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Select Publications
Researchers are successfully using the IncuCyte and live content imaging in a wide variety of scientific disciplines. We are proud to share this list of publications from the growing community of IncuCyte customers and collaborators. If we missed one, please send the citation to info@https://www.doczj.com/doc/f93546030.html,.
2013 Publications
Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway. McCormick AL, Roback L, Wynn G, Mocarski ES. Virology. 2013 Jan 20;435(2):250-7.
PMID: 23159167
The nanoparticulate Quillaja Saponin BBE is selectively active towards renal cell carcinoma. Hassan SB, Gullbo J, Hu K, Berenjian S, Morein B, Nygren P. Anticancer Res. 2013 Jan;33(1): 143-51.
PMID: 23267139
The molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function. Sütterlin P, Williams EJ, Chambers D, Saraf K, von Schack D, Reisenberg M, Doherty P, Williams G. Mol Cell Neurosci. 2013 Jan;52:20-30.
PMID: 23085403
2012 Publications
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors. McCormack E, Adams KJ, Hassan NJ, Kotian A, Lissin NM, Sami M, Muji? M, Osdal T, Gjertsen BT, Baker D, Powlesland AS, Aleksic M, Vuidepot A, Morteau O, Sutton DH, June CH, Kalos M, Ashfield R, Jakobsen BK. Cancer Immunol Immunother. 2012 Dec 22. [Epub ahead of print]
PMID: 23263452
Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides. Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Zhang W, Cheepala SB, Schuetz JD, Naren AP. J Biol Chem. 2012 Dec 21. [Epub ahead of print]
PMID: 23264633
Endoglin Requirement for BMP9 Signaling in Endothelial Cells Reveals New Mechanism of Action for Selective Anti-Endoglin Antibodies. Nolan-Stevaux O, Zhong W, Culp S, Shaffer K, Hoover J, Wickramasinghe D, Ruefli-Brasse A. PLoS One. 2012;7(12):e50920.
PMID: 23300529
Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1. Platonova N, Miquel G, Regenfuss B, Taouji S, Cursiefen C, Chevet E, Bikfalvi A. Blood. 2012 Dec 20.
PMID: 23264596
2
The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss. Feng Y, Wang Y, Wang Z, Fang Z, Li F, Gao Y, Liu H, Xiao T, Li F, Zhou Y, Zhai Q, Liu X, Sun Y, Bardeesy N, Wong KK, Chen H, Xiong ZQ, Ji H. Cancer Res. 2012 Dec 15;72(24):6502-6511. PMID: 23074285
Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec;303(12):C1292-300.
PMID: 23076793
Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis. Naik PK, Bozyk PD, Bentley JK, Popova AP, Birch CM, Wilke CA, Fry CD, White ES, Sisson TH, Tayob N, Carnemolla B, Orecchia P, Flaherty KR, Hershenson MB, Murray S, Martinez FJ, Moore BB; the COMET Investigators. Am J Physiol Lung Cell Mol Physiol. 2012 Dec;303(12):L1046-L1056. PMID: 23043074
Interferon-gamma-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells. Schmitt MJ, Philippidou D, Reinsbach SE, Margue C, Wienecke-Baldacchino A, Nashan D, Behrmann I, Kreis S. Cell Commun Signal. 2012 Dec 17;10(1):41.
PMID: 23245396
The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Todd JR, Scurr LL, Becker TM, Kefford RF, Rizos H. Oncogene. 2012 Dec 17.
PMID: 23246970
Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells. Ketola K, Kallioniemi O, Iljin K. PLoS One. 2012;7(12):e51470.
PMID: 23251544
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Sneddon JB, Borowiak M, Melton DA. Nature. 2012 Nov 29;491(7426):765-8.
PMID: 23041930
MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression. Presneau N, Eskandarpour M, Shemais T, Henderson S, Halai D, Tirabosco R, Flanagan AM. Br J Cancer. 2012 Nov 22.
PMID: 23175151
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer. McCleland ML, Adler AS, Shang Y, Hunsaker T, Truong T, Peterson D, Torres E, Li L, Haley B, Stephan JP, Belvin M, Hatzivassiliou G, Blackwood EM, Corson L, Evangelista M, Zha J, Firestein R. Cancer Res. 2012 Nov 15;72(22):5812-23.
PMID: 23139210
Improved proteomic profiling of the cell surface of culture-expanded human bone marrow multipotent stromal cells. Mindaye ST, Ra M, Lo Surdo J, Bauer SR, Alterman MA. J Proteomics. 2012 Nov 12;78C:1-14
PMID: 23153793
Identification of mutant KRas-dependent phenotypes using a panel of isogenic cell lines. Vartanian S, Bentley C, Brauer MJ, Li L, Shirasawa S, Sasazuki T, Kim JS, Haverty P, Stawiski E, Modrusan Z, Waldman T, Stokoe D. J Biol Chem. 2012 Nov 27.
