Lesson+4+听力补充材料
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LESSON FOURFinancePART A1. W: I see a new bookstore has just opened on Main Street.M: It may be a new store, but the books are far from new.Q: Which one of the following is true according to the man?2. W: Alice has been spending a lot of time at the library lately. M: Well. She's got a paper due and two final exams next week.Q: What has Alice probably been doing?3.W: It's going to cost a fortune to get my car fixed.M: Why don't you just trade it in for a new one?Q: What does the man suggest the woman do?4. M: Winter is over at last. Time to pack up my gloves and boots.W: I've been waiting for this for months.Q: How do you interpret what the woman said?5.W: How did the game go the other night? Did your team win?M: Are you kidding? That would be a first.Q: What does the man say about his team?6. M: The tickets for that rock concert will go on sale next Saturday at fiveo'clock.W: I heard that anyone who wants one had better get there sooner than that.Q: What is the implication of the woman?7. W: Your train will be ready for boarding in 15 minutes, Sir. Breakfast willbe offered in the dinning car.M: Good. I'll have just enough time to send a fax before leaving.Q: What does the man plan to do next?8. W: Shall I cut your hair for you?M: No way. Last time you almost made me bald.Q: What can be known from the conversation?9.M: So my advisor wants me to take the creative writing class that meetson Wednesday instead of the Monday class, because the instructor forthe Wednesday class is supposed to be great. But that means I have tospend a whole day on campus, every Wednesday.W: Well, but…especially in creative writing, the instructor can make a big difference in how much you get out of the class.Q: What does the woman imply the man should do?10. M: Would you like to try the new sea food restaurant tonight? I hear it'svery good.W: I have to give a presentation tomorrow, and I need to do a trial run.Q: What will the woman probably do tonight?11. W: Ah-oh. Somebody left his wallet here.M: See if there is some kind of identification in it.Q: What does the man suggest the woman do?12. W: Dr. Smith asked us to watch that special on the Civil War on TV thisweekend. Do you want to come over Saturday night?M: Oh, I'm supposed to help my cousin move then. It's being rebroadcast on Sunday afternoon, though. Is that OK for you?Q: Why does the man suggest they should watch the TV programme on Sunday?13.M: I don't know how I managed to break that platter. I'll be more thanhappy to buy you a new one.W: Forget about it. Some things just can't be helped.Q: What can be inferred about the woman , concerning the platter?14. W: I wonder if there's a bus that goes by the museum.M: The history museum on Main Street? Take one of these with 8-A on the front.Q: What does the man mean?15.M: It's pouring. We are never gonna make our flight if we don't leavesoon.W: Oh, don't worry so much. I'm sure we'll get there in plenty of time.Q: What information can you get from the woman?Part BPassage IThe GoldRushOne day in 1848, a remarkable discovery was made by a carpenter named Marshall. He happened to pick up some bright yellow particles from the water near his sawmill. Not knowing what they were, he took them to hismaster Mr. Sutter. Sutter immediately realized the importance of the discovery and sent a man to San Francisco to inform the governor of it so that he could get permission to found a settlement on both banks of the river. Unfortunately in the beginning, the man did not believe it. Only after a reporter from a weekly newspaper went to Sutter's sawmill to make a report, did the news spread all over the USA, and even to Europe.Within a month, thousands and thousands of people hurried towards California to search for the valuable metal. Soldiers deserted the army, sailors left their ships and all sorts of people gave up their jobs so as not to miss the chance of becoming rich. Large number of Europeans joined in the search, too. Crowds of people, ships and wagon trains rushed to the same destination. This was the California Gold Rush. While this went on, families were broken up, husbands were taken away from their wives and children from their parents. On their way to California, lots of worshippers of gold lost their lives before they got a single particle of it. Some of them were killed in storms at sea; some could not stand the extraordinary hardships, and died of hunger, cold or illness.The Gold Rush proved a disaster for Sutter himself. For years he tried to drive the prospectors off his land to keep the entire wealth for himself. The prospectors hated him very much, and did a great deal of damage to his business. All Sutter's houses were burned down and all his family, except for himself, were killed. At the end of his life, he became a beggar, whocontinually stopped passers-by in the street to tell them that gold is the devil.1. What lesson can we draw from this story?2.When did the news of the gold discovery spread all over the USA?3. Why were many families broken up and husbands taken away from their wives?4. What happened to Mr. Sutter in the end according to the story?5. What does the story tell us?II.1. In 1848.2. He picked them up from the water near his sawmill3.He sent a man to San Francisco to inform the governor about it so that he would be allowed to search for them.4.Thousands and thousands of people hurried towards California to search for the valuable metal.5. They did much damage to his business, burned down his houses and killedhis family.Passage II.Functions of MoneyThere is an ancient rhyme about money which goes like this:"How many uses does money have? Four.A means, a measure, a standard, a store. "This rhyme forms an excellent basis for a discussion of the main features and functions of money. Money is a means, it is a means of exchange. It enables us to exchange goods and services. Things valued in terms of money become commodities; they can be bought and sold. Money, whenever it is available, provides the opportunity to obtain useful things or replace old things with new ones.The second thing our rhyme tells us is that money is a measure. It serves as a measure of value. It enables us to measure the value of all kinds of goods and services. The items sold by a large store may be very different from each other, but all without exception can be measured by the same measuring rod, namely money. Two things which are not similar in any way may have the same price.Thirdly, money is a standard of value. This means that money itself possesses a value which can remain approximately constant. To serve as a standard, a thing or a substance must remain fixed and unchangeable in comparison with other things. The amount of money in a country should vary, but it should vary in a regular way. It should correspond to the quantity and value of goods and services available for exchange and circulation in that country; if this quantity and value increases, the amount of money in circulation should be proportionately increased.Finally, money is a "store." We store money just as we store other things. Money does not go bad, though in times of financial crisis it may lose some ofits value. It enables us to provide for future needs and situations. When we save money weekly or monthly and deposit it in a bank, our savings serve as a store of value in general; they give us the opportunity to make our choices later instead of making them immediately. When we store money we store the power to choose or to decide, so that we can use this power on future occasions.1. How many functions does money have?2. Why do we say that money is a means?3. What is the main feature of commodities?4. Which