DIAGNOSISANDTREATMENT
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•指南与共识•国际糖尿病足工作组《糖尿病足感染诊断与治疗指南(2019版)》解读徐俊1许樟荣21国家卫生健康委员会激素与发育重点实验室(天津医科大学),天津市代谢性疾病重点实验室,天津医科大学朱宪弈纪念医院&天津市内分泌研究所,糖尿病足病科300134; 2战略支援部队特色医学中心,北京100101通信作者:徐俊,Email:xujun602@ 163. com【摘要】国际糖尿病足工作组《糖尿病足感染诊断与治疗指南(2019版)》是按照患者-干预-比较-结局(P I C O)原则,从诊断到治疗提出了 8个临床问题,同时给出27条推荐要点,层层递进解决临床问题。
解读对每条推荐点的内涵和外延,结合临床,详细分析,着重突出临床的指导性、实用性、规范和统一性。
【关键词】糖尿病足;感染;骨髓炎;指南解读基金项目:国家自然科学基金(81670766)D0I:10. 3760/c m a.j. cnl21383-20200710-07077Interpretation of diagnosis and treatment guidelines for diabetic foot infection ( 2019 Edition) byinternational Working Group on Diabetic Foot Xu Jun , Xu Zhangrong2. 1JSHC Key Laboratory ofHormones and Development(Tianjin Medical University) ,Tianjin Key Laboratory of Metabolic Diseases 9Department of Diabetic Foot,Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute ofEndocrinology,Tianjin 300134,China' - Special Medical Center of Strategic Support Forces,Bejing W0 W I,ChinaCorresponding author-. Xu Jun,Email:****************【Abstract】According to the principle of patient-intervention-comparison-outcome (P I C O),the International Working G r oup on diabetic foot diagnosis and treatment (2019Edition) put forward 8 clinicalproblems from diagnosis to treatment of diabetic foot, and gave 27 recommendations to solve clinical problems step by step. T h e connotation and extension of each r e c o m m e n d e d point are interpreted. This interpreting gave detailed analysis according to daily clinical practice. T h e standardization and unity areemphasized.【Key words】Diabetic foot; Infection; Osteomyelitis; Guideline interpretingFund program :National Natural Science Foundation of China( 81670766)D O I:10. 3760/c m a.j. cnl21383-20200710-07077i背景国际糖尿病足工作组是一个专门致力于糖尿病 足诊断、治疗、护理、预防的全球性组织。
英语报导类作文模板及范文英文回答:Headline: The Rise of Smart Technology in Healthcare: Revolutionizing Diagnosis and Treatment。
Introduction:In recent years, the integration of smart technology into healthcare has accelerated at an unprecedented pace, transforming the way we diagnose, treat, and manage health conditions. From wearable devices to advanced imaging systems, smart technology is revolutionizing healthcare, offering a myriad of benefits for patients and healthcare providers alike.Body:1. Enhanced Diagnosis:Smart technology empowers healthcare professionals with sophisticated tools for early and precise diagnosis. Wearable devices, such as smartwatches and fitness trackers, continuously monitor vital signs and detect potentialhealth issues. Advanced imaging techniques, such as computerized tomography (CT) and magnetic resonance imaging (MRI), provide detailed cross-sectional images, enabling accurate diagnosis and personalized treatment plans.2. Personalized Treatment:Smart technology enables tailored treatment approaches that meet the unique needs of each patient. Electronichealth records (EHRs) provide a comprehensive medical history, allowing healthcare providers to make informed decisions. Telemedicine platforms facilitate remote consultations, improving accessibility to healthcare services for patients in remote areas or with limited mobility.3. Remote Monitoring:Remote monitoring devices, such as wearable sensors and implantable devices, allow healthcare providers to continuously monitor patients' health from afar. This enables early detection of health issues, timely interventions, and reduced hospital readmissions.4. Improved Patient Engagement:Smart technology fosters greater patient engagement by providing them with real-time access to their health data. Health apps and patient portals empower patients toactively participate in their healthcare decisions, leading to improved adherence to treatment plans and better health outcomes.5. Efficiency and Cost Savings:Smart technology streamlines healthcare processes, reducing administrative burden and costs. Electronic prescriptions eliminate errors and improve medication safety. Telemedicine platforms reduce the need for in-person consultations, saving travel time and costs for bothpatients and healthcare providers.Conclusion:The integration of smart technology into healthcare has revolutionized the field, empowering healthcare professionals with advanced tools for diagnosis, treatment, and patient engagement. The benefits of smart technology are wide-ranging, including enhanced diagnosis, personalized treatment, remote monitoring, improved patient involvement, and increased efficiency. As technology continues to advance, we can expect even more transformative applications in healthcare, leading tobetter health outcomes and a more connected and accessible healthcare system.中文回答:标题,智能技术在医疗保健中的崛起,诊断和治疗的革命。
Animal diagnosis and treatment technology(动物诊疗技术)动物诊疗技术可以说是现代兽医学的一个重要方面,伴随着科技的不断发展,动物诊疗技术也在不断的升级和改进,从最早的手工操作到现在的高科技医疗设备,都为动物的健康保驾护航。
今天我们就来探讨一下目前常见的动物诊疗技术。
