片人Line producer执行制片人Executive Producer制片人Co-Executive Producer广播制作人Broadcast Producer制作公司production house制片PA Production电视制片人Television Producer电视制片工程师Television Production Engineer执行导演First assistant director Co-Script editor总编Chief Editor高级编辑Senior Editor编辑助理,一般编导Assistant Editor执行编辑Managing Editor制作编辑Production Editor助理编辑Associate Editor总监制Production Supervisor监制Co- Production Supervisor技术监制Technical supervisor特效指导effects supervisor活动策划Events Planner编剧Screenwriter编审Script editor Coordinator摄影Photographer Production designer录音Sound Composer动画3D-animation制作组production crew导演Director /action director编辑主任Editorial Director摄影指导director of photography节目部主任Program Director电视导演Television Director广播节目总监Radio Program Director主要赞助商main sponsor联合赞助商co-sponsor领衔主演starring特别演出special appearance联合演出co-starring电台播音员Radio Announcer摄影助理camera assistant灯光师gaffer灯光助理lighting grip收音sound mixer特技指导stunt choreography剧照movie stills信息专员Information Support Specialist 公共关系Public Relations公共关系助理Public Relations Assistant研讨会协调员Symposium Coordinator 节目协调人Program Coordinator新闻记者Journalist校对Proofreader翻译员Translator排字工人Typesetter广告员Publicist记者Reporter专栏作家Columnist文件编辑Copy Editor通讯记者Correspondent作家Author作者Writer。
Society for General Microbiology – 149th Ordinary Meeting – University of East Anglia, Norwich – 10-13 September 2001 - 1 - CONTENTS Page
MAIN SYMPOSIUM Mycobacteria - new developments 3
GROUP SYMPOSIUM CELLS & CELL SURFACES GROUP Microbial lifestyles 7 Offered posters 8
CLINICAL MICROBIOLOGY GROUP Lower respiratory tract infections 11 Offered poster 13 EDUCATION GROUP Research supervision: how to get it right 15
ENVIRONMENTAL MICROBIOLOGY GROUP joint with the BRITISH PHYCOLOGICAL SOCIETY Microbial interactions in aquatic environments 17 Offered posters 20
FERMENTATION & BIOPROCESSING GROUP Bioprocess monitoring and control 27
MICROBIAL INFECTION GROUP Mobile genetic elements in bacterial virulence 31 Offered posters 33
PHYSIOLOGY, BIOCHEMISTRY & MOLECULAR GENETICS GROUP Metabolic engineering 41 Offered posters 43
SYSTEMATICS & EVOLUTION GROUP Classification and identification of clinically significant actinomycetes 47 Offered posters 49
PROMEGA PRIZE PRESENTATIONS 53
INDEX OF AUTHORS 57 LATE SUBMISSIONS 59 Society for General Microbiology – 149th Ordinary Meeting – University of East Anglia, Norwich – 10-13 September 2001 - 2 - Society for General Microbiology – 149th Ordinary Meeting – University of East Anglia, Norwich – 10-13 September 2001 - 3 -
MAIN SYMPOSIUM Mycobacteria - new developments
MONDAY 10 SEPTEMBER 2001 Systematics 0910 Mycobacteria in the 21st century NEIL STOKER London School of Hygiene and Tropical Medicine Tuberculosis and leprosy ravaged Europe for centuries, but incidence has fallen dramatically due to a number of social, biological and public health interventions. Scientifically, the 19th century saw the identification of the causative organisms, while the 20th century brought a vaccine, antibiotics, and the genome sequence. However, as we move into the 21st century, the incidence of TB is rising in many low-income countries, driven by the HIV pandemic. Multidrug-resistant strains of Mycobacterium tuberculosis have emerged, and large trials have shown BCG to be ineffective in the parts of the world that need it most. In addition, bovine tuberculosis is a major problem in the UK, but vaccination is not possible because it compromises skin testing. There is therefore a pressing need for novel antibiotics and a better vaccine. Because of their medical and veterinary importance, the mycobacteria are now the most deeply sequenced group of organisms. The combination of comparative genomic analysis, genetic tools such as targeted gene inactivation, and functional genomics technologies provide an opportunity for a quantum leap in our understanding of the biology of these pathogens. 0950 Systematics of mycobacteria MICHAEL GOODFELLOW Dept of Agricultural and Environmental Science, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU The rekindling of interest in mycobacterial systematics started with the Runyon revolution but continued to reverberate with the introduction and application of chemotaxonomy, molecular systematics and numerical phenetic taxonomy. The impact of the methods, both individually and collectively, in shaping the classification of mycobacteria and other mycolic acid containing actinomycetes will be covered. These organisms belong to the suborder Corynebacterineae which encompasses nine genera which form a distinct clade in the 16S rDNA tree. Over half of the 92 validly described species of Mycobacterium contain organisms that are considered to be pathogenic for animals and man. The importance of this classification in the recognition, characterisation and identification of putatively novel and established species of Mycobacterium will be highlighted. In addition, the integrated use of genotypic and phenotypic methods in unravelling the taxonomy of poorly studied, albeit clinically significant groups of mycobacteria will be illustrated. The prospects and implications of further improvements in the classification of mycobacteria will be considered. 1100 Comparative mycobacterial genomics S.T. COLE Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France Mycobacterium tuberculosis, the scourge of humanity, is one of the most successful and scientifically challenging pathogens of all time. The complete 4.41 Mb genome sequence is available for H37Rv, the paradigm strain for the slow-growing M. tuberculosis complex. Bioinformatic analysis led to the identification of ~4,000 genes in the genome sequence, and provided fresh insight into the biochemistry, physiology, genetics and immunology of this much-feared bacterium. The information and knowledge thus obtained is now catalyzing the conception of new prophylactic and therapeutic interventions against tuberculosis, and enhancing our understanding of the biology of the tubercle bacilli. The abundance of genes predicted to be involved in lipid and polyketide metabolism suggests that lipolysis is likely to be the major metabolic source of energy and carbon. Prominent amongst the "orphan" genes were two large families encoding novel, glycine-rich proteins of repetitive structure, the PE and PPE proteins. Over 8% of the genome is devoted to the production of these curious proteins of unknown function and this implies that they must play an important biological role. Comparative genomics of other members of the M. tuberculosis complex, using BAC-arrays, has uncovered a series of variable loci that may be responsible for a variety of phenotypic differences including host range and virulence. In parallel, the 3.3 Mb genome sequence of the related leprosy bacillus, Mycobacterium leprae, has been determined. Comparisons of the two sequences are mutually enriching and have revealed numerous pseudogenes and extensive genetic decay in M. leprae. Genome downsizing may account for the exceptionally slow growth of this unculturable pathogen while the evolution of M. leprae has naturally defined the minimal gene-set for mycobacteria.