of the following is true according to the passage?5. What happens to money in times of financial crisis?II.1. rhyme, features, functions2.measure, measure of value.3. similar, same price4. "store", store other things5. choose, decide, future occasions.Passage IIICredit CardsAmericans spend a lot of money in their daily lives. Working people spend money on transportation to and from work and on variousexpenses throughout the day. Americans enjoy shopping and buy many things that they need and want. They spend a lot of money on entertainment. They buy sports equipment, go to sporting events and do many things that cost money. However, many Americans don't pay with cash or write checks for these things. More and more, they pay for things with credit cards.Credit cards are small, rectangular plastic cards. Banks give these cards to their customers. When the customer buys something at a store, he shows his card at the store. This authorizes the store to charge the bank for the customer's purchase. The bank collects all the charges for each customer. Then once a month the bank requires the customer to pay all the charges for that month. The bank does not force the customer to pay the full amount. It allows the customer to pay for the charges in several payments over a period of time. However, the bank requires the customers to pay high interest on the unpaid part of the charges.In this way the bank allows customers to buy things they can not afford at one time. People can use the card to buy what they want and pay for it over a period of time. They also do not need to carry a lot of money. Part D1)hands, 2) success, 3) loyalty, 4) trumpet, 5) twilight, 6) rejoicing,7) poverty, 8) fruitful, 9) maximum, 10) shrink, 11) generation, 12) devotion 13) country 14) together, 15) freedom, 16) citizens, 17) strength,18) reward, 19) judge, 20) blessing。
Unit 4 Loans for the DreamPart ⅠGetting readyA. The following words will appear in this unit. Listen carefully and study the definitions.1. depreciation:2. overdraft;3. proposition:4. bearing:5. collateral:6. retailer:7. sue;8. mint:9. hoard:10. crunch:B. Listen to the following dialogues. Complete the exercises.Dialogue one: Tick the expenditure items mentioned by the speaker.A. You asked me where all the money goes. It's difficult to say exactly, but obviously we spend a lot of money on groceries. I enjoy cooking, and as we have a large family — four children — our food bill is quite big. We also like eating out — my wife and I probably go out to a restaurant about once a week. Unfortunately, there are no theatres round here, so we don't go to the theatre as much as we'd like. But we do spend money on our hobbies. I like doing jobs around the house —I'm one of the local DIY center's best customers — and I'm very keen on sailing — that's a very expensive hobby. I'm also very interested in antiques, especially clocks. You must let me show you my collection one day ...B. I'd like that. I wanted to ask you about holidays. Do you usually go abroad or stay in this coutry?A. We usually stay here. In fact, we spend very little on holidays. We have a small house near the sea and we usually go there. That's where I do my sailing. We did go away for a week last year, but that was exceptional.Dialogue two: Complete the chart. Use ticks to indicate whether the expenditures on those items are up, down or the same as last year. Supply the figures mentioned.A: So how much did we spend on entertainment this year?B: 2566.A: That's down a little on last year. And what's the figure for depreciation?B: 300, the same as last year.A: Hm, expenditure on secretarial expenses is up.B: Yes, there's a big increase there.A: What's the figure of 2612 for?B: Where's that?A: Six figures down.B: That's motor expenses.A: And what does this figure represent?B: Audit and accountancy costs.A: They're both up a lot.B: Yes, but expenditure on telephone and postage is down.It's half as much as last year.Part ⅡRaising money for buying a carA. Listen to the dialogue. Take notes. Then complete the summary.B: Well, good afternoon, Mr. Jackson.J: Good afternoon. I've come to see you to see whether it's possible to ... get an overdraft. I'm (I)want some money. [Yes] I'll tell you quite frankly what it is. I'm wanting to buy a new car. [Yes] I don't know whether it's possible to raise any money from the bank in this way.B: Er, I see no reason why not.J: I've got an old car ...B: What's your proposition?J: Well, I've got this old car which is an eight-year-old Morris 1000, and I don't think there's any point in having it repaired any more because it just isn't worth it. I feel that I could probably get about a hundred pounds for it and then that means that I would need about another four hundred-odd, three hundred and fifty ... [Mhm] er, on top of that, to buy a, a, not a new car exactly, but a newer one. [Mhm] Um, ...B: Do you use the car for your business, for your work?J: Er; yes I do, up to a point. That is to say, sometimes I take it to work and sometimes I don't, because I'm almost within walking distance of the College. [Mhm] Does this have some bearing on the, on the question of whether I can get an overdraft?B: No, I don't think so. I, er, it was just a matter of interest that I asked you, really. You think three hundred and fifty?J: I would say about three hundred and fifty to four hundred. With the other, with the other [Yes] hundred pounds then it would be about, er, five hundred pounds; well, one can get quite a decent car for five hundred pounds [Quite] — second hand, of course.B: Quite. And what sort of period of time could you repay us?J: Well, erm, this rather depends on you. Um, I would like to ... I, er, what is the normal procedure for such a sum of money?B: Well, for such a sum of money we could expect repayment within twenty-four months.J: Two years.B: Two years.J: I see.B: We are lenders in the short term, remember, not long term.J: Yes. Er, is there ... Do you, do I pay interest on this?B: You will pay interest on — well, the type of loan I have in mind is a Personal Loan, as I assume you've got no form of collateral to offer.J: What is — what is collateral?B: Well, have you any shares in any companies or life policies, deeds of houses, or anything like that?J: I have some Government Securities, is ... would this be ... sufficient?B: You have some Government Securities, and what is their value?J: Er, it's about ...B: Have you got the certificates?J: ... eight hundred pounds or so.B: About eight hundred pounds?J: Yes, but I don't want to ...B: You don't want ...J: ... cash them.B: No. No, well you wouldn't ... that wouldn't involve you in cashing them. I could grant you an Ordinary Loan where the interest to you would be less than on a Personal Loan, if you were willing to charge that Share Certificate to us.J: Yes. I see, um, er, is it, is it possible to er ... what's ... that, that would be the only security which you would need, in fact?B: I shouldn't need any other security, other than that ... [I see] not on a loan, not on a loan of that size. Or if you would agree to do it on a Personal Loan basis which [cough] I would not require any security whatever, as on a Personal Loan we have death cover and you are in regular employment, er, in, er, good-salaried employment, with a with a good, with a good salary, therefore I would not ask you for erm, any security. [Yes. Yes.] But the interest rate would be higher than on an Ordinary Loan. [Yes] I should charge you seven percent on a Personal Loan and that's on the original amount taken, whereas on an Ordinary Loan it would be at one and a half percent over Bank Rate, minimum six percent, and that would be calculated on a, on a day-to-day basis, so it does in