Irsogladine maleate_84504-69-8_DataSheet_MedChemExpress

Naglazyme® (galsulfase)(Intravenous)Document Number: MH-0084 Last Review Date: 02/01/2022Date of Origin: 11/28/2011Dates Reviewed: 12/2011, 02/2013, 02/2014, 12/2014, 10/2015, 10/2016, 10/2017, 10/2018, 02/2019,02/2020, 02/2021, 02/2022I.Length of AuthorizationCoverage will be provided for 12 months and may be renewed.II.Dosing LimitsA.Quantity Limit (max daily dose) [NDC Unit]:•Naglazyme 5 mg vial: 23 vials per 7 daysB.Max Units (per dose and over time) [HCPCS Unit]:•115 billable units every 7 daysIII.Initial Approval Criteria 1Coverage is provided in the following conditions:•Patient is at least 5 years of age; AND•Documented baseline 12-minute walk test (12-MWT), 3-minute stair climb test (3-MSCT), and/or pulmonary function tests (e.g., FEV1, etc.); AND•Documented baseline value for urinary glycosaminoglycan (uGAG); ANDMucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome) † Ф1,4,5•Patient has a definitive diagnosis of MPS VI as confirmed by the following:o Detection of pathogenic mutations in the ARSB gene by molecular genetic testing; ORo Arylsulfatase B (ASB) enzyme activity of <10% of the lower limit of normal in cultured fibroblasts or isolated leukocytes; AND▪Patient has normal enzyme activity of a different sulfatase (excluding patients with Multiple Sulfatase Deficiency [MSD]); AND▪Patient has an elevated urinary glycosaminoglycan (uGAG) level (i.e. dermatan sulfate or chondroitin sulfate) defined as being above the upper limit of normal bythe reference laboratory†FDA-approved indication(s); ‡Compendia recommended indication(s); ФOrphan DrugIV.Renewal Criteria 1,4,5Coverage can be renewed based on the following criteria:•Patient continues to meet indication-specific relevant criteria such as concomitant therapy requirements (not including prerequisite therapy), performance status, etc. identified insection III; AND•Absence of unacceptable toxicity from the drug. Examples of unacceptable toxicity include: anaphylaxis and hypersensitivity reactions, immune-mediated reactions, acute respiratorycomplications associated with administration, acute cardiorespiratory failure, severeinfusion reactions, spinal or cervical cord compression, etc.; AND•Disease response with treatment as defined by improvement or stability from pre-treatment baseline by the following:o Reduction in uGAG levels; AND▪Improvement in or stability of 12-minute walk test compared (12-MWT); OR▪Improvement in or stability of 3-minute stair climb test (3-MSCT); OR▪Improvement in or stability of pulmonary function testing (e.g., FEV1, etc.)V.Dosage/Administration 1Indication DoseMucopolysaccharidosis VI(MPS VI, Maroteaux-Lamy Syndrome) 1 mg/kg administered as an intravenous (IV) infusion oncea weekVI.Billing Code/Availability InformationHCPCS Code:•J1458 – Injection, galsulfase, 1 mg; 1 billable unit = 1 mgNDC:•Naglazyme 5 mg per 5 mL solution; single-use vial: 68135-0020-xxVII.References1.Naglazyme [package insert]. Novato, CA; BioMarin Pharmaceutical Inc.; December 2019.Accessed January 2022.2.Giugliani R, Harmatz P, Wraith JE. Management guidelines for mucopolysaccharidosis VI.Pediatrics. 2007 Aug;120(2):405-18.3.Giugliani R, Federhen A, Rojas MV, et al. Mucopolysaccharidosis I, II, and VI: Brief reviewand guidelines for treatment. Genet Mol Biol. 2010 Oct;33(4):589-604. Epub 2010 Dec 1.4.Vairo F, Federhen A, Baldo G, et al. Diagnostic and treatment strategies inmucopolysaccharidosis VI. Appl Clin Genet. 2015 Oct 30;8:245-55.5.Valaannopoulos V, Nicely H, Harmatz P, et al. Mucopolysaccharidosis VI. Orphanet J RareDis. 