PMID: 23188824
3 Irreversible inhibitors of c-Src kinase that target a nonconserved cysteine. Kwarcinski FE, Fox
CC, Steffey ME, Soellner MB. ACS Chem Biol. 2012 Nov 16;7(11):1910-7.
PMID: 22928736
Obtusilactone B from Machilus thunbergii Targets Barrier-to-autointegration Factor to Treat Cancer. Kim W, Lyu HN, Kwon HS, Kim YS, Lee KH, Kim DY, Chakraborty G, Choi KY, Yoon HS, Kim
KT. Mol Pharmacol. 2012 Nov 13.
PMID: 23150487
Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Segarra M, Ohnuki H,
Maric D, Salvucci O, Hou X, Kumar A, Li X, Tosato G. Blood. 2012 Nov 8;120(19):4104-15.
PMID: 23007403
The vascular disrupting agent STA-9584 exhibits potent antitumor activity by selectively
targeting microvasculature at both the center and periphery of tumors. Foley KP, Zhou D, Borella
C, Wu Y, Zhang M, Jiang J, Li H, Sang J, Korbut T, Ye J, Zhang X, Barsoum J, Sonderfan AJ. J
Pharmacol Exp Ther. 2012 Nov;343(2):529-38.
PMID: 22837008
Quantitative approaches to detect donor and passage differences in adipogenic potential and clonogenicity in human bone marrow-derived mesenchymal stem cells. Lo Surdo J, Bauer SR.
Tissue Eng Part C Methods. 2012 Nov;18(11):877-89.
PMID: 22563812
Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo. Waldmeier L, Meyer-Schaller N, Diepenbruck M, Christofori G. PLoS One. 2012;7(11):e48651.
PMID: 23144919
Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not
bone marrow precursor cells. Lin Y, Richards FM, Krippendorff BF, Bramhall JL, Harrington JA,
Bapiro TE, Robertson A, Zheleva D, Jodrell DI. Br J Cancer. 2012 Nov 6;107(10):1692-701.
PMID: 23037716
Modification of smoke toxicant yields alters the effects of cigarette smoke extracts on
endothelial migration: an in vitro study using a cardiovascular disease model. Fearon IM, Acheampong DO, Bishop E. Int J Toxicol. 2012 Nov;31(6):572-83.
PMID: 23129839
Automated Large-Scale Culture and Medium-Throughput Chemical Screen for Modulators of Proliferation and Viability of Human Induced Pluripotent Stem Cell-Derived Neuroepithelial-like
Stem Cells. McLaren D, Gorba T, Marguerie de Rotrou A, Pillai G, Chappell C, Stacey A, Lingard S,
Falk A, Smith A, Koch P, Brüstle O, Vickers R, Tinsley J, Flanders D, Bello P, Craig S. J Biomol
Screen. 2012 Oct 4. [Epub ahead of print]
PMID: 23042076
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase
β-TrCP1. Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich
CJ, McMahon JB, Colburn NH, Schmid T, Brüne B. PLoS One. 2012;7(10):e46567.
PMID: 23056346
4
Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression. Kohn EA, Yang YA, Du Z, Nagano Y, Van Schyndle CM, Herrmann MA, Heldman M, Chen JQ, Stuelten CH, Flanders KC, Wakefield LM. Mol Cancer Res. 2012 Oct;10(10):1389-99.
PMID: 22878587
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion. Dai M, Al-Odaini AA, Arakelian A, Rabbani SA, Ali S, Lebrun JJ. Breast Cancer Res. 2012 Sep 20;14(5):R127.
PMID: 22995475
Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity. Faraji F, Pang Y, Walker RC, Nieves Borges R, Yang L, Hunter KW. PLoS Genet. 2012 Sep;8(9):e1002926.
PMID: 23028344
ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms. Zaidi N, Royaux I, Swinnen JV, Smans K. Mol Cancer Ther. 2012 Sep;11(9):1925-35.
PMID: 22718913
High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production. Thon JN, Devine MT, Jurak Begonja A, Tibbitts J, Italiano JE Jr. Blood. 2012 Sep 6;120(10):1975-84.
PMID: 22665936
Passenger deletions generate therapeutic vulnerabilities in cancer. Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Nature. 2012 Aug 16;488(7411):337-42.
