卡托普利（Captopril）是一种血管紧张素转化酶抑制剂（ACE inhibitor或ACEI），被应用于治疗高血压和某些类型的充血性心力衰竭。
作为第一个具有商业价值的ACE抑制剂，由于其新的作用机制和革命性的开发过程，而且它对治疗高血压极为有效，因此它获得了商业上的成功，被认为是一个药物治疗上的突破。
卡托普利最早由百时美施贵宝公司（Bristol-Myers Squibb）生产，并在1978年后开始出售，商标名为开博通。
Captopril, drug typically used to control high blood pressure. It is also used to treat congestive heart failure, heart attacks, and kidney disease in diabetic patients. Captopril is classified as an ACE inhibitor. It works by interfering with angiotensin-converting enzymes (ACE) in the body, which influence salt and water retention. The result is relaxed artery walls and lowered blood pressure.Captopril should be taken one hour before a meal. Tablets are taken orally two or three times a day in doses ranging from 25 to 150 mg. Patients are often started on a small dosage, which is increased as needed. Captopril must be taken regularly to be effective, even after symptoms are relieved, which usually takes several weeks. Long-term use of this drug for months or years is not uncommon.Patients with kidney disease or impaired kidney function should use captopril with caution. Exercise or other physical activity should be approved by a doctor. This drug should not be taken by pregnant women, as it can harm the fetus, especially in the second and third trimesters. Breast-feeding women should be aware that captopril is known to appear in breast milk. Captopril has not been proven safe for children.Possible side effects include itching, skin rash, loss of taste, and extremely low blood pressure. Less common side effects include blurred vision, confusion, light-headedness, constipation, depression, fatigue, muscle pain or weakness, light sensitivity, nausea, peptic ulcer, sleepiness, fainting, wheezing stroke, or heart failure. A reaction that includes chest pain, sweating,vomiting, diarrhea, or swelling of the arms, legs, mouth, or throat (including difficulty swallowing) requires immediate medical attention. Yellowing of the skin or eyes may indicate a liver problem, which also requires immediate medical care.Although captopril may be prescribed in combination with a diuretic or digitalis (found in the drug digoxin), it can react adversely with these drugs. It also may react adversely with aspirin, certain blood pressure medications such as beta blockers, lithium, nitroglycerin, anti-inflammatory medications, and potassium supplements (including salt substitutes that contain potassium).『1』1【发现历史】1965年，1982年诺贝尔医学或生理学奖得主J·万恩(John Vane)是牛津大学的教授。