2010; 5: 5.6.Harmatz P, Giugliani R, Schwartz I, et al. Enzyme replacement therapy formucopolysaccharidosis VI: a phase 3, randomized, double-blind, placebo-controlled,multinational study of recombinant human N-acetylgalactosamine 4-sulfatase(recombinant human arylsulfatase B or rhASB) and follow-on, open-label extension study. JPediatr. 2006 Apr;148(4):533-539.Appendix 1 – Covered Diagnosis CodesICD-10 ICD-10 DescriptionE76.29 Other mucopolysaccharidosesAppendix 2 – Centers for Medicare and Medicaid Services (CMS)Medicare coverage for outpatient (Part B) drugs is outlined in the Medicare Benefit Policy Manual (Pub. 100-2), Chapter 15, §50 Drugs and Biologicals. In addition, National CoverageDetermination (NCD), Local Coverage Determinations (LCDs), and Local Coverage Articles (LCAs) may exist and compliance with these policies is required where applicable. They can be found at: https:///medicare-coverage-database/search.aspx. Additional indications may be covered at the discretion of the health plan.Medicare Part B Covered Diagnosis Codes (applicable to existing NCD/LCD/LCA): N/AMedicare Part B Administrative Contractor (MAC) JurisdictionsJurisdiction Applicable State/US Territory ContractorE (1) CA, HI, NV, AS, GU, CNMI Noridian Healthcare Solutions, LLCF (2 & 3) AK, WA, OR, ID, ND, SD, MT, WY, UT, AZ Noridian Healthcare Solutions, LLC5 KS, NE, IA, MO Wisconsin Physicians Service Insurance Corp (WPS)6 MN, WI, IL National Government Services, Inc. (NGS)H (4 & 7) LA, AR, MS, TX, OK, CO, NM Novitas Solutions, Inc.8 MI, IN Wisconsin Physicians Service Insurance Corp (WPS) N (9) FL, PR, VI First Coast Service Options, Inc.J (10) TN, GA, AL Palmetto GBA, LLCM (11) NC, SC, WV, VA (excluding below) Palmetto GBA, LLCNovitas Solutions, Inc.L (12) DE, MD, PA, NJ, DC (includes Arlington &Fairfax counties and the city of Alexandria in VA)K (13 & 14) NY, CT, MA, RI, VT, ME, NH National Government Services, Inc. (NGS)15 KY, OH CGS Administrators, LLC。

Package‘appeears’September15,2023Title Interface to'AppEEARS'NASA Web ServicesVersion1.1Description Programmatic interface to the NASA Application for Extracting and Exploring Analy-sis Ready Samples ser-vices(AppEEARS;<https:///>).The package provides easy access to analysis ready earth observation data in R.URL https:///bluegreen-labs/appeearsBugReports https:///bluegreen-labs/appeears/issuesDepends R(>=4.0)Imports httr,keyring,memoise,getPass,R6,sf,jsonlite,geojsonio,rstudioapiLicense AGPL-3ByteCompile trueRoxygenNote7.2.3Suggests rmarkdown,covr,testthat,terra,ncdf4,knitr,rlang,dplyr,ggplot2,patchworkVignetteBuilder knitrNeedsCompilation noAuthor Koen Hufkens[aut,cre](<https:///0000-0002-5070-8109>), Elio Campitelli[ctb](<https:///0000-0002-7742-9230>),BlueGreen Labs[cph,fnd]Maintainer Koen Hufkens<**********************>Repository CRANDate/Publication2023-09-1515:02:06UTCR topics documented:rs_build_task (2)rs_bundle (3)rs_delete (4)12rs_build_task rs_get_key (5)rs_layers (6)rs_list_task (7)rs_login (7)rs_logout (8)rs_products (8)rs_quality (9)rs_request (10)rs_set_key (12)rs_transfer (13)Index14 rs_build_task Build a task requestDescriptionBuilds a valid JSON formatted API request from either a tidy data frame with point based sub-tasks, or when a region of interest(roi)is specified coordinates(latitude/longitude)will be ignored and a bounding box for an sf or SpatRaster object will be used instead.Usagers_build_task(df,roi,format="geotiff")Argumentsdf a data frame with task name(task),subtask name(subtask),latitude,longitude, start(start)and end(end)date.roi a region of interest defined by a SpatRaster or sf object,the roi will override any point based data provided as latittude-longitude coordinates in the data frame formatfile format of the downloaded data