一、影像诊断技术1.X光影像技术X光影像技术是动物医疗中非常常见的诊断技术,它可以通过X光设备对动物体内的组织和器官进行成像,让兽医师更好地了解动物身体的内部情况。
X光影像技术对于因骨骼损伤、体内异物等引起的疾病诊断非常有帮助。
2.超声波诊断技术超声波诊断技术与X光技术不同,它可以更好地诊断软组织的疾病。
该技术主要利用超声波对动物进行成像,可以查看动物的内脏、血管、心脏等器官有无病变。
超声技术特别适用于妊娠动物的产前检查和胎儿的诊断,对于动物医疗的诊断工作非常有帮助。
二、外科诊疗技术1.激光手术相比传统手术方式,激光手术在动物诊疗中有很大的优势。
因为激光手术具有不出血、不结痂、无疼痛等特点,对于某些疾病的治疗效果也很显著。
目前,激光手术已广泛应用于动物肿瘤的治疗。
2.内窥镜技术内窥镜技术是通过一根细长的光纤管将内窥镜插入动物体内进行诊疗。
该技术可以运用于许多领域,如腔镜诊断、腔镜切除、腹腔镜和胸腔镜检查或手术等,其优点在于小切口、恢复快、残留病灶少等。
三、医学治疗1. 药物治疗药物治疗是目前常用的治疗方式之一,特别适用于内科疾病和感染疾病的治疗。
但在使用药物时,要注意使用剂量,防止药物过量损伤动物身体健康。
2. 免疫治疗在动物诊疗中,免疫治疗也常常被采用,特别对于某些疾病,如传染性疾病等。
通过给动物接种特定疫苗,可以刺激动物免疫系统产生对疾病的免疫力,从而避免疾病的传播和发生。
总之,目前动物诊疗技术已发展到了一个非常高级的水平,这些技术中既有高科技的医疗设备,也有经典而实用的诊疗方法。
通过这些技术的运用,人们可以更好地保护动物健康,为动物提供最优质的诊疗服务。
病程记录的诊疗计划英文回答:Diagnosis and Treatment Plan in the Course of Illness.In the course of illness, the diagnosis and treatment plan plays a crucial role in guiding the medical team and ensuring the best possible care for the patient. It serves as a roadmap, outlining the steps to be taken to manage the condition effectively. As a healthcare professional, I have had the opportunity to develop and implement diagnosis and treatment plans for various patients, and I understand the importance of tailoring the plan to the individual's specific needs.First and foremost, the diagnosis must be accurate and comprehensive. This involves conducting a thorough medical history review, physical examination, and ordering appropriate diagnostic tests. For example, if a patient presents with symptoms of chest pain and shortness ofbreath, a diagnosis of possible myocardial infarction may be made. In this case, an electrocardiogram, cardiac enzymes, and a stress test may be ordered to confirm the diagnosis.Once the diagnosis is established, the treatment plan can be formulated. It should be evidence-based and takeinto account the patient's medical history, comorbidities, and preferences. For instance, if a patient is diagnosed with type 2 diabetes, the treatment plan may include lifestyle modifications such as diet and exercise, as well as medication management. The plan should be realistic and achievable, with clear goals and objectives.Furthermore, the treatment plan should be communicated effectively to the patient and their family members. It is important to explain the rationale behind the chosen interventions, potential side effects, and expected outcomes. This helps to foster a collaborative relationship between the healthcare provider and the patient, promoting adherence to the treatment plan. For example, when prescribing a new medication, I would explain the purposeof the medication, how it works, and any potential side effects. I would also emphasize the importance of takingthe medication as prescribed and following up with regular appointments.Regular monitoring and reassessment are essential components of the treatment plan. This allows for adjustments to be made based on the patient's response to treatment and any changes in their condition. For instance, if a patient's blood pressure remains elevated despite medication, the treatment plan may need to be modified by increasing the dosage or adding another medication. Regular follow-up appointments and laboratory tests help to track progress and ensure the effectiveness of the treatment plan.In conclusion, the diagnosis and treatment plan in the course of illness is a dynamic process that requires accurate diagnosis, evidence-based treatment, effective communication, and regular monitoring. By tailoring theplan to the individual's needs and involving them in the decision-making process, we can ensure the best possible outcomes for the patient.中文回答:病程记录的诊疗计划。
误吸诊断标准指南最新版The latest version of the aspiration diagnosis guidelines is essential for healthcare professionals to accurately identify and treat patients with aspiration. 诊断标准指南的最新版对于医疗专业人员准确识别和治疗患有误吸的患者至关重要。
The guidelines provide evidence-based recommendations for the diagnosis of aspiration, including clinical criteria, imaging studies, and other diagnostic tests. 这些指南提供了基于证据的诊断误吸的建议,包括临床标准、影像学研究以及其他诊断测试。
Healthcare professionals should be well-informed about the latest guidelines to ensure that they are providing the best possible care for patients at risk of aspiration. 医疗专业人员应该熟知最新的指南,以确保他们为有误吸风险的患者提供最好的可能护理。
The guidelines also play a crucial role in standardizing the diagnosis and treatment of aspiration across different healthcare settings, ensuring consistency and quality of care. 这些指南在标准化不同医疗环境中误吸的诊断和治疗方面发挥着至关重要的作用,以确保护理的一致性和质量。
