Randomized study of maintenance vinorelbine in responders with advanced
non-small-cell lung cancer.
Westeel V, Quoix E, Moro-Sibilot D, Mercier M, Breton JL, Debieuvre D, Richard P, Haller MA, Milleron B, Herman D, Level MC, Lebas FX, Puyraveau M, Depierre A; French Thoracic Oncology Collaborative Group (GCOT).
Source
Chest Disease Department, Jean Minjoz University Hospital, Besan?on, France.
Abstract
BACKGROUND:
Prolongation of chemotherapy duration, usually referred to as maintenance chemotherapy, has been considered as an approach to improve survival of patients with advanced non-small-cell lung cancer (NSCLC). If the maintenance regimen differs from the induction regimen, patients will receive not only higher total doses of chemotherapy but also earlier delivery of non-cross-resistant agents. We conducted a randomized trial to compare maintenance vinorelbine therapy with observation in previously untreated patients who responded to induction treatment with mitomycin-ifosfamide-cisplatin (MIC).
METHODS:
Patients with stage IIIB NSCLC were treated with two monthly MIC cycles followed by radiotherapy; those with "wet" stage IIIB (pleural or pericardial involvement), with stage IIIB with supraclavicular node involvement, or stage IV (i.e., metastatic) NSCLC were treated with four monthly MIC cycles. Patients who responded to induction treatment were randomly assigned to receive intravenous vinorelbine at a dose of 25 mg x m(-2) x wk(-1) for 6 months or no further treatment. Survival comparisons used the log-rank test and the Cox regression adjusted for stage. All statistical tests were two-sided.
RESULTS:
A total of 573 patients were registered, of whom 227 responded to induction treatment and 181 were randomly assigned (91 to maintenance vinorelbine and 90 to observation) between January 1994 and March 2000. One- and 2-year survival rates were 42.2% and 20.1% in the vinorelbine arm and 50.6% and 20.2% in the observation arm, respectively (log-rank P = .48). The hazard ratio of survival after adjustment on stage, in the vinorelbine arm relative to the observation arm, was 1.08 (95% confidence interval = 0.79 to 1.47; P = .65). There was also no difference between arms in progression-free survival (log-rank P = .32).
CONCLUSION:
Maintenance vinorelbine did not improve survival of patients with advanced NSCLC who responded to induction MIC treatment. Nevertheless, other agents, including docetaxel and targeted agents, should be evaluated as maintenance agents before the concept is abandoned.
Phase III study of immediate compared with delayed docetaxel after front-line therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer.
Fidias PM, Dakhil SR, Lyss AP, Loesch DM, Waterhouse DM, Bromund JL, Chen R, Hristova-Kazmierski M, Treat J, Obasaju CK, Marciniak M, Gill J, Schiller JH.
Source
Massachusetts General Hospital, Center for Thoracic Cancers, 55 Fruit St, Boston, MA 02114, USA. pfidias2@https://www.doczj.com/doc/9c4095754.html,
Abstract
PURPOSE:
Gemcitabine plus carboplatin (GC) is active as front-line treatment for advanced non-small-cell lung cancer (NSCLC). For patients without progression, timing of second-line chemotherapy for optimum clinical benefit remains uncertain. This phase III, randomized trial assessed the efficacy and safety of docetaxel administered either immediately after GC or at disease progression.
PATIENTS AND METHODS:
The chemotherapy-na?ve patients enrolled had either stage IIIB NSCLC with pleural effusion or stage IV NSCLC. Gemcitabine (1,000 mg/m(2)) was administered on days 1 and 8 followed by carboplatin (area under the curve = 5) on day 1. After four 21-day cycles, patients who did not have progression were randomly assigned either to an immediate docetaxel group (docetaxel 75 mg/m(2) on day 1 every 21 days, with maximum of six cycles) or to a delayed docetaxel group. The primary end point was overall survival (OS) measured from random assignment. Additional analyses included tumor response, toxicity, progression-free survival (PFS), and quality of life (QOL).