PMID: 22895339
The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia. Eriksson A, Hermanson M, Wickstr?m M, Lindhagen E, Ekholm C, Jenmalm Jensen A, L?thgren A, Lehmann F, Larsson R, Parrow V, H?glund M. Blood Cancer J. 2012 Aug 3;2:e81.
PMID: 22864397
Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene? Hickey TE, Robinson JL, Carroll JS, Tilley WD. Mol Endocrinol. 2012 Aug;26(8):1252-67. PMID: 22745190
Time-lapse microscopy and classification of 2D human mesenchymal stem cells based on cell shape picks up myogenic from osteogenic and adipogenic differentiation. Seiler C, Gazdhar A, Reyes M, Benneker LM, Geiser T, Siebenrock KA, Gantenbein-Ritter B. J Tissue Eng Regen Med. 2012 Jul 19.
PMID: 22815264
Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Neilsen PM, Noll JE, Mattiske S, Bracken CP, Gregory PA, Schulz RB, Lim SP, Kumar R, Suetani RJ, Goodall GJ, Callen DF. Oncogene. 2012 Jul 16.
PMID: 22797073
5 STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory
protein. Sato T, Sako Y, Sho M, Momohara M, Suico MA, Shuto T, Nishitoh H, Okiyoneda T, Kokame
K, Kaneko M, Taura M, Miyata M, Chosa K, Koga T, Morino-Koga S, Wada I, Kai H. Mol Cell. 2012 Jul
13;47(1):99-110.
PMID: 22607976
Characterization of liposarcoma cell lines for preclinical and biological studies. Stratford EW,
Castro R, Daffinrud J, Sk?rn M, Lauvrak S, Munthe E, Myklebost O. Sarcoma. 2012;2012:148614.
PMID: 22911243
Non-ant ioxidant properties of α-tocopherol reduce the anticancer activity of several protein
kinase inhibitors in vitro. Pédeboscq S, Rey C, Petit M, Harpey C, De Giorgi F, Ichas F, Lartigue L.
PLoS One. 2012;7(5):e36811.
PMID: 22590613
FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and
metastasis and is associated with poor prognosis. Goldie SJ, Mulder KW, Tan DW, Lyons SK,
Sims AH, Watt FM. Cancer Res. 2012 Jul 1;72(13):3424-36.
PMID: 22564525
Expressed pseudogenes in the transcriptional landscape of human cancers. Kalyana-Sundaram
S, Kumar-Sinha C, Shankar S, Robinson DR, Wu YM, Cao X, Asangani IA, Kothari V, Prensner JR,
Lonigro RJ, Iyer MK, Barrette T, Shanmugam A, Dhanasekaran SM, Palanisamy N, Chinnaiyan AM.
Cell. 2012 Jun 22;149(7):1622-34.
PMID: 22726445
Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers,
influences migration, adhesion and activation of Rho GTPases. Mendoza-Naranjo A, Cormie P, Serrano AE, Hu R, O'Neill S, Wang CM, Thrasivoulou C, Power KT, White A, Serena T, Phillips AR,
Becker DL. PLoS One. 2012;7(5):e37374.
PMID: 22615994
SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. Costa G, Mazan A, Gandillet A, Pearson S, Lacaud G, Kouskoff V. Development. 2012 May;139(9):1587-98.
PMID: 22492353
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic
acid and Notch signalling. Torres J, Prieto J, Durupt FC, Broad S, Watt FM. PLoS One.
2012;7(4):e36405.
PMID: 22558462
Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates
PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells. Liu L, Wang YD, Wu J, Cui
J, Chen T. BMC Cancer. 2012 Apr 25;12:154.
PMID: 22533991
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S,
McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C, Salomoni P. Oncogene. 2012 Apr 23.
PMID: 22525272
6
Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system. Karlsson H, Frykn?s M, Larsson R, Nygren P. Exp Cell Res. 2012 Apr 2. [Epub ahead of print]
PMID:22487097
The effect of high concentration and exposure duration of nanoceria on human lens epithelial cells. Pierscionek BK, Li Y, Schachar RA, Chen W. Nanomedicine. 2012 Apr;8(3):383-90.
PMID: 21722619
Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo. Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW, Watt FM. J Invest Dermatol. 2012 Apr;132(4):1084-93.