New Coronavirus Pneumonia (COVID-19) Tenth Edition Diagnosis and Treatment Plan PPT - English Translation The following is an English translation of the New Coronavirus Pneumonia(COVID-19) Tenth Edition Diagnosis and Treatment Plan PPT. This edition presents the latest updates on the diagnosis and treatment guidelines for COVID-19.IntroductionThe outbreak of COVID-19, caused by the novel coronavirus, has posed unprecedented challenges to public health worldwide. In response, medical experts and researchers have been diligently working to develop effective strategies to prevent and treat this illness. This tenth edition of the diagnosis and treatment plan is a comprehensive and up-to-date guide for healthcare professionals involved in the management of COVID-19 patients.Diagnosis1.Epidemiological history:–Individuals with travel history to areas with ongoing COVID-19 transmission within the past 14 days.–Close contact with confirmed or suspected COVID-19 cases within the past 14 days.2.Clinical manifestations:–Fever, fatigue, dry cough, and other respiratory symptoms.–In severe cases, shortness of breath, chest pain, and other complications may occur.boratory tests:–Real-time reverse transcription-polymerase chain reaction (RT-PCR) testing for the detection of SARS-CoV-2 RNA.–Chest computed tomography (CT) scans may assist in the diagnosis, especially for patients with negative RT-PCR results but withtypical clinical manifestations.Treatment1.Isolation and supportive care:–Admit patients with confirmed or suspected COVID-19 to designated isolation wards.–Provide symptomatic treatment for fever, cough, and other respiratory symptoms.–Offer supportive care, including oxygen therapy and fluid management.2.Antiviral therapy:–Administer antiviral medications, such as lopinavir/ritonavir, in accordance with the prescribed dosage and duration.–Monitor the patient for adverse reactions and adjust the treatment regimen accordingly.3.Antibacterial therapy:–Use antibiotics cautiously, as appropriate, for patients with coexisting bacterial infections or complicated conditions.4.Respiratory support:–Provide supplemental oxygen therapy for patients with respiratory distress or hypoxemia.–In severe cases, consider invasive or non-invasive mechanical ventilation support.5.Prevention and control of complications:–Monitor and manage complications such as acute respiratory distress syndrome (ARDS), septic shock, and multiple organ dysfunction syndrome (MODS).6.Traditional Chinese medicine:–Apply traditional Chinese medicine in conjunction with Western medicine, based on the patient’s condition and expertrecommendations.Prevention1.Personal protection:–Wear masks, maintain good hand hygiene, and practice respiratory etiquette.–Avoid close contact with individuals showing symptoms of respiratory illness.–Follow local health authority guidelines for self-isolation and quarantine if necessary.2.Environmental control:–Implement regular cleaning and disinfection protocols in public places and frequently touched surfaces.–Ensure proper ventilation in indoor settings to minimize the risk of virus transmission.3.Health education:–Promote public awareness of COVID-19 prevention measures through educational campaigns and media.–Provide accurate and reliable information to counter the spread of misinformation.ConclusionThe New Coronavirus Pneumonia Tenth Edition Diagnosis and Treatment Plan PPT serves as an invaluable resource for healthcare professionals in managing the COVID-19 pandemic. It outlines the key diagnostic criteria, treatment strategies, and preventive measures necessary to combat this respiratory illness effectively. Adherence to these guidelines, along with continued research and collaboration, will help mitigate the impact of COVID-19 and protect public health worldwide.。
住院医院开诊断证明的流程1.患者需要在医院的诊所或者医务处领取申请表格。
The patient needs to obtain an application form at the hospital clinic or medical office.2.患者填写个人基本信息和病情描述,然后提交给医生或护士。
The patient fills out personal information and describes the illness, then submits it to the doctor or nurse.3.医生或护士会核实患者的个人信息和病情,然后安排相应的检查或治疗。
The doctor or nurse verifies the patient's personal information and illness, and then arranges appropriate tests or treatments.4.在医生的指导下,患者完成必要的检查和治疗。
Under the guidance of the doctor, the patient completes necessary tests and treatments.5.医生根据检查结果和临床表现,做出诊断并开具相应的诊断证明。
The doctor makes a diagnosis and issues the corresponding diagnosis certificate based on the test results and clinical presentation.6.诊断证明上会包括患者的基本信息、医院信息、诊断结果和签发日期等内容。
The diagnosis certificate will include the patient's basic information, hospital information, diagnosis results, and date of issue.7.患者需要在医院的财务处或相关窗口办理诊断证明手续。