either geotiff(the default)or netcdf4 Valuea valid AppEEARS JSON formatted taskExamples#define a task as a tidy data frame#multiple subtasks can be provideddf<-data.frame(task="task_name",subtask=c("sub_task"),latitude=c(36.206228),longitude=c(-112.127134),start=c("2018-01-01"),rs_bundle3 end=c("2018-01-15"),product=c("MCD12Q2.006"),layer=c("Greenup"))#build a taskrs_build_task(df)rs_bundle AppEEARS list of bundledfiles to downloadDescriptionReturns a data frame of all data ready for download as one bundleUsagers_bundle(task_id,user)Argumentstask_id task id for which to return thefile download bundleuser username used to sign upValuereturns a nested list offiles to downloadAuthor(s)Koen HufkensExamples##Not run:#get a list of datasetsrs_bundle(user="your_user_name",task_id="a_task_id")##End(Not run)4rs_delete rs_delete Delete AppEEARS task from queueDescriptionRemoves a task from the queue and or bufferUsagers_delete(task_id,user,purge=FALSE)Argumentstask_id AppEEARS task iduser username used to sign uppurge if TRUE,remove all previouslyfinished tasks from the task list(default=FALSE) Valuereturns the content of the API callAuthor(s)Koen HufkensExamples##Not run:#delete a single taskrs_delete(user="your_user_name",task_id="a_task_id")#delete all finished or crashed#jobs(if not deleted previously)rs_delete(user="your_user_name",purge=TRUE)##End(Not run)rs_get_key5 rs_get_key Retrieve NASA Earth Data passwordDescriptionReturns you token set by rs_set_keyUsagers_get_key(user)Argumentsuser username used to sign upValuethe password set using rs_set_key saved in the keychainAuthor(s)Koen HufkensSee Alsors_set_keyExamples##Not run:#set keyrs_set_key(user="*************",password="123")#get keyrs_get_key(user="*************")##End(Not run)6rs_layers rs_layers AppEEARS dataset layersDescriptionReturns a data frame of available layers for an AppEEARS productUsagers_layers(product)Argumentsproduct product for which to list the layersValuereturns a data frame with the AppEEARS datasetsAuthor(s)Koen HufkensSee Alsors_productsExamples#is the server reachableserver_check<-appeears:::rs_running(file.path(appeears:::rs_server(),"product"))#get a list of datasetsif(server_check){layers<-rs_layers("MCD43A4.006")print(layers$Layer)}rs_list_task7 rs_list_task AppEEARS list of tasks and statusDescriptionReturns a data frame of all submitted tasks either in full of when providing the diUsagers_list_task(task_id,user)Argumentstask_id task for which to list the status(if missing all tasks are listed)user username used to sign upValuereturns a data frame with the AppEEARS tasksAuthor(s)Koen HufkensExamples##Not run:#get a list of datasetsrs_list_task()##End(Not run)rs_login Checks AppEEARS loginDescriptionReturns a valid token for a session if successful otherwise fails with an error(stop())Usagers_login(user)Argumentsuser AppEEARS username8rs_productsValuereturns an AppEEARS session(bearer)tokenrs_logout Invalidates an AppEEARS bearer tokenDescriptionGiven a token it will log out/delete this token,invalidating it.Usagers_logout(token)Argumentstoken a Bearer token as returned by rs_login()Valuereturns if the session has closed TRUE/FALSErs_products AppEEARS dataset listDescriptionReturns a data frame of available data productsUsagers_products()Valuereturns a data frame with the AppEEARS datasetsAuthor(s)Koen HufkensSee Alsors_set_key rs_transfer rs_requestrs_quality9 Examples#is the server reachableserver_check<-appeears:::rs_running(file.path(appeears:::rs_server(),"product"))#get a list of datasetsif(server_check){products<-rs_products()}rs_quality List or translate AppEEARS quality metricsDescriptionReturns a data frame of all quality layers,or the