RESULTS:
Enrollment totaled 566 patients; 398 patients completed GC; 309 patients were randomly assigned equally to the two docetaxel treatment groups. Toxicity profiles were generally comparable for the docetaxel groups. Median PFS for immediate docetaxel (5.7 months) was significantly greater (P = .0001) than for delayed docetaxel (2.7 months). Median OS for immediate docetaxel (12.3 months) was greater than for delayed docetaxel (9.7 months), but the difference was not statistically significant (P = .0853). QOL results were not statistically different (P = .76) between docetaxel groups.
CONCLUSION:
We observed a statistically significant improvement in PFS and a nonstatistically significant increase in OS when docetaxel was administered immediately after front-line GC, without increasing toxicity or decreasing QOL.
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH.
Source
Vanderbilt University, Nashville, TN, USA. sandler@https://www.doczj.com/doc/9c4095754.html,
Erratum in
N Engl J Med. 2007 Jan 18;356(3):318.
Abstract
BACKGROUND:
Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has been shown to benefit patients with a variety of cancers.
METHODS:
Between July 2001 and April 2004, the Eastern Cooperative Oncology Group (ECOG) conducted a randomized study in which 878 patients with recurrent or advanced non-small-cell lung cancer (stage IIIB or IV) were assigned to chemotherapy with paclitaxel and carboplatin alone (444) or paclitaxel and carboplatin plus bevacizumab (434). Chemotherapy was administered every 3 weeks for six cycles, and bevacizumab was administered every 3 weeks until disease progression was evident or toxic effects were intolerable. Patients with squamous-cell tumors, brain metastases, clinically significant hemoptysis, or inadequate organ function or performance status (ECOG performance status, >1) were excluded. The primary end point was overall survival.
RESULTS:
The median survival was 12.3 months in the group assigned to chemotherapy plus bevacizumab, as compared with 10.3 months in the chemotherapy-alone group (hazard ratio for death, 0.79; P=0.003). The median
progression-free survival in the two groups was 6.2 and 4.5 months, respectively (hazard ratio for disease progression, 0.66; P<0.001), with corresponding response rates of 35% and 15% (P<0.001). Rates of clinically significant bleeding were 4.4% and 0.7%, respectively (P<0.001). There were 15 treatment-related deaths in the chemotherapy-plus-bevacizumab group, including 5 from pulmonary hemorrhage.
CONCLUSIONS:
The addition of bevacizumab to paclitaxel plus carboplatin in the treatment of selected patients with non-small-cell lung cancer has a significant survival benefit with the risk of increased treatment-related deaths. (https://www.doczj.com/doc/9c4095754.html, number, NCT00021060.)
2006 Massachusetts Medical Society
TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer.
Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A, Kris MG, Tran HT, Klein P, Li X, Ramies D, Johnson DH, Miller VA; TRIBUTE Investigator Group.
Source
University of Texas M.D. Anderson Cancer Center, Houston, USA. Abstract
PURPOSE:
Erlotinib is a potent reversible HER1/epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with single-agent activity in patients with non-small-cell lung cancer (NSCLC). Erlotinib was combined with chemotherapy to determine if it could improve the outcome of patients with NSCLC.
PATIENTS AND METHODS:
TRIBUTE randomly assigned patients with good performance status and previously untreated advanced (stage IIIB/IV) NSCLC to erlotinib 150 mg/d or placebo combined with up to six cycles of carboplatin and paclitaxel, followed by maintenance monotherapy with erlotinib. Random assignment was stratified by stage, weight loss in the previous 6 months, measurable disease, and treatment center. The primary end point was overall survival (OS). Secondary end points included time to progression (TTP), objective response (OR), and duration of response.
RESULTS:
There were 1,059 assessable patients (526 erlotinib; 533 placebo). Median survival for patients treated with erlotinib was 10.6 v 10.5 months for placebo (hazard ratio, 0.99; 95% CI, 0.86 to 1.16; P = .95). There was no difference in OR or median TTP. Patients who reported never smoking (72 erlotinib; 44 placebo) experienced improved OS in the erlotinib arm (22.5 v 10.1 months for placebo), though no other prespecified factors showed an advantage in OS with erlotinib. Erlotinib and placebo arms were equivalent in adverse events (except rash and diarrhea).