fact work out cheaper.J: I see. Yes.B. Now try this: listen to a more authentic version of the dialogue. First complete the chart to show the differences between the two loans. Then try to find the English equivalents of the Chinese expressions listed.Part ⅢHousing in the U.S.A. Listen to the material. Complete the outline. Then give the right words according to the explanations.In the U.S. today, the cost of housing is very high. It is common to pay one fourth to one third of a family's income on the place to live. The price of a house depends on its size and location. Big houses are more expensive than smaller ones. And houses closer to the center of big cities are more expensive than ones in the suburbs or in small towns.Regardless of the cost, it's usual for people to buy their houses over a period of time. When a family buys a house, it is necessary to borrow money from a bank to pay for it. Then they repay the bank in regular payments. This kind of bank loan is called a mortgage. Families can take 30 years to pay off the mortgage. Without a mortgage, it would be impossible for most people to own their houses.Many Americans don't own their own homes. They pay landlords to live in their homes. The money they pay for this is called rent. Usually it is cheaper to rent than it is to buy and to pay a mortgage. Also when something needs to be repaired, it is easy for the renter to ask the landlord to fix it.Some people rent houses, but most renters live in apartments. Apartment buildings are located in cities where it is too costly to build houses. Recently, it has become common for renters to buy their apartments. When this happens, the cost usually increases, but the money goes to pay off the mortgage. Apartments bought this way are called condominiums.Part ⅣMore about the topic: Consumer RightsA. Listen to an interview about consumer rights under English law. While listening for the first time, add more key words in the left-hand column. After the second listening, use key words to answer the questions.P - Presenter D - Dave WattsP: Many consumers are unaware of their rights in buying goods from shops and stores. Dave Watts of the Office of Fair Trading is here to explain exactly what your rights are under English law. Dave, first of all, what are the Acts that give the buyer rights?D: Well, Sandy, there are two Acts: there's the Sale of Goods Act and the Trades Descriptions Act and both cover the rights of a buyer in contracts that he or she enters into with traders.P: And ... um ... who are the "traders" exactly?D: Well, "traders" means any shop, doorstep salesman, street market stall or mail order firm.P: And so what is a "contract" then in ... in this respect?D: Well, if you buy anything from a trader, you have in fact entered into a contract with him.P: And do traders have obligations?D: Yes, they have three main obligations. The first one is that the goods are "of merchantable quality" ...P: Er ... hang on, what does "merchantable" mean?D: Well, that means "fit for the purpose", bearing in mind the price that you've paid for it, the nature of the goods and how they're described. For example, a pair of shoes which fall apart after two weeks' normal wear are not of merchantable quality. Very cheap or secondhand goods needn't be top quality but they must still fulfill this obligation. And the second obligation is that the goods are "fit for any particular purpose made known to the seller". And the third one is that the goods are "as described".P: "As described"?D: Yes, on the package or as illustrated or described on a display sign, or verbally by the seller himself.P: And ... um ... if you think you have cause for complaint, what should you do?D: Well, you must take the item back to the shop, unless it's too large or fragile to move, in which case the trader must collect it from you. And you'll be entitled to all or part of your money back, a cash refund, plus compensation for any loss or personal injury.P: Instead of taking it back to the shop, would it be a good idea to send it to the manufacturer?D: No, definitely not. It's the retailer's responsibility. But you could sue the manufacturer if you've suffered personal injury, say.P: Oh, and what about receipts — should you keep them or doesn't it matter if you throw them away?D: Well, the purpose of keeping receipts is so that you have some evidence of your purchase and also of the date of the purchase, which sometimes is very important. But the retailer's not within his rights to say "No refunds without a receipt".P: Suppose a retailer refuses to give a refund for faulty goods, even when he legally has to?D: Well, in that case you should go to your local Citizens' Advice Bureau or to the Trading Standards Office, sometimes called the "Consumer Advice Center".P: Oh, I see. And if the worst comes to the worst?D: Well, you may have to go to court and sue the seller for your money or for compensation. But that's very rare, I'm glad to say, as it's more costly for the retailer to defend themselves in court than it is to give you your money back.P: Dave, thank you very much.D: Thank you.B. Now listen again. Decide whether the statements after the interview are true or false. Put "T" or "F" in the brackets.Part ⅤDo you know ...?A Before you listen, answer the following questions.1. Do you like collecting coins?2. Do you think that collecting too many coins will cause a problem?B Now listen to the news report. Complete the chart. Then answer the questions with key words.A penny saved is a penny earned, but too many pennies saved is a big problem for the U.S. Federal Reserve Bank in Philadelphia.Some area stores have been asking customers to dig for exact change as their cash drawers have run short of pennies in recent weeks.Meanwhile, stores and banks have sharply increased their orders for pennies, though no one can point to a reason for a shortage except the accumulations that pile up on dressers, in jars and in piggy banks, Federal Reserve Bank spokesman Bob McCarthy said."People do not take time to put pennies back in their pockets," McCarthy said last Wednesday. "Everyone hoards."As area merchants feel the crunch, some have posted notes at cash registers asking customers for exact change.Chris McDowell, manager of a downtown Wawa Food Market, said he has run short ofpennies several times in the last two weeks, but customers have helped the cashiers cope.Sometimes a cashier will return a little extra money to make the change come out even. At other times a customer will hand over a dollar for a 98-cent item and wave away the change, he said.McDowell said he understood the tendency to pile up pennies."I have a five-gallon (18.93-litre) jug at home that I would say is three-fourths full of pennies. I just don't want to wrap them," he said.McCarthy said a national shortage would be unlikely, since the two U.S. mints in Philadelphia and Denver use most of their capacity producing pennies. He said the Philadelphia mint produces 40 million pennies a day, and the US$500 billion worth of U.S. currency in circulation worldwide includes 200 billion pennies.。
