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The information in this document is subject to change without notice and does not represent a commitment on the part of Native Instruments GmbH. The software described by this docu-ment is subject to a License Agreement and may not be copied to other media. No part of this publication may be copied, reproduced or otherwise transmitted or recorded, for any purpose, without prior written permission by Native Instruments GmbH, hereinafter referred to as Native Instruments.“Native Instruments”, “NI” and associated logos are (registered) trademarks of Native Instru-ments GmbH.ASIO, VST, HALion and Cubase are registered trademarks of Steinberg Media Technologies GmbH.All other product and company names are trademarks™ or registered® trademarks of their re-spective holders. Use of them does not imply any affiliation with or endorsement by them.Document authored by: David Gover and Nico Sidi.Software version: 2.8 (02/2019)Hardware version: MASCHINE MK3Special thanks to the Beta Test Team, who were invaluable not just in tracking down bugs, but in making this a better product.NATIVE INSTRUMENTS GmbH Schlesische Str. 29-30D-10997 Berlin Germanywww.native-instruments.de NATIVE INSTRUMENTS North America, Inc. 6725 Sunset Boulevard5th FloorLos Angeles, CA 90028USANATIVE INSTRUMENTS K.K.YO Building 3FJingumae 6-7-15, Shibuya-ku, Tokyo 150-0001Japanwww.native-instruments.co.jp NATIVE INSTRUMENTS UK Limited 18 Phipp StreetLondon EC2A 4NUUKNATIVE INSTRUMENTS FRANCE SARL 113 Rue Saint-Maur75011 ParisFrance SHENZHEN NATIVE INSTRUMENTS COMPANY Limited 5F, Shenzhen Zimao Center111 Taizi Road, Nanshan District, Shenzhen, GuangdongChina© NATIVE INSTRUMENTS GmbH, 2019. All rights reserved.Table of Contents1Welcome to MASCHINE (25)1.1MASCHINE Documentation (26)1.2Document Conventions (27)1.3New Features in MASCHINE 2.8 (29)1.4New Features in MASCHINE 2.7.10 (31)1.5New Features in MASCHINE 2.7.8 (31)1.6New Features in MASCHINE 2.7.7 (32)1.7New Features in MASCHINE 2.7.4 (33)1.8New Features in MASCHINE 2.7.3 (36)2Quick Reference (38)2.1Using Your Controller (38)2.1.1Controller Modes and Mode Pinning (38)2.1.2Controlling the Software Views from Your Controller (40)2.2MASCHINE Project Overview (43)2.2.1Sound Content (44)2.2.2Arrangement (45)2.3MASCHINE Hardware Overview (48)2.3.1MASCHINE Hardware Overview (48)2.3.1.1Control Section (50)2.3.1.2Edit Section (53)2.3.1.3Performance Section (54)2.3.1.4Group Section (56)2.3.1.5Transport Section (56)2.3.1.6Pad Section (58)2.3.1.7Rear Panel (63)2.4MASCHINE Software Overview (65)2.4.1Header (66)2.4.2Browser (68)2.4.3Arranger (70)2.4.4Control Area (73)2.4.5Pattern Editor (74)3Basic Concepts (76)3.1Important Names and Concepts (76)3.2Adjusting the MASCHINE User Interface (79)3.2.1Adjusting the Size of the Interface (79)3.2.2Switching between Ideas View and Song View (80)3.2.3Showing/Hiding the Browser (81)3.2.4Showing/Hiding the Control Lane (81)3.3Common Operations (82)3.3.1Using the 4-Directional Push Encoder (82)3.3.2Pinning a Mode on the Controller (83)3.3.3Adjusting Volume, Swing, and Tempo (84)3.3.4Undo/Redo (87)3.3.5List Overlay for Selectors (89)3.3.6Zoom and Scroll Overlays (90)3.3.7Focusing on a Group or a Sound (91)3.3.8Switching Between the Master, Group, and Sound Level (96)3.3.9Navigating Channel Properties, Plug-ins, and Parameter Pages in the Control Area.973.3.9.1Extended Navigate Mode on Your Controller (102)3.3.10Navigating the Software Using the Controller (105)3.3.11Using Two or More Hardware Controllers (106)3.3.12Touch Auto-Write Option (108)3.4Native Kontrol Standard (110)3.5Stand-Alone and Plug-in Mode (111)3.5.1Differences between Stand-Alone and Plug-in Mode (112)3.5.2Switching Instances (113)3.5.3Controlling Various Instances with Different Controllers (114)3.6Host Integration (114)3.6.1Setting up Host Integration (115)3.6.1.1Setting up Ableton Live (macOS) (115)3.6.1.2Setting up Ableton Live (Windows) (116)3.6.1.3Setting up Apple Logic Pro X (116)3.6.2Integration with Ableton Live (117)3.6.3Integration with Apple Logic Pro X (119)3.7Preferences (120)3.7.1Preferences – General Page (121)3.7.2Preferences – Audio Page (126)3.7.3Preferences – MIDI Page (130)3.7.4Preferences – Default Page (133)3.7.5Preferences – Library Page (137)3.7.6Preferences – Plug-ins Page (145)3.7.7Preferences – Hardware Page (150)3.7.8Preferences – Colors Page (154)3.8Integrating MASCHINE into a MIDI Setup (156)3.8.1Connecting External MIDI Equipment (156)3.8.2Sync to External MIDI Clock (157)3.8.3Send MIDI Clock (158)3.9Syncing MASCHINE using Ableton Link (159)3.9.1Connecting to a Network (159)3.9.2Joining and Leaving a Link Session (159)3.10Using a Pedal with the MASCHINE Controller (160)3.11File Management on the MASCHINE Controller (161)4Browser (163)4.1Browser Basics (163)4.1.1The MASCHINE Library (163)4.1.2Browsing the Library vs. Browsing Your Hard Disks (164)4.2Searching and Loading Files from the Library (165)4.2.1Overview of the Library Pane (165)4.2.2Selecting or Loading a Product and Selecting a Bank from the Browser (170)4.2.2.1[MK3] Browsing by Product Category Using the Controller (174)4.2.2.2[MK3] Browsing by Product Vendor Using the Controller (174)4.2.3Selecting a Product Category, a Product, a Bank, and a Sub-Bank (175)4.2.3.1Selecting a Product Category, a Product, a Bank, and a Sub-Bank on theController (179)4.2.4Selecting a File Type (180)4.2.5Choosing Between Factory and User Content (181)4.2.6Selecting Type and Character Tags (182)4.2.7List and Tag Overlays in the Browser (186)4.2.8Performing a Text Search (188)4.2.9Loading a File from the Result List (188)4.3Additional Browsing Tools (193)4.3.1Loading the Selected Files Automatically (193)4.3.2Auditioning Instrument Presets (195)4.3.3Auditioning Samples (196)4.3.4Loading Groups with Patterns (197)4.3.5Loading Groups with Routing (198)4.3.6Displaying File Information (198)4.4Using Favorites in the Browser (199)4.5Editing the Files’ Tags and Properties (203)4.5.1Attribute Editor Basics (203)4.5.2The Bank Page (205)4.5.3The Types and Characters Pages (205)4.5.4The Properties Page (208)4.6Loading and Importing Files from Your File System (209)4.6.1Overview of the FILES Pane (209)4.6.2Using Favorites (211)4.6.3Using the Location Bar (212)4.6.4Navigating to Recent Locations (213)4.6.5Using the Result List (214)4.6.6Importing Files to the MASCHINE Library (217)4.7Locating Missing Samples (219)4.8Using Quick Browse (221)5Managing Sounds, Groups, and Your Project (225)5.1Overview of the Sounds, Groups, and Master (225)5.1.1The Sound, Group, and Master Channels (226)5.1.2Similarities and Differences in Handling Sounds and Groups (227)5.1.3Selecting Multiple Sounds or Groups (228)5.2Managing Sounds (233)5.2.1Loading Sounds (235)5.2.2Pre-listening to Sounds (236)5.2.3Renaming Sound Slots (237)5.2.4Changing the Sound’s Color (237)5.2.5Saving Sounds (239)5.2.6Copying and Pasting Sounds (241)5.2.7Moving Sounds (244)5.2.8Resetting Sound Slots (245)5.3Managing Groups (247)5.3.1Creating Groups (248)5.3.2Loading Groups (249)5.3.3Renaming Groups (251)5.3.4Changing the Group’s Color (251)5.3.5Saving Groups (253)5.3.6Copying and Pasting Groups (255)5.3.7Reordering Groups (258)5.3.8Deleting Groups (259)5.4Exporting MASCHINE Objects and Audio (260)5.4.1Saving a Group with its Samples (261)5.4.2Saving a Project with its Samples (262)5.4.3Exporting Audio (264)5.5Importing Third-Party File Formats (270)5.5.1Loading REX Files into Sound Slots (270)5.5.2Importing MPC Programs to Groups (271)6Playing on the Controller (275)6.1Adjusting the Pads (275)6.1.1The Pad View in the Software (275)6.1.2Choosing a Pad Input Mode (277)6.1.3Adjusting the Base Key (280)6.1.4Using Choke Groups (282)6.1.5Using Link Groups (284)6.2Adjusting the Key, Choke, and Link Parameters for Multiple Sounds (286)6.3Playing Tools (287)6.3.1Mute and Solo (288)6.3.2Choke All Notes (292)6.3.3Groove (293)6.3.4Level, Tempo, Tune, and Groove Shortcuts on Your Controller (295)6.3.5Tap Tempo (299)6.4Performance Features (300)6.4.1Overview of the Perform Features (300)6.4.2Selecting a Scale and Creating Chords (303)6.4.3Scale and Chord Parameters (303)6.4.4Creating Arpeggios and Repeated Notes (316)6.4.5Swing on Note Repeat / Arp Output (321)6.5Using Lock Snapshots (322)6.5.1Creating a Lock Snapshot (322)6.5.2Using Extended Lock (323)6.5.3Updating a Lock Snapshot (323)6.5.4Recalling a Lock Snapshot (324)6.5.5Morphing Between Lock Snapshots (324)6.5.6Deleting a Lock Snapshot (325)6.5.7Triggering Lock Snapshots via MIDI (326)6.6Using the Smart Strip (327)6.6.1Pitch Mode (328)6.6.2Modulation Mode (328)6.6.3Perform Mode (328)6.6.4Notes Mode (329)7Working with Plug-ins (330)7.1Plug-in Overview (330)7.1.1Plug-in Basics (330)7.1.2First Plug-in Slot of Sounds: Choosing the Sound’s Role (334)7.1.3Loading, Removing, and Replacing a Plug-in (335)7.1.3.1Browser Plug-in Slot Selection (341)7.1.4Adjusting the Plug-in Parameters (344)7.1.5Bypassing Plug-in Slots (344)7.1.6Using Side-Chain (346)7.1.7Moving Plug-ins (346)7.1.8Alternative: the Plug-in Strip (348)7.1.9Saving and Recalling Plug-in Presets (348)7.1.9.1Saving Plug-in Presets (349)7.1.9.2Recalling Plug-in Presets (350)7.1.9.3Removing a Default Plug-in Preset (351)7.2The Sampler Plug-in (352)7.2.1Page 1: Voice Settings / Engine (354)7.2.2Page 2: Pitch / Envelope (356)7.2.3Page 3: FX / Filter (359)7.2.4Page 4: Modulation (361)7.2.5Page 5: LFO (363)7.2.6Page 6: Velocity / Modwheel (365)7.3Using Native Instruments and External Plug-ins (367)7.3.1Opening/Closing Plug-in Windows (367)7.3.2Using the VST/AU Plug-in Parameters (370)7.3.3Setting Up Your Own Parameter Pages (371)7.3.4Using VST/AU Plug-in Presets (376)7.3.5Multiple-Output Plug-ins and Multitimbral Plug-ins (378)8Using the Audio Plug-in (380)8.1Loading a Loop into the Audio Plug-in (384)8.2Editing Audio in the Audio Plug-in (385)8.3Using Loop Mode (386)8.4Using Gate Mode (388)9Using the Drumsynths (390)9.1Drumsynths – General Handling (391)9.1.1Engines: Many Different Drums per Drumsynth (391)9.1.2Common Parameter Organization (391)9.1.3Shared Parameters (394)9.1.4Various Velocity Responses (394)9.1.5Pitch Range, Tuning, and MIDI Notes (394)9.2The Kicks (395)9.2.1Kick – Sub (397)9.2.2Kick – Tronic (399)9.2.3Kick – Dusty (402)9.2.4Kick – Grit (403)9.2.5Kick – Rasper (406)9.2.6Kick – Snappy (407)9.2.7Kick – Bold (409)9.2.8Kick – Maple (411)9.2.9Kick – Push (412)9.3The Snares (414)9.3.1Snare – Volt (416)9.3.2Snare – Bit (418)9.3.3Snare – Pow (420)9.3.4Snare – Sharp (421)9.3.5Snare – Airy (423)9.3.6Snare – Vintage (425)9.3.7Snare – Chrome (427)9.3.8Snare – Iron (429)9.3.9Snare – Clap (431)9.3.10Snare – Breaker (433)9.4The Hi-hats (435)9.4.1Hi-hat – Silver (436)9.4.2Hi-hat – Circuit (438)9.4.3Hi-hat – Memory (440)9.4.4Hi-hat – Hybrid (442)9.4.5Creating a Pattern with Closed and Open Hi-hats (444)9.5The Toms (445)9.5.1Tom – Tronic (447)9.5.2Tom – Fractal (449)9.5.3Tom – Floor (453)9.5.4Tom – High (455)9.6The Percussions (456)9.6.1Percussion – Fractal (458)9.6.2Percussion – Kettle (461)9.6.3Percussion – Shaker (463)9.7The Cymbals (467)9.7.1Cymbal – Crash (469)9.7.2Cymbal – Ride (471)10Using the Bass Synth (474)10.1Bass Synth – General Handling (475)10.1.1Parameter Organization (475)10.1.2Bass Synth Parameters (477)11Working with Patterns (479)11.1Pattern Basics (479)11.1.1Pattern Editor Overview (480)11.1.2Navigating the Event Area (486)11.1.3Following the Playback Position in the Pattern (488)11.1.4Jumping to Another Playback Position in the Pattern (489)11.1.5Group View and Keyboard View (491)11.1.6Adjusting the Arrange Grid and the Pattern Length (493)11.1.7Adjusting the Step Grid and the Nudge Grid (497)11.2Recording Patterns in Real Time (501)11.2.1Recording Your Patterns Live (501)11.2.2The Record Prepare Mode (504)11.2.3Using the Metronome (505)11.2.4Recording with Count-in (506)11.2.5Quantizing while Recording (508)11.3Recording Patterns with the Step Sequencer (508)11.3.1Step Mode Basics (508)11.3.2Editing Events in Step Mode (511)11.3.3Recording Modulation in Step Mode (513)11.4Editing Events (514)11.4.1Editing Events with the Mouse: an Overview (514)11.4.2Creating Events/Notes (517)11.4.3Selecting Events/Notes (518)11.4.4Editing Selected Events/Notes (526)11.4.5Deleting Events/Notes (532)11.4.6Cut, Copy, and Paste Events/Notes (535)11.4.7Quantizing Events/Notes (538)11.4.8Quantization While Playing (540)11.4.9Doubling a Pattern (541)11.4.10Adding Variation to Patterns (541)11.5Recording and Editing Modulation (546)11.5.1Which Parameters Are Modulatable? (547)11.5.2Recording Modulation (548)11.5.3Creating and Editing Modulation in the Control Lane (550)11.6Creating MIDI Tracks from Scratch in MASCHINE (555)11.7Managing Patterns (557)11.7.1The Pattern Manager and Pattern Mode (558)11.7.2Selecting Patterns and Pattern Banks (560)11.7.3Creating Patterns (563)11.7.4Deleting Patterns (565)11.7.5Creating and Deleting Pattern Banks (566)11.7.6Naming Patterns (568)11.7.7Changing the Pattern’s Color (570)11.7.8Duplicating, Copying, and Pasting Patterns (571)11.7.9Moving Patterns (574)11.7.10Adjusting Pattern Length in Fine Increments (575)11.8Importing/Exporting Audio and MIDI to/from Patterns (576)11.8.1Exporting Audio from Patterns (576)11.8.2Exporting MIDI from Patterns (577)11.8.3Importing MIDI to Patterns (580)12Audio Routing, Remote Control, and Macro Controls (589)12.1Audio Routing in MASCHINE (590)12.1.1Sending External Audio to Sounds (591)12.1.2Configuring the Main Output of Sounds and Groups (596)12.1.3Setting Up Auxiliary Outputs for Sounds and Groups (601)12.1.4Configuring the Master and Cue Outputs of MASCHINE (605)12.1.5Mono Audio Inputs (610)12.1.5.1Configuring External Inputs for Sounds in Mix View (611)12.2Using MIDI Control and Host Automation (614)12.2.1Triggering Sounds via MIDI Notes (615)12.2.2Triggering Scenes via MIDI (622)12.2.3Controlling Parameters via MIDI and Host Automation (623)12.2.4Selecting VST/AU Plug-in Presets via MIDI Program Change (631)12.2.5Sending MIDI from Sounds (632)12.3Creating Custom Sets of Parameters with the Macro Controls (636)12.3.1Macro Control Overview (637)12.3.2Assigning Macro Controls Using the Software (638)12.3.3Assigning Macro Controls Using the Controller (644)13Controlling Your Mix (646)13.1Mix View Basics (646)13.1.1Switching between Arrange View and Mix View (646)13.1.2Mix View Elements (647)13.2The Mixer (649)13.2.1Displaying Groups vs. Displaying Sounds (650)13.2.2Adjusting the Mixer Layout (652)13.2.3Selecting Channel Strips (653)13.2.4Managing Your Channels in the Mixer (654)13.2.5Adjusting Settings in the Channel Strips (656)13.2.6Using the Cue Bus (660)13.3The Plug-in Chain (662)13.4The Plug-in Strip (663)13.4.1The Plug-in Header (665)13.4.2Panels for Drumsynths