CONCLUSION:
Erlotinib with concurrent carboplatin and paclitaxel did not confer a survival advantage over carboplatin and paclitaxel alone in patients with previously untreated advanced NSCLC. Never smokers treated with erlotinib and chemotherapy seemed to experience an improvement in survival and will undergo further investigation in future randomized trials.
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced
non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial.
Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F, Milanowski J, Karnicka-Mlodkowski H, Pesek M, Serwatowski P, Ramlau R, Janaskova T, Vansteenkiste J, Strausz J, Manikhas GM, Von Pawel J.
Source
Zentrum Fur Pneumologie Und Thoraxchirurgie, Krankenhaus D LVA, Germany. pneumo.onko@t-online.de
Abstract
PURPOSE:
Erlotinib is a potent inhibitor of the epidermal growth factor receptor tyrosine kinase, with single-agent antitumor activity. Preclinically, erlotinib enhanced the cytotoxicity of chemotherapy. This phase III, randomized, double-blind, placebo-controlled, multicenter trial evaluated the efficacy and safety of erlotinib in combination with cisplatin and gemcitabine as first-line treatment for advanced
non-small-cell lung cancer (NSCLC).
PATIENTS AND METHODS:
Patients received erlotinib (150 mg/d) or placebo, combined with up to six 21-day cycles of chemotherapy (gemcitabine 1,250 mg/m2 on days 1 and 8 and cisplatin 80 mg/m2 on day 1). The primary end point was overall survival (OS). Secondary end points included time to disease progression (TTP), response rate (RR), duration of response, and quality of life (QoL).
RESULTS:
A total of 1,172 patients were enrolled. Baseline demographic and disease characteristics were well balanced. There were no differences in OS (hazard ratio, 1.06; median, 43 v 44.1 weeks for erlotinib and placebo groups, respectively), TTP, RR, or QoL between treatment arms. In a small group of patients who had never smoked, OS and progression-free survival were increased in the erlotinib group; no other subgroups were found more likely to benefit. Erlotinib with chemotherapy was generally well tolerated; incidence of adverse events was similar between arms, except for an increase in rash and diarrhea with erlotinib (generally mild).
CONCLUSION:
Erlotinib with concurrent cisplatin and gemcitabine showed no survival benefit compared with chemotherapy alone in patients with chemotherapy-na?ve advanced NSCLC.
Inventory management Inventory Control On the so-called "inventory control", many people will interpret it as a "storage management", which is actually a big distortion. The traditional narrow view, mainly for warehouse inventory control of materials for inventory, data processing, storage, distribution, etc., through the implementation of anti-corrosion, temperature and humidity control means, to make the custody of the physical inventory to maintain optimum purposes. This is just a form of inventory control, or can be defined as the physical inventory control. How, then, from a broad perspective to understand inventory control? Inventory control should be related to the company's financial and operational objectives, in particular operating cash flow by optimizing the entire demand and supply chain management processes (DSCM), a reasonable set of ERP control