PMID:22189784
Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors. Tikoo A, Roh V, Montgomery KG, Ivetac I, Waring P, Pelzer R, Hare L, Shackleton M, Humbert P, Phillips WA. PLoS One. 2012;7(5):e36924. PMID: 22666336
Identification of fibroblast growth factor-8b target genes associated with early and late cell cycle events in breast cancer cells. Nilsson EM, Brokken LJ, Narvi E, Kallio MJ, H?rk?nen PL. Mol Cell Endocrinol. 2012 Mar 23. [Epub ahead of print]
PMID:22465097
15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells. Lehtinen L, Vainio P, Wikman H, Reemts J, Hilvo M, Issa R, Pollari S, Brandt B, Oresic M, Pantel K, Kallioniemi O, Iljin K. J Pathol. 2012 Mar;226(4):674-86.
PMID: 22072156
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S. Cancer Res. 2012 Mar 27. [Epub ahead of print]
PMID: 22440753
Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling. Gasperini P, Espigol-Frigole G, McCormick PJ, Salvucci O, Maric D, Uldrick TS, Polizzotto MN, Yarchoan R, Tosato G. Cancer Res. 2012 Mar 1;72(5):1157-69. Epub 2012 Jan 11. PMID:22237624
The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis. Salmela AL, Pouwels J, Kukkonen-Macchi A, Waris S, Toivonen P, Jaakkola K, M?ki-Jouppila J, Kallio L, Kallio MJ. Exp Cell Res. 2012 Mar 10;318(5):578-92.
PMID:22227008
A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro. Hughes A, Kleine-Albers J, Helfrich MH, Ralston SH, Rogers MJ. Calcif Tissue Int. 2012 Feb;90(2):151-62.
PMID: 22227882
7 N-cadherin expression level modulates integrin-mediated polarity and strongly impacts on the
speed and directionality of glial cell migration. Camand E, Peglion F, Osmani N, Sanson M,
Etienne-Manneville S. J Cell Sci. 2012 Feb 15;125(Pt 4):844-57.
PMID:22275437
Cellular growth kinetics distinguish a cyclophilin inhibitor from an HSP90 inhibitor as a selective inhibitor of hepatitis C virus. Beran RK, Sharma R, Corsa AC, Tian Y, Golde J, Lundgaard G,
Delaney WE 4th, Zhong W, Greenstein AE. PLoS One. 2012;7(2):e30286. Epub 2012 Feb 8.
PMID:22347373
A functional genetic screen reveals new regulators of β1-integrin activity. Pellinen T, Rantala JK, Arjonen A, Mpindi JP, Kallioniemi O, Ivaska J. J Cell Sci. 2012 Feb 1;125(Pt 3):649-61.
PMID: 22389402
Modulation and recruitment of inducible regulatory T cells by first trimester trophoblast cells, Ramhorst R, Fraccaroli L, Aldo P, Alvero AB, Cardenas I, Leiros CP, Mor G, Am J Reprod Immunol. 2012 Jan;67(1):17-27
PMID: 2189477.
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile
system for in vitro production of human neurons. Falk A, Koch P, Kesavan J, Takashima Y,
Ladewig J, Alexander M, Wiskow O, Tailor J, Trotter M, Pollard S, Smith A, Brüstle O. PLoS One.
2012;7(1):e29597. Epub 2012 Jan 17.
PMID:22272239
Feline neural progenitor cells II: Use of novel plasmid vector and hybrid promoter to drive expression of glial cell line-derived neurotrophic factor transgene. You XJ, Yang J, Gu P, Liew
CG, Klassen HJ. Stem Cells International. 2012 Article ID 604982
Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Sun Y, Wang BE, Leong KG, Yue P, Li L, Jhunjhunwala S, Chen D,
Seo K, Modrusan Z, Gao WQ, Settleman J, Johnson L. Cancer Res. 2012 Jan 15;72(2):527-36.
PMID: 22108827
Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress.
Ketola K, Hilvo M, Hy?tyl?inen T, Vuoristo A, Ruskeep?? AL, Ore?i? M, Kallionie mi O, Iljin K. Br J
Cancer. 2012 Jan 3;106(1):99-106.
PMID: 22215106
Multimodality animal rotation imaging system (MARS) for in vivo detection of intraperitoneal tumors. Pizzonia J, Holmberg J, Orton S, Alvero A, Viteri O, Mclaughlin W, Feke G, Mor G, Am J Reprod Immunol. 2012 Jan;67(1):84-90
PMID: 21951577
2011 Publications
Who needs microtubules? Myogenic reorganization of MTOC, Golgi complex and ER exit sites persists despite lack of normal microtubule tracks. Zaal KJ, Reid E, Mousavi K, Zhang T, Mehta A, Bugnard E, Sartorelli V, Ralston E. PLoS One. 2011;6(12):e29057.
PMID:22216166
8
Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long Term to Nucleoside Reverse Transcriptase Inhibitors (NRTIs). Liu Y, Nguyen P, Baris TZ, Poirier MC. Cardiovasc Toxicol. 2011 Dec 15. [Epub ahead of print].