and Internal Effects (667)13.4.3Panel for the Sampler (668)13.4.4Custom Panels for Native Instruments Plug-ins (671)13.4.5Undocking a Plug-in Panel (Native Instruments and External Plug-ins Only) (675)13.5Controlling Your Mix from the Controller (677)13.5.1Navigating Your Channels in Mix Mode (678)13.5.2Adjusting the Level and Pan in Mix Mode (679)13.5.3Mute and Solo in Mix Mode (680)13.5.4Plug-in Icons in Mix Mode (680)14Using Effects (681)14.1Applying Effects to a Sound, a Group or the Master (681)14.1.1Adding an Effect (681)14.1.2Other Operations on Effects (690)14.1.3Using the Side-Chain Input (692)14.2Applying Effects to External Audio (695)14.2.1Step 1: Configure MASCHINE Audio Inputs (695)14.2.2Step 2: Set up a Sound to Receive the External Input (698)14.2.3Step 3: Load an Effect to Process an Input (700)14.3Creating a Send Effect (701)14.3.1Step 1: Set Up a Sound or Group as Send Effect (702)14.3.2Step 2: Route Audio to the Send Effect (706)14.3.3 A Few Notes on Send Effects (708)14.4Creating Multi-Effects (709)15Effect Reference (712)15.1Dynamics (713)15.1.1Compressor (713)15.1.2Gate (717)15.1.3Transient Master (721)15.1.4Limiter (723)15.1.5Maximizer (727)15.2Filtering Effects (730)15.2.1EQ (730)15.2.2Filter (733)15.2.3Cabinet (737)15.3Modulation Effects (738)15.3.1Chorus (738)15.3.2Flanger (740)15.3.3FM (742)15.3.4Freq Shifter (743)15.3.5Phaser (745)15.4Spatial and Reverb Effects (747)15.4.1Ice (747)15.4.2Metaverb (749)15.4.3Reflex (750)15.4.4Reverb (Legacy) (752)15.4.5Reverb (754)15.4.5.1Reverb Room (754)15.4.5.2Reverb Hall (757)15.4.5.3Plate Reverb (760)15.5Delays (762)15.5.1Beat Delay (762)15.5.2Grain Delay (765)15.5.3Grain Stretch (767)15.5.4Resochord (769)15.6Distortion Effects (771)15.6.1Distortion (771)15.6.2Lofi (774)15.6.3Saturator (775)15.7Perform FX (779)15.7.1Filter (780)15.7.2Flanger (782)15.7.3Burst Echo (785)15.7.4Reso Echo (787)15.7.5Ring (790)15.7.6Stutter (792)15.7.7Tremolo (795)15.7.8Scratcher (798)16Working with the Arranger (801)16.1Arranger Basics (801)16.1.1Navigating Song View (804)16.1.2Following the Playback Position in Your Project (806)16.1.3Performing with Scenes and Sections using the Pads (807)16.2Using Ideas View (811)16.2.1Scene Overview (811)16.2.2Creating Scenes (813)16.2.3Assigning and Removing Patterns (813)16.2.4Selecting Scenes (817)16.2.5Deleting Scenes (818)16.2.6Creating and Deleting Scene Banks (820)16.2.7Clearing Scenes (820)16.2.8Duplicating Scenes (821)16.2.9Reordering Scenes (822)16.2.10Making Scenes Unique (824)16.2.11Appending Scenes to Arrangement (825)16.2.12Naming Scenes (826)16.2.13Changing the Color of a Scene (827)16.3Using Song View (828)16.3.1Section Management Overview (828)16.3.2Creating Sections (833)16.3.3Assigning a Scene to a Section (834)16.3.4Selecting Sections and Section Banks (835)16.3.5Reorganizing Sections (839)16.3.6Adjusting the Length of a Section (840)16.3.6.1Adjusting the Length of a Section Using the Software (841)16.3.6.2Adjusting the Length of a Section Using the Controller (843)16.3.7Clearing a Pattern in Song View (843)16.3.8Duplicating Sections (844)16.3.8.1Making Sections Unique (845)16.3.9Removing Sections (846)16.3.10Renaming Scenes (848)16.3.11Clearing Sections (849)16.3.12Creating and Deleting Section Banks (850)16.3.13Working with Patterns in Song view (850)16.3.13.1Creating a Pattern in Song View (850)16.3.13.2Selecting a Pattern in Song View (850)16.3.13.3Clearing a Pattern in Song View (851)16.3.13.4Renaming a Pattern in Song View (851)16.3.13.5Coloring a Pattern in Song View (851)16.3.13.6Removing a Pattern in Song View (852)16.3.13.7Duplicating a Pattern in Song View (852)16.3.14Enabling Auto Length (852)16.3.15Looping (853)16.3.15.1Setting the Loop Range in the Software (854)16.4Playing with Sections (855)16.4.1Jumping to another Playback Position in Your Project (855)16.5Triggering Sections or Scenes via MIDI (856)16.6The Arrange Grid (858)16.7Quick Grid (860)17Sampling and Sample Mapping (862)17.1Opening the Sample Editor (862)17.2Recording Audio (863)17.2.1Opening the Record Page (863)17.2.2Selecting the Source and the Recording Mode (865)17.2.3Arming, Starting, and Stopping the Recording (868)17.2.5Using the Footswitch for Recording Audio (871)17.2.6Checking Your Recordings (872)17.2.7Location and Name of Your Recorded Samples (876)17.3Editing a Sample (876)17.3.1Using the Edit Page (877)17.3.2Audio Editing Functions (882)17.4Slicing a Sample (890)17.4.1Opening the Slice Page (891)17.4.2Adjusting the Slicing Settings (893)17.4.3Live Slicing (898)17.4.3.1Live Slicing Using the Controller (898)17.4.3.2Delete All Slices (899)17.4.4Manually Adjusting Your Slices (899)17.4.5Applying the Slicing (906)17.5Mapping Samples to Zones (912)17.5.1Opening the Zone Page (912)17.5.2Zone Page Overview (913)17.5.3Selecting and Managing Zones in the Zone List (915)17.5.4Selecting and Editing Zones in the Map View (920)17.5.5Editing Zones in the Sample View (924)17.5.6Adjusting the Zone Settings (927)17.5.7Adding Samples to the Sample Map (934)18Appendix: Tips for Playing Live (937)18.1Preparations (937)18.1.1Focus on the Hardware (937)18.1.2Customize the Pads of the Hardware (937)18.1.3Check Your CPU Power Before Playing (937)18.1.4Name and Color Your Groups, Patterns, Sounds and Scenes (938)18.1.5Consider Using a Limiter on Your Master (938)18.1.6Hook Up Your Other Gear and Sync It with MIDI Clock (938)18.1.7Improvise (938)18.2Basic Techniques (938)18.2.1Use Mute and Solo (938)18.2.2Use Scene Mode and Tweak the Loop Range (939)18.2.3Create Variations of Your Drum Patterns in the Step Sequencer (939)18.2.4Use Note Repeat (939)18.2.5Set Up Your Own Multi-effect Groups and Automate Them (939)18.3Special Tricks (940)18.3.1Changing Pattern Length for Variation (940)18.3.2Using Loops to Cycle Through Samples (940)18.3.3Using Loops to Cycle Through Samples (940)18.3.4Load Long Audio Files and Play with the Start Point (940)19Troubleshooting (941)19.1Knowledge Base (941)19.2Technical Support (941)19.3Registration Support (942)19.4User Forum (942)20Glossary (943)Index (951)1Welcome to MASCHINEThank you for buying MASCHINE!MASCHINE is a groove production studio that implements the familiar working style of classi-cal groove boxes along with the advantages of a computer based system. MASCHINE is ideal for making music live, as well as in the studio. It’s the hands-on aspect of a dedicated instru-ment, the MASCHINE hardware controller, united with the advanced editing features of the MASCHINE software.Creating beats is often not very intuitive with a computer, but using the MASCHINE hardware controller to do it makes it easy and fun. You can tap in freely with the pads or use Note Re-peat to jam along. Alternatively, build your beats using the step sequencer just as in classic drum machines.Patterns can be intuitively combined and rearranged on the fly to form larger ideas. You can try out several different versions of a song without ever having to stop the music.Since you can integrate it into any sequencer that supports VST, AU, or AAX plug-ins, you can reap the benefits in almost any software setup, or use it as a stand-alone application. You can sample your own material, slice loops and rearrange them easily.However, MASCHINE is a lot more than an ordinary groovebox or sampler: it comes with an inspiring 7-gigabyte library, and a sophisticated, yet easy to use tag-based Browser to give you instant access to the sounds you are looking for.What’s more, MASCHINE provides lots of options for manipulating your sounds via internal ef-fects and other sound-shaping possibilities. You can also control external MIDI hardware and 3rd-party software with the MASCHINE hardware controller, while customizing the functions of the pads, knobs and buttons according to your needs utilizing the included Controller Editor application. We hope you enjoy this fantastic instrument as much as we do. Now let’s get go-ing!—The MASCHINE team at Native Instruments.MASCHINE Documentation1.1MASCHINE DocumentationNative Instruments provide many information sources regarding MASCHINE. The main docu-ments should be read in the following sequence:1.MASCHINE Getting Started: This document provides a practical approach to MASCHINE viaa set of tutorials covering easy and more advanced tasks in order to help you familiarizeyourself with MASCHINE.2.MASCHINE Manual (this document): The MASCHINE Manual provides you with a compre-hensive description of all MASCHINE software and hardware features.Additional documentation sources provide you with details on more specific topics:▪Controller Editor Manual: Besides using your MASCHINE hardware controller together withits dedicated MASCHINE software, you can also use it as a powerful and highly versatileMIDI controller to pilot any other MIDI-capable application or device. This is made possibleby the Controller Editor software, an application that allows you to precisely define all MIDIassignments for your MASCHINE controller. The Controller Editor was installed during theMASCHINE installation procedure. For more information on this, please refer to the Con-troller Editor Manual available as a PDF file via the Help menu of Controller Editor.▪Online Support Videos: You can find a number of support videos on The Official Native In-struments Support Channel under the following URL: https:///NIsupport-EN. We recommend that you follow along with these instructions while the respective ap-plication is running on your computer.Other Online Resources:If you are experiencing problems related to your Native Instruments product that the supplied documentation does not cover, there are several ways of getting help:▪Knowledge Base▪User Forum▪Technical Support▪Registration SupportYou will find more information on these subjects in the chapter Troubleshooting.1.2Document ConventionsThis section introduces you to the signage and text highlighting used in this manual. This man-ual uses particular formatting to point out special facts and to warn you of potential issues. The icons introducing these notes let you see what kind of information is to be expected:This document uses particular formatting to point out special facts and to warn you of poten-tial issues. The icons introducing the following notes let you see what kind of information can be expected:Furthermore, the following formatting is used:▪Text appearing in (drop-down) menus (such as Open…, Save as… etc.) in the software and paths to locations on your hard disk or other storage devices is printed in italics.▪Text appearing elsewhere (labels of buttons, controls, text next to checkboxes etc.) in the software is printed in blue. Whenever you see this formatting applied, you will find the same text appearing somewhere on the screen.▪Text appearing on the displays of the controller is printed in light grey. Whenever you see this formatting applied, you will find the same text on a controller display.▪Text appearing on labels of the hardware controller is printed in orange. Whenever you see this formatting applied, you will find the same text on the controller.▪Important names and concepts are printed in bold.▪References to keys on your computer’s keyboard you’ll find put in square brackets (e.g.,“Press [Shift] + [Enter]”).►Single instructions are introduced by this play button type arrow.→Results of actions are introduced by this smaller arrow.Naming ConventionThroughout the documentation we will refer to MASCHINE controller (or just controller) as the hardware controller and MASCHINE software as the software installed on your computer.The term “effect” will sometimes be abbreviated as “FX” when referring to elements in the MA-SCHINE software and hardware. These terms have the same meaning.Button Combinations and Shortcuts on Your ControllerMost instructions will use the “+” sign to indicate buttons (or buttons and pads) that must be pressed simultaneously, starting with the button indicated first. E.g., an instruction such as:“Press SHIFT + PLAY”means:1.Press and hold SHIFT.2.While holding SHIFT, press PLAY and release it.3.Release SHIFT.Unlabeled Buttons on the ControllerThe buttons and knobs above and below the displays on your MASCHINE controller do not have labels.。
Final Business PlanICH Q14: Analytical Procedure Development and Revision of Q2(R1) AnalyticalValidationdated 14 November 2018Endorsed by the Management Committee on 15 November 20181.The issue and its costs•What problem/issue is the proposal expected to tackle?Since there is no ICH guideline on Analytical Procedure Development, applicants often report analytical validation results alone and rarely present performance evaluation with analytical development outcomes. This makes regulatory communication unproductive when non-conventional (e.g., multivariate models for process control) analytical procedures are employed. Additionally, the lack of guideline impedes opportunities for the applicant to present a scientific basis for flexible regulatory approaches (e.g.,Quality by Design concept) to post-approval Analytical Procedure changes.The current Q2(R1) “Guideline on Validation of Analytical Procedures: Text and Methodology” is not directly applicable to analytical procedures such as Near Infrared (NIR) Spectroscopy. The lack of clear guidelines can lead to submissions with inadequate validation data for these analytical procedures, resulting in recursive information requests and responses, which can delay application approval. The delays are often the case for procedures reliant on multivariate models, a category for which no ICH validation guideline exists. Such methods are commonly used in process control and real time testing of pharmaceutical products. Taking into consideration the differences between multivariate and traditional methods, the current approach outlined in Q2(R1) is not sufficient to establish suitability of multivariate analysis methods using spectroscopic or spectrometric data.