strategy, and supported by appropriate information processing tools, tools to achieved in ensuring the timely delivery of the premise, as far as possible to reduce inventory levels, reducing inventory and obsolescence, the risk of devaluation. In this sense, the physical inventory control to achieve financial goals is just a means to control the entire inventory or just a necessary part; from the perspective of organizational functions, physical inventory control, warehouse management is mainly the responsibility of The broad inventory control is the demand and supply chain management, and the whole company's responsibility. Why until now many people's understanding of inventory control, limited physical inventory control? The following two reasons can not be ignored: First, our enterprises do not attach importance to inventory control. Especially those who benefit relatively good business, as long as there is money on the few people to consider the problem of inventory turnover. Inventory control is simply interpreted as warehouse management, unless the time to spend money, it may have been to see the inventory problem, and see the results are often very simple procurement to buy more, or did not do warehouse departments . Second, ERP misleading. Invoicing software is simple audacity to call it ERP, companies on their so-called ERP can reduce the number of inventory, inventory control, seems to rely on their small software can get. Even as SAP, BAAN ERP world, the field of
Agent controlled traffic lights Author：Danko A. Roozemond，Jan L.H. Rogier Provenance：Delft University of Technology Introduction The quality of (urban) traffic control systems is determined by the match between the control schema and the actual traffic patterns. If traffic patterns change, what they usually do, the effectiveness is determined by the way in which the system adapts to these changes. When this ability to adapt becomes an integral part of the traffic control unit it can react better to changes in traffic conditions. Adjusting a traffic control unit is a costly and timely affair if it involves human attention. The hypothesis is that it might offer additional benefit using self-evaluating and self-adjusting traffic control systems. There is already a market for an urban traffic control system that is able to react if the environment changes;the so called adaptive systems. "Real" adaptive systems will need pro-active calculated traffic information and cycle plans- based on these calculated traffic conditions- to be updated frequently. Our research of the usability of agent technology within traffic control can be split into two parts. First there is a theoretical part integrating agent technology and traffic control. The final stage of this research focuses on practical issues like implementation and performance. Here we present the concepts of agent technology applied to dynamic traffic control. Currently we are designing a layered model of an agent based urban traffic control system. We will elaborate on that in the last chapters. Adaptive urban traffic control Adaptive signal control systems must have a capability to optimise the traffic flow by adjusting the traffic signals based on current traffic. All used traffic signal control methods are based on feed-back algorithms using traffic demand