各科医生的英语表达英文回答:Doctors' Specialties in English.Allergist A doctor who specializes in diagnosing and treating allergies.Anesthesiologist A doctor who administers anesthesia during surgery and other medical procedures.Cardiologist A doctor who specializes in the diagnosis and treatment of heart and blood vessel diseases.Dermatologist A doctor who specializes in the diagnosis and treatment of skin diseases.Endocrinologist A doctor who specializes in the diagnosis and treatment of hormonal disorders.Gastroenterologist A doctor who specializes in the diagnosis and treatment of diseases of the digestive system.General practitioner (GP) A doctor who providesprimary care to patients of all ages.Geriatrician A doctor who specializes in the care of elderly patients.Gynecologist A doctor who specializes in the diagnosis and treatment of diseases of the female reproductive system.Hematologist A doctor who specializes in the diagnosis and treatment of blood disorders.Infectious disease specialist A doctor who specializes in the diagnosis and treatment of infectious diseases.Neurologist A doctor who specializes in the diagnosis and treatment of diseases of the nervous system.Obstetrician A doctor who specializes in the care ofwomen during pregnancy and childbirth.Ophthalmologist A doctor who specializes in the diagnosis and treatment of diseases of the eye.Orthopedic surgeon A doctor who specializes in the diagnosis and treatment of diseases of the musculoskeletal system.Otolaryngologist A doctor who specializes in the diagnosis and treatment of diseases of the ear, nose, and throat.Pathologist A doctor who specializes in the diagnosis of diseases by examining tissues and fluids.Pediatrician A doctor who specializes in the care of children and infants.Plastic surgeon A doctor who specializes in the reconstruction and repair of body tissues.Psychiatrist A doctor who specializes in the diagnosis and treatment of mental illnesses.Pulmonologist A doctor who specializes in thediagnosis and treatment of diseases of the respiratory system.Radiologist A doctor who specializes in the use of imaging techniques to diagnose and treat medical conditions.Rheumatologist A doctor who specializes in the diagnosis and treatment of rheumatic diseases, such as arthritis.Surgeon A doctor who performs surgical procedures to treat diseases and injuries.Urologist A doctor who specializes in the diagnosisand treatment of diseases of the urinary tract.Vascular surgeon A doctor who specializes in the diagnosis and treatment of diseases of the blood vessels.中文回答:各科医生的英语表达。
Medical Management 北京某医院医患双方对MDT诊疗模式的认知调查Investigation on Cognition of MDT Diagnosis and Treatment Model in Doctors and Patients in a Beijing Hospital□ 郭晓培 GUO Xiao-pei 王平 WANG PingAbstract目的 调查医患双方对MDT诊疗模式的认知情况,为有效开展MDT诊疗服务提供依据。
方法 对2019年4—6月门诊患者和医生进行随机问卷调查。
结果 收集患者问卷2117份,医生问卷117份。
不同年龄、不同文化程度患者对MDT诊疗模式的知晓率、参与率及主动参与意愿不同(p<0.001)。
患者最希望改进的就医环节是挂号(56.22%),最希望通过官方微信(60.53%)获取MDT诊疗模式相关知识,且对效果优势(84.91%)、适用情况(77.69%)需求最高,96.50%的患者希望医院推出更多MDT诊疗服务。
57.39%的医生清楚MDT诊疗模式,认为影响其实施的外部因素主要是缺乏相应机制、患者不了解、收费政策不明、尚无相应的教学模式,内部因素主要是固定模式难执行、缺少绩效激励、MDT宣传不够和流程不清晰。
结论 MDT诊疗模式知晓率、参与率、参与意愿受年龄和文化程度影响,应优化就医流程,重视宣传,创新管理举措,建立合理评价体系,促进医患“双赢”。
Objectives To investigate the cognition of MDT diagnosis and treatment model in doctors and patients, so as to provide reference for the effective implementation of MDT diagnosis and treatment services. Methods Random questionnaire survey was conducted in outpatient doctors and patients in a hospital in Beijing. Results A total of 2117 patient questionnaires and 117 doctor questionnaires were collected. Patients of different ages and education levels had different rates of awareness, participation and willingness to participate for the MDT diagnosis and treatment model (p<0.001). The patients mostly hoped to improve registration (56.22%) and to acquire knowledge about MDT diagnosis and treatment model through WeChat official accounts (60.53%). They had the highest demand for effect advantages (84.91%) and applicability (77.69%). And 96.50% of patients hoped that the hospital would provide more MDT diagnosis and treatment services. Of all the doctors, 57.39% of them were clearly aware of the MDT diagnosis and treatment model. They thought that the external factors affecting its implementation were mainly lack of corresponding mechanisms, low awareness of patients, unclear charge policies, and no corresponding teaching model, and that the internal factors were mainly difficulty in carrying out the fixed model, lack of performance incentives, inadequate publicity, and unclear process. Conclusion The rate of awareness, participation and willingness to participate for the MDT diagnosis and treatment model was affected by age and education. It was necessary to optimize the medical treatment process, pay attention to publicity, innovate management measures, establish a reasonable evaluation system to promote a "win-win" situation for doctors and patients.关键词 Key words:多学科协作 Multidisciplinary cooperation;诊疗模式 Diagnosis and treatment model; 医患双方 Doctors and patients;认知 Cognition作者单位:北京大学第一医院Peking University First Hospital Email:*****************通讯作者:王平基金项目:北京大学第一医院科研种子基金,编号:2018SF100中图分类号:R197.3;文献标识码:ADOI: 10.3969/j.issn.1671-9069.2021.03.0121977年由美国罗彻斯特大学精神病和内科学教授恩格尔(Engel)首先提出的“生物—心理—社会”医学模式,要求医院全方位、多角度关注患者,结合个体差异,整合各学科资源提供整体、全面的诊疗服务,做到“以患者为中心”[1]。
