胎盘部位滋养细胞肿瘤中NF-κBp65、CD44v6、Kiss-1的表达及相关性

胎盘部位滋养细胞肿瘤中NF-κBp65、CD44v6、Kiss-1的表达及相关性

辛礼辉;练玲芝;惠京

【期刊名称】《临床与实验病理学杂志》

【年(卷),期】2011(27)9

【摘 要】Purpose To investigate the significance of the expression and

correlation of NF-κBp65 , CD44v6 and Kiss-1 in placent site trophoblastic

tumor ( PSTT ). Methods The expression of NF-κBp65 , CD44v6 and Kiss-1 were detected in 20 normal chorionic villis,15 hydatidiform moles, 15

chorioepitheliomas, 10 PSTTs by immunohistochemisty PowerVision

method. Results There was a significant increasion of NF-κBp65 and

CD44v6 expression in the tissues of chorioepithelioma and PSTT compared

with that of chorionic villi and hydatidiform mole( P1 ＜ 0. 01 , P2 ＜ 0. 01 ).

And there was significant different NF-κBp65 expression between PSTT

and chorioepithelioma( P ＜ 0. 01 ). But no significant difference of

CD44v6 were found between PSTT and chorioepithelioma( P ＞ 0. 05 ).

There was a significant reduction of Kiss-1 expression in the tissues of

chorioepithelioma and PSTT compared with that of chorionic villi and

hydatidiform mole ( P ＜ 0. 01 ). But there was no significant difference

between PSTT and chorioepithelioma( P ＞ 0. 05 ). The expressions of NF-κBp65 and CD44v6 in all groups were positively correlation( r = 0. 356, P =

0. 005) , NF-κBp65 and Kiss-1 were negatively correlation( r = - 0. 527 ,P = 0. 000 ), CD44v6 and Kiss-1 were negatively correlation( r = - 0. 346, P =

0. 007 ). Conclusions The increased expression of NF-κBp65 and CD44v6

and the decreased expression of Kiss-1 may promote the invasion of PSTT.

They may play an important role in the invasion of PSTT.%目的 探讨细胞核因子-κBp65(NF-κBp65)、CD44v6、Kiss-1在胎盘部位滋养细胞肿瘤中的表达及相关性.方法 采用免疫组化PV 6000两步法检测20例正常早孕绒毛、15例葡萄胎、15例绒癌、10例胎盘部位滋养细胞肿瘤(placent site trophoblastic

tumor,PSTT)中NF-κBp65、CD44v6、Kiss-1的表达情况及相关性.结果 NF-κBp65、CD44v6分别在正常早孕绒毛、葡萄胎、PSTT、绒癌中表达呈升高趋势,差异有统计学意义(P1＜0.01、P2＜0.01).NF-κBp65、CD44v6在PSTT中表达高于正常早孕绒毛和葡萄胎中的表达,差异有统计学意义(P1＜0.01、P2＜0.01、P3＜0.01、P4＜0.05);NF-κBp65在PSTT和绒癌中表达差异有统计学意义(P＜0.01);CD44v6在PSTT和绒癌中表达差异无统计学意义(P>0.05).Kiss-1在正常早孕绒毛、葡萄胎、PSTT、绒癌中表达呈下降趋势,差异有统计学意义(P＜0.01).Kiss-1在PSTT中表达低于正常早孕绒毛和葡萄胎中的表达,差异有统计学意义(P1＜0.01,P2＜0.01);在PSTT和绒癌中表达差异无统计学意义(P>0.05).NF-κBp65和CD44v6呈正相关(r=0.356,P=0.005)和Kiss-1呈负相关(r=-0.527,P=0.000);CD44v6和Kiss-1呈负相关(r=-0.346,P=0.007).结论 NF-κBp65、CD44v6的高表达和Kiss-1的低表达可能在胎盘部位滋养细胞肿瘤的浸润转移中起重要作用.

【总页数】4页(P955-958)

【作 者】辛礼辉;练玲芝;惠京 【作者单位】天津医科大学病理学教研室,300070;天津医科大学病理学教研室,300070;天津医科大学病理学教研室,300070

【正文语种】中 文

【中图分类】R737.3

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