•What are the costs (social/health and financial) to our stakeholders associated with the current situation or associated with “non action”?Non-action leads to delayed access to medication and potential increase of costs to patients because of multiple rounds of information requests resulting in delay of approval. The current situation also deprives industry of an opportunity to present the knowledge obtained through applying the enhanced approaches to analytical procedures, and to provide a scientific basis for more robust methods and more flexible regulatory approach. Thus, currently more resources for change management are required and this will remain the case in the absence of Q2(R1) revision. In addition, new continuous manufacturing approaches being applied in the pharmaceutical industry (for both biologics and synthetic-based products) require fast, real time test methods (e.g.,NIR and Raman spectroscopy, and in the future mass spectrometry) to assure that the process is in a state of control all of the time.However, the current version of Q2(R1) does not provide guidance for validation of analytical methods based on multivariate data. Overall, the impetus for industry to develop robust analytical methods for such continuous processes is diminished and delays implementation of efficient processes for new drug manufacturing and quality control testing. The revisions proposed present a more comprehensive guideline to International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human UseICH Secretariat, Route Pré-Bois 20, P.O. Box 1894, 1215 Geneva, Switzerlanddevelop and validate analytical procedures and will reduce additional burden associated with repetitive regulatory review of applications for drug approval.2.Planning•What are the main deliverables?The objective of this proposal is to provide an opportunity to present the knowledge obtained through applying enhanced approaches to validation of analytical procedures, to provide the guidance on how to apply and to indicate a policy for more flexible regulatory approaches. The proposed guideline will facilitate selecting or identifying conditions for methods and/or model updates and re-validations that ease assessment of post-approval changes by regulatory agencies and enable more efficient and sound scientific and risk-based change management. Applying the enhanced approach for analytical procedures (i.e., Quality by Design) will contribute to the resource-efficient drug development and streamline post-approval CMC changes.•What resources (financial and human) would be required?Because activities are strongly interrelated, one Expert Working Group will be designated to establish the new Analytical Procedure Development and revise ICH Q2(R1). This dedicated Expert Working Group will potentially determine the feasibility to combine both documents in to one for simplification and clarity. An Expert Working Group composed of experts with knowledge and proficiency in the area of analytical chemistry and pharmaceutical control is needed.•What is the time frame of the project/milestones?By Fall 2018; Final Concept Paper, The first Face to Face EWG meetingSpring 2019; 2nd F2F EWG meetingFall 2019; 3rd F2F EWG meeting(Finish two drafts to be reviewed within Member/Observer parties for both).Spring 2020; 4th F2T EWG meeting(Step 2 for both)Spring 2021; 5th F2F EWG meeting(Step 4 for both)•What special actions to advance the topic through ICH, e.g. stakeholder engagement or training, can be anticipated either in the development of the guideline or for its implementation?Case studies can be collected to help discussion at EWG meeting and to form the basis of training materials of the guidelines when implemented.3.The impacts of the project•What are the likely benefits (social, health and financial) to our key stakeholders of the fulfilment of the objective?The proposal can provide timely access to new drugs for patients by elimination of multiple review cycles. In addition, clear guidance in this area may encourage the use of more advanced analytical procedures and modernization of existing methods, leading to more robust quality oversight by pharmaceutical drug manufacturers. •What are the regulatory implications of the proposed work – is the topic feasible(implementable) from a regulatory standpoint?These guidelines would have no legal issues, be in alignment with ICH Q8-12, and have no impact on the existing regional regulatory procedures.•Will the guideline have implications for the submission of content in the CTD/eCTD? If so, how will the working group address submission of content in the dossier? Will a consult be requested with the ICH M8 working group?Although the new guideline Q14 will be for S4, P4 and P5 of CTD, there will be no necessity to change the CTD/eCTD sections and ICH M8 documents.4.Post-hoc evaluation•How and when will the results of the work be evaluated?The benefits of these guidelines would be evaluated after the implementation.The impact of the new guideline could be evaluated based on the information described in the submitted document by a survey in all agencies.。
McEvoy and Farmer's Complete Guide to IVD Distribution in Chinahttps:///r/W875106C98AEN.htmlDate: May 2009Pages: 240Price: US$ 3,995.00 (Single User License)ID: W875106C98AENAbstractsWho is Who in Clinical Diagnostics in China, produced jointly with the firm McEvoy & Farmer, is the product of on-the-ground primary research on Chinese labs conducted in fall and winter 2008. Included in this report:Market Size Estimate by Major Category (Chemistry, Critical Care Chemistry, Urine Chemistry, Hematology, Flow Cytometry, Coagulation, Immunochemistry, Molecular Testing, Other IVD)Country Industry OverviewChinese Hospital StatisticsProfiles of 42 International Diagnostic Companies with operations in ChinaProfiles of 130 Domestic Diagnostic CompaniesProfiles of 24 Local Distributors, indicating the companies they distribute forThe Chinese market represents a significant opportunity for IVD diagnostic companies. But actionable information about this emerging market is often difficult to get. Only with an exhaustive, on-the-ground research team can a company truly understand the chinese market. Now, a resource is available that can make on-the-ground research available to all companies at a fraction of the cost.Published jointly with trusted Asian IVD market experts, this Kalorama report is acomplete survey of the IVD market in China today. Market size for major categories of the IVD market, products on the market, important Chinese market trends and intense company profiles are part of this exhaustive study.This country of 1.3 billion people is now America’s sixth largest export market, and China’s economy, while showing some effects of the world recession, has been less impacted than other nations and is showing growth, although not as rapid as in recent years. A number of recent events and trends in the Chinese healthcare environment are making China an increasingly attractive market opportunity for in vitro diagnostics companies. The increasing numbers of private laboratories and expanded reference laboratories are expanding the market for tests of all kinds.Although there are a number of challenges for diagnostic manufacturers to understand and overcome, the market for clinical diagnostics in China (both reagents and instruments) remains one of the most promising emerging markets in the world.ContentsCOUNTRY SUMMARYMarket TotalsWhat is New in ChinaThe Healthcare System in ChinaMedical InsuranceA Brief Guide to the BureaucracyPrivate and Reference LaboratoriesPrivate Medical PracticeProduct RegistrationReimbursementTendersReagent RentalQuality ControlVacuum Tube ConversionSecond hand InstrumentsImported and Domestic Sales INTERNATIONAL MANUFACTURER PROFILESAbbott LaboratoriesABXAcon Biotech/InvernessAdaltisAffymetrixAgilent TechnologiesApplied BiosystemsArkrayAudit DiagnosticsBeckman CoulterBDBioneer TradeBio Rad LaboratoriesbioMérieuxDiaSorinDiaSys Diagnostic SystemsEppendorfEuroimmunFujirebio/CanAg DiagnosticsHitachi High Technologies CorporationHospitexHumanInverness MedicalJei Daniel (JD) BiotechJokohMedicine Devices Company (MDC) Melet Schloesing LaboratoriesMP BiomedicalsOrtho ClinicalDiagnosticsPerkinElmerPromegaQiagenRadiometerRandoxR BiopharmRocheSiemens Healthcare Diagnostics StagoSysmex CorporationThermoFisherVirionSerionYD DiagnosticsDOMESTIC MANUFACTURER PROFILES3V BioengineeringAccuBio TechAddcare Bio TechAi De Diagnostic (IND)AmpllyAntai DiagnosticsAudicom Medical InstrumentAutobio DiagnosticsAVE Science & TechnologyB & E Scientific InstrumentBasoDiagnosticsBeijing Genomics Institute (BGI Healthcare)Biocell InstituteBiocreateBiocup Biotech CompanyBioer TechnologyBiosino BiotechnologyBiote CompanyBioway BiotechnologyBlue Cross Bio MedicalBowlinman Sunshine Science & TechnologyCaihong Analytical InstrumentCaltech GroupCapitalBio CorporationCaretium Medical InstrumentsChang Chun Brother BiotechChangdao BiotechnologyChemClin Bio Tech / China Diagnostics Medical Chemtron BiotechChina Medical/Yuande Bio Medical EngineeringCondor Teco Medical TechnologyCornley Hi TechDa An GeneDecipher BioscienceDirui IndustrialDL Medical BiotechDoubleQ LabDragon MedicalElikan Biological TechnologyFenghua BioengineeringFengHui Medical Science & Technology First Sun ElectronicFosun DiagnosticsGenetel PharmaceuticalsGenius ElectronicsGoldsite DiagnosticsHai Tai BiologicalHaoyuan BiotechnologyHeal Force/Nison InstrumentHealthDigitHongcheng (HC) BiopharmaceuticalHongshi Medical TechnologyHope Industry and TradeHua Sin ScienceHua Tong Medical InstrumentHuaguan Biochip CompanyHuatai Biotechnology IndustrialHuayang Analysis InstrumentHybriBioInTec ProductsJian Ye Medical EquipmentinSangTe Medicine InstrumentKanghua Biotech CompanyKehua Bio EngineeringKinghawk TechnologyLabnovation TechnologiesLandwind International Medical Science LaoLa ElectronicLeadman Biochemistry TechnologyLengguang TechnologyLingyi Medical ScienceLivzon GroupLongx TechnologiesMaker Science TechnologyMaysun TechnologyMaxcom ElectronicMD Pacific TechnologyMeiyilin Electronics InstrumentMerit Choice BioengineeringMindray Medical ElectronicsModern Gold BiotechnologyNanfen Medical Biochemical InstrumentNeusoft Medical SystemsNew MoonNewScen Coast Bio PharmaceuticalOption Science & Technology Development Company Perlong GroupPG Biotech/QiagenPrecil InstrumentProcan ElectronicsRayto Life and Analytical SciencesRich Science IndustryRongsheng Biotech.Runbio Biotech .Sanco InstrumentSan Jose Medical Products..Sciarray BiotechSciendox Bio-Technology CompanySenlong Biotech..Share SunShensuo Medical DiagnosticsShenzhen New Industries Biomedical Engineering (SNIBE) Shining Sun TechnologySinnowa Medical Science & TechnologySTAC Medical Science & TechnologySteellex Scientific InstrumentStrong Biotechnologies...Success Technology DevelopmentSun BiotechSunostik Biomedical TechnologySym-Bio Lifescience.Tecom ScienceTechcompTellgen LifeTiangen Biotech...TianHai Medical Equipment (THME)Tianlong Science and TechnologyTigsun Biotinge Science & TechnologyTZD Technological.Urit Medical ElectronicWanCheng Bio-elect.Wantai BiologicalWasson An-Ze Bio-tech Company..WearmaxWeirikang Biological TechnologyW.H.P.M. Bioresearch & Technology/Hemosure Wondfo BiotechXun-Da Medical InstrumentYasen IndustrialYaxin Sheng WuZhong Tai BiotechZJ Bio-TechDISTRIBUTOR PROFILESAdvanced Clinical Laboratory Science (ACLS)Ailex Technology.....AusBio LaboratoriesBio-Asia DiagnosticsBiochem GroupBio-Star Technology DevelopmentChindex InternationalChinMax Medical SystemsDiamond BiotechnologyDong Hu Instrument/East LakeFu Li Tai (FLT) MeditecGene CompanyGiantech Medical Science & TechnologyGolden-Grand Medical Hongtex Bio-techLangkaNewtime TradingRainbow-Mega Scientific InstrumentScience International/Science LaboratoriesSunlionSuns-GroupTruth EnterpriseUnited Science InternationalVastec Medical..Zhi Cheng Biotech.Appendix: China’s Hospitals by Province.I would like to orderProduct name:McEvoy and Farmer's Complete Guide to IVD Distribution in ChinaProduct link:https:///r/W875106C98AEN.htmlPrice:US$ 3,995.00 (Single User License / Electronic Delivery)If you want to order Corporate License or Hard Copy, please, contact our CustomerService:*************************PaymentTo pay by Credit Card (Visa, MasterCard, American Express, PayPal), please, clickbutton on product page https:///r/W875106C98AEN.htmlTo pay by Wire Transfer, please, fill in your contact details in the form below:First name:Last name:Email:Company:Address:City:Zip code:Country:Tel:Fax:Your message:**All fields are requiredCustumer signature _______________________________________Please, note that by ordering from you are agreeing to our Terms& Conditions at https:///docs/terms.htmlTo place an order via fax simply print this form, fill in the information belowand fax the completed form to +44 20 7900 3970。
元器件交易网CY7C63743CY7C63722/23CY7C63743enCoRe™ USBCombination Low-Speed USB & PS/2Peripheral ControllerTABLE OF CONTENTS1.0 FEATURES (5)2.0 FUNCTIONAL OVERVIEW (6)2.1 enCoRe USB - The New USB Standard (6)3.0 LOGIC BLOCK DIAGRAM (7)4.0 PIN CONFIGURATIONS (7)5.0 PIN ASSIGNMENTS (7)6.0 PROGRAMMING MODEL (8)6.1 Program Counter (PC) (8)6.2 8-bit Accumulator (A) (8)6.3 8-bit Index Register (X) (8)6.4 8-bit Program Stack Pointer (PSP) (8)6.5 8-bit Data Stack Pointer (DSP) (9)6.6 Address Modes (9)6.6.1 Data (9)6.6.2 Direct (9)6.6.3 Indexed (9)7.0 INSTRUCTION SET SUMMARY (10)8.0 MEMORY ORGANIZATION (11)8.1 Program Memory Organization (11)8.2 Data Memory Organization (12)8.3 I/O Register Summary (13)9.0 CLOCKING (14)9.1 Internal/External Oscillator Operation (15)9.2 External Oscillator (16)10.0 RESET (16)10.1 Low-voltage Reset (LVR) (16)10.2 Brown Out Reset (BOR) (16)10.3 Watchdog Reset (WDR) (17)11.0 SUSPEND MODE (17)11.1 Clocking Mode on Wake-up from Suspend (18)11.2 Wake-up Timer (18)12.0 GENERAL PURPOSE I/O PORTS (18)12.1 Auxiliary Input Port (21)13.0 USB SERIAL INTERFACE ENGINE (SIE) (22)13.1 USB Enumeration (22)13.2 USB Port Status and Control (22)14.0 USB DEVICE (24)14.1 USB Address Register (24)14.2 USB Control Endpoint (24)14.3 USB Non-control Endpoints (25)14.4 USB Endpoint Counter Registers (26)15.0 USB REGULATOR OUTPUT (27)16.0 PS/2 OPERATION (27)17.0 SERIAL PERIPHERAL INTERFACE (SPI) (28)17.1 Operation as an SPI Master (29)17.2 Master SCK Selection (29)17.3 Operation as an SPI Slave (29)17.4 SPI Status and Control (30)17.5 SPI Interrupt (31)17.6 SPI Modes for GPIO Pins (31)18.0 12-BIT FREE-RUNNING TIMER (31)19.0 TIMER CAPTURE REGISTERS (32)20.0 PROCESSOR STATUS AND CONTROL REGISTER (35)21.0 INTERRUPTS (36)21.1 Interrupt Vectors (37)21.2 Interrupt Latency (37)21.3 Interrupt Sources (37)22.0 USB MODE TABLES (42)23.0 REGISTER SUMMARY (47)24.0 ABSOLUTE MAXIMUM RATINGS (48)25.0 DC CHARACTERISTICS (48)26.0 SWITCHING CHARACTERISTICS (50)27.0 ORDERING INFORMATION (55)28.0 PACKAGE DIAGRAMS (55)LIST OF FIGURESFigure 8-1. Program Memory Space with Interrupt Vector Table (11)Figure 8-2. Data Memory Organization (12)Figure 9-1. Clock Oscillator On-chip Circuit (14)Figure 9-2. Clock Configuration Register (Address 0xF8) (14)Figure 10-1. Watchdog Reset (WDR, Address 0x26) (17)Figure 12-1. Block Diagram of GPIO Port (one pin shown) (19)Figure 12-2. Port 0 Data (Address 0x00) (19)Figure 12-3. Port 1 Data (Address 0x01) (19)Figure 12-4. GPIO Port 0 Mode0 Register (Address 0x0A) (20)Figure 12-5. GPIO Port 0 Mode1 Register (Address 0x0B) (20)Figure 12-6. GPIO Port 1 Mode0 Register (Address 0x0C) (20)Figure 12-7. GPIO