炎琥宁联合利巴韦林治疗小儿疱疹性咽峡炎的疗效分析

利巴韦林联合炎琥宁治疗小儿疱疹性咽峡炎的效果观察目的探讨利巴韦林联合炎琥宁治疗小儿疱疹性咽峡炎的临床效果。

方法选取2011年1月～2014年10月于本院诊治的疱疹性咽峡炎患儿104例，将其随机分为治疗组（56例）和对照组（48例），治疗组在常规综合治疗的基础上给予利巴韦林联合炎琥宁治疗，对照组在常规综合治疗的基础上单用炎琥宁治疗。

比较两组的临床疗效。

结果治疗组总有效率为98.2%，高于对照组的72.9%，差异有统计学意义（P＜0.05）。

结论利巴韦林联合炎琥宁治疗疱疹性咽峡炎效果显著，不良反应少，值得临床推广。

[Abstract] Objective To investigate the clinical effect of ribavirin combined with Yanhuning in treatment of infantile herpangina. Methods 104 cases of children diagnosed as herpangina in our hospital from January 2011 to October 2014 were seleced，and were randomly divided into treatment group （56 cases）and control group （48 cases）.Treatment group were given with ribavirin combined with Yanhuning on the basis of routine treatment，control group were taken with Yanhuning simply on the basis of routine treatment.The efficacy of the two groups was compared. Results The total effective rate of treatment group was 98.2%，higher than 72.9% of control group，the difference was significant （P＜0.05）. Conclusion Ribavirin combined with Yanhuning has significant effect in treatment of herpangina，with less adverse reaction，it is worthy of clinical popularization and application.[Key words] Herpangina；Ribavirin；Yanhuning；Infantile疱疹性咽峡炎为儿科常见病、多发病[1-3]，是小儿急性上呼吸感染中的一种特殊类型，该疾病多由A组柯萨奇病毒感染引起，呼吸道合胞病毒、流感病毒等亦可导致发病[4]。

注射用炎琥宁治疗疱疹性咽峡炎100例疗效观察【摘要】目的探索炎琥宁注射液对疱疹性咽峡炎的治疗作用。

方法将100例疱疹性咽峡炎随机分炎琥宁治疗组和利巴韦林对照组，每组各50例，炎琥宁治疗组予以炎琥宁注射液5-10mg/kg.d加入5%葡萄糖液100-250ml静脉滴注一日一次，疗程3-5天。

利巴韦林对照组予以利巴韦林注射液10-15mg/kg.d分两次加入5%葡萄糖液100-250ml静脉滴注，疗程3-5天。

观察两组疗效，结果炎琥宁在退热时间，疱疹缩小，消失时间，症状全部消失时间均较利巴韦林组快，差异有显著性（p<0.05）。

结论炎琥宁治疗小儿疱疹性咽峡炎疗效优于利巴韦林，值得临床推广。

【关键词】炎琥宁；疱疹性咽峡炎；利巴韦林；疗效观察疱疹性咽峡炎是小儿科常见病，多发病，近年来有增多趋势，且并发症逐渐增多，可造成严重后果，我科采用炎琥宁注射液治疗小儿疱疹性咽峡炎，疗效满意，无毒副作用，现报告如下。

1临床资料一般资料2009年6月--2009年11月在我科门诊确诊为疱疹性咽峡炎的患儿100例，均符合《诸福棠实用儿科学》疱疹性咽峡炎的诊断标准[1]，所有病例均有发热，体温在38.5℃-40.5℃.咽腭弓，软腭，悬雍垂上疱疹，年龄8个月～4岁，发病至就诊时间均为1天左右，将患儿随机分成两组。