translation of a quality layer value into plain language.Usagers_quality(product,layer,value)Argumentsproduct AppEEARS product namelayer name of a product quality control layervalue quality control value to translateValuereturns a data frame of all AppEEARS quality layers,or those associated with a product.When a value is provided this qualityflag will be translated from bitwise representation to plain language.Author(s)Koen HufkensExamples##Not run:#get a list of quality layers for all data productsrs_quality()##End(Not run)10rs_requestrs_request AppEEARS data request and downloadDescriptionStage a data request,and optionally download the data to disk.Alternatively you can only stage requests,logging the request URLs to submit download queries later on using rs_transfer.Usagers_request(request,user,transfer=TRUE,path=tempdir(),time_out=3600,job_name,verbose=TRUE)rs_request_batch(request_list,workers=2,user,path=tempdir(),time_out=7200,total_timeout=length(request_list)*time_out/workers,verbose=TRUE)Argumentsrequest nested list with query parameters following the layout as specified on the AppEEARS APIs pageuser user(email address or ID)provided by the AppEEARS data service,used toretrieve the token set by rs_set_keytransfer logical,download data TRUE or FALSE(default=TRUE)path path were to store the downloaded datatime_out individual time out for each requestjob_name optional name to use as an RStudio job and as output variable name.It has to bea syntactically valid name.verbose show feedback on processingrequest_list a list of requests that will be processed in parallel.workers maximum number of simultaneous request that will be submitted to the service.Most services are limited to~20concurrent requests(default=2).rs_request11 total_timeout overall timeout limit for all the requests in seconds.(note that the overall timeout on a session is48h)Valuethe path of the downloaded(requestedfile)or the an R6object with download/transfer informationAuthor(s)Koen HufkensSee Alsors_set_key rs_transferExamples##Not run:#specifiy a task/request as a#data framedf<-data.frame(task="grand canyon",subtask=c("test1","test2"),latitude=c(36.206228,36.206228),longitude=c(-112.127134,-112.127134),start=c("2018-01-01","2018-01-01"),end=c("2018-01-15","2018-01-15"),product=c("MOD11A2.061","MCD12Q2.006"),layer=c("LST_Day_1km","Dormancy"))#build a proper JSON querytask<-rs_build_task(df=df)#request the task to be executedrs_request(request=task,user="earth_data_user",transfer=TRUE,path="~/some_path",verbose=TRUE)##End(Not run)12rs_set_keyrs_set_key Set NASA Earth Data passwordDescriptionSaves the token to your local keychain under a service called"appeears".Usagers_set_key(user,password)Argumentsuser user used to sign up for the AppEEARS data service(this is not the email ad-dress,but the true user name!)password used to sign up for AppEEARSDetailsIn systems without keychain management set the option keyring_backend to‘file‘(i.e.options(keyring_backend ="file"))in order to write the keychain entry to an encryptedfile.This mostly pertains to headlessLinux systems.The keychainfiles can be found in~/.config/r-keyring.ValueIt invisibly returns the user.Author(s)Koen HufkensSee Alsors_get_keyExamples##Not run:#set keyrs_set_key(user="test",password="123")#get keyrs_get_key(user="test")#leave user and key empty to open a browser window to the service s website#and type the key interactivelyrs_get_key()rs_transfer13 ##End(Not run)rs_transfer AppEEARS data transfer functionDescriptionReturns the contents of the requested url as a NetCDFfile downloaded to disk or the current status of the requested transfer.Usagers_transfer(task_id,user,path=tempdir(),verbose=TRUE)Argumentstask_id