Lesson 4Section ITask 1: Weather ForecastA.Multiple Choice. 1 — 2: acB.Fill in the following chart.Task 2: The 5 O’clock NewsA.Fill in the following chart.B.Give brief answers to the following questions based on the news report.1.It was closed down by government authorities.2.Testing confirmed that the town had been poisoned be the dumping of toxic chemicals intown dumps.3. 3 weeks ago.4.200.5.Headaches, stomachaches, faintness and dizziness.6.Toxic wastes had leaked into the ground and contaminated the water supply.7.All the residents should leave the area, until the chemical company responsible for thetoxic waste can determine whether the town can be cleaned up and made safe again.C.True of False Questions. 1—6: FTTFFTD.Fill in the following blanks (based on the news report).Teams Playing Result(1) Mexico — France 7 to 6(2) Canada — Argentina 3 to 3(3) Italy — Haiti2 to 1(with 30 minutes left to go)Section IITask 1: What Do You Like for Entertainment?A.Blank-filling.Reporter: Deborah TylerInterviewee: Students of the Brooklyn Academy of Dramatic ArtsMajor: Benny Gross —— pianoKimberley Martins —— modern danceB.Fill in the following chart about how often Benny and Kimberley go to the eight forms ofartistic entertainment.C.Rearrange the forms of artistic entertainment that Benny and Kimberley like, beginningwith the form that each one likes best.Benny: (3)—(1)—(4)—(6)—(2)—(8)Kimberley: (2)—(4)—(1)—(7)—(3)—(8)Task 2: Are You a Heavy Smoker?A.True or False Questions. 1—6: TFTTFTB.Multiple Choice. 1—6: cbcbacC.Blank-filling.Name: Doris BradleySex: femaleAge: 32Amount: 3 packets of 20 a weekFirst experience:Time: at the age of 17Place: at a partyOffered by: boyfriend, not husbandFeeling; awfully grown-upLater: started smoking 2 or 3 a day and gradually increased.Experience of giving up smoking: twice1. Time: 6 months before getting marriedReason: saving upResult: only cut it down from 30 a day, still smoked a little2. Time: when expecting a babyReason: according to doctor’s adviceResult: gave up completely for 7 or 8 months and took it up a couple of weeks after the baby was born, because the baby was being bottle fed.Time when she smokes most:1. watching TV2. reading books3. in company4. with friendsTime when she never smokes:1. doing the housework2. on an empty stomachSection IIITask 1: Learning to Predict1.Answer: They’d be exhausted at the end of each performance.Reason: “Otherwise” suggests a result of the opposite condition.2.Answer: I enjoyed it very much.Reason: “Apart from that I must say”often suggests an opposite statement to earlier comments.3.Answer: I stayed up late to finish it.Reason: “And” suggests that the speaker would finish the book at one sit.4.Answer: the book never really got started at all.Reason: After an opinion of agreement, the phrase “in fact” suggests a further comment;the expression “it’s only honest to say” usually introduces a confession-something which is probably not as good as the one mentioned.5.Answer: I tend to ski p parts that don’t really hold my interest.Reason: “Otherwise” suggests a result of the opposite condition.6.Answer: it was rather long.Reason: “I must admit” suggests an agreement to the other person’s opinion.Task 2: DictationBooks Belong to the PastSir,I visited my old school yesterday. It hasn’t changed in thirty years. The pupils were sitting in the same desks and reading the same books. When are schools going to move into the modern world? Books belong to the past. In our homes radio and television bring us knowledge of the world. We can see and hear the truth for ourselves. If we want entertainment most of us prefer a modern film to a classical novel. In the business world computers store information, so that we no longer need encyclopaedias and dictionaries. But in the schools teachers and pupils still use books. There should be a radio and television set in every classroom, and a library of tapes and records in every school. The children of today will rarely open a book when they leave school. The children of tomorrow won’t need to read and Write at all.M. P. MillerLondon听力原文:Lesson 4Announcer: And now over to Marsha Davenport for today's weather forecast. Marsha?Weather reporter: Thanks, Peter. Well, as you can see from the weather map, there's varied weather activity across the United States and Canada today. Let's start with the west coast, where it's raining from British Columbia down to northern Californi a. The high in Seattle will be 50 degrees. Southern California will be in better shape today—they'll have sunny skies and warmer temperatures. We're looking for a high of 78 degrees in San Diego. The mid-west will be having clear but windy weather. Oklahoma City will see a high of 65 and sunny skies, with very strong winds. Down in Houston we're looking for cloudy skies and a high of 69. Over to the east in Miami we expect the thermometer to reach 64 degrees, but it'll be cloudy and quite windy. Up in the northeast, it looks like winter just won't let go! New Y ork City will be having another day of heavy rains, high winds, and cold temperatures, with a high of only 35 degrees expected. Further north in Montreal it's even colder—28 degrees, with snow flurries expected today. Over in Toronto it's sunny but a cold 30 degrees.And that's this morning's weather forecast. We'll have a complete weather update today at noon.News anchor: Good evening. I'm Charles McKay, and this is the 5 o'clock evening news. The top story this hour: The town of Delta has been declared a health haz ard. The entire town of Delta was closed down by government authorities yesterday, after testing confirmed t hat the town had been poisoned by the dum ping of toxic chemicals in town dumps. Suspicions were first aroused three weeks ago, when 200 people telephoned t he hospital complaining of headaches, stomachaches, faint ness, and dizz iness. An investigation revealed that toxic wastes had leaked into the ground and contaminated the water supply. People were being poisoned by their drinking water and by the fruits and vegetables they were eating from their gardens. In fact, any contact they had with soil or water was dangerous. Government authorities have ordered all residents to leave the area until the chemical company responsible for the toxic waste can determine whether the town can be cleaned up and made safe again.And now here's Sarah Cooper with tonight's Consumer Report. Sarah?Consumer reporter: Thank you Charles, and good evening. There was some good news for beer drinkers today: A recent study of 17,000 Canadians shows t hat people who drink beer moderately are healthier than people who drink other alcoholic beverages, such as wine or liquor. Researchers say they don't yet know exactly why this is so. They found, however, that moderate beer drinkers reported less illness and appeared to have a lower risk of death from heart disease. Good health seemed to be connectedto the amount of beer consumed and the regularity of drinking. People w ho drank beer one or more times a day reported the lea st amount of illness. Heavy drinkers, however—people who drank 35 or more pints of beer a week—reported more illness.The war against cigarette smoking is heating up again. Legislation was introduced today that would make it illegal to advertise cigarettes, cigars, or any other tobacco product in any form of media. That means ads would be banned from newspapers, magaz ines, television, radio, and billboards. The legislation would also prevent tobacco manufacturers from sponsoring sporting events and from giving away free samples. This is the strongest anti-smoking legislation that has been introduced to date. Cigarette manufacturers insist that the legislation would be useless. In fact, they claim that in parts o f the country where advertising has already been prohibited, cigarette smoking has actually increased.That concludes t he Consumer Report for tonight. Let's go over now to Jerry Ryan and find out what's happening in the world of sports. Jerry?Sports announcer: Thanks, Sarah, and good evening sports fans. It was an e xciting day in world soccer. Mexico defeated France 7 to 6, in a close game that offered spectators plenty of excitement. The game between Canada and Argentina ended in a tie, 3 to 3. And in a game that's still in progress, Italy is leading Haiti 2 to 1, with 30 minutes left to go.T une in