治疗组50例，男35例，女15例，对照组50例，男37例，女13例，两组在年龄、性别、病程及血常规、胸片差异无显著性，具有可比性.。

2治疗方法治疗组：予以炎琥宁注射液（海口康力元制药有限公司生产）5-10mg/kg.d加入5%葡萄糖液100-250ml静脉滴注一日一次。

对照组：予以利巴韦林注射液（天津药业集团新郑股份有限公司生产）10-15mg/kg.d分两次加入5%葡萄糖液100-250ml静脉滴注。

以上两组病例均给予应用对症，支持疗法，并适当使用抗生素。

治疗前、后查血常规、肝功能、尿常规。

3治疗结果3.1治疗标准显效：用药2天后体温下降至正常，食欲好转，咽峡疱疹缩小，无溃疡形成。

炎琥宁治疗小儿疱疹性咽峡炎的临床疗效观察目的:观察炎琥宁治疗小儿疱疹性咽峡炎的临床意义。

方法:疱疹性咽峡炎患儿82例,随机分为治疗组42例、对照组40例,分别采用炎琥宁和利巴韦林治疗。

结果:治疗组显效率和总有效率分别为88.1%和95.2%,对照组为50.0%和72.5%,组间差异有统计学意义(P＜0.01)。

结论:炎琥宁治疗疱疹性咽峡炎临床疗效明显,依从性好。

标签：疱疹性咽峡炎;炎琥宁;利巴韦林疱疹性咽峡炎是小儿常见的一种多由病毒引起的上呼吸道疾病,多有发热、流涎、厌食、哭闹等症状,查体多见咽部黄白色疱疹,治疗多以抗病毒为主,收集我科2007年3月～2008年3月应用炎琥宁治疗的疱疹性咽峡炎42例,取得了良好的临床效果,现报道如下:1 资料与方法1.1 一般资料收集2007年3月～2008年3月我科诊治的疱疹性咽峡炎患儿82例,病例选择条件:①年龄4个月～5岁,突然发热、咽疼、哭闹、流涎、拒食。

②查体:咽充血,咽后壁可见数个或数十个黄白色疱疹,直径1～3 mm,周围有红晕。

③病变局限于咽峡部而不波及口腔前部,也不发生于牙龈及颊黏膜。

④局部淋巴结不肿大。

⑤血白细胞计数正常或略低,无异常淋巴细胞。

采用随机法分为治疗组42例和对照组40例,两组患儿在性别、年龄及病程等方面比较,差异均无统计学意义(P>0.05)。

1.2 方法两组患儿均在相同的支持及对症治疗的基础上,治疗组给予炎琥宁冻干粉5～10 mg/(kg·d)肌注,每日2次,对照组给予利巴韦林注射液10 mg/(kg·d),肌注,每日2次,疗程均为5 d,比较两组症状和体征改善情况。

1.3 疗效判断标准显效:3 d内体温正常,饮食好转,疱疹缩小,无溃疡形成。

有效:4 d内体温恢复正常,饮食好转,疱疹减少并逐渐消失,无溃疡形成。

无效:5 d以上,体温仍不能恢复正常,疱疹不愈,形成溃疡。

1.4 统计学处理计数资料采用χ2检验,计量资科采用t检验,P＜0.05为差异有统计学意义,采用统计学软件SPSS 13.0完成。

儿童疱疹性咽峡炎应用炎琥宁联合利巴韦林治疗的效果观察目的探讨炎琥宁联合利巴韦林治疗儿童疱疹性咽峡炎的临床效果。

方法选择本院104例儿童疱疹性咽峡炎患儿随机分为治疗组和对照组，治疗组在常规综合治疗的基础上给予炎琥宁联合利巴韦林治疗，对照组在常规综合治疗的基础上单用利巴韦林治疗，比较两组治疗效果。