脑卒中诊断标准最新指南20201.脑卒中是一种严重的疾病,需要及时进行诊断和治疗。
Stroke is a serious disease that requires timely diagnosis and treatment.2.脑卒中诊断标准的最新指南于2020年发布。
The latest guidelines for the diagnosis of stroke were issued in 2020.3.医生通常会通过临床症状和影像学检查来诊断脑卒中。
Doctors typically diagnose stroke using clinical symptoms and imaging tests.4.中风的症状包括突然出现的头痛、视力模糊、肢体无力等。
Symptoms of stroke include sudden onset of headache, blurred vision, and weakness in the limbs.5.脑卒中的诊断需排除其他可能的疾病。
Diagnosis of stroke requires ruling out other possible diseases.6.脑卒中的影像学检查可以包括CT扫描和MRI。
Imaging tests for stroke can include CT scans and MRI.7.确诊脑卒中后,医生会根据病情严重程度制定治疗方案。
After confirming a stroke diagnosis, doctors will developa treatment plan based on the severity of the condition.8.脑卒中的治疗通常包括溶栓、手术和康复训练。
Treatment for stroke typically involves thrombolysis, surgery, and rehabilitation training.9.脑卒中后的康复训练对患者的康复非常重要。
重庆市特殊病种办理流程1.首先,患者需要去当地医院的专科门诊进行就诊。
First, the patient needs to go to the specialist clinic at the local hospital for consultation.2.医生会进行初步诊断,并给出治疗方案。
The doctor will make an initial diagnosis and provide a treatment plan.3.如果需要进一步诊疗或特殊治疗,医生会向患者开具特殊病种证明。
If further diagnosis or special treatment is needed, the doctor will issue a special disease certificate to the patient.4.患者凭借特殊病种证明,可到当地卫生局进行备案登记。
With the special disease certificate, the patient can go to the local health bureau for registration.5.卫生局会对患者的病情和治疗方案进行审核。
The health bureau will review the patient's condition and treatment plan.6.审核通过后,患者将获得特殊病种诊疗通知单。
After the review is approved, the patient will receive a special disease diagnosis and treatment notification.7.凭借通知单,患者可以在规定医疗机构进行特殊病种的治疗。
With the notification, the patient can receive treatment for the special disease at designated medical institutions.8.在治疗过程中,患者需遵守医生的建议,并定期复诊。
CHIN ESEM EDICAL SCIENCESJOU RN ALDIAGNOSIS AN D T REATM EN T OF THE M ALIGN AN T GESTATION AL TROPHOBLASTIC TUM OR W ITH PU LM ON ARY M ET AST ASISCOM PLICAT ED W IT H PU LMON ARY TUBERCU LOSISYang J iaxin(杨佳欣),Xiang Yang *(向 阳),Chong Qingguo**(崇庆国),Yang Xiuyu (杨秀玉)and Song H ong zhao (宋鸿钊)Peking Union Medical Colleg e H ospital ,CAM S&PUM C ,Be ijing 100730Receiv ed fo r publicatio n Jan .4,1999.*Co rresponding autho r .**Sh ey ang People ’s Hospital,J iang su Prov ince 224300 Key words g estatio nal trophoblastic tumor ;pulmona ry metastasis ;pulmo nary tuberculosis Objective .To ev aluate the diag no sis and treatment fo r ma l ig nant g esta tiona l tropho blastic tumor (M GT T)with pulmonary meta stasis complica ted with pulmo nar y tuberculosis. Methods .To a nalyze ten cases o f M G T T with pulmonary metastasis complicated with pulmonary tu-berculo sis in our hospital f rom 1980to 1997r et rospectiv ely . Results .Fro m the x-ray film,there a re g reat resemblances between M G T T with pulmonary metasta sis a nd pulmo nar y tuberculosis.Of 10patients,7of them w ere ex amined o ut pulmonary tuberculosis during the chemotherapy of M G T T .Pulmonary tuberculosis appea red six months befor e chemo thera py in three cases.All of the patients w ere t rea ted with multiag ent chemotherapy.Sev en patients achicev ed a complete remission ,2patients dev eloped drug resistance and died of cerebral haemor rhag e and cerebral herniation ,1w oman who had achiev ed a complete remissio n fro m M G T T for 14month s died of mil iar y tuberculosis . Conclusion .It is v ery impor ta nt to make differentia l diag nosis of the M G T T with pulmo nar y metasta-sis complicated with pulmo nar y tuberculosis .T rying to av oid ex cessiv e anti -tumor treatment owing to mis-take pulmo na ry tuberculo s is for pulmonary metastasis,and av oiding missing an oppor tunity of a nti-tuber-culosis tr eatment because of missed diag no sis should be emphasized.INTRODUC TION Malignant gestational trophoblastic tum ors (M GTT )are w ell recog nized as having a propensity fordisseminatio n ,particularly to the pulm onary parenchy-ma .Pulmona ry inv olvement is the most common site ofm etastasis with M GTT ,occurring in about 80%of pa-tients with metastatic disease .The radiologic features of trophoblastic pulmonary m etastases hav e been w ell de-scribed and include alv eolar,nodular and miliary pat-terns as w ell as pleural fluid and sig ns of pulmo nary ar-terial occlusion.The lung is the usual site of the prima-Chin Med Sci J December 1999Vol.14,No.4P.229-232ry pulmonary tuberculosis and the principal o rgan in-volv ed of the reactivation tuberculosis(1,2).The M GT T w ith pulm onary metastasis complicated with pulmonary tuberculosis(TB)resem ble each other at both the x-ray films and respiratory system sym ptom s. If lacking the vigilance of tuberculous infection,the docto r usually conclude the infectio n to tumor metasta-sis.So the result is not only delay the treatm ent of ac-tive TB,but also im pair the isolation of infectious source and threaten o ther