tonight at 11 for a complete sports update.Reporter: Well here I am at the Brooklyn Academy of Dramatic Arts. I'm asking different students here about their favouriteforms of artistic entertainment. Pop or classical concerts? Art galleries or t he theatre? The ballet or t he opera? The first person I'm going to talk to is Benny Gross. Benny comes from New Y ork and he's 20 years old and he's studying the piano. Benny, helloand welcome to our programme.Benny: Hi, thanks.Reporter: So, first question Benny—have you ever been to an art gallery?Benny: Y es, lots of times.Reporter: And the ballet, have you ever been to the ballet?Benny: Y es, a few times. It's all right, I quite like it.Reporter: And what about classical concerts?Benny: Y es, of course, many many times.Reporter: Erm—next—have you ever been to an exhibition, Benny?Benny: Oh, yes—I love going to photographic exhibitions.Reporter: Do you? Now, ne xt question—what about a ... folk concert?Benny: No, never. I think folk music is aw ful.Reporter: Ok. And the opera? Have you ever been to the opera?Benny: Y es. Two or three times. It's a little difficult but I quite like it.Reporter: And a pop concert?Benny: No, never.Reporter: And finally—have you ever been to the theatre?Benny: Y es, once or twice, but I didn't like it much.Reporter: Ok Benny. Now the ne xt thing is—which do you like best from this list of eight forms of artistic entertainment? Benny: Well I like going to classical concerts best because I'm a musician, and I love classical music.Reporter: Ok and what next?Benny: Erm let's see—next, art galleries I think. And then, e xhibitions.Reporter: OK—art galleries, then exhibitions. Then? The theatre?Benny: No, I don't think so, I don't really like the theatre.Reporter: The ballet? The opera? Which do you prefer of t hose two?Benny: The opera.Reporter: So of the theatre and the ballet, w hich do you prefer?Benny: Erm, t he ballet I think because there's the music. I can always enjoy t he music if I don't always like the dancing. Reporter: Right, well, thanks very much, Benny.Benny: Y ou're welcome.Reporter: My next guest is Kimberley Martins. What are you studying here, Kimberley?Kimberley: Modern dance. I want to be a professional dancer when I leave.Reporter: OK, so here we go. First question—have you ever been to an art gallery?Kimberley: Y es, lots of times.Reporter: And have you ever been to t he ballet? Stupid question I think.Kimberley: Y es, a bit. Of course I have. I go almost every night if I can.Reporter: And what about classical concerts?Kimberley: Y es—there are classical concerts here a lot—the other students perform here and I go to those when I can.Reporter: What about e xhibitions—have you ever—?Kimberley: Oh yes, lots of times—I like exhibitions—e xhibitions about famous people—dancers, actors, you know—Reporter: Mmm. And what about a folk concert? Have you ever been to one of them?Kimberley: No, I don't like folk music very much.Reporter: What about the opera?Kimberley: No, never. I don't really like opera. It's a bit too heavy for me.Reporter: A pop concert?Kimberley: Y es. I saw Madonna once. She was fantastic—she's a really great dancer.Reporter: And have you ever been to t he theatre?Kimberley: Y es, I have.Reporter: Right. Thank you Kimberley. My ne xt question is—w hich do you like best of all? And I think I know the answer.Kimberley: Y es—ballet, of course. After that, e xhibitions. And after that, art galleries.Reporter: OK.Kimberley: Erm, what's left. Can I see the list?Reporter: Y es, of course.Kimberley: Erm, let me see—oh, it's difficult—I suppose—what next?—er—classical concerts, pop concerts, the theatre. Well, I think pop concerts next, I like going to those. Then I don't know. Classical concerts or the theatre? Classical concerts I th ink. So that leaves the theatre after them. OK?Reporter: Great. And many thanks for talking to us, Kimberley.Kimberley: Y ou're welcome.Salesgirl: Y es?Mrs. Bradley: Six packets of Rothmans and three of Silk Cut please.Salesgirl: Six Rothmans ... and three Silk Cut. That's ... six fifty fives—three pound thirty ... three Silk C ut—one forty-four ... That's four pound seventy-four altogether. Thank you. 26p. change ... and your stamps.Interviewer: Excuse me madam.Mrs. Bradley: Y es?Interviewer: I wonder whether you'd help us. We're doing a survey on smokers' habits. Would you mind ...?Mrs. Bradley: Well ... I'm in a bit of a hurry actuallyInterviewer: It'll only take a few minutes. We'd very much appreciate your help.Mrs. Bradley: Well all right. I can spare that I suppose.Interviewer: Thank you. Y ou are a smoker ... of course?Mrs. Bradley: Y es I'm afraid I am. My husband is too. As you can see ... I've just bought the week's ration.Interviewer: Would you describe yourself as being a heavy smoker?Mrs. Bradley: Heavy ... no. I wouldn't call three packets of twenty a week heavy smoking. That's not even ten a day. No ... a light smoker. My husband ... he's different ...Interviewer: Y es?Mrs. Bradley: I get in twice as many a week for him. He smokes twenty or more a day.Interviewer: Y ou wouldn't describe him as a chain-smoker ...?Mrs. Bradley: No ... he's not as bad as that.Interviewer: Right ... Thank you Mrs. ...?Mrs. Bradley: Bradley. Doris Bradley.Interviewer: ... Mrs. Bradley. Y ou and your husband smoke cigarettes I see. What about cigars ... a pipe ... Does your husband ...?Mrs. Bradley: Oh he's never smoked a pipe. He's the restless, nervy type. I always associate pipe-smoking with people of another kind ... the calm contented type ... As for cigars I suppose he never smokes more than one a year—after his Christmas dinner. Of course I only smoke cigarettes.Interviewer: Right. Now let's keep to you Mrs. Bradley. When and why—if that's not asking too much—did you begin to smoke? Can you remember?Mrs. Bradley: Y es ... I remember very well. I'm thirty-two now ... so I m ust have been ... er ... yes ... seventeen ... when I had my first cigarette. It was at a party and—you know—at that age you want to do everything your friends do. So w hen my boyfriend—not my husband—when he offered me a cigarette I accepted it. I remember feeling awfully grown-up about it. Then I started smoking ... let's see now ... just two or three a day ... and I gradually increased.Interviewer: I see. That's very clear. Now ... Might I ask if you have ever tried to give up smoking?Mrs. Bradley: Y es—twice. The first time about six months before getting married. Oh t hat was because I was saving up and ... yes ... I used to smoke more in those days. Sometimes thirty a day. So I decided to give it up—but only succeeded I'm afraid in cutting it dow n. I still smoked a little ...Interviewer: And the second time?Mrs. Bradley: Oh the second time I did manage to give up completely for a while. I was expecting ... and the doctor advised me not to smoke at all. I went for about ... seven or eight months ... without a single cigarette.Interviewer: Then you took it up again.Mrs. Bradley: Y es ... a couple of weeks after the baby was born. It was all right then because the baby was being bottle fed anyway.Interviewer: Good. That's interesting. So if you'd been breast-feeding you would have gone for longer without smoking?Mrs. Bradley: Definitely. It's what the doctors advise. Though not all mothers do as their doctors say ...Interviewer: Now Mrs. Bradley. When do you smoke most?Mrs. Bradley: Erm ... When I'm sitting watching TV or ... or ... reading a book ... but especially I'm with ... when I'm in company. Y es ... that's it ... when I'm with friends. I never smoke when I'm doing the housework ... never ... There's always too much to do. Interviewer: Do you ever smoke at meal times?Mrs. Bradley: I always have ... one cigarette after a meal. Never on an empty stomach. Which reminds me—I must be going. My husband will be waiting for his lunch. And Keith ... he's my son.Interviewer: Just one more question and that'll be all.Mrs. Bradley: Well if you insist.Interviewer: How would you describe the effect that smoking has on you?Mrs. Bradley: What do you mean?Interviewer: Well ... Does smoking—for e xample—make you excitable ... keep you awake ...?Mrs. Bradley: Oh no—quite the contrary. As I told you before I smoke most at times when I'm most relaxed. Though quite honestly I ... don't really know whether I smoke because I'm relaxed or ... er ... you know ... in order to relax. Now I really must be ... Please excuse me. I see you're ... you're carrying a tape-recorder. This won't be on the radio, will it?Interviewer: No Mrs. Bradley ... I'm afraid not. But we do thank you all the same.Mrs. Bradley: Right. Goodbye.Interviewer: Goodbye Mrs. Bradley.