结果治疗组总有效率为98.1%，对照组总有效率为75.0%，治疗组总有效率明显高于对照组（P＜0.05）。

结论炎琥宁联合利巴韦林治疗儿童疱疹性咽峡炎疗效显著，且无毒副作用，值得临床推广应用。

[Abstract] Objective To study the clinical effect of dehydroandrographolide succinate and ribavirin in treatment of children herpangina. Methods 104 cases of children were randomly divided into treatment group and control group. On the basis of the routine comprehensive treatment，patients in treatment group were given dehydroandrographolide succinate and ribavirin treatment，while patients in control group were only given ribavirin treatment，the treatment effect of two groups was compared. Results The total effective rate of the treatment group was 98.1%，while it was 75.0% in the control group. Therefore the curative effect of the treatment group was significantly better than the control group （P＜0.05）. Conclusion The clinical effect of combination treatment of dehydroandrographolide succinate and ribavirin on children herpangina is good with no toxic side effects，is worthy of clinical popularization and application.[Key words] Herpangina；Dehydroandrographolide succinate；Ribavirin疱疹性咽峡炎是小儿急性上呼吸道感染中一种特殊的类型，是儿科多发病和常见病，主要由柯萨奇病毒引起，流感病毒及呼吸道合胞病毒等亦可导致发病[1]。

炎琥宁联合利巴韦林治疗小儿病毒性肺炎的疗效及对炎症因子的影响目的探究炎琥寧联合利巴韦林治疗小儿病毒性肺炎的疗效及对炎症因子的影响。

方法选取我院2015年1月～2017年4月间收治的180例小儿病毒性肺炎患儿为研究对象，根据随机数字表法将其分为实验组与对照组，每组90例，对照组患者予以利巴韦林治疗，实验组在此基础上予以炎琥宁治疗，观察统计两组患者的临床疗效、主要症状消失时间、不良反应、治疗前后血清中炎症因子肿瘤坏死因子（TNF）-α、白介素（IL）-6和IL-8水平变化。

结果治疗前，两组患儿所有指标均无统计学差异（P>0.05）；治疗后，实验组发热、咳嗽消失和肺部湿啰音吸收时间均显著短于对照组（P＜0.05），实验组治疗总有效率（94.44%）显著高于对照组（84.44%）（P＜0.05），且炎症因子TNF-α、IL-6和IL-8水平的改善程度显著优于对照组（P＜0.05），两组患儿的不良反应发生率无统计学差异（P>0.05）。

结论炎琥宁联合利巴韦林治疗小儿病毒性肺炎，可有效抑制炎症反应，改善感染症状，疗效显著，安全可靠。

[Abstract] Objective To explore the curative effect of Potassium Sodium Dehydroandroan Drographolide Succinate combined with ribavirin on the infantile viral pneumonia and its influence on inflammatory factors. Methods 180 cases of infantile viral pneumonia in our hospital from January 2015 to April 2017 were selected as the research object，and according to the random number table method，they were divided into the experimental group and the control group，90 cases in each group. The control group received the ribavirin treatment，and based on that，the experimental group received the Potassium Sodium Dehydroandroan Drographolide Succinate treatment. The clinical effect，the disappearance time of the cardinal symptom，adverse reactions，the serum inflammatory factor tumor necrosis factor （TNF）-α，the interleukin（IL）-6 and IL-8 level change of patients in two groups before and after the treatment were observed and statistically analyzed. Results Before the treatment，there were no significant differences of all patients indexes between the two groups （P> 0.05）. after the treatment，the fever，cough disappearance time and lung wet rales absorption time of the experimental group were significantly shorter than those of the control group （P＜0.05），the total effective rate （94.44%）of the experimental group was significantly higher than the control group （84.44%）（P＜0.05）. And the level of tumor necrosis factor （TNF）-α，the interleukin（IL）-6 and IL-8 improved significantly better than the control group （P＜0.05）. The adverse reactions of the two groups had no significant difference （P>0.05）. Conclusion Potassium Sodium Dehydroandroan drographolide Succinate combined with ribavirin in the treatment of infantile viral pneumonia can effectively inhibit inflammation，improve the symptoms of infection，and it has obvious curative effect，which is safe and reliable.[Key words] Potassium sodium dehydroandroan drographolide succinate；Ribavirin；Infantile viral pneumonia；Inflammatory factors病毒性肺炎为小儿常患的肺炎类型，是由流感病毒、巨细胞病毒、呼吸道合胞病毒、副流感病毒等引起的呼吸道综合征，因小儿机体抵抗力低下，对致病菌的抵抗力不足，故好发于15个月～5岁婴幼儿[1-2]。