Port 1 Mode1 Register (Address 0x0D) (20)Figure 12-8. Port 2 Data Register (Address 0x02) (21)Figure 13-1. USB Status and Control Register (Address 0x1F) (23)Figure 14-1. USB Device Address Register (Address 0x10) (24)Figure 14-2. Endpoint 0 Mode Register (Address 0x12) (25)Figure 14-3. USB Endpoint EP1, EP2 Mode Registers (Addresses 0x14 and 0x16) (26)Figure 14-4. Endpoint 0,1,2 Counter Registers (Addresses 0x11, 0x13 and 0x15) (26)Figure 17-1. SPI Block Diagram (28)Figure 16-1. Diagram of USB-PS/2 System Connections (28)Figure 17-2. SPI Data Register (Address 0x60) (29)Figure 17-3. SPI Control Register (Address 0x61) (30)Figure 17-4. SPI Data Timing (31)Figure 18-1. Timer LSB Register (Address 0x24) (31)Figure 18-2. Timer MSB Register (Address 0x25) (32)Figure 18-3. Timer Block Diagram (32)Figure 19-1. Capture Timers Block Diagram (33)Figure 19-2. Capture Timer A-Rising, Data Register (Address 0x40) (33)Figure 19-3. Capture Timer A-Falling, Data Register (Address 0x41) (34)Figure 19-4. Capture Timer B-Rising, Data Register (Address 0x42) (34)Figure 19-5. Capture Timer B-Falling, Data Register (Address 0x43) (34)Figure 19-6. Capture Timer Status Register (Address 0x45) (34)Figure 19-7. Capture Timer Configuration Register (Address 0x44) (34)Figure 20-1. Processor Status and Control Register (Address 0xFF) (35)Figure 21-1. Global Interrupt Enable Register (Address 0x20) (38)Figure 21-2. Endpoint Interrupt Enable Register (Address 0x21) (39)Figure 21-3. Interrupt Controller Logic Block Diagram (40)Figure 21-4. Port 0 Interrupt Enable Register (Address 0x04) (40)Figure 21-5. Port 1 Interrupt Enable Register (Address 0x05) (40)Figure 21-6. Port 0 Interrupt Polarity Register (Address 0x06) (41)Figure 21-7. Port 1 Interrupt Polarity Register (Address 0x07) (41)Figure 21-8. GPIO Interrupt Diagram (41)Figure 26-1. Clock Timing (51)Figure 26-2. USB Data Signal Timing (51)Figure 26-3. Receiver Jitter Tolerance (52)Figure 26-4. Differential to EOP Transition Skew and EOP Width (52)Figure 26-5. Differential Data Jitter (52)Figure 26-7. SPI Slave Timing, CPHA = 0 (53)Figure 26-6. SPI Master Timing, CPHA = 0 (53)Figure 26-8. SPI Master Timing, CPHA = 1 (54)Figure 26-9. SPI Slave Timing, CPHA = 1 (54)LIST OF TABLESTable 8-1. I/O Register Summary (13)Table 11-1. Wake-up Timer Adjust Settings (18)Table 12-1. Ports 0 and 1 Output Control Truth Table (21)Table 13-1. Control Modes to Force D+/D– Outputs (24)Table 17-1. SPI Pin Assignments (31)Table 19-1. Capture Timer Prescalar Settings (Step size and range for FCLK = 6 MHz) (35)Table 21-1. Interrupt Vector Assignments (37)Table 22-1. USB Register Mode Encoding for Control and Non-Control Endpoints (42)Table 22-2. Decode table for Table 22-3: “Details of Modes for Differing Traffic Conditions” (44)Table 22-3. Details of Modes for Differing Traffic Conditions (45)Table 28-1. CY7C63722-XC Probe Pad Coordinates in microns ((0,0) to bond pad centers) (57)1.0 Features•enCoRe™ USB - enhanced Component Reduction—Internal oscillator eliminates the need for an external crystal or resonator—Interface can auto-configure to operate as PS/2 or USB without the need for external components to switch between modes (no GPIO pins needed to manage dual mode capability)—Internal 3.3V regulator for USB pull-up resistor—Configurable GPIO for real-world interface without external components•Flexible, cost-effective solution for applications that combine PS/2 and low-speed USB, such as mice, gamepads, joysticks, and many others.•USB Specification Compliance—Conforms to USB Specification, Version 2.0—Conforms to USB HID Specification, Version 1.1—Supports 1 Low-Speed USB device address and 3 data endpoints—Integrated USB transceiver—3.3V regulated output for USB pull-up resistor•8-bit RISC microcontroller—Harvard architecture—6-MHz external ceramic resonator or internal clock mode—12-MHz internal CPU clock—Internal memory—256 bytes of RAM—8 Kbytes of EPROM—Interface can auto-configure to operate as PS/2 or USB—No external components for switching between PS/2 and USB modes—No GPIO pins needed to manage dual mode capability•I/O ports—Up to 16 versatile General Purpose I/O (GPIO) pins, individually configurable—High current drive on any GPIO pin: 50 mA/pin current sink—Each GPIO pin supports high-impedance inputs, internal pull-ups, open drain outputs or traditional CMOS outputs —Maskable interrupts on all I/O pins•SPI serial communication block—Master or slave operation—2 Mbit/s transfers•Four 8-bit Input Capture registers—Two registers each for two input pins—Capture timer setting with 5 prescaler settings—Separate registers for rising and falling edge capture—Simplifies interface to RF inputs for wireless applications•Internal low-power wake-up timer during suspend mode—Periodic wake-up with no external components•Optional 6-MHz internal oscillator mode—Allows fast start-up from suspend mode•Watchdog Reset (WDR)•Low-voltage Reset at 3.75V•Internal brown-out reset for suspend mode•Improved output drivers to reduce EMI•Operating voltage from 4.0V to 5.5VDC•Operating temperature from 0 to 70 degrees Celsius•CY7C63723 available in 18-pin SOIC, 18-pin PDIP•CY7C63743 available in 24-pin SOIC, 24-pin PDIP•CY7C63722 available in DIE form•Industry standard programmer support2.0 Functional Overview2.1enCoRe USB - The New USB StandardCypress has re-invented its leadership position in the low-speed USB market with a new family of innovative microcontrollers. Introducing...enCoRe USB—“enhanced Component Reduction.” Cypress has leveraged its design expertise in USB solutions to create a new family of low-speed USB microcontrollers that enables peripheral developers to design new products with a minimum number of components. At the heart of the enCoRe USB technology is the breakthrough design of a crystal-less oscillator. By integrating the oscillator into our chip, an external crystal or resonator is no longer needed. We have also integrated other external components commonly found in low-speed USB applications such as pull-up resistors, wake-up circuitry, and a 3.3V regulator. All of this adds up to a lower system cost.The CY7C637xx is an 8-bit RISC One Time Programmable (OTP) microcontroller. The instruction set has been optimized specif-ically for USB and PS/2 operations, although the microcontrollers can be used for a variety of other embedded applications. The CY7C637xx features up to 16 general purpose I/O (GPIO) pins to support USB, PS/2 and other applications. The I/O pins are grouped into two ports (Port 0 to 1) where each pin can be individually configured as inputs with internal pull-ups, open drain outputs, or traditional CMOS outputs with programmable drive strength of up to 50 mA output drive. Additionally, each I/O pin can be used to generate a GPIO interrupt to the microcontroller. Note the GPIO interrupts all share the same “GPIO” interrupt vector. The CY7C637xx microcontrollers feature an internal oscillator. With the presence of USB traffic, the internal oscillator can be set to precisely tune to USB timing requirements (6 MHz ±1.5%). Optionally, an external 6-MHz ceramic resonator can be used to provide a higher precision reference for USB operation. This clock generator reduces the clock-related noise emissions (EMI). The clock generator provides the 6- and 12-MHz clocks that remain internal to the microcontroller.The CY7C637xx has 8 Kbytes of EPROM and 256 bytes of data RAM for stack space, user variables, and USB FIFOs.These parts include low-voltage reset logic, a watchdog timer, a vectored interrupt controller, a 12-bit free-running timer, and capture timers. The low-voltage reset (LVR) logic detects when power is applied to the device, resets the logic to a known state, and begins executing instructions at EPROM address 0x0000. LVR will also reset the part when V CC drops below the operating voltage range. The watchdog timer can be used to ensure the firmware never gets stalled for more than approximately 8 ms. The microcontroller supports 10 maskable interrupts in the vectored interrupt controller. Interrupt sources include the USB Bus-Reset, the 128-µs and 1.024-ms outputs from the free-running timer, three USB endpoints, two capture timers, an internal wake-up timer and the GPIO ports. The timers bits cause periodic interrupts when enabled. The USB endpoints interrupt after USB transactions complete on the bus. The capture timers interrupt whenever a new timer value is saved due to a selected GPIO edge event. The GPIO ports have a level of masking to select which GPIO inputs can cause a GPIO interrupt. For additional flexibility, the input transition polarity that causes an interrupt is programmable for each GPIO pin. The interrupt polarity can be either rising or falling edge.The free-running 12-bit timer clocked at 1 MHz provides two interrupt sources as noted above (128 µs and 1.024 ms). The timer can be used to measure the duration of an event under firmware control by reading the timer at the start and end of an event, and subtracting the two values. The four capture timers save a programmable 8 bit range of the free-running timer when a GPIO edge occurs on the two capture pins (P0.0, P0.1).The CY7C637xx includes an integrated USB serial interface engine (SIE) that supports the integrated peripherals. The hardware supports one USB device address with three endpoints. The SIE allows the USB host to communicate with the function integrated into the microcontroller. A 3.3V regulated output pin provides a pull-up source for the external USB resistor on the D– pin.The USB D+ and D– USB pins can alternately be used as PS/2 SCLK and SDATA signals, so that products can be designed to respond to either USB or PS/2 modes of operation. PS/2 operation is supported with internal pull-up resistors on SCLK and SDATA, the ability to disable the regulator output pin, and an interrupt to signal the start of PS/2 activity. No external components are necessary for dual USB and PS/2 systems, and no GPIO pins need to be dedicated to switching between modes. Slow edge rates operate in both modes to reduce EMI.3.0 Logic Block Diagram4.0 Pin Configurations5.0 Pin AssignmentsNameI/O CY7C63723CY7C63743CY7C63722Description18-Pin 24-Pin 25-Pad D–/SDATA,D+/SCLK I/O 121315161617USB differential data lines (D– and D+), or PS/2 clock and data signals (SDATA and SCLK)P0[7:0]I/O1, 2, 3, 4,15, 16, 17, 181, 2, 3, 4,21, 22, 23, 241, 2, 3, 4,22, 23, 24, 25GPIO Port 0 capable of sinking up to 50 mA/pin, or sinking controlled low or high programmable current.Can also source 2 mA current, provide a resistive pull-up, or serve as a high-impedance input. P0.0 and P0.1 provide inputs to Capture Timers A and B, respec-tively.P1[7:0]I/O5, 145, 6, 7, 8,17, 18, 19, 205, 6, 7, 8,18, 19, 20, 21IO Port 1 capable of sinking up to 50 mA/pin, or sinking controlled low or high programmable current. Can alsosource 2 mA current, provide a resistive pull-up, or serve as a high-impedance input.Wake-Up 12-bit Timer USB &D+,D–P1.0–P1.7Interrupt ControllerPort 0P0.0–P0.7GPIO8-bit RISC Xtal RAM 256 Byte EPROM 8K ByteCoreBrown-out Reset XcvrWatch Timer Dog 3.3V Port 1GPIO Capture TimersUSB Engine PS/2Internal Oscillator Oscillator Low ResetVoltage RegulatorTimerSPIXTALOUTXTALIN/P2.1VREG/P2.01234569111516171819202221P0.0P0.1P0.2P0.3P1.0P1.2VSS VREG/P2.0P0.6P1.5P1.1P1.3D+/SCLK P1.7D–/SDATA VCC14P0.710VPPXTALIN/P2.1XTALOUT121378P1.4P1.62423P0.4P0.524-pin SOIC/PDIPCY7C6374312346781011121315161817P0.0P0.1P0.2P0.3VSS VREG/P2.0P0.4P0.6P0.7D+/SCLK D–/SDATA VCC18-pin SOIC/PDIPP0.59VPPXTALIN/P2.1XTALOUTCY7C63723514P1.0P1.1Top View4 5 6 7 8 93 P 0.21 P 0.0 2 P 0.125 P 0.4 24 P 0.523 P 0.622 21 20 19 1811121314151617P0.3P1.0P1.2P1.4P1.6 VSS VSS V P P X T A L I N /P 2.1V R E G X T A L O U T V C C D -/S D A T A D+/SCLK P0.7P1.1P1.3P1.5P1.7CY7C63722-XCDIE106.0 Programming ModelRefer to the CYASM Assembler User’s Guide for more details on firmware operation with the CY7C637xx microcontrollers.6.1Program Counter (PC)The 14-bit program counter (PC) allows access for up to 8 Kbytes of EPROM using the CY7C637xx architecture. The program counter is cleared during reset, such that the first instruction executed after a reset is at address 0x0000. This instruction is typically a jump instruction to a reset handler that initializes the application.The lower 8 bits of the program counter are incremented as instructions are loaded and executed. The upper 6 bits of the program counter are incremented by executing an XPAGE instruction. As a result, the last instruction executed within a 256-byte “page”of sequential code should be an XPAGE instruction. The assembler directive “XPAGEON” will cause the assembler to insert XPAGE instructions automatically. As instructions can be either one or two bytes long, the assembler may occasionally need to insert a NOP followed by an XPAGE for correct execution.The program counter of the next instruction to be executed, carry flag, and zero flag are saved as two bytes on the program stack during an interrupt acknowledge or a CALL instruction. The program counter, carry flag, and zero flag are restored from the program stack only during a RETI instruction.Please note the program counter cannot be accessed directly by the firmware. The program stack can be examined by reading SRAM from location 0x00 and up.6.28-bit Accumulator (A)The accumulator is the general-purpose, do everything register in the architecture where results are usually calculated.6.38-bit Index Register (X)The index register “X” is available to the firmware as an auxiliary accumulator. The X register also allows the processor to perform indexed operations by loading an index value into X.6.48-bit Program Stack Pointer (PSP)During a reset, the program stack pointer (PSP) is set to zero. This means the program “stack” starts at RAM address 0x00 and “grows” upward from there. Note that the program stack pointer is directly addressable under firmware control, using the MOV PSP ,A instruction. The PSP supports interrupt service under hardware control and CALL, RET, and RETI instructions under firmware control.During an interrupt acknowledge, interrupts are disabled and the program counter, carry flag, and zero flag are written as two bytes of data memory. The first byte is stored in the memory addressed by the program stack pointer, then the PSP is incremented.The second byte is stored in memory addressed by the program stack pointer and the PSP is incremented again. The net effect is to store the program counter and flags on the program “stack” and increment the program stack pointer by two.The return from interrupt (RETI) instruction decrements the program stack pointer, then restores the second byte from memory addressed by the PSP . The program stack