(Pause.)Salesgirl: How's it going then?Interviewer: Fine. Give us a packet of Seniors, will you. I'm dying for a smoke.Salesgirl: That's 60p.Interviewer: What about you. Don't you smoke ...?(1) Interviewer: Why do the actors wear roller-skates?Designer: Well, they're all playing trains, you see.Interviewer: Trains?Designer: Y es, singing trains and they have to skate all round the audience at very high speeds. We've designed special lightweight costumes for them out of foam rubber, otherwise (pause) they'd be exhausted at t he end of each performance.(2) I found it took me rather a long time to get into the book. I mean, I kept wondering when we were going to begin with the plot, when we were going to get the actual story. Apart from that I must say that (pause) I enjoyed it very much.(3) I found it very exciting and moving. I couldn't put it down and (pause) I stayed up very late to finish it.(4) Well, I do agree with Jane that the book took a long time to start. In fact, for me, it's only honest to say that (pause) the book never really got started at all.(5) I'm one of those impatient readers who want to get straight into a book from the beginning. Otherwise (pause) I tend to skip parts that don't really hold my interest.(6) A: I'm afraid I did quite a lot of skipping wit h Alan Bailey's novel. And with over five hundred pages it was a bit of a disappointment really.B: Y es, I must admit that (pause) it was rather long.Books Belong to the PastSir,I visited my old school yesterday. It hasn't changed in thirty years. The pupils were sitting in the same desks and reading the same books. When are schools going to move into the modern world? Books belong to the p ast. In our homes radio and television bring us knowledge of the world. We can see and hear the truth for ourselves. If we want entertainment most of us prefer a modern film to a classical novel. In the business world computers store information, so that we no longer need encyclopaedias and dictionaries. But in the schools teachers and pupils still use books. There should be a radio and television set in every cla ssroom, and a library of tapes and records in every school. The children of today will rarely open a book when they leave school. The children of tomorrow won't need to read and write at all.M.P. MillerLondon。
Unit1 I go to school at 8:00 Lesson4 一、Listen and number. 听录音,给下列图片排序。
( ) ( ) ( ) ( ) ( )二、Listen and judge. 听录音,判断正误,正确的写“T”,错误的写“F”。
( ) 1. ( ) 2. ( ) 3.( ) 4. ( ) 5. ( ) 6.三、Listen and circle. 听录音,圈出你所听到的内容。
1. My brother ______(plays ping-pong/plays baseball) at 5:00.2. Ted doesn’t ______(do the high jump/do the long jump) at 4:30.3. Peter _______(does the housework/do the homework) at 9:40.4. Lisa often listens to music on ________(Saturdays/ Sundays).5. My mother is a teacher. She teaches them _____(English/Chinese).6. Every _________(morning/evening), she always reads books.7. Gao Wei doesn’t ______(take a walk/fly a kite) in the evening.8. My little sister _____( watches TV/plays games) every evening.9. Jim doesn’t ______(go to school/go swimming) on Sundays.四、Look and choose. 选择与短语相符的图片。
( ) 1. cook breakfast ( ) 2. take a walk( ) 3. play games ( ) 4. teach EnglishA. B. C. D.五、Read and fill in the blanks.读句子,根据句意和首字母提示补全单词。
四年级下册同步第4单元听力录音材料.Unit4听力材料课堂精练PartALet’slearn一、你将听到一段天气预报,了解各大城市的天气情况后,请在相应的表格内打勾。
Goodorning.Thisistheeatherreport.It’shotinBeijing.It’scoldinHarbin.It’sarinHongong.It’scoolinLhasa.Let’stal一.听录音,圈出你所听到的图片的字母编号。
It’shottoday.It’sspring.It’sar.It’scold.Putonyourcoat.It’scooltoday.Icanearyshirt.canIearyseater?yes,youcan.二.听录音,判断下面各图是否与录音内容相符,相符的在该图片下面的括号里打“√”,不符的打“×”。
It’scooltoday.Putonyourseater.o,canIearyshirttoday?No,youcan’t.It’sartoday.Taeoffyourjacet.Theseareyshoes.Ilietheveryuch.It’scoldinHongong.三、听录音,将句子补充完整。
It’sartoday.Let’splayfootball.Theseareyjeansandpants.hatcolourareyourshoes?Theyareblueandhite.四、根据录音中听到的问题,把下面每组中最合适的答案选出来。
canIearyT-shirt?It’sartoday.canIearyjacet?hereareyshoes?hatcolourareyourjeans?hoseisthissirt?PartBLet’slearn一、听录音,将下面每组中你认为符合录音内容的图片下面的字母画一圆圈圈住。
It’srainytoday.hat’stheeatherlietoday?It’ssunny.It’scloudy.Taeyourraincoat.It’ssnoy.Putonyourcoat.It’sindytoday.Let’sflyites.二、听录音,判断下面各图是否与录音内容相符,相符的在该图片下面的括号里打“√”,不符的打“×”。
新概念频道为⼤家整理的新概念英语第四册听⼒原⽂:Knowledge and progress,供⼤家参考。
更多阅读请查看本站频道。
Knowledge and progress 知识和进步 First listen and then answer the following question. 听录⾳,然后回答以下问题。
In what two areas have people made no 'progress' at all? Why does the idea of progress loom so large in the modern world? Surely because progress of a particular kind is actually taking place around us and is becoming more and more manifest. Although mankind has undergone no general improvement in intelligence or morality, it has made extraordinary progress in the accumulation of knowledge. Knowledge began to increase as soon as the thoughts of one individual could be communicated to another by means of speech. With the invention of writing, a great advance was made, for knowledge could then be not only communicated but also stored. Libraries made education possible, and education in its turn added to libraries: the growth of knowledge followed a kind of compound interest law, which was greatly enhanced by the invention of printing. All this was comparatively slow until, with the coming of science, the tempo was suddenly raised. Then knowledge began to be accumulated according to a systematic plan. The trickle became a stream; the stream has now become a torrent. Moreover, as soon as new knowledge is acquired, it is now turned to practical account. What is called 'modern civilization' is not the result of a balanced development of all man's nature, but of accumulated knowledge applied to practical life. The problem now facing humanity is: What is going to be done with all this knowledge? As is so often pointed out, knowledge is a two-edged weapon which can be used equally for good or evil. It is now being used indifferently for both. Could any spectacle, for instance, be more grimly whimsical than that of gunners using science to shatter men's bodies while, close at hand, surgeons use it to restore them? We have to ask ourselves very seriously what will happen if this twofold use of knowledge, with its ever-increasing power, continues. G.N.M.TYRRELL The Personality of Man New words and expressions ⽣词与短语 loom v. 赫然耸起 manifest adj.明显的 morality n. 道德 communicate v. 交流,交际 compound adj. 复合的 enhance v. 增进 tempo n. 速率 trickle n. 涓涓细流 torrent n. 滔滔洪流 humanity n. ⼈类 indifferently adv. 不在乎地 grimly adv. 可怖地 whimsical adj. 怪诞的 shatter v. 毁坏 twofold adj. 双重的 本⽂参考译⽂ 为什么进步这个概念在现代世界显得如此突出?⽆疑是因为有⼀种特殊的进步实际上正在我们周围发⽣,⽽且变得越来越明显。
七年级英语下册Unit4.听力材料Unit 4第一节听下面五个句子,从题中所给的A、B、C三个选项中选出与其意思相符的图片。
每个句子读两遍。
1. (W) Grandma asks me to do the dishes.2. You must keep quiet in the school library.3. Nick, remember to bring your eraser.4. I think it’s in the kitchen.5. Sara likes listening to music very much.第二节听下面五段对话。
