Tramadol hydrochloride_36282-47-0_DataSheet_MedChemExpress

附件1（略）托曲珠利溶液说明书和标签（一）托曲珠利溶液说明书【兽药名称】通用名称：托曲珠利溶液商品名称：百球清英文名称：Toltrazuril Solution汉语拼音：Tuoquzhuli Rongye【主要成分】托曲珠利【性状】本品为无色至棕色澄清溶液。

【药理作用】三嗪酮类广谱抗球虫药。

杀球虫机理是干扰球虫细胞核的分裂和线粒体的呼吸及代谢功能，并使内质网膨大，出现空泡，从而使球虫死亡。

对鸡的堆型、布氏、巨型、和缓、毒害和柔嫩艾美耳球虫，以及火鸡的腺状、大艾和小艾等艾美耳球虫均具有杀灭作用，对其他抗球虫药耐药的虫株亦有效。

主要作用于球虫裂殖生殖和配子生殖阶段，对球虫两个无性生殖周期均有作用，如抑制裂殖体、小配子体的核分裂和小配子体的壁形成体。

不影响鸡对球虫产生免疫力，可用于治疗和预防禽球虫病。

本品安全范围大，禽可耐受10倍以上的推荐剂量。

家禽内服后，50%以上被吸收。

吸收后药物主要分布于肝和肾，且迅速被代谢成砜类化合物，在雏鸡体内的半衰期约为2天。

【适应证】用于防治鸡球虫病。

【用法与用量】以托曲珠利计。

混饮：每1L水，鸡25mg，一日1次，连用2日。

【不良反应】按推荐的用法与用量使用，未见不良反应。

【注意事项】1.请勿用于已知对本品过敏的动物。

2.稀释后的药液超过48小时不宜给鸡饮用。

3.同其他抗寄生虫类制剂，频繁和重复使用同一类活性物质的抗原虫药或低估活禽重量而导致用药不足，都有可能产生耐药性。

4.过量服用会导致饮用水摄入减少。

在超过10倍以上推荐剂量时，曾观察到此现象。

5.药液稀释超过1000倍可能会析出结晶而影响药效。

但过高的浓度会影响鸡的饮水量。

6.已知对活性成分过敏者应避免接触本品。

使用本品时应佩戴安全防护手套。

给药时，不得进食、喝水或抽烟。

用后洗手。

该兽药制剂为碱性溶液。

眼睛或皮肤接触后，需用大量干净的水冲洗接触区域。

7.请勿吞咽。

如意外吞食，请立即就医，并出示说明书或标签。

8.未使用的兽药产品应由危险废物收集中心处理，如与生活垃圾一起处理，请务必注意防止其进入废水中。

Endotoxin Removal Solution Catalog Number E4274Product DescriptionEndotoxins are lipopolysaccharides (LPS), a major component of the Gram-negative bacterial cell wall, and are commonly found as contaminants in plasmid DNA preparations from E. coli. Endotoxins are large, negatively charged molecules that co-purify with DNA on ion exchange and size exclusion columns and in CsCl banding. Endotoxins are extremely potent stimulators of the mammalian immune system and are toxic to primary cells and to animals. The endotoxin toxicity is an obstacle to in vitro and in vivo transfection experiments.Non-ionic detergents, traditionally used for separation of integral membrane proteins,1 can be utilized for removal of endotoxins from DNA solutions by phase separation.2The solubility behavior of a detergent in a dilute, aqueous solution at physiological salt and pH conditions is strongly dependent upon the temperature of the solution. At low temperatures, the detergent forms a clear, micellar solution, but above the cloud point temperature, the micelles form larger, turbid aggregates and ultimately fuse to form a separate phase. The lower phase is detergent-enriched and the detergent-depleted upper phase contains detergent at a concentration slightly above the critical micellar concentration (CMC). Amphiphilic and hydrophobic molecules associated with the micelles of the detergent will aggregate within the detergent-enriched phase, while the soluble, hydrophilic molecules will remain in the detergent-depleted upper phase.Extraction of endotoxin contaminated DNA solutions with the appropriate non-ionic detergent will separate the hydrophilic DNA from the amphiphilic endotoxin. The amphiphilic endotoxin will associate with the lower phase, while the DNA will remain in the upper, detergent-depleted phase.2Reagents and equipment required, but not provided • Water, Molecular Biology Reagent, Catalog Number W4502• E-TOXATE® Water, Catalog Number 2107, or Tris-EDTA (TE) buffer 100×, Catalog NumberT9285• DNA solution (0.5 ml), ~ 1 mg/ml in E-TOXATE®Water or TE buffer• 3 M sodium acetate solution, pH 7.5.