PMID:22170576
Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Vainio P, Lehtinen L, Mirtti T, Hilvo M,
Sepp?nen-Laakso T, Virtanen J, Sankila A, Nordling S, Lundin J, Rannikko A, Ore?i? M, Kallioniemi O, Iljin K. Oncotarget. 2011 Dec;2(12):1176-90.
PMID: 22202492
TLR4-dependent GM-CSF protects against lung injury in gram-negative bacterial pneumonia. Standiford LR, Standiford TJ, Newstead MJ, Zeng X, Ballinger MN, Kovach MA, Reka AK, Bhan U. Am J Physiol Lung Cell Mol Physiol. 2011 Dec 9. [Epub ahead of print]
PMID: 22160309
Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion. Bj?rkman M, Ostling P, H?rm? V, Virtanen J, Mpindi JP, Rantala J, Mirtti T, Vesterinen T, Lundin M, Sankila A, Rannikko A, Kaivanto E, Kohonen P, Kallioniemi O, Nees M. Oncogene.2011 Nov 28. [Epub ahead of print]
PMID: 22120715
Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint. Yang C, Tang X, Guo X, Niikura Y, Kitagawa K, Cui K, Wong ST, Fu L, Xu B. Mol Cell. 2011 Nov 18;44(4):597-608
PMID: 22099307
The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling. Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ. Dev Cell. 2011 Nov 15;21(5);835-47
PMID: 22033112
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM. Oncogene. 2011 Nov 10;30(45); 4590-600
PMID: 21602881
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Robinson DR, Kalyana-Sundaram S, Wu YM, Shankar S, Cao X, Ateeq B, Asangani IA, Iyer M, Maher CA, Grasso CS, Lonigro RJ, Quist M, Siddiqui J, Mehra R, Jing X, Giordano TJ, Sabel MS, Kleer CG, Palanisamy N, Natrajan R, Lambros MB, Reis-Filho JS, Kumar-Sinha C, Chinnaiyan AM. Nat Med. 2011 Nov 20;17(12):1646-51.
PMID:22101766
Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy, Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM, Wong TW, Rupnow BA. Mol Cancer Res. 2011 Nov;9(11):1551-61
PMID: 21954435
Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells in vitro. Gomez-Lopez S, Wiskow O, Favaro R, Nicolis SK, Price DJ, Pollard SM, Smith A, Glia. 2011 Nov;59(11);1588-99
PMID: 21766338
9 Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11. Noll JE, Jeffery J, Al-Ejeh F, Kumar R, Khanna KK, Callen DF, Neilsen PM. Oncogene. 2011 Oct 10. [Epub ahead of print]
PMID: 21986947
A Novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies. Heider KH, Kiefer K, Zenz T, Volden M, Stilgenbauer S, Ostermann E, Baum A, Lamche H, Kupcu Z, Jacobi A, Muller S, Hirt U, Adolf GR, Borges E. Blood. 2011 Oct 13;118(15):4159-68
PMID: 21795744
Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models. Harma V, Knuuttila M, Virtanen J, Mirtti T, Kohonen P, Kovanen P, Happonen A, Kaewphan S, Ahonen I, Kallioniemi O, Grafstrom R, Lotjonen J, Nees M, Oncogene. 2011 Sep 26. [Epub ahead of print]
PMID: 21996742
The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein. Bruyere E, Jonckheere N., Frenois F, Mariette C, Van Seuningen I, Biochem Biophys Res Commun. 2011 Sep 23;413(2):325-9
PMID: 21889495
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors. Parmentier-Batteur S, Finger EN, Krishnan R, Rajapakse HA, Sanders JM, Kandpal G, Zhu H, Moore KP, Regan CP, Sharma S, Hess JF, Williams TM, Reynolds IJ, Vacca JP, Mark RJ, Nantermet PG. J Neurochem. 2011 Sep;118(6);1016-31
PMID: 21796568
FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H. Blood. 2011 Aug 25;118(8):2285-95
PMID: 21652675
Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells. Alvero AB, Montagna MK, Holmberg JC, Craveiro V, Brown D, Mor G, Mol Cancer Ther. 2011 Aug;10(8); 1385-93
PMID: 21677151
Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact, Leivonen SK, Rokka A, Ostling P, Kohonen P, Corthals G, Kallioniemi O, Perala M.