每段对话后有一个小题,从题中所给的A、B、C三个选项中选出最佳选项。
每段对话读两遍。
6. W: Nick, do you make your bed at your home?M: No, I don’t. My father makes it for me every day.7. W: Tony, your desk is really dirty. You need to clean it.M: OK, Mom.8. M: Tina, what about going to the violin club on Saturday morning?W: Oh, sorry. I have to practice playing the piano.9. M: Mr. Gao wants Jerry to go to the classroom. Do you know where Jerry is?W: Yes. He’s in the dining hall.10. M: Do your parents drive you to school, Sara?W: No, they don’t. I have to ride to school.第三节听下面三段材料。
How do vaccines work?In 1796, the scientist Edward Jenner injected material from a cowpox (牛痘)virus into an eight-year-old boy with a hunch that this would provide the protection needed to save people from deadly outbreaks of the related smallpox(天花)virus. It was a success. The eight-year-old was inoculated against the disease, and this became the first ever vaccine. But why did it work? To understand how vaccines function, we need to know how the immune system defends us against contagious diseases in the first place. When foreign microbes invade us, the immune system triggers a series of responses in an attempt to identify and remove them from our bodies. The signs that this immune response is working are the coughing, sneezing, inflammation and fever we experience, which work to trap, deter and rid the body of threatening things, like bacteria. These innate immune (固有免疫,非特异性免疫)responses also trigger our second line of defense, called adaptive immunity(适应性免疫). Special cells called B cells and T cells are recruited to fight microbes, and also record information about them, creating a memory of what the invaders look like and how best to fight them. This know-how becomes handy if the same pathogen invades the body again. Despite this smart response, there's still a risk involved. The body takes time to learn how to respond to pathogens and to build up these defenses. And even then, if a body is too weak or young to fight back when it's invaded, it might face very serious risk if the pathogen isparticularly severe. But what if we could prepare the body's immune response, readying it before someone even got ill? This is where vaccines come in. Using the same principles that the body uses to defend itself, scientists use vaccines to trigger the body's adaptive immune system without exposing humans to the full strength disease. This has resulted in many vaccines, which each work uniquely, separated into many different types. First, we have live attenuated vaccines(减毒活疫). These are made of the pathogen itself, but a much weaker and tamer version. Next, we have inactive vaccines(灭活疫苗), in which the pathogens have been killed. The weakening and inactivation in both types of vaccine ensures that pathogens don't develop into the full-blown disease. But just like a disease, they trigger an immune response, teaching the body to recognize an attack by making a profile of pathogens in preparation. The downside is that live attenuated vaccines can be difficult to make, and because they are live and quite powerful, people with weaker immune systems can't have them, while inactive vaccines don't create long-lasting immunity. Another type, the subunit vaccine(亚单位疫苗)is only made from one part of the pathogen called an antigen(抗原), the ingredient that actually triggers the immune response. By even further isolating specific components of antigens like proteins or polysaccharides, these vaccines can prompt specific responses. Scientists are now building a whole new range of vaccines called DNA vaccines(DNA疫苗). For this variety, they isolatethe very genes that make the specific antigens, the body needs to trigger its immune response to specific pathogens. When injected into the human body, those genes instruct cells in the body to make the antigens. This causes a stronger immune response and prepares the body for any future threats, and because the vaccine only includes specific genetic material, it doesn't contain any other ingredients from the rest of the pathogen that could develop into the disease and harm the patient. If these vaccines become a success, we might be able to build more effective treatments for invasive pathogens in years to come. Just like Edward Jenner's amazing discovery spurred on modern medicine all those decades ago, continuing the development of vaccines might even allow us to treat diseases like HIV, malaria or Ebola one day.What causes antibiotic resistance?What if I told you there are trillions of tiny bacteria all around you? it's true. Microorganisms called bacteria were some of the first life forms to appear on earth. Though they consist of only a single cell, their total biomass is greater than that of all plants and animals combined. And they live virtually everywhere, on the ground, in the water, on your kitchen table, on your skin, even inside you. Don't reach for the panic button just yet. Although you have 10 times more bacterial cells inside you than your body has human cells, many of these bacteria are harmless or even beneficial,helping digestion and immunity. But there are a few bad apples that can cause harmful infections, from minor inconveniences to deadly epidemics. Fortunately, there are amazing medicines designed to fight bacterial infections. Synthesized from chemicals or occurring naturally in things like mold, these antibiotics kill or neutralize bacteria by interrupting cell wall synthesis, or interfering with vital processes like protein synthesis, all while leaving human cells unharmed. The deployment of antibiotics over the course of the 20th century has rendered many previously dangerous diseases easily treatable. But today, more and more of our antibiotics are becoming less effective. Did something go wrong to make them stop working? The problem is not with the antibiotics but the bacteria they were made to fight, and the reason lies in Darwin’s theory of natural selection. Just like any other organisms, individual bacteria can undergo random mutations. Many of these mutations are harmful or useless, but every now and then, one comes along that gives its organism in edge in survival. And for a bacterium, a mutation making it resistant to a certain antibiotic gives quite the edge. As the non-resistant bacteria are killed off, which happens especially quickly in antibiotic-rich environments like hospitals, there is more room and resources for the resistant ones to thrive, passing along only the mutated genes that help them do so. Reproduction isn't the only way to do this. Some can release their DNA upon death to be picked up by other bacteria, while others use a method called “conjugation”, connectingthrough pili(菌毛)to share their genes. Over time, the resistant genes proliferate, creating entire strains of resistant super bacteria. So how much time do we have before these superbugs take over? Well, in some bacteria, it's already happened. For instance, some strands of staphylococcus aureus (金黄色葡萄球菌), which causes everything from skin infections to pneumonia(肺炎)and sepsis(败血症), have developed into MRSA (耐甲氧西林金黄色葡萄球菌), becoming resistant to beta-lactam(内酰胺)antibiotics like penicillin(青霉素),methicillin(甲氧西林)and oxacillin(苯唑西林). Thanks to a gene that replaces the protein beta-lactams normally target and bind to, MRSA can keep making its cell walls unimpeded. Other super bacteria like salmonella(沙门氏菌)even sometimes produce enzymes like beta-lactams that break down antibiotic attackers before they can do any damage. And E. coli(大肠杆菌), a diverse group of bacteria that contains strains that cause diarrhea and kidney failure, can prevent the function of antibiotics like