• 2-Propanol, Catalog Number I9516, or Ethanol, 190 proof, Catalog Number E7148; 200 proof, CatalogNumber E7023• 70% Ethanol• E-TOXATE®reagents Kits, Catalog Numbers 210A1, 210B1 or 210C1• Ice bucket• Heat block or incubator at 37 °C• Microcentrifuge at room temperature• 1.5 or 2 ml sterile microcentrifuge tubes• Endotoxin-free pipet tips (40-200 µl, 200-1000 µl) Precautions and DisclaimerThis product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.StorageStore at room temperature.Note: Removal of endotoxins from DNA preparations can be performed either during the final stage of DNApreparation, or during an earlier stage.Procedures for Endotoxin RemovalDuring the final stage of DNA preparationNote: The procedure described below was performed on plasmid DNA produced in E. coli DH5α cells.• Losses of up to 50% of the DNA are expected. • Use of a DNA concentration above therecommended 1 mg/ml reduces the efficiency ofthe procedure.1. Pipette 500 µl of the DNA solution into a sterilemicrocentrifuge tube.2. Add 50 µl of the 3 M sodium acetate solution to theDNA sample.3. Incubate on ice for 5 minutes.4. Add 100 µl of cold Endotoxin Removal Solution.5. Mix thoroughly and incubate on ice for 10 minutes.The solution should be light blue and clear.6. Incubate the tube at 37 °C for 20 to 30 minutes oruntil the phases separate.7. Spin for 5 minutes at 3000 x g in themicrocentrifuge. The upper phase is colorless and clear, while the lower phase is blue.8. Carefully transfer the upper phase containing theDNA to a clean microcentrifuge tube.9. Repeat steps 4 through 8 twice.10. Add 0.6× volume of 2-propanol. Mix by inversion atroom temperature and centrifuge at 15,000 x g for30 minutes at 4 °C. Alternatively, add2.5× volumes of ethanol. Incubate overnight at –20°C or 20 minutes at –70 °C and centrifuge at15,000 x g for 30 minutes at 4 °C.11. Carefully remove the supernatant12. Wash the DNA pellet twice with cold 70% ethanol.Remove the supernatant.13. Air-dry the pellet.14. Suspend the DNA in 100 µl of endotoxin free wateror TE buffer.15. Determine DNA concentration and endotoxin levelsusing endotoxin assay reagents and compare tothe starting material. During an earlier stage of DNA preparationThis procedure is based on the alkaline lysis of E. coli DH5α cells.3 The endotoxins are removed immediately after alkaline cell lysis, neutralization, and a clarification step. The resulting high salt solution is suitable for the endotoxin removal step. It is performed under “endotoxin free” conditions. The plasticware used is either sterile and disposable, or NaOH-treated. The buffers are prepared with endotoxin free water.1. Add the Endotoxin Removal Solution (0.2× volume)to the cold, crude DNA solution.2. Incubate on ice and mix occasionally by inversionto obtain a homogenous, clear blue solution3. Incubate at 37 °C for 20 to 30 minutes until thephase separation is obvious.4. Spin for 5 minutes at low speed (3000 x g) at roomtemperature.5. Transfer the upper aqueous phase to an endotoxinfree container.6. Proceed with the DNA purification by any method.Use endotoxin-free buffers and containers. References1. Bordier, C., J. Biol. Chem., 256, 1604-1607, (1981).2. Cotten, M. et al., Gene Therapy, 1, 239-246,(1994).3. Sambrook et al., Molecular Cloning, a LaboratoryManual, 2nd Ed. p. 1.38RK,PHC 09/05-1Sigma brand products are sold through Sigma-Aldrich, Inc.Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side ofthe invoice or packing slip.。

核准和修改日期马来酸替加色罗片说明书请仔细阅读说明书并在医师指导下使用。

[药品药品名称名称名称]]通用名称：马来酸替加色罗片商品名称：泽马可®英文名称：Tegaserod Hydrogen Maleate Tablets汉语拼音：Ma Lai Suan Ti Jia Se Luo Pian[成份成份]]活性成份：马来酸替加色罗化学名称：3-（5-甲氧基-1H-吲哚-3-亚甲基）-N-戊基-亚胺胍马来酸盐，化学结构式：H 3C COOH COOH .N N H NHNH N H O CH 3分子式：C 16H 23N 5O.C 4H 4O 4分子量：417.5[性状性状]]本品为白色至微黄色片，表面有大理石样花纹。