Mol Cell Proteomics. 2011 Jul;10(7);M110.005322
PMID: 21512034
Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset
of hematopoietic development. Ferreras C, Lancrin C, Lie-A-Ling M, Kouskoff V, Lacaud G. Blood. 2011 Jul 21;118(3);594-7
PMID: 21498670
Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular
iron depletion as a promising strategy for cancer treatment. Gullbo J, Frykn?s M, Rickardson L, Darcy P, H?gg M, Wickstr?m M, Hassan S, Westman G, Brnjic S, Nygren P, Linder S, Larsson R. Biochem Pharmacol. 2011 Jul 15;82(2);139-47
PMID: 21531212
10
Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF K B pathway. Chefetz I, Holmberg J, Alvero AB, Visintin I, Mor G, Cell Cycle. 2011 Jul 1;10(13):2206-14
PMID: 21623171
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line. Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, Blumberg PM. Biochem Pharmacol. 2011 Jun 1;81(11);1296-308.
PMID: 21458422
Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing’s and osteogenic sarcoma models. Beltran PJ, Chung YA, Moody G, Mitchell P, Cajulis E, Vonderfecht S, Kendall R, Radinsky R, Calzone FJ. J Pharmacol Exp Ther. 2011 Jun;337(3);644-54
PMID: 2138591
AMPK regulates metabolism and survival in response to ionizing radiation. Zannella VE, Cojocari D, Hilgendorf S, Vellanki RN, Chung S, Wouters BG, Koritzinsky M.Radiother Oncol.2011 Jun;99(3);293-9
PMID: 21715037
Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells. Sun Y, Hu J, Zhou L, Pollard SM, Smith A. J Cell Sci. 2011 Jun1;124(Pt 11):1867-77
PMID: 21558414
Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells. Kedei N, Lubart E, Lewin NE, Telek A, Lim L, Mannan P, Garfield SH, Kraft MB, Keck GE, Kolusheva S, Jelinek R, Blumberg PM., Chembiochem. 2011 May 16;12(8);1242-51.
PMID: 21542090
Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells. Holmes KA, Hurtado A, Brown GD, Launchbury R, Ross-Innes CS, Hadfield J, Odom DT, Carroll JS. Proc Natl Acad Sci U S A. 2011 May 2. [Epub ahead of print] PMID: 21536917
Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. Oudin MJ, Gajendra S, Williams G, Hobbs C, Lalli G, Doherty P. J Neurosci. 2011 Mar 16;31(11):4000-11.
PMID: 21411643
High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle-assembly checkpoint. Niittym?ki I, Gylfe A, Laine L, Laakso M, Lehtonen HJ, Kondelin J, Tolvanen J, Nousiainen K, Pouwels J, J?rvinen H, Nuorva K, Mecklin JP, M?kinen M, Ristim?ki A, Orntoft TF, Hautaniemi S, Karhu A, Kallio MJ, Aaltonen LA. Carcinogenesis. 2011 Mar;32(3):305-11. Epub 2010 Dec 16.
PMID: 21163887
Osteogenic differentiation of miniature pig mesenchymal stem cells in 2D and 3D environment. Juhasova J, Juhas S, Klima J, Strnadel J, Holubova M. Motlik J. Physiol Res. 2011;60(3);559-71 PMID: 21401296
11 Chromosomal Instability Confers Intrinsic Multidrug Resistance. Lee AJ, Endesfelder D, Rowan
AJ, Walther A, Birkbak NJ, Futreal PA, Downward J, Szallasi Z, Tomlinson IP, Howell M, Kschischo M, Swanton C. Cancer Res. 2011 Mar 1;71(5):1858-1870.
PMID: 21363922
Role of transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic
and functional-based study. Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, M?ller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K, Flanagan AM. J Pathol. 2011 Feb;223(3):327-
35
PMID: 21171078
The Role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.Shalaby A, Presneau N, Ye H, Halai D, Berisha F, Idowu B, Leithner A, Liegl B, Briggs TR,
Bacsi K, Kindblom LG, Athanasou N, Amary MF, Hogendoorn PC, Tirabosco R, Flanagan AM. J Pathol. 2011 Feb;223(3);336-46
PMID: 21171079
CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression. Liu Z, Yang X, Li Z, McMahon C, Sizer C, Barenboim-Stapleton L, Bliskovsky V, Mock B, Ried T, London WB, Maris J, Khan J, Thiele CJ. Cell Death Differ. 2011 Jan 21. [Epub ahead of print]
PMID: 21252912
Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin. Niego B, Samson AL, Petersen KU, Medcalf RL. Brain Res.2011 Mar
24;1381:38-51. Epub 2011 Jan 15.
