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2011药理考卷

2011药理考卷
2011药理考卷

2011-年药理学考试卷

专业班级学号姓名

核分人:

一、A型题(最佳选择题)

每题的备选答案中只有一个最佳答案。

(每小题1分,共40分)

1.药物与受体结合后,是激动受体还是阻断受体,取决于( ) A.药物剂量大小B.药物是否具有亲和力

C.药物作用强度D.药物是否具有内在活性E.药物脂溶性大小

2.某一弱碱性药物的pKa值为8.5,如果尿液pH值增加1个单位,则该药在尿液中非解离型与解离型浓度比( ) A.提高1倍B.提高2倍

C.提高10倍D.降低1倍

E.降低10倍

3.阿托品对内脏平滑肌松弛作用最显著的是( ) A.支气管平滑肌B.胆道平滑肌

C.胃幽门括约肌D.子宫平滑肌

E.痉挛状态的胃肠平滑肌

4.某药物的量效关系曲线因某种因素的影响而平行右移,则表明( ) A.作用机制改变B.效能改变

C.作用性质改变D.效价强度改变

E.作用靶点改变

5.某药物t1/2为8h,单剂量给药后,药物在体内基本消除完全所需的时间为

( ) A.10h 左右B.20h 左右

C.24h 左右D.40h 左右

E.120h 左右

6.连续用药极易产生耐受性的抗心绞痛药物是( ) A.硝酸甘油B.硝苯地平

C.硝普钠D.普萘洛尔

E.维拉帕米

7.一级动力学消除的特点( ) A.t1/2不是恒定值B.为一种恒速消除动力学

C.为一种少数药物的消除方式D.消除速度与初始血药浓度有关E.单位时间内实际消除的药量随时间递减

8.碘解磷定可解救有机磷农药中毒的药理基础是( ) A.促进胆碱酯酶再生B.生成磷酰化解磷定

C.生成磷酰化胆碱酯酶D.具有阿托品样作用

E.可促进乙酰胆碱再摄取

9.拮抗参数pA2等于( ) A.pK a B.pK B

C.- lg[B] D.pD2

E.E max

10.地西泮不具有下列哪项作用( ) A.抗惊厥作用B.对快动眼睡眠影响小

C.抗抑郁作用D.镇静、催眠、抗焦虑作用E.中枢性肌肉松弛作用

11.下列有关胰岛素的药理作用描述不正确的是( ) A.促进糖原分解B.促进葡萄糖氧化和酵解C.促进脂肪合成并抑制其分解D.激活细胞膜Na+-K+-ATP酶E.促进氨基酸转运和蛋白质合成

12.糖皮质激素诱发和加重感染的主要原因是( ) A.病人对激素不敏感B.激素用量不足

C.未同服足量、有效的抗菌药D.激素降低机体的防御能力E.激素促使病原微生物生长繁殖

13.金葡菌所致急慢性骨髓炎患者最好选用( ) A.金霉素B.林可霉素C.四环素

D.土霉素E.麦白霉素

14.第二代头孢菌素的特点中叙述错误的是( ) A.对铜绿假单胞菌有效B.肾毒性较第一代小

C.对多数G—菌作用明显增强D.对多种β—内酰胺酶较稳定E.对G+ 菌作用与第一代相仿或略差

15.H1和H2受体激动可引起的共同效应是( ) A.气管平滑肌收缩B.胃酸分泌增加C.心率加快

D.血管扩张E.肠蠕动增加

16.喹诺酮类药物抗革兰氏阳性菌的重要靶点是( ) A.细菌DNA回旋酶B.细菌二氢蝶酸合成酶

C.细菌二氢叶酸合成酶D.细菌肽酰基转移酶

E.细菌拓扑异构酶Ⅳ

17.可乐定的降压作用能被育亨宾所取消,但不受哌唑嗪的影响,说明可乐定的作用( ) A.与激动中枢的α2受体有关B.与激动中枢的α1受体有关C.与阻断中枢的α2受体有关D.与阻断中枢的α1受体有关E.与以上均无关

18.可用于治疗尿崩症的利尿药是( ) A.呋塞米B.氢氯噻嗪C.螺内酯D.氨苯蝶啶E.乙酰唑胺

19.以下微生物中不属于氨基糖苷类抗生素的抗菌谱范围的是( ) A.G-杆菌B.部分G+球菌C.厌氧菌D.结核杆菌E.绿脓杆菌

20.以下抗结核药物中不属于一线药的是( ) A.异烟肼B.利福平C.链霉素D.环丝氨酸E.乙胺丁醇

21.药物产生副反应的药理学基础是()A.药物所用剂量过大 B.患者的肝肾功能不良

C.药理效应的选择性低 D.血药浓度过高

E.患者产生特异质反应

22.以下具有首关效应的是()A.硝酸甘油舌下给药从口腔黏膜吸收经肝代谢后药效降低

B.肌注苯巴比妥被肝药酶代谢后,进入体循环药量减少

C.口服地西泮经肝药酶代谢后,进入体循环的药量减少

D.硫喷妥钠吸收后储存于脂肪组织使体循环药量减少

E.异丙肾上腺素雾化吸入经肝代谢后体循环药量减少

23.某一弱酸性药物在pH为3.4的液体中有50%的药物解离,则其pKa值约为()。

A.1.4 B.2.4 C.3.4 D.4.4 E.5.4

24.受体阻断药的含义是药物()