quinolones(喹诺酮), by actively booting any invaders that managed to enter the cell. But there is good news. Scientists are working to stay one step ahead of the bacteria, and although development of new antibiotics has slowed in recent years, the World Health Organization(WHO,世界卫生组织)has made it a priority to develop novel treatments. Other scientists are investigating alternate solutions such as phage(噬菌体)therapy or using vaccines to prevent infections. Most importantly, curbing the excessive andunnecessary use of antibiotics such as for minor infections that can resolve on their own as well as changing medical practice to prevent hospital infections can have a major impact, by keeping more non-resistant bacteria alive as competition for resistant strains. In the war against super bacteria, deescalation may sometimes work better than an evolutionary arms race.The accident that changed the world London,1928: a group of mold spores surf a breeze through a lab. They drift onto a petri dish(培养皿), and when they land, they germinate a medical revolution. This lab belongs to Alexander Fleming, a Scottish scientist investigating the properties of infectious(传染性的)bacteria (细菌). At this time, Fleming is away on vacation. When he returns, he finds a colony of mold growing on a petri dish he'd forgotten to place in his incubator. And around this colony of mold is a zone completely and unexpectedly clear of bacteria. In studying this mysterious phenomenon, Fleming came to realize that the mold was creating some kind of compound that was killing the bacteria. The mold was a species in the Penicillium genus, so Fleming dubbed the antibacterial compound “penicillin”. What Fleming stumbled upon was a microbial defense system. The penicillium mold constantly produces penicillin in order to defend itself from threats, such as nearby bacterial colonies that might consume its resources. Penicillin destroys many types of bacteria by disrupting synthesis of theircell walls. These walls get their strength from a thick, protective mesh of sugars and amino acids that are constantly being broken down and rebuilt. Penicillin binds to one of the compounds that weaves this mesh together and prevents the walls from being reconstructed at a critical phase. Meanwhile, penicillin stimulates the release of highly reactive molecules that cause additional damage. Eventually, the cell’s structure breaks down completely. This two-pronged attack is lethal to a wide range of bacteria whether in petri dishes, our bodies, or elsewhere. It's not, however, harmful to our own cells because those don't have cell walls. For a decade or so after Fleming's discovery, penicillin remain a laboratory curiosity. But during World War Ⅱ, researchers figured out how to isolate the active compound and grow the mold in larger quantities. They then went on to win the Nobel prize for their work. Teams at Oxford and several American drug companies continued development, and within a few years it was commercially available. Penicillin and similar compounds quickly transformed the treatment of infections. For the time being, they remain some of the most important, life-saving antibiotics(抗生素)used in medicine. However, the more we use any antibiotic, the more bacteria evolve resistance to it. In the case of penicillin, some bacteria produce compounds that can break down the key structure that interferes with cell wall synthesis. As antibiotic use has increased, more and more bacteria have evolved this defense, making these antibiotics ineffective against agrowing number of bacterial infections. This means it's essential that doctors not overprescribe the drug. Meanwhile, 5 to 15 percent of patients in developed countries self-identify as allergic(过敏的)to penicillin, making it the most commonly reported drug allergy. However, the vast majority (over 90 percent) of people who think they're allergic to penicillin actually are not. Why the misperception? Many patients acquire the allergy label as children, when a rash(皮疹)appears after they're treated for an infection with penicillin or closely related drugs. The rash is often blamed on penicillin, while the more likely culprit is the original infection or a reaction between the infection and the antibiotic. However, genuine penicillin allergies, where our immune systems mistake penicillin for an attacker, do occur rarely and can be very dangerous. So if you think you're allergic but don't know for sure, your best bet is to visit an allergist. They will complete an evaluation that will confirm whether or not you have the allergy. Even if you do have a penicillin allergy, your immune cells that react to the drug may lose their ability to recognize it. In fact, about 80 percent of people who are allergic to penicillin outgrow their allergy within ten years. This is great news for people who currently identify as allergic to penicillin; the drug may one day save their lives as it has done for so many others.Biosimilars: Complex Copycat Drugs Drugs come in different sizes, from small simple molecules like aspirin togiant complex biological drugs like monoclonal antibodies(单克隆抗体). In recent years, biological drugs or biologics have revolutionized treatments for cancers, metabolic diseases and inflammatory disorders. In 2016, roughly a quarter of all global drug sales were biologics. But there's a problem. These drugs are incredibly difficult and time-consuming to make, so there are often prohibitively expensive. That may be about to change. The patents on many biologics will soon expire, which means that competitors can try to make cheaper copycat versions called biosimilars (生物仿制药). Making a generic version of a small molecule drug isn't too difficult. Chemists can reverse-engineer the structure and use familiar synthesis techniques to create an exact copy. But biologics are much more challenging. Making an exact copy is impossible because of the size and complexity. And the original manufacturers have no incentive to share their assembly plan, so the biosimilar developers have to start from scratch. First, developers need to reproduce the basic structure as best they can, based on careful analysis of batches of products and published data. Then they need to replicate the three-dimensional drug with functional parts. This is such a complex process that scientists rely on cultures of living cells to assemble the drug for them. By ceding control to this black-box system of living cells, the exact synthesis pathway remains hidden and is impossible to fully control. Another issue is that small differences in these live cultures like temperature, PH, nutrients, and so on can cause chemical modificationswhich can affect the biologics’ function and safety. So the team must experiment to find the right conditions to make the drug in their own lab. Once it's been made, the new drug must undergo stringent tests to check that its chemistry and function are similar to the originator drug. For example, it needs to undergo functional tests to make sure it binds to its target. Then the new drug needs to be compared to the originator drug in clinical trials to make sure it works as well as its predecessor and doesn't set off an immune reaction or have any other unexpected effects in the body. No biosimilar will ever be identical to the originator drug, but modest chemical differences are acceptable if the drug passes these rigorous tests in clinical trials. This whole process can take more than ten years, but it’s an effort worth making if it means that some blockbuster biologic drugs become more affordable and accessible for patients in the coming years. Some say that biosimilars could reduce global healthcare spending by US$160 billion over the next five years.。