data -varying from years to a couple of minutes - in the past. Current adaptive systems often operate on the basis of adaptive green phases and flexible co-ordination in (sub)networks based on measured traffic conditions (e.g., UTOPIA-spot,SCOOT). These methods are still not optimal where traffic demand changes rapidly within a short time interval. The basic premise is that existing signal plan generation tools make rational decisions about signal plans under varying conditions; but almost none of the current available tools behave pro-actively or have meta-rules that may change behaviour of the controller incorporated into the system. The next logical step for traffic control is the inclusion of these meta-rules and pro active and goal-oriented behaviour. The key aspects of improved control, for which contributions from artificial intelligence and artificial intelligent agents can be expected, include the capability of dealing with conflicting objectives; the capability of making pro-active decisions on the basis of temporal analysis; the ability of managing, learning, self adjusting and responding to non-recurrent and unexpected events (Ambrosino et al.., 1994).
机械设计 摘要：机器是由机械装置和其它组件组成的。它是一种用来转换或传递能量的装置，例如：发动机、涡轮机、车辆、起重机、印刷机、洗衣机、照相机和摄影机等。许多原则和设计方法不但适用于机器的设计，也适用于非机器的设计。术语中的“机械装置设计”的含义要比“机械设计”的含义更为广泛一些，机械装置设计包括机械设计。在分析运动及设计结构时，要把产品外型以及以后的保养也要考虑在机械设计中。在机械工程领域中，以及其它工程领域中，所有这些都需要机械设备，比如：开关、凸轮、阀门、船舶以及搅拌机等。 关键词：设计流程设计规则机械设计 设计流程 设计开始之前就要想到机器的实际性，现存的机器需要在耐用性、效率、重量、速度，或者成本上得到改善。新的机器必需具有以前机器所能执行的功能。 在设计的初始阶段，应该允许设计人员充分发挥创造性，不要受到任何约束。即使产生了许多不切实际的想法，也会在设计的早期，即在绘制图纸之前被改正掉。只有这样，才不致于阻断创新的思路。通常,还要提出几套设计方案，然后加以比较。很有可能在这个计划最后决定中,使用了某些不在计划之内的一些设想。 一般的当外型特点和组件部分的尺寸特点分析得透彻时，就可以全面的设计和分析。接着还要客观的分析机器性能的优越性，以及它的安全、重量、耐用性，并且竞争力的成本也要考虑在分析结果之内。每一个至关重要的部分要优化它的比例和尺寸，同时也要保持与其它组成部分相协调。 也要选择原材料和处理原材料的方法。通过力学原理来分析和实现这些重要的特性，如那些静态反应的能量和摩擦力的最佳利用，像动力惯性、加速动力和能量；包括弹性材料的强度、应力和刚度等材料的物理特性，以及流体润滑和驱动器的流体力学。设计的过程是重复和合作的过程，无论是正式或非正式的进行，对设计者来说每个阶段都很重要。 最后，以图样为设计的标准，并建立将来的模型。如果它的测试是符合事先要
文献翻译 原文 Combining JSP and Servlets The technology of JSP and Servlet is the most important technology which use Java technology to exploit request of server, and it is also the standard which exploit business application .Java developers prefer to use it for a variety of reasons, one of which is already familiar with the Java language for the development of this technology are easy to learn Java to the other is "a preparation, run everywhere" to bring the concept of Web applications, To achieve a "one-prepared everywhere realized." And more importantly, if followed some of the principles of good design, it can be said of separating and content to create high-quality, reusable, easy to maintain and modify the application. For example, if the document in HTML embedded Java code too much (script), will lead the developed application is extremely complex, difficult to read, it is not easy reuse, but also for future maintenance and modification will also cause difficulties. In fact, CSDN the JSP / Servlet forum, can often see some questions, the code is very long, can logic is not very clear, a large number of HTML and Java code mixed together. This is the random development of the defects. Early dynamic pages mainly CGI (Common Gateway Interface, public Gateway Interface) technology, you can use different languages of the CGI programs, such