A.与受体有较强的亲和力,无内在活性

B.与受体有较强的亲和力,且有较强内在活性

C.与受体有较强的亲和力,但内在活性较弱

D.与受体有较弱的亲和力,但无内在活性

E.对受体的亲和力小而内在活性大

25.反复应用某一药物后,机体对该药的敏感性降低,称为()

A.依赖性 B.成瘾性 C.耐受性

D.习惯性 E.耐药性

26.阿托品抗感染性休克的主要机制是()

A.抗菌、抗毒素作用 B.抗迷走神经,兴奋心脏作用

C.解除血管痉挛,改善微循环 D.扩张支气管,缓解呼吸困难

E.兴奋中枢,对抗中枢抑制E.复活胆碱酯酶

27.无尿休克的患者宜选的药物是()

A.新斯的明 B.肾上腺素 C.去甲肾上腺素

D.可拉明 E.多巴胺

28.β受体阻断药()

A.可使心率加快、心排出量增加 B.有时可诱发或加重哮喘发作

C.促进脂肪分解 D.促进肾素分泌

E.升高眼内压作用

29.苯巴比妥连续应用产生耐药性的主要原因是()

A.被血浆中假性胆碱酯酶迅速水解破坏 B.诱导肝药酶使自身代谢加快

C.以原形经肾脏排泄加快 D.被单胺氧化酶迅速水解破坏

E.重新分布,储存于脂肪组织

30.诱导肝药酶,并可与其他药物产生相互作用的是()A.苯妥英钠 B.丙戊酸钠 C.乙琥胺D.硫酸镁 E.氯硝西泮

31.能反射性增加心肌耗氧量的降压药是()A.利血平B.肼屈嗪C.普萘洛尔

D.卡托普利E.氢氯噻嗪

32.抗消化性溃疡药的分类及代表药搭配正确的是()A.H2受体阻断药——奥美拉唑B.胃酸分泌抑制剂——氢氧化镁C.抗酸药——硫糖铝D.粘膜保护药——米索前列醇E.质子泵抑制剂——西米替丁

33.不属于氟喹诺酮类药物的药理学特点是()A.抗菌谱广,对G+和G-菌都有效B.口服较易吸收

C.适用于呼吸系统和尿路感染D.对支原体、衣原体敏感E.与头孢菌素有交叉耐药性

34.氯霉素的不良反应中与剂量、疗程无关的是()A.可逆性白细胞减少B.再生障碍性贫血C.二重感染D.灰婴综合征E.胃肠道反应

35.关于糖皮质激素抗炎机制不正确的是:()A.糖皮质激素结合受体,进入核内发挥作用

B.抑制炎症介质的产生与释放

C.减少脂皮素-1合成

D.抑制细胞因子的产生

E.抗炎的同时有可能降低机体的防御功能

36.大环内酯类药物对下述何菌无效()A.肺炎球菌B.流感杆菌C.大肠杆菌

D.军团菌E.结核杆菌

37.卡托普利的作用机制为()A.使血管紧张素Ⅱ生成减少B.竞争性拮抗血管紧张素Ⅱ

C.抑制肾素的生成D.直接扩张血管

E.抑制神经末稍释放去甲肾上腺素

38.抑制核苷酸还原酶的抗恶性肿瘤药是()A.氟尿嘧啶B.6-巯基嘌呤C.羟基脲

D.阿糖胞苷E.甲氨蝶呤

39.主要用于控制间日疟复发和传播的药物是:()A.奎宁B.伯氨喹C.氯喹

D.青蒿素E.乙胺嘧啶

40.服用四环素引起伪膜性肠炎,应如何抢救()A.服用头孢菌素B.服用林可霉素C.服用土霉素

D.服用万古霉素E.服用青霉素

二、填空题(每空1分,共10分)

1、药物的量效关系曲线可分为量反应和两种。

2、难以预料的不良反应有和特异质反应。

3、稳态血药浓度是指给药速度和相等。

4、药物的依赖性包括身体依赖性和。

5、N1受体主要分布于和肾上腺髓质嗜铬细胞。

6、多巴胺对肾脏的作用是舒张肾血管、增加肾血流量和。

7、普萘洛尔对心脏的不良反应表现为心力衰竭、等。

8、常用三环类抗抑郁药有、阿米替林等。

9、左旋多巴的不良反应主要由于左旋多巴在外周脱酸生成引起的。

10、吗啡急性中毒解救药物是。

三、名词解释(每题3分,共15分)1.效能

2.抗菌后效应

3.一级动力学消除

4.首过效应

5.调节痉挛

1、简述ACEI临床用途。

2、简述阿托品药理作用特点。

3、简述氨基糖苷类抗生素的不良反应。

4、简述抗消化性溃疡药物的分类。

1.为什么肾上腺素是抢救过敏性休克的首选药物?2.试述奎尼丁抗心律失常的药理学基础及临床应用。

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