PMID: 21241677
Loss of p38Gamma MAPK induces pleiotropic mitotic defects and massive cell death. Kukkonen-Macchi A, Sicora O, Kaczynska K, Oetken-Lindholm C, Pouwels J, Laine L, Kallio MJ. J Cell Sci. 2011
Jan 15;124(Pt 2):216-27
PMID: 21172807
RAC3 is a pro-migratory co-activator of ERα. Walker MP, Zhang M, Le TP, Laine M, Greene GL. Oncogene. 2011 Jan 10 [Epub ahead of print].
PMID: 21217774
2010 Publications
Peroxisome Proliferator-Activated Receptor-γ Activation Inhibits Tumor Metastasis by Antagonizing Smad3-Mediated Epithelial-Mesenchymal Transition.Reka AK, Kurapati H, Narala
VR, Bommer G, Chen J, Standiford TJ, Keshamouni VG. Mol Cancer Ther. 2010 Dec;9(12):3221-32. PMID: 21159608
Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer
cells identifies an oncogenic profile for GINS2. Rantala JK, Edgren H, Lehtinen L, Wolf M, Kleivi K,
Vollan HK, Aaltola AR, Laasola P, Kilpinen S, Saviranta P, Iljin K, Kallioniemi O. Neoplasia. 2010
Nov;12(11):877-88.
PMID:21082043
12
Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling. Landgraf KE, Santell L, Billeci KL, Quan C, Young JC, Maun HR, Kirchhofer D, Lazarus RA. J Biol Chem. 2010 Dec 17;285(51):40362-72. Epub 2010 Oct 11.
PMID: 20937841
Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, Anizon F, Moreau P, Koskinen PJ. Mol Cancer. 2010 Oct 19;9(1):279. [Epub ahead of print].
PMID: 20958956
RasGRP3 Contributes to formation and maintenance of the prostate cancer phenotype.Yang D, Kedei N, Li L, Tao J, Velasquez JF, Michalowski AM, Tóth BI, Marincsák R, Varga A,Bíró T, Yuspa SH, Blumberg PM. Cancer Res. 2010 Oct 15;70(20):7905-17. Epub 2010 Sep 28.
PMID: 20876802
Expression of Neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility. Hayes N, Blackburn E, Boyle M, Russell G, Frost T, Morgan B, Gullick W. Enodcr Relat Cancer 2010 Oct 19 [Epub ahead of print].
PMID 20959441
Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D. Nature. 2010 Sep 9;467(7312):179-84.
PMID: 20829789
Imaging-based chemical screens using normal and glioma-derived neural stem cells. Danovi D, Falk A, Humphreys P, Vickers R, Tinsley J, Smith AG, Pollard SM. Biochem Soc Trans.2010 Aug;38(4):1067-71.
PMID: 20659005
Serum response factor is an essential transcription factor in megakaryocytic maturation. Halene S, Gao Y, Hahn K, Massaro S, Italiano JE Jr, Schulz V, Lin S, Kupfer GM, Krause DS. Blood. 2010 Sep 16;116(11):1942-50. Epub 2010 Jun 4.
PMID: 20525922
Selenoproteins are essential for proper keratinocyte function and skin development. Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, Hatfield DL. PLoS One. 2010 Aug 18;5(8):e12249.
PMID: 20805887
The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma.
Bralten LB, Gravendeel AM, Kloosterhof NK, Sacchetti A, Vrijenhoek T, Veltman JA, van den Bent MJ, Kros JM, Hoogenraad CC, Sillevis Smitt PA, French PJ. Oncogene.2010 Aug 16. [Epub ahead of print]
PMID: 20711234
Glycogen synthase kinase 3 regulates PAX3–FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells.
Zeng FY, Dong H, Cui J, Liu L, Chen T., Biochem Biophys Res Commun. 2010 Jan 1;391(1):1049-1055. Epub 2009 Dec 6.
PMID: 19995556
13 Performance of Mouse Neural Stem Cells as a Screening Reagent: Characterization of PAC1 Activity in Medium-Throughput Functional Assays.
Lodge AP, Langmead CJ, Daniel G, Anderson G, Werry T., J Biomol Screen. 2010 Feb;15(2):159-68.
Epub 2009 Dec 30.
PMID: 20042531
A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. H?rm? V, Virtanen J, M?kel? R, Happonen A, Mpindi JP, Knuuttila M, Kohonen P, L?tj?nen J, Kallioniemi O, Nees M. PLoS One. 2010 May 3;5(5):e10431.
PMID: 20454659
Src Family Kinase Inhibitor Saracatinib (AZD0530) Impairs Oxaliplatin Uptake in Colorectal Cancer Cells and Blocks Organic Cation Transporters.Morrow CJ, Ghattas M, Smith C, B?nisch
H, Bryce RA, Hickinson DM, Green TP, Dive C. Cancer Res. 2010 Jun 15. [Epub ahead of print].