R6rs_request)query output or task iduser user(email address)used to sign up for the AppEEARS data service,used to retrieve the token set by rs_set_key.path path were to store the downloaded dataverbose show feedback on data transfersValuedata on disk as specified by a rs_requestAuthor(s)Koen HufkensSee Alsors_set_key rs_requestExamples##Not run:#set keyrs_set_key(user="test",password="123")#request data and grab url and try a transferr<-rs_request(request,"test",transfer=FALSE)#check transfer,will download if availablers_transfer(r$get_task_id(),user="test")##End(Not run)Indexrs_build_task,2rs_bundle,3rs_delete,4rs_get_key,5,12rs_layers,6rs_list_task,7rs_login,7rs_logout,8rs_products,6,8rs_quality,9rs_request,8,10,13rs_request_batch(rs_request),10rs_set_key,5,8,10,11,12,13rs_transfer,8,10,11,1314。

第2期张化，等.依托咪酯调节AMPK/NLRP3信号通路对急性心肌梗死大鼠心肌损伤的影响[8]ZOU Haibo,SUN Xiaofeng.Effects of cyclosporin A pre-treatmentcombined with etomidate post-treatment on lung injury induced by limb ischemia-reperfusion in rats[J].J Int Med Res,2020, 48(7):300060520934627-300060520934636.[9]XIE Dili,LI Min,YU Kang,et al.Etomidate alleviates cardiacdysfunction,fibrosis and oxidative stress in rats with myocardial ischemic reperfusion injury[J].Ann Transl Med,2020,8(18): 1181-1189.[10]杨帆,卞海,倪子婷,等.益气养阴化痰通络方对大鼠急性心肌梗死的保护作用[J].中成药,2023,45(4):1328-1331. [11]马蒂达,吴洋,王显,等.桃叶珊瑚苷通过AMPK/NLRP3通路对心肌梗死大鼠心功能的影响及机制[J].贵州医科大学学报,2021,46(7):773-780.[12]GAUTADOTTIR K,GUDMUNDSDOTTIR I J,SIGURDSSON M I,et al.Acute myocardial infarction in young adults:incidence,risk factors and prognosis[J].Laeknabladid,2022,108(10):439-445.[13]SCHÄFER A,KÖNIG T,BAUERSACHS J,et al.Noveltherapeutic strategies to reduce reperfusion injury after acute myocardial infarction[J].Curr Probl Cardiol,2022,47(12): 101398-101416.[14]BLAS-VALDIVIA V,MORAN-DORANTES D N,ROJAS-FRANCO P,et al.C-Phycocyanin prevents acute myocardial infarction-induced oxidative stress,inflammation and cardiac damage[J].Pharm Biol,2022,60(1):755-763.[15]ZHAO Di,LIU Ketong,WANG Jian,et al.Syringin exertsanti-inflammatory and antioxidant effects by regulating SIRT1 signaling in rat and cell models of acute myocardial infarction[J].Immun Inflamm Dis,2023,11(2):e775-e788.[16]JAFAROVA DEMIRKAPU M,KARABAG S,AKGUL H M,et al.The effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats[J].Eur Rev Med Pharmacol Sci,2022,26(1):211-217.[17]LYU Zhenqian,WANG Feng'e,ZHANG Xingfeng,et al.Etomidate attenuates the ferroptosis in myocardial ischemia/ reperfusion rat model via Nrf2/HO-1pathway[J].Shock, 2021,56(3):440-449.[18]PU J L,HUANG Z T,LUO Y H,et al.Fisetin mitigates hepaticischemia-reperfusion injury by regulating GSK3β/AMPK/ NLRP3inflammasome pathway[J].Hepatobiliary Pancreat Dis Int,2021,20(4):352-360.[19]ZHANG Jing,HUANG Lelin,SHI Xing,et al.Metforminprotects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3inflammasome pathway[J].Aging(Albany NY),2020,12(23):24270-24287.[20]YIN Miaomiao,XU Yinmei.The protective effects ofetomidate against interleukin-1β(IL-1β)-induced oxidative stress,extracellular matrix alteration and cellular senescence in chondrocytes[J].Bioengineered,2022,13(1):985-994.（责任编辑：幸建华）美国FDA批准Lenmeldy（atidarsagene autotemcel）用于儿童治疗异染性脑白质营养不良美国FDA于2024年3月18日批准Lenmeldy（atidarsagene autotemcel）用于儿童治疗异染性脑白质营养不良（metachromatic leukodystrophy，MLD），适用于症状前晚期婴儿型MLD、症状前早期幼年型MLD、早期症状性早期幼年型MLD的患者。