as VB, C / C + + or Delphi, and so on. Though the technology of CGI is developed and powerful, because of difficulties in programming, and low efficiency, modify complex shortcomings, it is gradually being replaced by the trend. Of all the new technology, JSP / Servlet with more efficient and easy to program, more powerful, more secure and has a good portability, they have been many people believe that the future is the most dynamic site of the future development of technology. Similar to CGI, Servlet support request / response model. When a customer submit a request to the server, the server presented the request Servlet, Servlet responsible for handling requests and generate a response, and then gave the server, and then from the server sent to
Increasing an individual’s quality of life via their intelligent home The hypothesis of this project is: can an individual?s quality of life be increased by integrating “intelligent technology” into their home environment. This hypothesis is very broad, and hence the researchers will investigate it with regard to various, potentially over-lapping, sub-sections of the population. In particular, the project will focus on sub-sections with health-care needs, because it is believed that these sub-sections will receive the greatest benefit from this enhanced approach to housing. Two research questions flow from this hypothesis: what are the health-care issues that could be improved via “intelligent housing”, and what are the technological issues needing to be so lved to allow “intelligent housing” to be constructed? While a small number of initiatives exist, outside Canada, which claim to investigate this area, none has the global vision of this area. Work tends to be in small areas with only a limited idea of how the individual pieces contribute towards a greater goal. This project has a very strong sense of what it is trying to attempt, and believes that without this global direction the other initiatives will fail to address the large important issues described within various parts of this proposal, and that with the correct global direction the sum of the parts will produce much greater rewards than the individual components. This new field has many parallels with the field of business process engineering, where many products fail due to only considering a sub-set of the issues, typically the technology subset. Successful projects and implementations only started flow when people started to realize that a holistic approach was essential. This holistic requirement also applies to the field of “smart housing”; if we genuinely want it to have benefit to the community rather than just technological interest. Having said this, much of the work outlined below is extremely important and contains a great deal of novelty within their individual topics. Health-Care and Supportive housing： To date, there has been little coordinated research on how “smart house” technologies can assist frail seniors in remaining at home, and/or reduce the costs experienced by their informal caregivers. Thus, the purpose of the proposed research is to determine the usefulness of a variety of residential technologies in helping