[适应症适应症]]用于女性便秘型肠易激惹综合征患者缓解症状的短期治疗。

规格]][规格6mg用法用量]][用法用量推荐剂量是一次6mg，一日2次，饭前口服，用药期限可长至12周。

肝功能不全患者轻度肝功能不全患者使用时不需调整剂量，然而，对于该患者人群，替加色罗应慎用。

对于中、重度肝病患者，现尚缺乏足够使用该药的研究资料，因此不建议此类患者使用。

肾功能不全患者轻、中度肾功能不全患者使用时均不需调整剂量。

不推荐严重肾功能衰竭患者应用。

不良反应]][不良反应2198名患者参与了有安慰剂对照的长达12周的临床试验，除了腹泻之外，替加色罗治疗组不良事件的发生率与安慰剂组相似。

接受替加色罗治疗的患者中，有11.7%的患者报告有腹泻，而安慰剂组为5.4%。

在绝大多数的病例中, 腹泻常发生治疗开始阶段(中位数为9), 为一过性的(持续时间的中位数为2天)。

服用本品发生腹泻者多为单次发作，在大多数情况下，腹泻会发生在服用本品进行治疗的第一周内。

因腹泻而停止治疗的比例替加色罗组为1.6%，安慰剂组为0.5%。

在临床试验中, 少数患者(0.04%)出现临床显著的腹泻, 包括住院, 低血容量症, 低血压, 以及需要静脉补液。

SAFETY DATA SHEET IN ACCORDANCE WITH 91/155/EEC Page 1 of 4DATASHEET RENEGITE1. Identification of the substance1.1 Trademark : - RENEGITE1.2 Description : - Sulphamic Acid (solid)1.3 Distributed by : - Bravilor Bonamat B.V. Pascalstraat 20NL-1704 RD Heerhugowaard (The Netherlands)- Tel. +31 (0)72 5751751- Fax. +31 (0)72 57517582. Composition / information on ingredients2.1 Description : - Sulphamic Acid (~100%) (Syn.: Aminosulfinic Acid)2.2 Formula : - H2NSO3H2.3 MM : - 97.09 g/mol2.4 CAS. No. : - 5329-14-62.5 EEC. No. : - 016-026-00-02.6 Einecs No. : - 226-218-83. Hazards identification3.1 Health hazards : - Irritating to the eyes and skin3.2 Ecology : - Harmful to aquatic organisms- May cause long-term adverse effects in the aquatic environment3.3 Fire hazard : - Non combustible4. First aid measures4.1 After skin contact : - Wash off with plenty of water / shower- Remove contaminated clothing- Do not remove clothing in case this sticks to the skin- Cover wounds in a sterile way4.2 After contact with the eyes : - Rinse out with plenty of water with the eyelids held wide open- Summon the help of a ophthalmologist- Do not use a chemical neutralising agent4.3 After inhalation : - Let the victim breathe fresh air4.4 After swallowing : - Rinse the mouth with plenty of water- Make the victim drink plenty of water- Try to prevent vomiting of the victim- Do not give a chemical antidote- Summon medical help immediately- Ingestion of large quantities: transport to hospital immediately- Show the package / vomit to the doctor / in the hospital5. Fire-fighting measures5.1 Suitable extinguishing media : -In adaptation to materials stored in the immediate neighbourhood5.2 Special risks: -Development of hazardous combustion gases or vapours is possiblein the event of fire5.3 Special protecting clothing : -Do not stay in the danger zone without suitable chemical protectionclothing and self contained breathing apparatus5.4 Other information : - Contain escaping vapours with water- Prevent fire-fighting water from entering surface water or groundwaterSAFETY DATA SHEET IN ACCORDANCE WITH 91/155/EEC Page 2 of 4DATASHEET RENEGITE6. Accidental release measures6.1 Person related precautions : -Avoid generation of dust-Do not inhale dust- Avoid substance contact6.2 Procedures for cleaning /absorption : -Take up dry-Forward for disposal-Clean up affected area with plenty of water-Clean the clothing and material used afterward6.3 Environment : - Prevent the substance from entering in the environment7. Handling and storage7.1 Handling : -No additional requirements7.2 Storage : -Store in a dry place- Store in tightly closed container-Storage temperature at +15° C to 25° C- The data on storage temperature applies to the entire pack7.3 Keep away from : -Heat sources- oxidising agents- (strong) bases- easy combustible materials- metals- halogens8. Personal Protection / exposure protection8.1 Personal protective equipment:Respiratory protection : -Required when dusts are generatedEye protection : -RequiredHand protection : -RequiredProtective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substance handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier.8.2 Industrial hygiene : -Change contaminated clothing-Application of skin-protective barrier cream is recommended-Wash hands after working with the substance9. Physical and chemical propertiesForm : - SolidColour : - WhiteOdour : - OdourlessMelting temperature : - 205°C (decomposition)Boiling temperature : - Not availableDensity : - 2130 kg/m3Bulk density : - ~600 kg/m3Solubility in water : - 213 g/l (at 20° C)- 470 g/l (at 80° C)pH : - 1.18 (1 g/100 ml water at 25° C)Thermal decomposition : - 209 ° CSAFETY DATA SHEET IN ACCORDANCE WITH 91/155/EEC Page 3 of 4DATASHEET RENEGITE10 Stability and reactivity10.1 Conditions to be avoided : - Strong heating10.2 Substances to be avoided : - Halogens- Alkalis- Oxidising agents (i.e. Nitrates, Nitrites, Nitric acids)- Metals with water10.3 Hazardous decompositionproducts: - In the event of fire: Ammonia, Nitrous gases, Sulphur oxides11. Toxicological information11.1 Acute Toxicity : - LD50 (oral rat): 3160 mg/kg11.2 Specific symptoms withanimal tests : - Eye irritation test: strong irritant effect - Skin irritation test: strong irritant effect11.3 Further toxicologicalinformation : - After inhalation of dust: irritation in the respiratory tract, coughing, dyspnoea - After skin contact: irritant effect- After eye contact: strong irritant effect- After swallowing: irritation of mucous membranes n the mouth, pharynx, oesophagus and gastrointestinal tract11.4 Over sensitiveness : - No sensitising effect11.5 Further information : - The product should be handled with the care usual when dealing withchemicals12. Ecological information12.1 Ecotoxic effects : - Quantitative data on the ecological effects of this product are not available 12.2 Biological effects : - Harmful effect on aquatic organisms- Harmful effect due to pH-shift12.3 Further ecological data : - May cause long-term adverse effects in aquatic environments- Do not allow to enter waters, waste water or soil- When handled and used competently no ecological problems are tobe expected13. Disposal considerations13.1 Product : - There are no uniform EC-regulations for the disposal of chemicals orresidues. Chemical residues in general count as special waste, thedisposal of which is regulated in the EC member states throughharmonised laws and regulations. We recommend that the authoritiesin charge or an approved disposal company is contacted to advice onhow to dispose of this special waste.13.2 Packaging : - Handle contaminated packaging in the same way as the substance itself- Disposal in compliance with the official regulations- If not specified differently, non contaminated packaging may betreated like household waste or re-cycledSAFETY DATA SHEET IN ACCORDANCE WITH 91/155/EEC Page 4 of 4DATASHEET RENEGITE14. Transport information14.1 Transport over land ADR/RID and GGVS/GGVE (Germany)VS/GGVE class : - 8 Number and letter : - 16cGG ADR/RID class : - 8 Number and letter : - 16cMarking : - 2967 Sulfaminsäure14.2 Transport by inland vessel ADN/ADNRNo data available14.3 Transport over sea IMDG/GGVS (sea)IMDG/GGVS - class : - 8 UN - number : - 2967EMS : - 8-08 MFAG : - 700Correct technical marking : - SULPHAMIC ACID Packaging group : - III14.4 Transport by air ICAO-TI en IATA-DGRICAO/IATA - class : - 8 UN- / ID- number : - 2967Correct technical name : - SULPHAMIC ACID Packaging group : - III14.5 The transport regulations are cited according to international regulations and in the form applicable inGermany (GGVS/GGVE). Possible national deviations in other countries are not considered.15. Regulatory information15.1 Hazard symbol : - Xi - Irritating15.2 R-phrases : - 36/38 - Irritating to eyes and skin- 52/53 - Harmful to aquatic organisms, may cause long-termadverse effects in the aquatic environment15.3 S-phrases : - (2) - (Keep out of reach of children)26 In case of contact with eyes, rinse immediately with plentyof water and seek medical advice- 28 - After contact with the skin, wash immediately with plenty ofwater- 61 - Avoid release to the environment. Refer to specialinstructions/ safety data sheets15.4 NOTE :15.5 EEC LIST : - EC no. 226-218-8 (EC label)15.6 German regulationsWater polution class : - 1 (slightly polluting substance) (own classification)16. Additional informationDate of issue : - 06 March 2002The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of theproperties of the product. The receiver and the users of the product are responsible for a proper use in conformity with the existing legislation and regulations.。