patient’s health in the same w ard.Therefore,during the treatment of the M GTT, it is im portant to increase recog nition of the complicated pulmonary TB.In this paper,w e retrospectively ana-lyze ten cases of M GT T with pulmonary metastasis complicated with pulmonary TB trea ted in our hospital from1980to1997.The etiology,differential diag nosis and treatm ent for this condition are discussed..C LIN ICAL DATAA retrospectiv e review of the cases presenting to the PUMC hospital between J an.1980and Dec.1997 w as performed,using the computerised data base,cases w ith TB were identified.Data on10patients with pul-mo nary metastases of M GTT complicated with pul-mo nary TB on plain chest roentgenog raphy w ere re-view ed.Data w ere retriev ed from m edical records on all pa tients.Medical reco rds were review ed to determine the patient’s ag e,sites of metastasis,inital human chorionic g onadotropin(h CG)lev el,presenting symp-toms,treatment and outcome. Of10pa tients of the M GTT w ith pulmona ry m etastasis complicated with pulmonary TB,8cases w ere choriocarcinom a,2cases w ere inv asiv e m ole.The av erage age w as30y ears old(ranged from21~43 y ears old).Th ree cases were secondary to hydatidifo rm m ole,2cases de v eloped after full term delivery and5 cases after miscarriage(2of spontaneous abortion,1of drug abortion,2of induced abortion).Pulmona ry m etastasis happened in all patients.Th ree patients com-plicated w ith vaginal metastasis,2patients had adrenal m etastasis and1patient complica ted with cerebral m etastases. Of10patients,pulmonary TB appeared six m onths before chem otherapy3in cases,the o ther7 cases appeared during the treatm ent.Seven cases show ed cav ernous pulm noary TB,2cases w ere infiltra-tive pulmonary TB.The other one presented tuberculo-ma.Ex cept tuberculoma case without obv ious afternoon low-g rade fe v er and lassitude,the sy mptoms of the o th-er9patients w ere typical:afternoon low-g rade fev er, lassitude,w eakness,cough and hemoptysis.On the X-ray films,7cases show ed cavity tuberculous foci,the o ther3cases show ed nodolous or patchy shadows chang e.Sputum acid-fast bacilli of8patients were posi-tive for many times.The location of TB:4cases o n the upper lobe of left lung;3cases on the upper lobe of right lung;2cases on upper and middle lobe of right lung;1case with miliary TB of lung. All of ten patients w ere treated by combination chemotherapy.The chemotherapeutic courses rang ed from6to17.The chemo therapy regimens included5-Fu com bined chemotherapy(5Fu+V CR+KSM+ AT1258or VCR+5Fu+KSM),EM A/CO regim en (V P16+M TX+KSM+C TX+V CR)and PVB regi-men(DDP+V CR+Bleomycin).Antituberculosis treatment(isoniazid,etham butal,streptom ycin,ri-fam pin)initiated in all patients after TB diag nosis w as clea r.The course ranged from6~12m onths. Th ree patients w ho had persistent pulmona ry nod-ules after antitumor and antituberculosis chemotherapy hav e undergone pulmonary resection.Pathologic diag-nosis after operation confirmed the coexistence of pul-mo nary TB and m etastases.TB PCR test were positiv e in these three cases. Treatm ent result:The blood hCG le v el declined to normal after4to6courses of chemotherapy in7pa-tients,their chest X-ray films show ed that the metasta-sis shadow reduced in size till to disappear.These7pa-tients achiev ed a complete remission.They all alive and free of the diseases at least18months after completing antitumor and antituberculosis chem otherapy and con-tinue on follow up at our hospital.Tw o patients dev el-oped drug resistance,of w hom w ere salvaged by m ulti-modality therapy with com binatio n chemo therapy and adjuvant radiotherapy and surgery,their blood h CG level didn’t reduce to normal and x-ray films show ed the shadow s had never disappeared.One of them x-ray films appeared new nodulous and patchy shadow s.Bo th of them died of tum or ex tensive metastasis.Another w oman who achieved serologic remission for8months has relapsed.She has been salvaged with a combination of chemotherapy and surg ery.She achie v ed a complete remission from M GTT and pulm onary TB for14 m onths.Unfortunately she died of respirato ry failure due to pulmonary TB relapse.DISC USSION The modern manag ement of M GTT has resulted in a cure rate in excess of90%(3).This success has been the result of effective use of the tumo r marker of human cho rionic gonadotrophin,the inherent sensitivi-ty of trophblastic tumo rs to chemo therapy,the referral of patients to centralised specialist units for surv e illance and treatment,and the recog nition of high rish factorsw hich identify pa tients who should be trea ted w ith ag-g ressive chemotherapy regimen,salvage surgery and occasionally irradiatio n.The FIGO staging system uses on anatomical distribution.Stag eⅢex tends to the lungs and in Stag eⅣ,metastases are present at other