经肝动脉化疗栓塞联合肿瘤间质治疗肝癌临床研究

肝癌肿瘤切除术后患者应用肝动脉介入化疗栓塞术治疗的效果观察作者：王义大来源：《现代养生·上半月》2024年第04期【摘要】目的探討肝癌肿瘤切除术后患者应用肝动脉介入化疗栓塞术（TACE）对血清肿瘤指标及预后的影响。

方法选取医院2019年1月- 2020年6月收治的76例原发性肝癌患者作为研究对象，在组间基线资料均衡的原则上，随机分为对照组和观察组，各38例。

所有患者均采用肝癌肿瘤切除术治疗，观察组在术后给予TACE治疗，比较治疗前及治疗8周后两组患者血清甲胎蛋白（AFP）、甲胎蛋白异质体L3（AFP-L3）、高尔基体蛋白-73（GP-73）变化及3年生存情况。

结果治疗前，两组患者血清AFP、AFP-L3及GP-73F表达水平比较差异无统计学意义（P>0.05）；治疗8周后，两组患者的AFP、AFP-L3及GP-73F表达水平均明显降低，但观察组患者的各项指标均低于对照组，差异有统计学意义（P<0.05）。

两组患者1年生存率比较差异无统计学意义（P>0.05）；观察组患者2年生存率（81.57%）、3年生存率（65.79%）均高于对照组（52.63%和39.47%），差异有统计学意义（P<0.05）。

结论 TACE 可显著降低肝癌肿瘤切除术患者血清AFP、AFP-L3及GP-73等肿瘤指标，提高近期生存率，临床疗效满意。

【关键词】肝动脉介入栓塞术；肝癌；肿瘤因子；预后中图分类号 R735.7 文献标识码 A 文章编号 1671-0223（2024）07--03Observation on the therapeutic effect of transcatheter arterial chemoembolization in patients with liver cancer after tumor resection Wang Yida. General Surgery Department 2， Linyi Cancer Hospital， Linyi 276000， China【Abstract】 Objective To explore the effect of transcatheter arterial chemoembolization （TACE） on serum tumor markers and prognosis in patients after liver cancer tumor resection. Methods A total of 76 patients with primary liver cancer admitted to the hospital from January 2019 to June 2020 were selected as the study subjects. Based on the principle of balanced baseline data between groups， they were randomly divided into a control group and an observation group， with 38 cases in each group. All patients were treated with liver cancer tumor resection， and the observation group received TACE treatment after surgery. The serum levels of alpha fetoprotein （AFP）， alpha fetoprotein heterogeneity L3 （AFP L3）， golgi apparatus protein-73 （GP-73）， and 3-year survival status of the two groups of patients were compared before and 8 weeks after treatment.Results Before treatment， there was no statistically significant difference in the expression levels of serum AFP， AFP-L3， and GP-73F between the two groups of patients（P>0.05）; After 8 weeks of treatment， the expression levels of AFP， AFP-L3， and GP-73F in both groups of patients were significantly reduced， but the various indicators of the observation group were lower than those of the control group， with statistical significance （P<0.05）. There was no statistically significant difference in 1-year survival rates between the two groups of patients （P>0.05）; The 2-year survival rate （81.57%） and 3-year survival rate （65.79%） of the observation group patients were higher than those of the control group （52.63% and 39.47%），and the difference was statistically significant （P<0.05）. Conclusion TACE can significantly reduce serum tumor markers such as AFP， AFP-L3， and GP-73 in patients undergoing liver cancer tumor resection， improve short-term survival rate， and achieve satisfactory clinical efficacy.【Key words】 Transcatheter arterial chemoembolization; Hepatocellular carcinoma; Tumor factors; Prognosis原发性肝癌是临床三大恶性肿瘤之一，肝癌肿瘤切除术是原发性肝癌患者的首选治疗手段，但由于该病早期无明显症状，多数患者确诊时已为中晚期，单纯手术治疗很难达到根治的效果，导致预后生存时间短，生存质量差。