pointer is decremented again and the first byte is restored from memory addressed by the PSP . After the program counter and flags have been restored from stack, the interrupts are enabled. The effect is to restore the program counter and flags from the program stack, decrement the program stack pointer by two, and re-enable interrupts.The call subroutine (CALL) instruction stores the program counter and flags on the program stack and increments the PSP by two.XTALIN/P2.1IN 912136-MHz ceramic resonator or external clock input, or P2.1 inputXTALOUT OUT1013146-MHz ceramic resonator return pin or internal oscillator outputV PP 71011Programming voltage supply, ground for normal operation V CC111415Voltage supplyVREG/P2.0 81112Voltage supply for 1.3-k Ω USB pull-up resistor (3.3V nominal). Also serves as P2.0 input.V SS699, 10Ground5.0 Pin Assignments (continued)NameI/O CY7C63723CY7C63743CY7C63722Description18-Pin 24-Pin 25-PadThe return from subroutine (RET) instruction restores the program counter, but not the flags, from program stack and decrements the PSP by two.Note that there are restrictions in using the JMP, CALL, and INDEX instructions across the 4-KB boundary of the program memory. Refer to the CYASM Assembler User’s Guide for a detailed description.6.58-bit Data Stack Pointer (DSP)The data stack pointer (DSP) supports PUSH and POP instructions that use the data stack for temporary storage. A PUSH instruction will pre-decrement the DSP, then write data to the memory location addressed by the DSP. A POP instruction will read data from the memory location addressed by the DSP, then post-increment the DSP.During a reset, the Data Stack Pointer will be set to zero. A PUSH instruction when DSP equals zero will write data at the top of the data RAM (address 0xFF). This would write data to the memory area reserved for a FIFO for USB endpoint 0. In non-USB applications, this works fine and is not a problem.For USB applications, the firmware should set the DSP to an appropriate location to avoid a memory conflict with RAM dedicated to USB FIFOs. The memory requirements for the USB endpoints are shown in Section 8.2. For example, assembly instructions to set the DSP to 20h (giving 32 bytes for program and data stack combined) are shown below:MOV A,20h; Move 20 hex into Accumulator (must be D8h or less to avoid USB FIFOs)SWAP A,DSP; swap accumulator value into DSP register6.6Address ModesThe CY7C637xx microcontrollers support three addressing modes for instructions that require data operands: data, direct, and indexed.6.6.1DataThe “Data” address mode refers to a data operand that is actually a constant encoded in the instruction. As an example, consider the instruction that loads A with the constant 0x30:•MOV A, 30hThis instruction will require two bytes of code where the first byte identifies the “MOV A” instruction with a data operand as the second byte. The second byte of the instruction will be the constant “0xE8h”. A constant may be referred to by name if a prior “EQU” statement assigns the constant value to the name. For example, the following code is equivalent to the example shown above:•DSPINIT: EQU 30h•MOV A,DSPINIT6.6.2Direct“Direct” address mode is used when the data operand is a variable stored in SRAM. In that case, the one byte address of the variable is encoded in the instruction. As an example, consider an instruction that loads A with the contents of memory address location 0x10h:•MOV A, [10h]In normal usage, variable names are assigned to variable addresses using “EQU” statements to improve the readability of the assembler source code. As an example, the following code is equivalent to the example shown above:•buttons: EQU 10h•MOV A,[buttons]6.6.3Indexed“Indexed” address mode allows the firmware to manipulate arrays of data stored in SRAM. The address of the data operand is the sum of a constant encoded in the instruction and the contents of the “X” register. In normal usage, the constant will be the “base” address of an array of data and the X register will contain an index that indicates which element of the array is actually addressed:•array: EQU 10h•MOV X,3•MOV A,[x+array]This would have the effect of loading A with the fourth element of the SRAM “array” that begins at address 0x10h. The fourth element would be at address 0x13h.7.0 Instruction Set SummaryRefer to the CYASM Assembler User’s Guide for detailed information on these instructions. Note that conditional jump instructions (i.e., JC, JNC, JZ, JNZ) take 5 cycles if jump is taken, 4 cycles if no jump.MNEMONIC Operand Opcode Cycles MNEMONIC Operand Opcode Cycles HALT 007NOP 204ADD A,expr data014INC A acc214ADD A,[expr] direct026INC X x224ADD A,[X+expr] index037INC [expr] direct237ADC A,expr data044INC [X+expr] index248ADC A,[expr] direct056DEC A acc254ADC A,[X+expr] index067DEC X x264SUB A,expr data074DEC [expr] direct277SUB A,[expr] direct086DEC [X+expr] index288SUB A,[X+expr] index097IORD expr address295SBB A,expr data0A4IOWR expr address2A5SBB A,[expr] direct0B6POP A2B4SBB A,[X+expr] index0C7POP X2C4OR A,expr data0D4PUSH A2D5OR A,[expr] direct0E6PUSH X2E5OR A,[X+expr] index0F7SWAP A,X2F5AND A,expr data104SWAP A,DSP305AND A,[expr] direct116MOV [expr],A direct315AND A,[X+expr] index127MOV [X+expr],A index326XOR A,expr data134OR [expr],A direct337XOR A,[expr] direct146OR [X+expr],A index348XOR A,[X+expr] index157AND [expr],A direct357CMP A,expr data165AND [X+expr],A index368CMP A,[expr] direct177XOR [expr],A direct377CMP A,[X+expr] index188XOR [X+expr],A index388MOV A,expr data194IOWX [X+expr] index396MOV A,[expr] direct1A5CPL 3A4MOV A,[X+expr] index1B6ASL 3B4MOV X,expr data1C4ASR 3C4MOV X,[expr] direct1D5RLC 3D4reserved 1E RRC 3E4XPAGE 1F4RET 3F8MOV A,X404DI 704MOV X,A414EI 724MOV PSP,A604RETI 738CALL addr50 - 5F10JMP addr80-8F5JC addr C0-CF 5 (or 4) CALL addr90-9F10JNC addr D0-DF 5 (or 4)JZ addr A0-AF 5 (or 4)JACC addr E0-EF7JNZ addr B0-BF 5 (or 4)INDEX addr F0-FF148.0 Memory Organization8.1Program Memory Organization[1]After reset Address14 -bit PC0x0000Program execution begins here after a reset.0x0002USB Bus Reset interrupt vector0x0004128-µs timer interrupt vector0x0006 1.024-ms timer interrupt vector0x0008USB endpoint 0 interrupt vector0x000A USB endpoint 1 interrupt vector0x000C USB endpoint 2 interrupt vector0x000E SPI interrupt vector0x0010Capture timer A interrupt Vector0x0012Capture timer B interrupt vector0x0014GPIO interrupt vector0x0016Wake-up interrupt vector0x0018Program Memory begins here0x1FDF8 KB PROM ends here (8K - 32 bytes). See Note below Figure 8-1. Program Memory Space with Interrupt Vector TableNote:1.The upper 32 bytes of the 8K PROM are reserved. Therefore, the user’s program must not overwrite this space.8.2Data Memory OrganizationThe CY7C637xx microcontrollers provide 256 bytes of data RAM. In normal usage, the SRAM is partitioned into four areas: program stack, data stack, user variables and USB endpoint FIFOs as shown below:After reset Address8-bit DSP8-bit PSP0x00Program Stack Growth(User’s firmware movesDSP)8-bit DSP User Selected Data Stack GrowthUser Variables0xE8USB FIFO for Address A endpoint 20xF0USB FIFO for Address A endpoint 10xF8USB FIFO for Address A endpoint 0Top of RAM Memory0xFFFigure 8-2. Data Memory Organization8.3I/O Register SummaryI/O registers are accessed via the I/O Read (IORD) and I/O Write (IOWR, IOWX) instructions. IORD reads the selected port into the accumulator. IOWR writes data from the accumulator to the selected port. Indexed I/O Write (IOWX) adds the contents of X to the address in the instruction to form the port address and writes data from the accumulator to the specified port. Note that specifying address 0 with IOWX (e.g., IOWX 0h) means the I/O port is selected solely by the contents of X.Note:All bits of all registers are cleared to all zeros on reset, except the Processor Status and Control Register (Figure20-1). All registers not listed are reserved, and should never be written by firmware. All bits marked as reserved should always be written as 0 and be treated as undefined by reads.Table 8-1. I/O Register SummaryRegister Name I/O Address Read/Write Function Fig. Port 0 Data0x00R/W GPIO Port 012-2 Port 1 Data0x01R/W GPIO Port 112-3 Port 2 Data0x02R Auxiliary input register for D+, D–, VREG, XTALIN 12-8 Port 0 Interrupt Enable0x04W Interrupt enable for pins in Port 021-4 Port 1 Interrupt Enable0x05W Interrupt enable for pins in Port 121-5 Port 0 Interrupt Polarity 0x06W Interrupt polarity for pins in Port 021-6 Port 1 Interrupt Polarity 0x07W Interrupt polarity for pins in Port 121-7 Port 0 Mode0 0x0A W Controls output configuration for Port 012-4 Port 0 Mode10x0B W12-5 Port 1 Mode00x0C W Controls output configuration for Port 112-6 Port 1 Mode10x0D W12-7 USB Device Address0x10R/W USB Device Address register14-1 EP0 Counter Register0x11R/W USB Endpoint 0 counter register14-4 EP0 Mode Register0x12R/W USB Endpoint 0 configuration register14-2 EP1 Counter Register0x13R/W USB Endpoint 1 counter register14-4 EP1 Mode Register0x14R/W USB Endpoint 1 configuration register14-3 EP2 Counter Register0x15R/W USB Endpoint 2 counter register14-4 EP2 Mode Register0x16R/W USB Endpoint 2 configuration register14-3 USB Status & Control0x1F R/W USB status and control register13-1 Global Interrupt Enable0x20R/W Global interrupt enable register21-1 Endpoint Interrupt Enable0x21R/W USB endpoint interrupt enables21-2 Timer (LSB)0x24R Lower 8 bits of free-running timer (1 MHz)18-1 Timer (MSB)0x25R Upper 4 bits of free-running timer18-2 WDR Clear0x26W Watchdog Reset clear-Capture Timer A Rising0x40R Rising edge Capture Timer A data register19-2 Capture Timer A Falling0x41R Falling edge Capture Timer A data register19-3 Capture Timer B Rising0x42R Rising edge Capture Timer B data register19-4 Capture Timer B Falling0x43R Falling edge Capture Timer B data register19-5 Capture TImer Configuration0x44R/W Capture Timer configuration register19-7 Capture Timer Status0x45R Capture Timer status register19-6 SPI Data0x60R/W SPI read and write data register17-2 SPI Control0x61R/W SPI status and control register17-3 Clock Configuration0xF8R/W Internal / External Clock configuration register9-2 Processor Status & Control0xFF R/W Processor status and control20-1。
REVISION HISTORYDECLARATIONTABLE OF CONTENTS5.3. DC Electrical Characteristics2.6.Memory Subsystem&Touch G-SENSORSPI1_CLK UART3_RX42 DDR3_D743 VCC3_DRAM79 AGND80 VRPSDC0_CMD 111PF3PE9 CSI_D6LCD_D10 141PD10PC19 163 VCC4function 0);3)Type: signal directionPC7 Input PC8 InputPE4 Input PE5 InputSignal Name DescriptionOthersVRP Reference voltageV IH High-Level Input Voltage V IL Low-Level Input VoltageFigure 5-1. Power Up Sequence5.5.2.Power Up Reset Sequence RequirementsThe device has a system reset signal to reset the board. When asserted, the following steps give an example of power up reset sequence supported by the R8 device.•AVCC ,VDD_CPU and VCC_DRAM can be powered up simultaneously.•VDD_INT can be powered up after VDD_CPU is powered up, the time difference is T1ms.•VCC can be powered up after VDD_INT is powered up, the time difference is T2ms.Figure 5-2. Power Up Reset Sequence5.5.3.Resume Power Up Sequence from Super Standby ModeTo resume a power up sequence when the device is in Super Standby mode:•VCC_DRAM and AVCC remains powered up always.•VDD_CPU can be powered up firstly.•VDD_INT can be powered up after VDD_CPU is powered up, the time difference is T1ms.•VCC can be powered up after VDD_INT is powered up, the time difference is T2ms.Figure 5-3. Exit Super Standby and Resume Power Up Sequence5.5.4.Power Down Sequence RequirementsTo reduce power consumption,the R8 can be partially powered down.The section lists the power down requirements in each mode.In Super Standby mode,•VCC_DRAM and AVCC must be kept powered up.•VDD_CPU,VDD_INT and VCC are powered down simultaneously.•VCC voltage fall time is more longer than VDD_INT.VDD_CPUVDD_CPU6.PIN ASSIGNMENT6.2.PACKAGE DIMENSIONThe following diagram shows the package dimension of R8.。
PRIMERGY BladeFrame System configurator and order-information guide June 2012ContentsInstructionsConfiguration diagramConfigurator0System softwareI System Unit BF200II System unit BF400 S2III Upgrade System Unit BF400IV Dual (Intel) Processing Blades (BFi20)V Dual (AMD) Processor Blades (BFa20)VI Quad (Intel) Processind Blades (BFi40))VII Quad (AMD) Processing Blades (BFa40)VIII Dummy Processing BladeChange reportPRIMERGY ServerInstructionsThis document contains basic product and configuration information that will enable you to configure your system viaSystem-Architect.Only the tool "System-Arcitect" will ensure a fast and proper configuration of your PRIMERGY server or your complete PRIMERGY Rack system.Please pay attention to the naming conventions: BF400 S2System unit with up to 24 Processing Blades,improved performance, power options and housingBF200System unit with up to 6 Processing BladesBFi202-way Processing Blade, (Intel)BFi20S5/62-way Processing Blade, Quad Core CPUs (Intel)BFa202-way Processing Blade, (AMD)BFa20S22-way Processing Blade, Dual Core CPUs (AMD)BFi404-way Processing Blade, (Intel)BFi40S24-way Processing Blade, Dual Core CPUs (Intel)BFa404-way Processing Blade, (AMD)BFa40S24-way Processing Blade, Dual Core CPUs (AMD)You can configure your individual PRIMERGY BladeFrame system in order to adjust your specific requirements.The System configurator is divided into several chapters that are identical to the current price list and PC-/ System-Architect.Please follow the lines. If there is a junction, you can choose which way or component you would like to take. Go throughthe configurator by following the lines from the top to the bottom.Please note that there are information symbols which indicate necessary information.For further information see:/products/standard_servers/index.html(internet)https:///com/order-supply/configurators/primergy_config/current/Pages/default.aspx(extranet)Prices and availability see price list and PC-/ System-ArchitectSubject to change and errors exceptedFujitsu Technology Solutions x86 PRIMERGY Server 2 of 20Configuration diagram BF200 BladeFrame chassis incl. Control BladesSystem Unit BF200 ( I )Blade plane with connectors at the rear sideBright color: includeddark color: configurableExtension slots front sideS l o t 5: P r o c e s s i n g B l a d e (o r D u m m y P r o c e s s i n g B l a d e )S l o t 6: P r o c e s s i n g B l a d e (o r D u m m y P r o c e s s i n g B l a d e )S l o t C 2: C o n t r o l B l a d e w i t h s w i t c hS l o t C 1: C o n t r o l B l a d e w i t h s w i t c hS l o t 1: P r o c e s s i n g B l a d e (o r D u m m y P r o c e s s i n g B l a d e )S l o t 2: P r o c e s s i n g B l a d e (o r D u m m y P r o c e s s i n g B l a d e )S l o t 3: P r o c e s s i n g B l a d e (o r D u m m y P r o c e s s i n g B l a d e )S l o t 4: P r o c e s s i n g B l a d e (o r D u m m y P r o c e s s i n g B l a d e )Fujitsu Technology Solutions x86 PRIMERGY Server3 of 20Configuration diagram BF400 S2 BladeFrame chassis incl. Control BladesSystem Unit BF400 S2 ( II )Bright color: included dark color: configurableFujitsu Technology Solutions x86 PRIMERGY Server 4 of 20Alternative C (for Demo System)Alternative D (for Evaluation System)Fujitsu Technology Solutions x86 PRIMERGY Server 5 of 20Fujitsu Technology Solutions x86 PRIMERGY Server 6 of 20Fujitsu Technology Solutions x86 PRIMERGY Server7 of 20Fujitsu Technology Solutions x86 PRIMERGY Server8 of 20Fujitsu Technology Solutions x86 PRIMERGY Server9 of 20Fujitsu Technology Solutions x86 PRIMERGY Server10 of 20System configurator and order-information guidePRIMERGY BladeFrame Status: 2012-05-30 Change Report。