USA SAFETY DATA SHEET1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct name:VERSILOK 254Product Use/Class: Acrylic Adhesive, Part 2 of 2LORD Corporation111 LORD DriveCary, NC 27511-7923 USATelephone: 814 868-3180Non-Transportation Emergency: 814 763-2345Chemtrec 24 Hr Transportation Emergency No.800 424-9300 (Outside Continental U.S. 703 527-3887)EFFECTIVE DATE: 11/18/20202. HAZARDS IDENTIFICATIONGHS CLASSIFICATION:Acute toxicity Inhalation - Dust and MistCategory 4 - 63.1% of the mixture consists of ingredient(s) of unknown toxicity.Reproductive toxicity Category 2Specific target organ systemic toxicity (single exposure) Category 1 Nervous systemSpecific target organ systemic toxicity (repeated exposure) Category 1 Nervous systemSpecific target organ systemic toxicity (repeated exposure) Category 2 Adrenal glandHazardous to the aquatic environment - acute hazard Category 1Hazardous to the aquatic environment - chronic hazard Category 1GHS LABEL ELEMENTS:Symbol(s)Signal WordD ANGERHazard StatementsHarmful if inhaled.Suspected of damaging fertility or the unborn child.Causes damage to organs.(Nervous system)Causes damage to organs through prolonged or repeated exposure.(Nervous system)May cause damage to organs through prolonged or repeated exposure.(Adrenal gland)Very toxic to aquatic life.Very toxic to aquatic life with long lasting effects.Precautionary StatementsPreventionObtain special instructions before use.Do not handle until all safety precautions have been read and understood.Use personal protective equipment as required.Do not breathe dust/fume/gas/mist/vapors/spray.Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Use only outdoors or in a well-ventilated area.Avoid release to the environment.300000001064ResponseCall a POISON CENTER or doctor/physician if you feel unwell.IF exposed: Call a POISON CENTER or doctor/physician.Specific treatment (see supplemental first aid instructions on this label).IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Collect spillage.StorageStore locked up.Disposal:Dispose of contents/container in accordance with waste/disposal laws and regulations of your country or particular locality.Other Hazards:This product contains component(s) which have the following warnings; however based on the GHS classification criteria of your country or locale, the product mixture may be outside the respective category(s).Acute: Dermal absorption possible. May cause eye irritation. May cause respiratory tract irritation. May causeheadache and nausea. See Section 11 for additional information. May be harmful if swallowed. Ingestion is not an expected route of entry in industrial or commercial uses.Chronic: Repeated or prolonged skin contact may cause allergic reactions with susceptible persons. Chronicexposure to the tricresyl phosphate in this product may cause adrenal, reproductive and developmental effects based on animal data. See Section 11 for additional information.withheld.FIRST AID - EYE CONTACT: Flush eyes immediately with large amount of water for at least 15 minutes holding eyelids open while flushing. Get prompt medical attention.FIRST AID - SKIN CONTACT: Flush contaminated skin with large amounts of water while removing contaminated clothing. Wash affected skin areas with soap and water. Get medical attention if symptoms occur.FIRST AID - INHALATION: Move person to fresh air. Restore and support continued breathing. If breathing is difficult, give oxygen. Get immediate medical attention.FIRST AID - INGESTION: If swallowed, do not induce vomiting. Call a physician or poison control center immediately for further instructions. Never give anything by mouth if victim is rapidly losing consciousness, unconscious or convulsing.SUITABLE EXTINGUISHING MEDIA: Carbon Dioxide, Dry Chemical, Foam, Water FogUNSUITABLE EXTINGUISHING MEDIA: Not determined for this product.SPECIFIC HAZARDS POSSIBLY ARISING FROM THE CHEMICAL: Keep containers tightly closed. Closed containers may rupture when exposed to