sites.Therefore pulmonary involv ement sig nifies Stage Ⅲdisease using the FIGO eriteria and brain or adrenal involv em ent sig nify StageⅣand g enerally leads to hig h risk classification.Pulmonary involv ement by g estation-al trophoblastic tumor continues to be a comm on and challenging clinical problem(4).In this study,ten pa-tients w ith metastatic M GTT had pulm onary inv olve-ment on plain chest film and had extensive pulmona ry tum ors at the time of presentation. Se v en cases of ten patients in this report w ere ex-amined out pulmonary TB during the chemotherapy. The anti-tumor chemo therapy drug s could reduce the o rganic imm unity and result in TB bacteria latent in body or in enviro nment to make room by chance,then TB was acquired.The relations of pathogenesis will be further study about bo th sites of metastasis and TB at the same side of lung in all the ten patient.One consid-eration is inv olved in tuberculosis lesion damag ed or in-fluenced pulmonary blood circulato ry and immunity w here tumor cell remains or dev elops.Another consid-eration is metastatic tum ors destroy no rmal lung tissue and produce a suitable environment for TB dev elop-ment.When both are present in the sam e time and at same pulmonary pa renchyma,TB lesions exacerbate because tumor cells inv ade blood vessels and lym phatic vessels at the same site.It also maybe tumor cells in-vade a quiescent tuberculosis foci,m ake it resolvent and discharge the bacteria.Although the risks of being in-fected by TB and being inv aded by tumor cells w ere as-sumed to be independent,by virtue of its ability to de-stroy the pulmonary and the immune system,tum or cells hav e emerged at most im portant risk factor for prog ressio n of TB infection to clinical disease(5). It is hard to differentiate X-ray film betw een pul-mo nary m etastasis and pulmonary TB.Pulmona ry m etastasis after chemotherapy may also manifest cavi-ty,but more is nodulous-shadow(D>5cm).It has never been seen that patchy shadows show the appear-ance of cavity after chemotherapy.GTT patients with pulmonary inv olv ement may present w ith symptoms of dyspnea,cough,hemoptysis,o r signs and symptoms of pulmonary hy pertension.The pulmona ry metastases may be ex tensiv e and may cause respirato ry faiure and death.Patients with pulmonary TB may also present the same sy mptoms abov e w ith or without afternoon low-g rade fever,w eakness,and lassitude.The tuber-culin skin test and sputum acid-fast bacilli sm ear,which detect the presence of Mycobacterium tuberculosis in-fectio n,can be used to measure the prevalence of infec-tion.Clinically,com bining history and symptoms is the usual way to disting uish them,otherwise the TB is eas-ily mistake m etastasis and tumor is missed as TB.Gen-erally,w e should be o n alert for the possibility of com-plicated pulm onary TB when the following situation ex-ists:1)afternoon low-g rade fever with unknow n reason appears after tumor controlled by chem otherapy and h CG lev el declined to normal2)Lung shadow appears again after disappearence,but blood hCG le v el is nor-mal.3)clinical curativ e effect doesn’t accord w ith X-ray e v olution. Patients with metastatic M GTT are generally treated with initial combination,rather than single-a-gent chemotherapy.Adjuvant surgical procedures espe-cially hy sterectomy and thoracotomy,m ay be of use in removing know n foci of chemotherapy-resistant disease in selected patients with peresistent o r recurrent hig h-risk metastatic M GTTs. Fo r treatm ent,w hen the diag nosis of complicated TB is clear,the standardized,effective short-course an-ti-tuberculosis treatment should be used.Because the combination of many kinds of chemo theraptic drugs, the side effects are heavier.So it is necessary to select chemical drug s prudently and carefully and avoid using drugs w hich seriously influence bone marrow and liv er during anti-tumor or anti-TB regim ens.Meanw hile, biphenyl dicarbosyla te and other supportiv e treatment to liv er should be added.Drug resistance is also a seri-ous problem for TB treatment,therefore,surgical ther-apy may play a important role in the management of a selected subset of those patients(6).Due to the im-provement of technolog y of anesthesia and operation, surgery should be performed in patients with persistant pulmonary nodules on chest roentgenography after bo th anti-tumor and anti-TB treatment.Before performing pulmonary resectio n,it is im portant to exclude the pos-sibility of activ e disease elsewhere.Patients who are considered candidates for pulmonary resection should be reevaluated w ith computed tomog raphic scans of the brain,tho rax and abdomen and simultaneous cerebral spinal fluid and serum hCG lev els to search for occult ex tra pulmonary metastases.If the patients has not un-der-gone hysterectomy,activ e pelvic disease should be