元件認證指南目錄飲用水處理系統和元件認證指南章節-----------------------------------------------------------------------------------頁碼序--------------------------------------------------------------------------------------1-4 概況-----------------------------------------------------------------------------------5常見問題-----------------------------------------------------------------------------6-8 NSF標準規定-----------------------------------------------------------------------9-15 認證-----------------------------------------------------------------------------------15-18 與供應商合作-----------------------------------------------------------------------19詞彙表--------------------------------------------------------------------------------20-24 附錄A--------------------------------------------------------------------------------25附錄B--------------------------------------------------------------------------------26附錄C--------------------------------------------------------------------------------27-28 聯絡資訊-----------------------------------------------------------------------------29序NSF International(簡稱NSF)成立於1944年,為一個致力於公共衛生安全以及環境保護的機構。
3GPP TS 36.331 V13.2.0 (2016-06)Technical Specification3rd Generation Partnership Project;Technical Specification Group Radio Access Network;Evolved Universal Terrestrial Radio Access (E-UTRA);Radio Resource Control (RRC);Protocol specification(Release 13)The present document has been developed within the 3rd Generation Partnership Project (3GPP TM) and may be further elaborated for the purposes of 3GPP. The present document has not been subject to any approval process by the 3GPP Organizational Partners and shall not be implemented.This Specification is provided for future development work within 3GPP only. The Organizational Partners accept no liability for any use of this Specification. Specifications and reports for implementation of the 3GPP TM system should be obtained via the 3GPP Organizational Partners' Publications Offices.KeywordsUMTS, radio3GPPPostal address3GPP support office address650 Route des Lucioles - Sophia AntipolisValbonne - FRANCETel.: +33 4 92 94 42 00 Fax: +33 4 93 65 47 16InternetCopyright NotificationNo part may be reproduced except as authorized by written permission.The copyright and the foregoing restriction extend to reproduction in all media.© 2016, 3GPP Organizational Partners (ARIB, ATIS, CCSA, ETSI, TSDSI, TTA, TTC).All rights reserved.UMTS™ is a Trade Mark of ETSI registered for the benefit of its members3GPP™ is a Trade Mark of ETSI registered for the benefit of its Members and of the 3GPP Organizational PartnersLTE™ is a Trade Mark of ETSI currently being registered for the benefit of its Members and of the 3GPP Organizational Partners GSM® and the GSM logo are registered and owned by the GSM AssociationBluetooth® is a Trade Mark of the Bluetooth SIG registered for the benefit of its membersContentsForeword (18)1Scope (19)2References (19)3Definitions, symbols and abbreviations (22)3.1Definitions (22)3.2Abbreviations (24)4General (27)4.1Introduction (27)4.2Architecture (28)4.2.1UE states and state transitions including inter RAT (28)4.2.2Signalling radio bearers (29)4.3Services (30)4.3.1Services provided to upper layers (30)4.3.2Services expected from lower layers (30)4.4Functions (30)5Procedures (32)5.1General (32)5.1.1Introduction (32)5.1.2General requirements (32)5.2System information (33)5.2.1Introduction (33)5.2.1.1General (33)5.2.1.2Scheduling (34)5.2.1.2a Scheduling for NB-IoT (34)5.2.1.3System information validity and notification of changes (35)5.2.1.4Indication of ETWS notification (36)5.2.1.5Indication of CMAS notification (37)5.2.1.6Notification of EAB parameters change (37)5.2.1.7Access Barring parameters change in NB-IoT (37)5.2.2System information acquisition (38)5.2.2.1General (38)5.2.2.2Initiation (38)5.2.2.3System information required by the UE (38)5.2.2.4System information acquisition by the UE (39)5.2.2.5Essential system information missing (42)5.2.2.6Actions upon reception of the MasterInformationBlock message (42)5.2.2.7Actions upon reception of the SystemInformationBlockType1 message (42)5.2.2.8Actions upon reception of SystemInformation messages (44)5.2.2.9Actions upon reception of SystemInformationBlockType2 (44)5.2.2.10Actions upon reception of SystemInformationBlockType3 (45)5.2.2.11Actions upon reception of SystemInformationBlockType4 (45)5.2.2.12Actions upon reception of SystemInformationBlockType5 (45)5.2.2.13Actions upon reception of SystemInformationBlockType6 (45)5.2.2.14Actions upon reception of SystemInformationBlockType7 (45)5.2.2.15Actions upon reception of SystemInformationBlockType8 (45)5.2.2.16Actions upon reception of SystemInformationBlockType9 (46)5.2.2.17Actions upon reception of SystemInformationBlockType10 (46)5.2.2.18Actions upon reception of SystemInformationBlockType11 (46)5.2.2.19Actions upon reception of SystemInformationBlockType12 (47)5.2.2.20Actions upon reception of SystemInformationBlockType13 (48)5.2.2.21Actions upon reception of SystemInformationBlockType14 (48)5.2.2.22Actions upon reception of SystemInformationBlockType15 (48)5.2.2.23Actions upon reception of SystemInformationBlockType16 (48)5.2.2.24Actions upon reception of SystemInformationBlockType17 (48)5.2.2.25Actions upon reception of SystemInformationBlockType18 (48)5.2.2.26Actions upon reception of SystemInformationBlockType19 (49)5.2.3Acquisition of an SI message (49)5.2.3a Acquisition of an SI message by BL UE or UE in CE or a NB-IoT UE (50)5.3Connection control (50)5.3.1Introduction (50)5.3.1.1RRC connection control (50)5.3.1.2Security (52)5.3.1.2a RN security (53)5.3.1.3Connected mode mobility (53)5.3.1.4Connection control in NB-IoT (54)5.3.2Paging (55)5.3.2.1General (55)5.3.2.2Initiation (55)5.3.2.3Reception of the Paging message by the UE (55)5.3.3RRC connection establishment (56)5.3.3.1General (56)5.3.3.1a Conditions for establishing RRC Connection for sidelink communication/ discovery (58)5.3.3.2Initiation (59)5.3.3.3Actions related to transmission of RRCConnectionRequest message (63)5.3.3.3a Actions related to transmission of RRCConnectionResumeRequest message (64)5.3.3.4Reception of the RRCConnectionSetup by the UE (64)5.3.3.4a Reception of the RRCConnectionResume by the UE (66)5.3.3.5Cell re-selection while T300, T302, T303, T305, T306, or T308 is running (68)5.3.3.6T300 expiry (68)5.3.3.7T302, T303, T305, T306, or T308 expiry or stop (69)5.3.3.8Reception of the RRCConnectionReject by the UE (70)5.3.3.9Abortion of RRC connection establishment (71)5.3.3.10Handling of SSAC related parameters (71)5.3.3.11Access barring check (72)5.3.3.12EAB check (73)5.3.3.13Access barring check for ACDC (73)5.3.3.14Access Barring check for NB-IoT (74)5.3.4Initial security activation (75)5.3.4.1General (75)5.3.4.2Initiation (76)5.3.4.3Reception of the SecurityModeCommand by the UE (76)5.3.5RRC connection reconfiguration (77)5.3.5.1General (77)5.3.5.2Initiation (77)5.3.5.3Reception of an RRCConnectionReconfiguration not including the mobilityControlInfo by theUE (77)5.3.5.4Reception of an RRCConnectionReconfiguration including the mobilityControlInfo by the UE(handover) (79)5.3.5.5Reconfiguration failure (83)5.3.5.6T304 expiry (handover failure) (83)5.3.5.7Void (84)5.3.5.7a T307 expiry (SCG change failure) (84)5.3.5.8Radio Configuration involving full configuration option (84)5.3.6Counter check (86)5.3.6.1General (86)5.3.6.2Initiation (86)5.3.6.3Reception of the CounterCheck message by the UE (86)5.3.7RRC connection re-establishment (87)5.3.7.1General (87)5.3.7.2Initiation (87)5.3.7.3Actions following cell selection while T311 is running (88)5.3.7.4Actions related to transmission of RRCConnectionReestablishmentRequest message (89)5.3.7.5Reception of the RRCConnectionReestablishment by the UE (89)5.3.7.6T311 expiry (91)5.3.7.7T301 expiry or selected cell no longer suitable (91)5.3.7.8Reception of RRCConnectionReestablishmentReject by the UE (91)5.3.8RRC connection release (92)5.3.8.1General (92)5.3.8.2Initiation (92)5.3.8.3Reception of the RRCConnectionRelease by the UE (92)5.3.8.4T320 expiry (93)5.3.9RRC connection release requested by upper layers (93)5.3.9.1General (93)5.3.9.2Initiation (93)5.3.10Radio resource configuration (93)5.3.10.0General (93)5.3.10.1SRB addition/ modification (94)5.3.10.2DRB release (95)5.3.10.3DRB addition/ modification (95)5.3.10.3a1DC specific DRB addition or reconfiguration (96)5.3.10.3a2LWA specific DRB addition or reconfiguration (98)5.3.10.3a3LWIP specific DRB addition or reconfiguration (98)5.3.10.3a SCell release (99)5.3.10.3b SCell addition/ modification (99)5.3.10.3c PSCell addition or modification (99)5.3.10.4MAC main reconfiguration (99)5.3.10.5Semi-persistent scheduling reconfiguration (100)5.3.10.6Physical channel reconfiguration (100)5.3.10.7Radio Link Failure Timers and Constants reconfiguration (101)5.3.10.8Time domain measurement resource restriction for serving cell (101)5.3.10.9Other configuration (102)5.3.10.10SCG reconfiguration (103)5.3.10.11SCG dedicated resource configuration (104)5.3.10.12Reconfiguration SCG or split DRB by drb-ToAddModList (105)5.3.10.13Neighbour cell information reconfiguration (105)5.3.10.14Void (105)5.3.10.15Sidelink dedicated configuration (105)5.3.10.16T370 expiry (106)5.3.11Radio link failure related actions (107)5.3.11.1Detection of physical layer problems in RRC_CONNECTED (107)5.3.11.2Recovery of physical layer problems (107)5.3.11.3Detection of radio link failure (107)5.3.12UE actions upon leaving RRC_CONNECTED (109)5.3.13UE actions upon PUCCH/ SRS release request (110)5.3.14Proximity indication (110)5.3.14.1General (110)5.3.14.2Initiation (111)5.3.14.3Actions related to transmission of ProximityIndication message (111)5.3.15Void (111)5.4Inter-RAT mobility (111)5.4.1Introduction (111)5.4.2Handover to E-UTRA (112)5.4.2.1General (112)5.4.2.2Initiation (112)5.4.2.3Reception of the RRCConnectionReconfiguration by the UE (112)5.4.2.4Reconfiguration failure (114)5.4.2.5T304 expiry (handover to E-UTRA failure) (114)5.4.3Mobility from E-UTRA (114)5.4.3.1General (114)5.4.3.2Initiation (115)5.4.3.3Reception of the MobilityFromEUTRACommand by the UE (115)5.4.3.4Successful completion of the mobility from E-UTRA (116)5.4.3.5Mobility from E-UTRA failure (117)5.4.4Handover from E-UTRA preparation request (CDMA2000) (117)5.4.4.1General (117)5.4.4.2Initiation (118)5.4.4.3Reception of the HandoverFromEUTRAPreparationRequest by the UE (118)5.4.5UL handover preparation transfer (CDMA2000) (118)5.4.5.1General (118)5.4.5.2Initiation (118)5.4.5.3Actions related to transmission of the ULHandoverPreparationTransfer message (119)5.4.5.4Failure to deliver the ULHandoverPreparationTransfer message (119)5.4.6Inter-RAT cell change order to E-UTRAN (119)5.4.6.1General (119)5.4.6.2Initiation (119)5.4.6.3UE fails to complete an inter-RAT cell change order (119)5.5Measurements (120)5.5.1Introduction (120)5.5.2Measurement configuration (121)5.5.2.1General (121)5.5.2.2Measurement identity removal (122)5.5.2.2a Measurement identity autonomous removal (122)5.5.2.3Measurement identity addition/ modification (123)5.5.2.4Measurement object removal (124)5.5.2.5Measurement object addition/ modification (124)5.5.2.6Reporting configuration removal (126)5.5.2.7Reporting configuration addition/ modification (127)5.5.2.8Quantity configuration (127)5.5.2.9Measurement gap configuration (127)5.5.2.10Discovery signals measurement timing configuration (128)5.5.2.11RSSI measurement timing configuration (128)5.5.3Performing measurements (128)5.5.3.1General (128)5.5.3.2Layer 3 filtering (131)5.5.4Measurement report triggering (131)5.5.4.1General (131)5.5.4.2Event A1 (Serving becomes better than threshold) (135)5.5.4.3Event A2 (Serving becomes worse than threshold) (136)5.5.4.4Event A3 (Neighbour becomes offset better than PCell/ PSCell) (136)5.5.4.5Event A4 (Neighbour becomes better than threshold) (137)5.5.4.6Event A5 (PCell/ PSCell becomes worse than threshold1 and neighbour becomes better thanthreshold2) (138)5.5.4.6a Event A6 (Neighbour becomes offset better than SCell) (139)5.5.4.7Event B1 (Inter RAT neighbour becomes better than threshold) (139)5.5.4.8Event B2 (PCell becomes worse than threshold1 and inter RAT neighbour becomes better thanthreshold2) (140)5.5.4.9Event C1 (CSI-RS resource becomes better than threshold) (141)5.5.4.10Event C2 (CSI-RS resource becomes offset better than reference CSI-RS resource) (141)5.5.4.11Event W1 (WLAN becomes better than a threshold) (142)5.5.4.12Event W2 (All WLAN inside WLAN mobility set becomes worse than threshold1 and a WLANoutside WLAN mobility set becomes better than threshold2) (142)5.5.4.13Event W3 (All WLAN inside WLAN mobility set becomes worse than a threshold) (143)5.5.5Measurement reporting (144)5.5.6Measurement related actions (148)5.5.6.1Actions upon handover and re-establishment (148)5.5.6.2Speed dependant scaling of measurement related parameters (149)5.5.7Inter-frequency RSTD measurement indication (149)5.5.7.1General (149)5.5.7.2Initiation (150)5.5.7.3Actions related to transmission of InterFreqRSTDMeasurementIndication message (150)5.6Other (150)5.6.0General (150)5.6.1DL information transfer (151)5.6.1.1General (151)5.6.1.2Initiation (151)5.6.1.3Reception of the DLInformationTransfer by the UE (151)5.6.2UL information transfer (151)5.6.2.1General (151)5.6.2.2Initiation (151)5.6.2.3Actions related to transmission of ULInformationTransfer message (152)5.6.2.4Failure to deliver ULInformationTransfer message (152)5.6.3UE capability transfer (152)5.6.3.1General (152)5.6.3.2Initiation (153)5.6.3.3Reception of the UECapabilityEnquiry by the UE (153)5.6.4CSFB to 1x Parameter transfer (157)5.6.4.1General (157)5.6.4.2Initiation (157)5.6.4.3Actions related to transmission of CSFBParametersRequestCDMA2000 message (157)5.6.4.4Reception of the CSFBParametersResponseCDMA2000 