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Helicobacter pylori: Stories of discoveryOn 1979, pathologists Warren in patients with chronic gastritis of the gastric antral mucosa tissue slices were observed on a curved bacteria, and found that the bacteria adjacent gastric mucosa are inflammation is present, thus realize the bacteria and chronic gastritis may have close relationship.1981, Department of Gastroenterology clinicians to Marshall and Warren cooperation, with their 100 patients undergoing gastroscopy and biopsy of the stomach of patients were enrolled in this study, the presence of bacteria and that this is associated with gastritis.They also found, the bacteria also exists in all patients with duodenal ulcers, most patients with gastric ulcer and gastric cancer patients with gastric mucosa in half.After many times of failure, 1982 April, Marshall finally from gastric mucosa biopsy samples were successfully cultured and isolated the bacterium.To further substantiate this bacteria is the arch-criminal cause of gastritis, Marshall and another doctor Morris at drink containing the bacteria culture fluid, the results of a serious illness.Based on these results, Marshall and Warren proposed Helicobacter pylori related chronic gastritis and peptic ulcer etiology.On April 5, 1984, they published in the medical journal the lancet world authority. "" (lancet).Results once published, immediately in the International Gastroenterology sensation, lifted the research upsurge all over the world.The world each big pharmaceutical companies have invested heavily in developing related drugs, professional publications "HH" emerge as the times require World magazine, HH General Assembly held regularly, related HH of too many to count.Through human trials, antibiotic treatment and epidemiological research, Helicobacter pylori in gastritis and gastric ulcer disease in the role of gradually clear, scientists on the pathogenic mechanisms are cognized.In October 3, 2005, the Swedish Academy announced Rawlins card card, 2005 annual Nobel Prize in physiology or medicine awarded the two scientists for their discovery of the bacterium Helicobacter pylori as well as such in gastritis and gastric ulcer disease in rats.Medicine on the bacteria and stomach disease cognition is relatively slow, they always think there is any bacteria capable of long time in stomach acid environment.And after a more detailed study, including Marshall who drank the in vitro Bacillus get gastritis, and antibiotic treatment, the medical profession began to change the perception of the stomach.In 1994, the United States National Institutes of Health (NIH) presented the most common gastritis diseases caused by Helicobacter pylori, in the course of treatment should be added to antibiotics.On the correct understanding of the bacteria before, gastric ulcer patients usually to neutralize stomach acid and decreased secretion of drugs to treat, but after this treatment will relapse after most.And gastritis patients will take basic bismuth salicylate, this method usually effective, at that time, people still do not know the mechanism, then found the drugs in salicylate will kill the stomach coli, may be used as antibiotics.At present, this kind of disease with antibiotics to kill the bacteria.Helicobacter pylori is the mankind has only one known stomach bacteria, other types of HH also in part of the mammalian and bird found in vivo.Chronic ulcer, can lead to cancer, and gastric Helicobacter pylori WHO announced for microbial carcinogen, is also the first can be carcinogenic in prokaryotes.译文：幽门螺杆菌发现故事1979年，病理学医生Warren在慢性胃炎患者的胃窦黏膜组织切片上观察到一种弯曲状细菌，并且发现这种细菌邻近的胃黏膜总是有炎症存在，因而意识到这种细菌和慢性胃炎可能有密切关系。