excluded radiog raphically with angiog rapy or ultrasono-g ually,h CG level remission one to two w eeks after resection of an isolated pulmonary nodule predicts a fav orable outcome.More im portant point is that surgery is an effectiv e treatment method for this condi-tion.The coordination of chem otherapy,surgery re-quires the early diagnosis of pulmo nary TB and metas-tases,and physic ians with ex perience in the manage-ment of this disease. In sum mary,even though it is difficult to differen-tiate the pulmonary TB w ith pulmonary metastasis of M GT T on X-ray film s,clinical sy mptoms provide early clue fo r the physicians.Both of them need the stan-dardized and effective m ultiagent chemotherapy.REFERENC ES1.Raviglione M C,Snider DE,Ko chi A.Global epidemio log y oftuberculosis.JAM A,1995,273:220-226.2.Li Q,Zha ng RG,Ch en L H,et al.Clinical inv estigation on42cases of pulmonar y tuberculoma.Chin J T uberc Respir Dis,1997,20:104-106.3.Lurain JR.M anagement of high-risk g estatio nal troph obla stic disease.J Reprod M ed,1998,43:44-52.4.Bakri YN,Berkow its RS,Khan J,et a l.Pulmo nar y m etas-tases of gesta tional t rophoblastic tumo r.J Reprod M ed, 1994,39:175-8.5.Lu JS.Th e diag no sis and r ela tion betw een th e lung ca ncerand pulmo na ry tuberculosis.Chin J Tuberc Respir Dis,1982, 5:251-53.6.Soper JT.Surg ical therapy fo r gesta tional tr ophoblastic dis-ease.J Reprod M ed,1994,39:168-173.A Correlativ e Study on Serum Lp(a)in Patients of CerebralInfarction with that in Their ChildrenLi Chunsheng(李春盛),Li Cai(李 彩),Li Aimin(李爱民),Zhou Rongbin(周荣斌),and Gao Xiulan(高秀兰)Emergency Department,General Hospital of Beijing com mand,Beijing100700 Serum lipoprote in(a){Lp(a)}lev el is g enetically determined and remains almost constant throughout life.Its ele v ation has sig nificant familiar centripetal ten-dency.Based on its properties,we selected the patients w ith cerebral infarction(CI)and definite family histo ry of the disease and their children for the assay of serum Lp(a)level and inv estigated the co rrelation of the level in parental to that in filial g eneration and its clinical sig-nificance.We measured serum Lp(a)level in216pa-tients with CI and definite family history of cerebral vascular diseases and the ir children com pared with that in46normal co ntrol subjects and their children.Re-sults showed the correlation coeffic ient of Lp(a)in nor-ma persons with that in the ir children is0.68(P< 0.0001);the co rrelation coefficient of Lp(a)in the pa-tients w ith CI with that in their children is also0.68(P <0.0001),showing in bo th situations there is v ery significant correlation and the results support the ma rked inherent character of the serum concentration of Lp(a).The concentration of serum Lp(a)in the group of patients with CI is significantly higher than that in the no rmal controls(549.96±341.1mg/L n=216, 215.9±135.74mg/L n=46,P<0.0001),demon-strating that the co ncentra tion of serum Lp(a)is closely related to CI and it is one of the risk factors of the dis-ease.The serum Lp(a)concentration in the children of cases with CI is significantly higher than that in the children of normal persons(422.89±304.2mg/L n= 216,144.6±106.9m g/L n=46,P<0.0001),indi-cating that the serum Lp(a)co ncentration is g enetically determined,and the incidence of cerebral vascular dis-eases in children of patiernts with CI is higher than that in the children of normal persons,strong ly supporting that the disease has inherent character.The serum Lp (a)concentration in cases with CI accom panied by dia-betes mellitus(DM)is no t significantly different from that in the cases without DM(524.39±332.1mg/L n =89,489.56±363.4mg/L n=127,P>0.05), demonstrating that DM dose not affect serum Lp(a) concentratio n.The serum Lp(a)concentration in cases w ith CI accompanied by coro nary arterial diseases (CAD)is sig nificantly different from that in the cases w ithout CAD(584.74±345.3mg/L n=61,465.63±321.4mg/L n=155,P<0.01),the serum Lp(a)level in the former cases be ing sig nificantly higher than that in the latter cases.The results demonstrate that CI and CAD a re closely related,and their common cause is atherosclerosis.The serum Lp(a)lev el in cases w ith CI accom panied by sy stemic hypertension(SH)is not sig-nificantly different from that in the cases without S H (533.6±367.4mg/L n=120,499.4±342.3mg/L n =96,P>0.05),indicating that although SH is one of the risk factors of CI,it is not related to the serum Lp (a)concentration,and Lp(a)is the independent risk factor of CI.W e conclude tha t serum Lp(a)level is ge-netic,independent and critical risk factor for CI.Its concentratio n indicated the severity of a therosclerosi. The serum Lp(a)le v el in the children of patients with definite family history of cerebrovascular disease is m ea-sured for im portant significance of prev enting cerebral infarction.。