Sodium_tauroglycocholate_DataSheet_MedChemExpress

DOI：10.16658/ki.1672-4062.2024.01.019司美格鲁肽联合达格列净、二甲双胍在肥胖型2型糖尿病合并非酒精性脂肪肝患者中的疗效分析叶娟，陈冬，邱振汉，吴盛钊安徽省淮南市寿县人民医院内分泌科，安徽寿县232200[摘要]目的研究司美格鲁肽联合达格列净、二甲双胍在肥胖型2型糖尿病（Type 2 Diabetes Mellitus， T2DM）合并非酒精性脂肪肝（Non-alcoholic Fatty Liver， NAFLD）患者中的疗效。

方法选取2021年6月—2023年6月安徽省淮南市寿县人民医院内分泌科收治的80例肥胖型T2DM合并NAFLD患者为研究对象。

根据随机数表法分为对照组和观察组，各40例。

对照组给予二甲双胍联合达格列净治疗，观察组在对照组基础上联合司美格鲁肽治疗。

比较两组治疗12周后的疗效以及药物不良反应发生率。

结果观察组胰岛素抵抗指数、血糖指标、血脂指标、肝功能指标均显著低于对照组，差异有统计学意义（P均<0.05）；观察组体质指数为（28.19±0.92）kg/m2，低于对照组的（30.12±1.47）kg/m2，差异有统计学意义（P<0.05）；两组不良反应发生率比较，差异无统计学意义（P>0.05）。

结论肥胖型T2DM合并NAFLD患者治疗中，相对于单纯使用达格列净、二甲双胍治疗，联合司美格鲁肽在降低血糖、血脂、肝酶，改善胰岛功能方面效果更优，且不良反应无明显增加。

[关键词] 司美格鲁肽；达格列净；二甲双胍；肥胖；2型糖尿病；非酒精性脂肪肝[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2024）01（a）-0019-04Efficacy of Smaglutide Combined with Dapagliflozin and Metformin in Pa⁃tients with Obese Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver DiseaseYE Juan, CHEN Dong, QIU Zhenhan, WU ShengzhaoDepartment of Endocrinology, Huainan Shouxian People's Hospital, Shouxian, Anhui Province, 232200 China[Abstract] Objective To study the efficacy of semiglutide combined with dapagliflozin and metformin in patients with obese type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Methods A total of 80 obese patients with T2DM combined with NAFLD were selected from the department of endocrinology of Shouxian People's Hospital from June 2021 to June 2023. They were divided into control group and observation group according to ran⁃dom number table method, 40 cases each. The control group received metformin with dagagliflozin, and the observa⁃tion group was treated with semegallutide on the basis of the control group. Comparing the efficacy and the incidence of adverse drug reactions after 12 weeks of treatment. Results The homa-ir insulin resistance index, blood glucose in⁃dex, blood lipid index and liver function index were significantly lower than that of the control group, and the differ⁃ences were statistically significant (all P<0.05). The body mass index in the observation group was (28.19±0.92) kg/m2, which was lower than (30.12±1.47) kg/m2in the control group , and the difference was statistically significant (P< 0.05). The incidence of adverse reactions was not significant (P>0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion In the treatment of obese T2DM [作者简介]叶娟（1990-），女，硕士，主治医师，研究方向为内分泌科与代谢病。

【药物名称】胆酸钠 Sodium Tauroglycocholate
【药物类别】利胆药
【药物别名】牛胆酸钠，胆盐 Sodium Cholate，Bile Salt
【制剂规格】片剂：0.1g；胶囊：0.2g。

【药理毒理】
分子的立体构象具有亲水和疏水两个侧面，能降低油/水两相之间的表面张力，是较强的乳化剂。

使疏水的脂类在水中乳化成细小的微团，既增加脂肪在小肠中与脂肪酶的接触面积，有利于消化酶的作用，又可使高度乳化的脂肪微粒直接由肠黏膜吸收，促进脂类的利用。

【适应证】胆道瘘管长期引流及胆汁缺乏，也用于脂肪消化不良和慢性胆囊炎等。

【不良反应】偶有胆内压升高，诱发胆绞痛。

【用法用量】口服：0.1g～0.4g/次，3次/日。

【注意事项】服药前须先引流胆汁。

胆道完全性梗阻，在未作外引流前禁用，以免增高胆道内压力而使病情恶化。

【生产单位】资料暂缺。

oset0europe15胆碱酯酶umollsec8426674101315252378胆碱酯酶umollsec985789118370296443creatinekinasecknacactivatedeuropeasia5肌酸激酶umollsec215172258704563845creatinekinaseckrosalkiothermodied5肌酸激酶umollsec212169254713570855creatinealkalinepicratekineticcartridgecrsumoll188150225510408612creatinealkalinepicratekineticmodularcre3creatineenzymaticcredigoxinimmunoturbidimetric地高辛nmoll107339271407gammaglutamyltransferaseggtszasz5谷氨酰转肽酶umollsec0927249gammaglutamyltransferaseggtszaszifcc20025谷氨酰转肽酶umollsec1070853128257206309glucoseglucoseoxidaseoxygenconsumptionglu3葡萄糖mmoll462148glucosehexokinase0glu葡萄糖mmoll493394591155ironferrozinenodeproteinizationumoll428118lactatelacticacidenzymatic乳酸umolllactatedehydrogenaseldhlactatepyruvate5乳酸脱氢酶umollsec234281281502401602lactatedehydrogenaseldhlactatepyruvateifcc20025乳酸脱氢酶umollsec291611489733lipasecolorimetriclip5脂肪酶umollsec0590154magnesiumcalmagitemmoll0830163phenobarbitalimmunoturbidimetric苯巴比妥umollphenytoinimmunoturbidimetricumoll423865phosphorusphosphomolybdateuvcartridgepo4mmoll115240p

Erratum佚名【期刊名称】《Journal of Integrative Agriculture》【年(卷),期】2024(23)3【摘要】For the paper,Identification and epitope mapping of anti-p72 single-chain antibody against African swine fever virus based on phage display antibody library,published in Journal of Integrative Agriculture 2023,Vol.22,No.9,on page 2834-2847,the authors regret to apprise about a post-publication mistake in Fig.7 of the article.There are errors in the flow cytometry analysis.The new corrected Fig.7 is provided in this corrigendum to match with the corresponding text.【总页数】1页(PI0001)【正文语种】中文【中图分类】G23【相关文献】1.Erratum to “Application and Perception of Potassium Iodide Following Silver Diamine Fluoride Treatment”, Materials Sciences and Applications, Vol. 13 (2022), 506-5182.Erratum to "Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder"3.Erratum to: PHOSPHO1 Serves as a Key Metabolism-Related Biomarker in the Tumorigenesis of Diffuse Large B-cellLymphoma4.Erratum to:Deriving Temporal and Vertical Distributions ofMethane in Xianghe Using Ground-based Fourier Transform Infrared and Gas-analyzer因版权原因，仅展示原文概要，查看原文内容请购买。