extreme heat. Use water spray to keep fire exposed containers cool. During a fire, irritating and/or toxic gases and particulate may be generated by thermal decomposition or combustion.SPECIAL PROTECTIVE EQUIPMENT AND PRECAUTIONS FOR FIRE-FIGHTERS: Wear full firefighting protective clothing, including self-contained breathing apparatus (SCBA). If water is used, fog nozzles are preferable.PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES: Avoid breathing vapors. Avoid contact. Use appropriate respiratory protection for large spills or spills in confined area.ENVIRONMENTAL PRECAUTIONS: Do not contaminate bodies of water, waterways, or ditches, with chemical or used container.METHODS AND MATERIALS FOR CONTAINMENT AND CLEANUP: Notify appropriate authorities if necessary. Avoid contact. Keep non-essential personnel away from spill area. Scoop spilled material into an appropriate container for proper disposal. (If necessary, use inert absorbent material to aid in containing the spill).HANDLING: Keep closure tight and container upright to prevent leakage. Avoid skin and eye contact. Wash thoroughly after handling. Do not handle until all safety precautions have been read and understood.STORAGE: Store only in well-ventilated areas. Keep container closed when not in use.INCOMPATIBILITY: Amines, acids, water, hydroxyl, or active hydrogen compounds.Engineering controls: Sufficient ventilation in pattern and volume should be provided in order to maintain air contaminant levels below recommended exposure limits.PERSONAL PROTECTION MEASURES/EQUIPMENT:RESPIRATORY PROTECTION: Use a NIOSH approved air-purifying organic vapor respirator if occupational limits are exceeded. For emergency situations, confined space use, or other conditions where exposure limits may be greatly exceeded, use an approved air-supplied respirator. For respirator use observe OSHA regulations (29CFR1910.134) or use in accordance with applicable laws and regulations of your country or particular locality.SKIN PROTECTION: Use neoprene, nitrile, or rubber gloves to prevent skin contact.EYE PROTECTION: Use safety eyewear including safety glasses with side shields and chemical goggles where splashing may occur.OTHER PROTECTIVE EQUIPMENT: Use disposable or impervious clothing if work clothing contamination is likely. Remove and wash contaminated clothing before reuse.HYGIENIC PRACTICES: Wash hands before eating, smoking, or using toilet facility. Food or beverages should not be consumed anywhere this product is handled or stored. Wash thoroughly after handling.Typical values, not to be used for specification purposes.ODOR: Epoxy VAPOR PRESSURE: N.D.APPEARANCE: Gray VAPOR DENSITY: Heavier than AirPHYSICAL STATE: Liquid LOWER EXPLOSIVE LIMIT: Not ApplicableUPPER EXPLOSIVE LIMIT: Not ApplicableFLASH POINT:≥ 201 °F, 93 °CSetaflash Closed CupBOILING RANGE: N.A.EVAPORATION RATE: Not Applicable AUTOIGNITION TEMPERATURE:N.D.DENSITY: 1.44 g/cm3 (11.97 lb/gal) DECOMPOSITION TEMPERATURE:N.D. VISCOSITY, DYNAMIC: N.D.ODOR THRESHOLD: N.D.VISCOSITY, KINEMATIC: N.D.SOLUBILITY IN H2O: Insoluble VOLATILE BY WEIGHT: 0.03 %pH: N.A.VOLATILE BY VOLUME: 0.05 %FREEZE POINT: N.D. VOC CALCULATED: 0 lb/gal, 0 g/l0 g/lN.D. METHOD 24: 0.85 lbs/gal COEFFICIENT OF WATER/OILDISTRIBUTION:LEGEND: N.A. - Not Applicable, N.E. - Not Established, N.D. - Not DeterminedHAZARDOUS POLYMERIZATION: Hazardous polymerization will not occur under normal conditions. STABILITY: Product is stable under normal storage conditions.CONDITIONS TO AVOID: High temperatures.INCOMPATIBILITY: Amines, acids, water, hydroxyl, or active hydrogen compounds.HAZARDOUS DECOMPOSITION PRODUCTS: Carbon monoxide, carbon dioxide, aldehydes, Oxides