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Dapivirine_244767-67-7_DataSheet_MedChemExpress

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Product Name:Dapivirine

CAS No.: 244767-67-7

Cat.No.:HY-14266Product Data Sheet

Cat. No.:HY14266

MWt:329.40

Formula:C20H19N5

Purity :>98%

DMSO24mg/ml;Water<1

mg/mlSolubility:

Mechanisms:

Biological Activity:

Diii(TMC120TMC120R147681)iNNRTIfHIVtitithIC50f24 Pathways:Anti-infection; Target:NNRTIs

Pathways:Anti-infection; Target:HIVDMSO 24 mg/ml; Water

1 mg/ml

Dapivirine(TMC 120, TMC 120 R147681) is a NNRTI for HIV reverse transcriptase with IC50 of 24

nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI- resistant isolates.

IC50 value: 24 nM [1]

Target: HIV reverse transcriptase; NNRTIs

in vitro: TMC120-R147681 is a diarylpyrimidine with high activity against wild-type and mutant HIV. A

24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV

infection, whereas 10-fold-higher concentrations blocked cell-associated HIV, TMC120-R147681

apparentlyblockedinfectionintheprimaryculturesata10nMconcentrationbutsecondarycultures

References:

[1]. Van Herrewege Y, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-

781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9.apparently blocked infection in the primary cultures at a 10 nM concentration, but secondary cultures

revealed that a 100 nM concentration was needed to completely prevent proviral integration [1].

Dapivirine is well tolerated by epithelial cells, T cells, macrophages, and cervical tissue explants with

CC50 (50% cytotox...

[2]. Fletcher P, et al. Inhibition of human immunodeficiency virus type 1 infection by the candidate

microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Feb;53(2):487-95.

[3]. Di Fabio S, et al. Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-

nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation. AIDS. 2003 Jul 25;17(11):1597-604.

[4]. Nel AM, et al. Pharmacokinetics of 2 dapivirine vaginal microbicide gels and their safety vs.

Hydroxyethyl cellulose-based universal placebo gel. J Acquir Immune Defic Syndr. 2010Oct;55(2):161-9

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

www.medchemexpress.com Oct;55(2):161-9.

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Pranlukast_hemihydrate_COA_22422_MedChemExpress

Pranlukast_hemihydrate_COA_22422_MedChemExpress

Inhibitors, Agonists, Screening Certificate of Analysis

PHYSICAL AND CHEMICAL PROPERTIES Molecular Formula:C27H23N5O4 .1/2H2OMolecular Weight:490.51Storage:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthChemical Structure:

ANALYTICAL DATA Appearance:White to off-white (Solid)1 H NMR Spectrum:Consistent with structureLCMS:Consistent with structurePurity (LCMS):99.89%Conclusion:The product has been tested and complies with the given specifications.Product Name:Pranlukast (hemihydrate)Cat. No.:HY-B0290ACAS No.:150821-03-7Batch No.:22422Chemical Name:Benzamide, N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-, hydrate (2:1)

Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852,

Daclatasvir_dihydrochloride_COA_25987_MedChemExpress

Daclatasvir_dihydrochloride_COA_25987_MedChemExpress

Inhibitors, Agonists, Screening Certificate of Analysis

PHYSICAL AND CHEMICAL PROPERTIES Molecular Formula:C40H52Cl2N8O6Molecular Weight:811.80Storage:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthChemical Structure:

ANALYTICAL DATA Appearance:White to off-white (Solid)1 H NMR Spectrum:Consistent with structureLCMS:Consistent with structurePurity (LCMS):99.70%Conclusion:The product has been tested and complies with the given specifications.Product Name:Daclatasvir (dihydrochloride)Cat. No.:HY-10465CAS No.:1009119-65-6Batch No.:25987Chemical Name:Carbamic acid, N,N'-[[1,1'-biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester, hydrochloride (1:2)

Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852,

NSC 23766_733767-34-5_DataSheet_MedChemExpress

NSC 23766_733767-34-5_DataSheet_MedChemExpress

Product Name:NSC 23766

CAS No.: 733767-34-5

Cat. No.:HY-15723Product Data Sheet

MWt:421.58

Formula:C24H35N7

Purity :>98%

Solubility:

DMSO

Mechanisms:

Biological Activity:

NSC23766isaspecificinhibitorofthebindingandactivationofRACGTPasewithIC50of~50μM;

Pathways:GPCR/G protein; Target:Ras

NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of 50 does not inhibit the closely related targets, Cdc42 or RhoA.

IC50 value: 50 uM

Target: RAC GTPase

in vitro: NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF

specification. NSC23766 effectively inhibits Rac1 binding and activation by the Rac-specific GEF

Trio or Tiam1 in a dose-dependent manner without interfering with the closely related Cdc42 or

RhoA binding or activation by their respective GEFs or with Rac1 interaction with BcrGAP or effector

Resiquimod_144875-48-9_DataSheet_MedChemExpress

Resiquimod_144875-48-9_DataSheet_MedChemExpress

Product Name:Resiquimod

CAS No.: 144875-48-9

Cat. No.:HY-13740Product Data Sheet

MWt:314.38

Formula:C17H22N4O2

Purity :>98%

Solubility:DMSO ≥

10 mg/mL (warmed to 60y

Mechanisms:

Biological Activity:

Resiquimod(R848)isapotentsyntheticagonistofTLR7/TLR8thatpossessesantiviraland Pathways:MAPK; Target:TLR

Pathways:NF-KB; Target:TLRg(

°C)

Resiquimod (R-848) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and

antitumoral activities. Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. It increases the levels of cytokines such as TNF-α, IL-6 and IFN-α.

IC50 Value:

Target: TLR7/TLR8

in vitro: Resiquimod, like CD40, stimulates antibody secretion, cytokine production, protection from

apoptosis, and CD80 upregulation. In addition, it shows synergy with signals delivered by the B cell