message (157)5.6.5UE Information (158)5.6.5.1General (158)5.6.5.2Initiation (158)5.6.5.3Reception of the UEInformationRequest message (158)5.6.6 Logged Measurement Configuration (159)5.6.6.1General (159)5.6.6.2Initiation (160)5.6.6.3Reception of the LoggedMeasurementConfiguration by the UE (160)5.6.6.4T330 expiry (160)5.6.7 Release of Logged Measurement Configuration (160)5.6.7.1General (160)5.6.7.2Initiation (160)5.6.8 Measurements logging (161)5.6.8.1General (161)5.6.8.2Initiation (161)5.6.9In-device coexistence indication (163)5.6.9.1General (163)5.6.9.2Initiation (164)5.6.9.3Actions related to transmission of InDeviceCoexIndication message (164)5.6.10UE Assistance Information (165)5.6.10.1General (165)5.6.10.2Initiation (166)5.6.10.3Actions related to transmission of UEAssistanceInformation message (166)5.6.11 Mobility history information (166)5.6.11.1General (166)5.6.11.2Initiation (166)5.6.12RAN-assisted WLAN interworking (167)5.6.12.1General (167)5.6.12.2Dedicated WLAN offload configuration (167)5.6.12.3WLAN offload RAN evaluation (167)5.6.12.4T350 expiry or stop (167)5.6.12.5Cell selection/ re-selection while T350 is running (168)5.6.13SCG failure information (168)5.6.13.1General (168)5.6.13.2Initiation (168)5.6.13.3Actions related to transmission of SCGFailureInformation message (168)5.6.14LTE-WLAN Aggregation (169)5.6.14.1Introduction (169)5.6.14.2Reception of LWA configuration (169)5.6.14.3Release of LWA configuration (170)5.6.15WLAN connection management (170)5.6.15.1Introduction (170)5.6.15.2WLAN connection status reporting (170)5.6.15.2.1General (170)5.6.15.2.2Initiation (171)5.6.15.2.3Actions related to transmission of WLANConnectionStatusReport message (171)5.6.15.3T351 Expiry (WLAN connection attempt timeout) (171)5.6.15.4WLAN status monitoring (171)5.6.16RAN controlled LTE-WLAN interworking (172)5.6.16.1General (172)5.6.16.2WLAN traffic steering command (172)5.6.17LTE-WLAN aggregation with IPsec tunnel (173)5.6.17.1General (173)5.7Generic error handling (174)5.7.1General (174)5.7.2ASN.1 violation or encoding error (174)5.7.3Field set to a not comprehended value (174)5.7.4Mandatory field missing (174)5.7.5Not comprehended field (176)5.8MBMS (176)5.8.1Introduction (176)5.8.1.1General (176)5.8.1.2Scheduling (176)5.8.1.3MCCH information validity and notification of changes (176)5.8.2MCCH information acquisition (178)5.8.2.1General (178)5.8.2.2Initiation (178)5.8.2.3MCCH information acquisition by the UE (178)5.8.2.4Actions upon reception of the MBSFNAreaConfiguration message (178)5.8.2.5Actions upon reception of the MBMSCountingRequest message (179)5.8.3MBMS PTM radio bearer configuration (179)5.8.3.1General (179)5.8.3.2Initiation (179)5.8.3.3MRB establishment (179)5.8.3.4MRB release (179)5.8.4MBMS Counting Procedure (179)5.8.4.1General (179)5.8.4.2Initiation (180)5.8.4.3Reception of the MBMSCountingRequest message by the UE (180)5.8.5MBMS interest indication (181)5.8.5.1General (181)5.8.5.2Initiation (181)5.8.5.3Determine MBMS frequencies of interest (182)5.8.5.4Actions related to transmission of MBMSInterestIndication message (183)5.8a SC-PTM (183)5.8a.1Introduction (183)5.8a.1.1General (183)5.8a.1.2SC-MCCH scheduling (183)5.8a.1.3SC-MCCH information validity and notification of changes (183)5.8a.1.4Procedures (184)5.8a.2SC-MCCH information acquisition (184)5.8a.2.1General (184)5.8a.2.2Initiation (184)5.8a.2.3SC-MCCH information acquisition by the UE (184)5.8a.2.4Actions upon reception of the SCPTMConfiguration message (185)5.8a.3SC-PTM radio bearer configuration (185)5.8a.3.1General (185)5.8a.3.2Initiation (185)5.8a.3.3SC-MRB establishment (185)5.8a.3.4SC-MRB release (185)5.9RN procedures (186)5.9.1RN reconfiguration (186)5.9.1.1General (186)5.9.1.2Initiation (186)5.9.1.3Reception of the RNReconfiguration by the RN (186)5.10Sidelink (186)5.10.1Introduction (186)5.10.1a Conditions for sidelink communication operation (187)5.10.2Sidelink UE information (188)5.10.2.1General (188)5.10.2.2Initiation (189)5.10.2.3Actions related to transmission of SidelinkUEInformation message (193)5.10.3Sidelink communication monitoring (195)5.10.6Sidelink discovery announcement (198)5.10.6a Sidelink discovery announcement pool selection (201)5.10.6b Sidelink discovery announcement reference carrier selection (201)5.10.7Sidelink synchronisation information transmission (202)5.10.7.1General (202)5.10.7.2Initiation (203)5.10.7.3Transmission of SLSS (204)5.10.7.4Transmission of MasterInformationBlock-SL message (205)5.10.7.5Void (206)5.10.8Sidelink synchronisation reference (206)5.10.8.1General (206)5.10.8.2Selection and reselection of synchronisation reference UE (SyncRef UE) (206)5.10.9Sidelink common control information (207)5.10.9.1General (207)5.10.9.2Actions related to reception of MasterInformationBlock-SL message (207)5.10.10Sidelink relay UE operation (207)5.10.10.1General (207)5.10.10.2AS-conditions for relay related sidelink communication transmission by sidelink relay UE (207)5.10.10.3AS-conditions for relay PS related sidelink discovery transmission by sidelink relay UE (208)5.10.10.4Sidelink relay UE threshold conditions (208)5.10.11Sidelink remote UE operation (208)5.10.11.1General (208)5.10.11.2AS-conditions for relay related sidelink communication transmission by sidelink remote UE (208)5.10.11.3AS-conditions for relay PS related sidelink discovery transmission by sidelink remote UE (209)5.10.11.4Selection and reselection of sidelink relay UE (209)5.10.11.5Sidelink remote UE threshold conditions (210)6Protocol data units, formats and parameters (tabular & ASN.1) (210)6.1General (210)6.2RRC messages (212)6.2.1General message structure (212)–EUTRA-RRC-Definitions (212)–BCCH-BCH-Message (212)–BCCH-DL-SCH-Message (212)–BCCH-DL-SCH-Message-BR (213)–MCCH-Message (213)–PCCH-Message (213)–DL-CCCH-Message (214)–DL-DCCH-Message (214)–UL-CCCH-Message (214)–UL-DCCH-Message (215)–SC-MCCH-Message (215)6.2.2Message definitions (216)–CounterCheck (216)–CounterCheckResponse (217)–CSFBParametersRequestCDMA2000 (217)–CSFBParametersResponseCDMA2000 (218)–DLInformationTransfer (218)–HandoverFromEUTRAPreparationRequest (CDMA2000) (219)–InDeviceCoexIndication (220)–InterFreqRSTDMeasurementIndication (222)–LoggedMeasurementConfiguration (223)–MasterInformationBlock (225)–MBMSCountingRequest (226)–MBMSCountingResponse (226)–MBMSInterestIndication (227)–MBSFNAreaConfiguration (228)–MeasurementReport (228)–MobilityFromEUTRACommand (229)–Paging (232)–ProximityIndication (233)–RNReconfiguration (234)–RNReconfigurationComplete (234)–RRCConnectionReconfiguration (235)–RRCConnectionReconfigurationComplete (240)–RRCConnectionReestablishment (241)–RRCConnectionReestablishmentComplete (241)–RRCConnectionReestablishmentReject (242)–RRCConnectionReestablishmentRequest (243)–RRCConnectionReject (243)–RRCConnectionRelease (244)–RRCConnectionResume (248)–RRCConnectionResumeComplete (249)–RRCConnectionResumeRequest (250)–RRCConnectionRequest (250)–RRCConnectionSetup (251)–RRCConnectionSetupComplete (252)–SCGFailureInformation (253)–SCPTMConfiguration (254)–SecurityModeCommand (255)–SecurityModeComplete (255)–SecurityModeFailure (256)–SidelinkUEInformation (256)–SystemInformation (258)–SystemInformationBlockType1 (259)–UEAssistanceInformation (264)–UECapabilityEnquiry (265)–UECapabilityInformation (266)–UEInformationRequest (267)–UEInformationResponse (267)–ULHandoverPreparationTransfer (CDMA2000) (273)–ULInformationTransfer (274)–WLANConnectionStatusReport (274)6.3RRC information elements (275)6.3.1System information blocks (275)–SystemInformationBlockType2 (275)–SystemInformationBlockType3 (279)–SystemInformationBlockType4 (282)–SystemInformationBlockType5 (283)–SystemInformationBlockType6 (287)–SystemInformationBlockType7 (289)–SystemInformationBlockType8 (290)–SystemInformationBlockType9 (295)–SystemInformationBlockType10 (295)–SystemInformationBlockType11 (296)–SystemInformationBlockType12 (297)–SystemInformationBlockType13 (297)–SystemInformationBlockType14 (298)–SystemInformationBlockType15 (298)–SystemInformationBlockType16 (299)–SystemInformationBlockType17 (300)–SystemInformationBlockType18 (301)–SystemInformationBlockType19 (301)–SystemInformationBlockType20 (304)6.3.2Radio resource control information elements (304)–AntennaInfo (304)–AntennaInfoUL (306)–CQI-ReportConfig (307)–CQI-ReportPeriodicProcExtId (314)–CrossCarrierSchedulingConfig (314)–CSI-IM-Config (315)–CSI-IM-ConfigId (315)–CSI-RS-Config (317)–CSI-RS-ConfigEMIMO (318)–CSI-RS-ConfigNZP (319)–CSI-RS-ConfigNZPId (320)–CSI-RS-ConfigZP (321)–CSI-RS-ConfigZPId (321)–DMRS-Config (321)–DRB-Identity (322)–EPDCCH-Config (322)–EIMTA-MainConfig (324)–LogicalChannelConfig (325)–LWA-Configuration (326)–LWIP-Configuration (326)–RCLWI-Configuration (327)–MAC-MainConfig (327)–P-C-AndCBSR (332)–PDCCH-ConfigSCell (333)–PDCP-Config (334)–PDSCH-Config (337)–PDSCH-RE-MappingQCL-ConfigId (339)–PHICH-Config (339)–PhysicalConfigDedicated (339)–P-Max (344)–PRACH-Config (344)–PresenceAntennaPort1 (346)–PUCCH-Config (347)–PUSCH-Config (351)–RACH-ConfigCommon (355)–RACH-ConfigDedicated (357)–RadioResourceConfigCommon (358)–RadioResourceConfigDedicated (362)–RLC-Config (367)–RLF-TimersAndConstants (369)–RN-SubframeConfig (370)–SchedulingRequestConfig (371)–SoundingRS-UL-Config (372)–SPS-Config (375)–TDD-Config (376)–TimeAlignmentTimer (377)–TPC-PDCCH-Config (377)–TunnelConfigLWIP (378)–UplinkPowerControl (379)–WLAN-Id-List (382)–WLAN-MobilityConfig (382)6.3.3Security control information elements (382)–NextHopChainingCount (382)–SecurityAlgorithmConfig (383)–ShortMAC-I (383)6.3.4Mobility control information elements (383)–AdditionalSpectrumEmission (383)–ARFCN-ValueCDMA2000 (383)–ARFCN-ValueEUTRA (384)–ARFCN-ValueGERAN (384)–ARFCN-ValueUTRA (384)–BandclassCDMA2000 (384)–BandIndicatorGERAN (385)–CarrierFreqCDMA2000 (385)–CarrierFreqGERAN (385)–CellIndexList (387)–CellReselectionPriority (387)–CellSelectionInfoCE (387)–CellReselectionSubPriority (388)–CSFB-RegistrationParam1XRTT (388)–CellGlobalIdEUTRA (389)–CellGlobalIdUTRA (389)–CellGlobalIdGERAN (390)–CellGlobalIdCDMA2000 (390)–CellSelectionInfoNFreq (391)–CSG-Identity (391)–FreqBandIndicator (391)–MobilityControlInfo (391)–MobilityParametersCDMA2000 (1xRTT) (393)–MobilityStateParameters (394)–MultiBandInfoList (394)–NS-PmaxList (394)–PhysCellId (395)–PhysCellIdRange (395)–PhysCellIdRangeUTRA-FDDList (395)–PhysCellIdCDMA2000 (396)–PhysCellIdGERAN (396)–PhysCellIdUTRA-FDD (396)–PhysCellIdUTRA-TDD (396)–PLMN-Identity (397)–PLMN-IdentityList3 (397)–PreRegistrationInfoHRPD (397)–Q-QualMin (398)–Q-RxLevMin (398)–Q-OffsetRange (398)–Q-OffsetRangeInterRAT (399)–ReselectionThreshold (399)–ReselectionThresholdQ (399)–SCellIndex (399)–ServCellIndex (400)–SpeedStateScaleFactors (400)–SystemInfoListGERAN (400)–SystemTimeInfoCDMA2000 (401)–TrackingAreaCode (401)–T-Reselection (402)–T-ReselectionEUTRA-CE (402)6.3.5Measurement information elements (402)–AllowedMeasBandwidth (402)–CSI-RSRP-Range (402)–Hysteresis (402)–LocationInfo (403)–MBSFN-RSRQ-Range (403)–MeasConfig (404)–MeasDS-Config (405)–MeasGapConfig (406)–MeasId (407)–MeasIdToAddModList (407)–MeasObjectCDMA2000 (408)–MeasObjectEUTRA (408)–MeasObjectGERAN (412)–MeasObjectId (412)–MeasObjectToAddModList (412)–MeasObjectUTRA (413)–ReportConfigEUTRA (422)–ReportConfigId (425)–ReportConfigInterRAT (425)–ReportConfigToAddModList (428)–ReportInterval (429)–RSRP-Range (429)–RSRQ-Range (430)–RSRQ-Type (430)–RS-SINR-Range (430)–RSSI-Range-r13 (431)–TimeToTrigger (431)–UL-DelayConfig (431)–WLAN-CarrierInfo (431)–WLAN-RSSI-Range (432)–WLAN-Status (432)6.3.6Other information elements (433)–AbsoluteTimeInfo (433)–AreaConfiguration (433)–C-RNTI (433)–DedicatedInfoCDMA2000 (434)–DedicatedInfoNAS (434)–FilterCoefficient (434)–LoggingDuration (434)–LoggingInterval (435)–MeasSubframePattern (435)–MMEC (435)–NeighCellConfig (435)–OtherConfig (436)–RAND-CDMA2000 (1xRTT) (437)–RAT-Type (437)–ResumeIdentity (437)–RRC-TransactionIdentifier (438)–S-TMSI (438)–TraceReference (438)–UE-CapabilityRAT-ContainerList (438)–UE-EUTRA-Capability (439)–UE-RadioPagingInfo (469)–UE-TimersAndConstants (469)–VisitedCellInfoList (470)–WLAN-OffloadConfig (470)6.3.7MBMS information elements (472)–MBMS-NotificationConfig (472)–MBMS-ServiceList (473)–MBSFN-AreaId (473)–MBSFN-AreaInfoList (473)–MBSFN-SubframeConfig (474)–PMCH-InfoList (475)6.3.7a SC-PTM information elements (476)–SC-MTCH-InfoList (476)–SCPTM-NeighbourCellList (478)6.3.8Sidelink information elements (478)–SL-CommConfig (478)–SL-CommResourcePool (479)–SL-CP-Len (480)–SL-DiscConfig (481)–SL-DiscResourcePool (483)–SL-DiscTxPowerInfo (485)–SL-GapConfig (485)。