of phosphorusEXPOSURE PATH: Refer to section 2 of this SDS.SYMPTOMS:Refer to section 2 of this SDS.TOXICITY MEASURES:Germ cell mutagenicity: No classification proposedCarcinogenicity: No classification proposedReproductive toxicity: Category 2 - Suspected of damaging fertility or the unborn child.Components contributing to classification: Tricresyl phosphate.TOXICOLOGICAL INFORMATION:Historical data on Tricresyl phosphate (TCP) has shown neurological effects associated with levels of the ortho isomer within TCP. The manufacturer of the TCP in this product has noted on their SDS that the TCP does not exhibit negative neurological effects based on toxicology and epidemiology studies. This LORD product may contain a very small amount of the ortho isomer. However, LORD analytical testing of the raw material containing TCP indicates no ortho isomer present. Also, based on the TCP manufacturer's information, the LORD product content should not exceed225ppm, if present at all.ECOTOXICITY:PERSISTENCE AND DEGRADABILITY:Not determined for this product.BIOACCUMULATIVE: Not determined for this product.MOBILITY IN SOIL: Not determined for this product.OTHER ADVERSE EFFECTS: Not determined for this product.DISPOSAL METHOD: Disposal should be done in accordance with Federal (40CFR Part 261), state and local environmental control regulations. If waste is determined to be hazardous, use licensed hazardous waste transporter and disposal facility.US DOT RoadProper Shipping Name: Environmentally hazardous substances, liquid, n.o.s.Hazard Class: 9SECONDARY HAZARD: NoneUN/NA Number: 3082Packing Group: IIIEmergency Response Guide Number: 171For US DOT non-bulk road shipments this material may be classified as NOT REGULATED. For the most accurate shipping information, refer to your transportation/compliance department regarding changes inpackage size, mode of shipment or other regulatory descriptors.IATA CargoPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: 9LIMDGPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: F-AThe listed transportation classification applies to non-bulk shipments. It does not address regulatory variations due to changes in package size, mode of shipment or other regulatory descriptors. For the most accurate shipping information, refer to your transportation/compliance department.U.S. FEDERAL REGULATIONS: AS FOLLOWS:SARA SECTION 313This product contains the following substances subject to the reporting requirements of Section 313 of Title III of the Superfund Amendment and Reauthorization Act of 1986 and 40 CFR part 372.:Chemical Name CAS Number Weight % Less ThanDibenzoyl peroxide94-36-0 5.0%TOXIC SUBSTANCES CONTROL ACT:INVENTORY STATUSThe chemical substances in this product are on the TSCA Section 8 Inventory.EXPORT NOTIFICATIONThis product contains the following chemical substances subject to the reporting requirements of TSCA 12(B) if exported from the United States:NoneUnder HazCom 2012 it is optional to continue using the HMIS rating system. It is important to ensure employees have been trained to recognize the different numeric ratings associated with the HazCom 2012 and HMIS schemes.HMIS RATINGS - HEALTH: 2* FLAMMABILITY: 1 PHYSICAL HAZARD: 1* - Indicates a chronic hazard; see Section 2Revision: Company LogoEffective Date: 11/18/2020The information contained herein is, to the best of our knowledge and belief, accurate. However, since the conditions of handling and use are beyond our control, we make no guarantee of results, and assume no liability for damages incurred by use of this material. It is the responsibility of the user to comply with all applicable federal, state and local laws and regulations.。