PMID: 20551056
Double-regulated oncolytic adenovirus-mediated interleukin-24 overexpression exhibits potent antitumor activity on gastric adenocarcinoma. Wei N, Fan JK, Gu JF, Liu XY. Hum Gene Ther.
2010 Jul;21(7):855-64.
PMID: 20163249
A novel role for wnt/ca signaling in actin cytoskeleton remodeling and cell motility in prostate cancer. Wang Q, Symes AJ, Kane CA, Freeman A, Nariculam J, Munson P, Thrasivoulou C, Masters
JR, Ahmed A. PLoS One. 2010 May 4;5(5):e10456.
PMID: 20454608
The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain.Goncalves MB, Williams EJ, Yip P, Yá?ez-Mu?oz RJ, Williams G, Doherty P. Br J Pharmacol.
2010 Mar;159(5):1118-25. Epub 2010 Feb 5.
PMID: 20136845
Exploiting the superior protein resistance of polymer brushes to control single cell adhesion
and polarisation at the micron scale.Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He
X, Watt FM, Huck WT. Biomaterials. 2010 Jun;31(18):5030-41. Epub 2010 Mar 26.
PMID: 20347135
Use of cryopreserved cell aliquots in the high-throughput screening of small interfering RNA libraries. Swearingen EA, Fajardo F, Wang X, Watson JE, Quon KC, Kassner PD. J Biomol Screen.
2010 Jun;15(5):469-77. Epub 2010 Apr 6.
PMID: 2037186
2009 Publications
Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment.van den Beucken T, Ramaekers CH, Rouschop K, Koritzinsky M, Wouters BG. Radiother Oncol. 2009 Sep;92(3):437-42. Epub 2009 Jul 15.
PMID: 19615771
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens.
Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R, Bayani J, Head R, Lee M, Bernstein M, Squire JA, Smith A, Dirks P., Cell Stem Cell. 2009 Jun 5; 4(6):568-80.
PMID: 19497285
14
Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.
Ward RJ, Lee L, Graham K, Satkunendran T, Yoshikawa K, Ling E, Harper L, Austin R, Nieuwenhuis E, Clarke ID, Hui CC, Dirks PB., Cancer Research. 2009 Jun. 1; 69(11):4682-90.
PMID: 19487286
7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: A novel compound capable of inducing cell death in epithelial ovarian cancer stem cells.
Green JM, Alvero AB, Kohen F, Mor G., Cancer Biology & Therapy. 2009 Sep. 17;8(18).
PMID: 19738422
Stem-like ovarian cancer cells can serve as tumor vascular progenitors. Alvero AB, Fu HH, Holmberg J, Visintin I, Mor L, Marquina CC, Oidtman J, Silasi DA, Mor G. Stem Cells2009 Oct;27(10):2405-13.
PMID: 19658191
Necl2 regulates epidermal adhesion and wound repair. Giangreco A, Jensen KB, Takai Y, Miyoshi J, Watt FM. Development. 2009 Oct;136(20):3505-14.
PMID: 19783739
Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.Kunz C, Focke F, Saito Y, Schuermann D, Lettieri T, Selfridge J, Sch?r P. PLoS Biol. 2009 Apr 28;7(4):e91.
PMID: 19402749
2008 Publications
Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, Willatt L, Falk A, Cattaneo E, Smith A. Mol Cell Neurosci. 2008 Jun;38(2):245-58. Epub 2008 Mar 18.
PMID: 18450476
Generation of bone marrow derived murine dendritic cells for use in 2-photon imaging.
Matheu MP, Sen D, Cahalan MD, Parker I., Journal of Visual Experimentation. 2008 Jul. 9;(17). pii: 773. doi: 10.3791/773. PMID: 19066518
Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. Finney BA, del Moral PM, Wilkinson WJ, Cayzac S, Cole M, Warburton D, Kemp PJ, Riccardi D. J Physiol. 2008 Dec 15;586(Pt 24):6007-19. Epub 2008 Oct 27.
PMID: 18955379
The application of cell-based label-free technology in drug discovery.Xi B, Yu N, Wang X, Xu X, Abassi YA. Biotechnol J. 2008 Apr;3(4):484-95.
PMID: 18412175
15
2007 Publications
Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells.
Tran CN, Lundy SK, White PT, Endres JL, Motyl CD, Gupta R, Wilke CM, Shelden EA, Chung KC, Urquhart AG, Fox DA., American Journal of Pathology. 2007 Nov. 171(5):1588-98.
PMID: 178232
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