REFINITIVDATASCOPE SELECTVERSION 14.0 RELEASE NOTESDOCUMENT VERSION 1.1Date of Issue: May 2020Legal Information © Refinitiv 2020. All Rights Reserved. Republication or redistribution of Refinitiv content, including by framing or similar means, is prohibited without the prior written consent of Refinitiv. Refinitiv and the Refinitiv logo are trademarks of Refinitiv and its affiliated companies.Contents ContentsAbout this Document (4)Overview (4)In this Document (4)Related Documentation (4)Service & Support (5)Feedback (5)Your Personal Information (5)Release Highlights (6)Announcements (8)Production Environment Migration (8)New Date for Removing Legacy Timeseries Pricing / Single Historical Price Reports (8)Service Performance Enhancements (8)DataScope Select 14.0 Release Notes (9)Adoption of the Refinitiv Brand (9)Release Highlights by Report Type (9)Third-Party Data Changes (12)Refinitiv Evaluated Pricing Service (12)New & Updated Fields (13)New Fields (13)Expanded Field Coverage (17)Updated Field Coverage (18)Field Mapping Updates (18)Field Permissioning Updates (19)Field Data Type Changes (19)Field Definition Changes (20)About this DocumentOverviewDataScope Select is a hosted data extraction platform that provides access to global pricing,validated terms and conditions, historical data content, corporate actions, cross-reference and legal entity and compliance data. Cross-asset support includes equities, funds, derivatives, money/foreign exchange, warrants, fixed income securities, commodities and sell-side estimates, as well as user-defined securities (credit default swap, interest rate swap, and over-the-counter equity optioncontracts).In this DocumentThis document details the new and enhanced features and content available in the DataScope SelectRelated DocumentationThe complete DataScope Select documentation set is available on the DataScope Select product page via MyRefinitiv.The DataScope Select documentation set includes:•Quick Start GuideGets you started using the DataScope Select user interface and provides a high-leveloverview of the extraction creation process. This document is intended for users who are newto the DataScope Select product.•User GuideProvides an overview of the DataScope Select user interface and instructions for creatinginstrument lists, report templates, and schedules for extractions. This comprehensivedocument provides details related to each step in the extraction creation process.•Data Content GuideProvides definitions, data types, and maximum field widths for all data fields available forextraction. Fields are presented by report template type in Excel format, which allows foreasy viewing, filtering and integration into your own internal systems.•FTP User GuideDescribes the DataScope Select FTP Hosted Service and provides instructions for creatingthe report request file required for transferring input lists, report templates, and schedules.•REST API HelpRest API Help enables you to explore the API Reference Tree for the most detailed APIdocumentation, supplemented by working C# and HTTP code examples and thoroughexplanations of key REST API processing principles. REST API Help is available via theDataScope Select Help menu.•SOAP API Programmer GuidesThis three-document set provides instructions for using the SOAP API. Note that the SOAPAPI has been replaced with the Rest API, DataScope Sele ct’s n ext generation API designedaround REST (Representational State Transfer) architecture. Client are encouraged to usethe REST API I to take advantage of the full offering of extraction capabilities available inDataScope Select.•ISO 15022 User GuideIntroduces the ISO 15022 Service and provides detailed information on the event coverageavailable via DataScope Select. Also describes the process for retrieving and understandingequity- and fixed income-related messages processed via the DataScope SelectHTTP/HTTPS and FTP/SFTP platforms.Service & SupportThe Refinitiv Statement of Service is available on MyRefinitiv. MyRefinitiv is the Refinitiv portal that provides a single access point for timesaving support services, along with billing, user management, and information. For support using DataScope Select, please raise a query by accessing Help & Support at MyRefinitiv.You are encouraged to subscribe to the following support channels to keep informed of changes to products and data, and to be notified of any service issues or changes:•Change Notifications•Product change notifications detail new, enhanced, or changed functionality, which may require your action, in products that you use.•Content change notifications alert you to upcoming changes to real-time and historical data across all asset classes that are relevant to you.•RIC change notifications inform you of planned changes to Reuters Instrument Codes.•Service AlertsYou can subscribe to alerts about planned maintenance and unplanned service issuesaffecting your products and services, and be notified via SMS or email.FeedbackWe invite your comments, corrections, and suggestions about this document: access the Feedback option under Help & Support at MyRefinitiv. Your feedback helps us continue to improve our user assistance.Your Personal InformationRefinitiv is committed to the responsible handling and protection of personal information. We invite you to review our Privacy Statement, which describes how we collect, use, disclose, transfer, and store personal information when needed to provide our services and for our operational and business purposes.Release HighlightsThe following table summarizes the new and updated features and content to be implemented in DataScope Select 14.0, preceded by important announcements.Production Environment Migration•As announced in PCN 11664, Refinitiv will carry out a change to migrate DataScope Select to an alternate production environment for the current production environment. The move to the new site provides a modern production environment that supports high performance, reliability and availability. The migration will occur as part of the20-21 June 2020 weekend maintenance activities.•As of the migration date, the DNS for all DataScope Select URLs (Internet and Private access) will switch to the alternate environment. If you access DataScope Select via hostname-based URLs, you will be routed to the new environment automatically. This is the recommended best practice for accessing DataScope Select, as this configuration requires no changes to youraccess scripts or browser bookmarks.•If you access DataScope Select via IP addresses, you will need to update your access scripts and firewalls with the new IPs, originally made available for the April testing. Rerouting to the new environment as of the implementation date will not happen automatically if you are using IP addresses.•To ensure preparedness for the migration, Refinitiv requires that DataScope Select clients confirm their connectivity to the new environment. A testing opportunity will be available on 07 June 2020. From 00:30-03:30 GMT, clients will be able to test connectivity to the newenvironment and validate DataScope Select functionality through the user interface, FTP and API platforms.•Please see PCN 11664 for the required actions for updating Internet and Private Network access via hostnames and IPs, as well as for details on the product impact during the testing window.New Date for Removing Legacy Timeseries Pricing / Single Historical Price Reports•As a reported to an update to PCN 10897, the date for removing Timeseries Pricing and Single Historical Price reports from DataScope Select in place of the Price History andSingle Price History reports has been postponed to 25 September 2020. Doing so will enable Refinitiv to continue addressing data mapping issues and allow clients additional testing time.•Updates will be added to the PCN as they are known. In the interim, please reach out to your local account team for assistance with the migration process.Service Performance Enhancements•To ensure the stability and continuity of DataScope Select service for all clients, we have implemented changes to REST API call limits and updated search rules across the API andAdoption of the Refinitiv BrandUser Interface Changes•In this release, the DataScope Select user interface will be updated to reflect the Refinitiv brand. These changes are visual only and include new product logos and updates to colors,fonts, etc. No client action is required, and there are no changes to content or functionality.Here is an example of the new Sign In screen:•Please note that updates to DataScope Select URLs to reflect the Refinitiv brand are currently under review will be announced in a future notification with ample notice to allow you toprepare for these updates.Release Highlights by Report TypeBond Schedules•The Bond Schedules report has been enhanced to include new fields for accessing Coupon Schedules data for government/corporate and municipal instruments. Access to these fieldsrequires MACE permissions.•Compounding Frequency Code•Compounding Frequency Description•Coupon Calculation Method Code•Coupon Calculation Method Description•Coupon Class Code•Coupon Class Code Description•Interest Rate Code•Interest Rate Description•Resettable Flag•Coverage of the existing Coupon Rate fields has been expanded to include municipalsComposite•The data retrieval logic for CIC for futures and options has been updated as part of an enhancement to remap CIC for exchange-traded instruments. Access to this field requiresPremium Reference permissioning.•The Shareholdings Disclosure offering has been updated to include additional MiFID and Shareholdings Disclosure fields. Previously, access to these fields in Composite reportsrequired Terms and Conditions and other permissions. Now, they will also be available toclients who have Shareholding Disclosure permissions.•Conversion Ratio•Conversion RIC•Most Relevant Market Segment MIC - ESMA•Most Relevant Market Segment MIC - FCA•Operating MIC•Relevant Competent Authority - ESMA•Relevant Competent Authority - FCAComposite & Terms and Conditions•New fields have been added to support the new Uniform Mortgage-Backed Security (UMBS) that was implemented by the FHFA, FHLMC, and FNMA as of 03 June 2019:•Has Mirror Pool CUSIP•Has Mirror Pool Exchanged Amount•Has Mirror Pool Exchanged Date•Is Mirror Pool•UMBS FlagComposite, Terms and Conditions, EOD Pricing & Ratings•Bank loan coverage has been expanded with the addition of three new fields: •Traded Item Signing Date•Deal Amendment Signing Date•Traded Item Subsequent Signing DateIntraday Pricing•Several new fields will be added in response to client requests.Price History / Single Price History•Universal Close Price for fixed income instruments and funds will now populate. This update will enable clients to migrate from the legacy Timeseries Pricing / Single Historical Pricereports, which will EOL on 25 September 2020.Price History / Single Price History & Elektron Timeseries•Null codes for reporting non-trading days in Price History / Single Price History and Elektron Timeseries reports have been added in this release. Now, when an extraction runs on a non-trading day, or there is no trading activity for that date, null codes, rather than blank fields, will be output in extractions. The following null codes are supported:•-9999401 - No trade, including suspended; no activity for money data•-9999402 - Market holidayNote that to retrieve null codes in extractions, you must have R eturn Null Code Values inExtraction Pricing Fields selected in your Preferences.•This enhancement aligns with current null code reporting in Timeseries Pricing and Single Price History extraction reporting and is intended for clients who are migrating from theselegacy reports to the new Price History and Single Price History reports.Ratings•New fields, LEI of the Rating Agency Branch and LEI of the Endorsing Rating Agency Branch, have been added to the Ratings report for Last Update queries only. These fields will beblank for Range and Schedule Delta queries. They will populate in a future release.Terms & Conditions•SFTR Security Type has been added to Terms and Conditions reports to identify the classification type of the security or collateral according to Securities Financing TransactionRegulation (SFTR). Examples of supported codes include:Third-Party Data ChangesNOTE: Please make sure to review the Quarterly Notification for a summary of product changes announced by our third-party data suppliers. This includes notifications of name, price andpolicy changes. Key third-party changes are identified belowStockholm Interbank Offered Rates Moving from NASDAQ to SFBF/GRSS •As announced in DN107791,the Administration and delivery of the Stockholm Interbank Offered Rates (STIBOR) will be transferred from NASDAQ to the Swedish FinancialBenchmark Facility (SFBF), subsidiary of Global Rate Set Systems (GRSS). New pricing and commercial policies will apply.•DataScope Select clients wishing to access real time STIBOR benchmarks, currently available via subscription to the Nasdaq Nordic Fixed Income Fixings (OMD) and Nasdaq Nordic Fixed Income Totalview (OMF) services, will be required to order the new real time STIBORSwedish Benchmark service and sign a direct subscription agreement with Swedish Financial Benchmark Facility (SFBF) prior to the data move. Embargoed 24 hour data will be available for Tick History and non-permissioned DataScope Select clients and redistributors.•Redistribution of both the real-time (SDSTIBOR) and delayed (SDSTIBORDLD) STIBOR benchmark content is allowed however prior approval and a direct subscription agreementwith the Swedish Financial Benchmark Facility (SFBF) are required prior to the data beingpermissionedReuters Polls Moving to Orderable, Fee-liable Service•As announced originally in the DataScope Select 13.2 Release Notes and in DN105137, and the updated in DN109295 full coverage of Reuters Polls for economic data, central bank policy rates, foreign exchange polls and money market/bond yield polls will move to an orderable,fee-liable service. This content is also available as a StarMine FTP for individual use.•DataScope Select and Tick History clients must have a license in place by 01 June 2020 to continue accessing this content. Please contact your account team for details.New Commercial Policy for DTCC US Corporates Reference Data •As announced in PCN 11656, due to a new commercial policy from the Depository Trust & Clearing Corporation (DTCC), the DTCC US Corporates Reference Data service, offered inDataScope products across several Refinitiv-owned packages, will become orderable and fee-liable.•As of 01 July 2020, access to reference data, including corporate actions events, amount outstanding and coupon changes, for DTCC-sourced US corporate bonds, will be available to entitled clients only. Please contact your account team for details.Refinitiv Evaluated Pricing ServiceAskTRPS Price Challenge Retention Update•AskTRPS has undergone a price challenge retention update to save two years of clients’ price challenges instead of the entire history. Please make sure to save your price challenges toyour computer to have a permanent record of them. DataScope Select is not intended to beused as an archiving service. Please contact your Refinitiv Evaluating Pricing ServiceSpecialist with questions or concerns.New & Updated FieldsNew FieldsBond SchedulesComposite & Terms and ConditionsElektron TimeseriesEOD PricingIntraday PricingPrice HistoryRatingsTick History Intraday SummariesClose Ask Size Close Bid Size High Ask Size High Bid Size Low Ask Size Low Bid Size Open Ask Size Open Bid Size EquityFutures & OptionsExpanded Field CoverageBond SchedulesComposite & EOD Pricing Composite & Terms and ConditionsPrice HistoryUpdated Field CoverageComposite, Terms and Conditions, EOD Pricing & RatingsField Mapping UpdatesField Permissioning Updates CompositeField Data Type ChangesAll ReportsField Definition Changes All ReportsIntraday Pricing。
《METTL14通过m6A修饰调节LINC02747在非小细胞肺癌的作用研究》篇一一、引言非小细胞肺癌(NSCLC)是肺癌的主要类型,其发病率和死亡率居高不下,已成为全球关注的健康问题。
因此,探究非小细胞肺癌的发生发展机制及其有效治疗策略具有重大的医学价值。
近年来,长链非编码RNA(lncRNA)在肿瘤发生发展中的调控作用逐渐受到关注。
其中,LINC02747作为一种新发现的lncRNA,在多种癌症中表现出重要的生物学功能。
而甲基转移酶相关蛋白14(METTL14)则是参与m6A(N6-甲基腺嘌呤)修饰的关键酶。
本文旨在探讨METTL14通过m6A修饰对LINC02747在非小细胞肺癌中的作用及机制。
二、研究背景与目的m6A修饰是一种常见的RNA修饰方式,对基因的表达具有重要影响。
METTL14作为m6A甲基转移酶的核心成分,其在RNA上的修饰作用广泛。
而LINC02747作为一种新发现的lncRNA,在多种癌症中表现出异常表达,其具体功能尚不明确。
因此,本研究旨在探讨METTL14通过m6A修饰对LINC02747在非小细胞肺癌中的调控作用及机制,以期为非小细胞肺癌的诊治提供新的思路和靶点。
三、研究方法本研究采用细胞实验、分子生物学实验及生物信息学分析等方法,首先通过生物信息学分析预测METTL14与LINC02747的关联;其次,通过细胞实验验证METTL14与LINC02747的相互作用;最后,探讨METTL14通过m6A修饰对LINC02747的表达及功能的影响。
四、研究结果1. 通过生物信息学分析,我们发现METTL14与LINC02747存在关联,提示两者可能在非小细胞肺癌中具有相互作用。
2. 细胞实验证实,METTL14与LINC02747在非小细胞肺癌细胞中存在相互作用,且这种相互作用受到m6A修饰的调控。
3. 分子生物学实验表明,METTL14通过m6A修饰调节LINC02747的表达,进而影响非小细胞肺癌细胞的增殖、迁移和侵袭等生物学行为。