研究论文英文摘要翻译 【摘要】本文作者在多年从事学报论文摘要的撰写与翻译、审核与校对的工作中，发现我院科研论文作者提交的英文摘要撰写和翻译错误，有不少值得改善的地方。同时也提醒即将发表论文的作者，在撰写或翻译论文摘要时注意的一些理由。本文对我院英文论文的发表、摘要的撰写和英语翻译具有积极的指导。 【关键词】摘要翻译 【注】本论文受《具有军事特色的网络文化大学英语课程体系研究》科研项目支持。 （） 目前，科技论文与信息的国际交流日益频繁。但许多期刊数据库只免费提供摘要的阅读，许多国外读者只能阅读摘要来判断是否阅读全文。因此摘要的英文翻译对于论文的国际引用次数、检索率具有十分的。除非是在英语国家生活工作很长时间英语功底非常扎实，我院一般论文作者撰写摘要很大程度上是把已经写好的中文摘要翻译成英文，在撰写或翻译时有不少方面注意。 .摘要的英文翻译原则 英文摘要标题实词首字母要大写 汉语文章的标题不存在大小写之分，但有字体大小的不同。英语除了字体不同之外，还有大小写字母之分。，英文摘要的标题的实词要大写，非句首介词等虚词不大写。例如一篇论文标题为“基于静态舒适性分析的装甲车辆驾驶舱人机匹配研究”的文章英语译名为
“ ？鄄？蒺”（摘自年学报第期“基于静态舒适性分析的装甲车辆驾驶舱人机匹配研究”，作者：谢成林刘维平）。在此标题中除了两个介词“”之外，其它实词首字母大写。其次，复合词只需第一个单词首字母大写。仍以上述标题为例，复合形容词“？鄄”中只需将“”首字母“”大写，连字符后面的“”则不大写。再者，标题中较长（个字母以上）的虚词也要大写。如标题“ （非拆解发动机探伤）”中介词“”大写。此外，位于首位或末尾的虚词也大写。如：（装备采购原则研究）。 摘要标题翻译的名词化 摘要一般不是完整的句子，不含谓语动词。我院学报上见到的中文论文标题几乎较长的名词性结构或介词结构短语，很少看到完整的句子。因此在译成英文时，也大多以名词短语的形式出现，一般不包含谓语成分。比如，有篇论文标题为“履带车辆转向性能指标修正与实验研究”，就是一个以“研究”为核心词的偏正词组。其译文也是如此，只是英文中核心词的位置放到前面，如“ ”（摘自学报年“履带车辆转向性能指标修正与实验研究”，作者：宋海军高连华）。 .作者姓名的翻译要规范化 作者姓名的汉语拼音要规范 在科研论文的撰写、编辑中，经常见到姓名汉语拼音书写不够规范甚至错误的现象。根据国家颁布的《中国人名汉字拼音字母拼写法》（）的规定，姓名拼音可归纳为以下点。. 汉语姓名的拼音法以普通
9个常用的国外英文论文文献数据库 9个论文文献数据库，科研搬砖，阅读涨姿势，论文写作小帮手！先说说什么是数据库：学术科研中说的「数据库」和「文献数据库」，往往是一种的形式，这个的贮存了大量文献数据（比如论文）可以简单的理解为一个网络图书馆。 数据库中的论文往往都是耗费了大量的时间和精力整理出来的，还有很多是需要购买才可以放在互联网上的，再加上维护这个本身就耗费颇多，因此这些数据库通常不是完全免费的，你可以在上面免费查找文献，浏览摘要等简介容，但是如果你要下载文献，就要付钱。 大学因为科研和教学需要，常年要下载大量的论文材料，所以就会和数据库的经营者签订很多协议，例如包年，就是给一定量的钱，然后就可以无限制下载论文。也有按照下载的数量进行计费。那英语作为世界第一学术语言，有哪些数据库是值得大家分享的呢？1、Wiley InterScience(英文文献期刊)Wiley InterScience是John Wiely & Sons公司创建的动态在线容服务，1997年开始在网上开通。通过InterScience，Wiley公司以许可协议形式向用户提供在线访问全文容的服务。Wiley InterScience收录了360多种科学、工程技术、医疗领域及相关专业期刊、30多种大型专业
参考书、13种实验室手册的全文和500多个题目的Wiley 学术图书的全文。网址：onlinelibrary.wiley./其中被SCI 收录的核心期刊近200种。期刊具体学科划分为：Business,Finance & Management (商业、金融和管理)、Chemistry (化学)、Computer Science（计算机科学）、Earth Science （地球科学）、Education （教育学）、Engineering （工程学）、Law（法律）、Life and Medical Sciences （生命科学与医学）、Mathematics and Statistics（数学统计学）、Physics （物理）、Psychology （心理学）。 2. ICPSRICPSR全称为Inter-university Consortium for Political and Social Research，即美国校际社会科学数据共享联盟。成立于1962年，位于美国密西根大学安娜堡分校(University of Michigan- Ann Arbor, 1817-)，储存超过17000种调查研究资料，如军队官兵总名册，遗嘱、遗嘱查验与税收纪录，是现在世界上最大的社会科学数据中心，拥有600多个成员机构，包括大学和各种研究中心。网址：https://www.doczj.com/doc/9c4095754.html,/icpsrweb/landing.jsp其中400多个成员机构在美国，我国的国家人口发展研究战略课题组，大学，大学，科技大学，浸会大学也是成员之一。 3. IEEE 电气电子工程师学会IEEE（Institute of Electrical & Electronics Engineers）是电子信息领域最著名的跨国性学
外文文献及翻译 题目：利用固定化过氧化氢酶 回收纺织品漂染的废水 专业食品科学与工程 学生姓名梁金龙 班级B食品072 学号0710308119 指导教师郑清
利用固定化过氧化氢酶回收纺织品漂染的废水 Silgia A. Costa1, Tzanko Tzanov1, Filipa Carneiro1, Georg M. Gübitz2 &Artur Cavaco-Paulo1,? 1纺织工程系, 米尼奥大学, 4810吉马尔, 葡萄牙 2环境生物技术系, 格拉茨技术大学, 8010格拉茨, 奥地利 ?作者联系方式(Fax: +351 253 510293; E-mail: artur@det.uminho.pt) 关键词：过氧化氢酶的固定化，酶稳定，过氧化氢，纺织印染 摘要 过氧化氢酶固定在氧化铝载体上并用戊二醛交联，在再循环塔反应器和CSTR反应器中研究贮存稳定性，温度和pH值对酶的活性。固定化酶的在的活性维持在44％，pH值11（30?C），对照组是活性为90％，pH值7（80?C），过氧化氢酶固定化的半衰期时间被提高到2小时（pH12，60?C）。用过氧化氢漂白织物后，洗涤过程中的残留水被固定化酶处理，可以用于再次印染时，记录实验数据。 1 序言 由于新的法规的出台，从生态经济的角度来看（Dickinson1984年），对于纺织行业中存在的成本和剩余水域的污染问题，必须给予更多的关注。过氧化氢是一种漂白剂，广泛应用于工业纺织工艺（Spiro & Griffith1997年）。在去除H2O2时，会消耗大量的水和能源（Weck 1991, St?hr & Petry 1995），以避免对氧气敏感的染料（Jensen 2000）产生后续问题。过氧化氢酶可用于降低过氧化氢的含量（Vasudevan & Thakur 1994, Emerson et al. 1996），从而减少水分消耗或方便回收印染洗涤液。过氧化氢酶的使用主要问题出在漂白时温度和清洗液碱度过高。以前，我们试图通过筛选新的嗜热嗜碱的微生物（Paar et al. 2001）或使用不同的酶稳定剂（Costa et al. 2001）来解决此问题。但是染料与蛋白质之间的潜在相互作用（Tzanov et al. 2001a, b）表明，可溶性过氧化氢酶的使用是不恰当的。固定化过氧化氢酶的使用还有一种选择(Costa et al. 2001, Amar et al. 2000)。在这项研究中，我们对氧化铝进行共价固定并使用戊二醛作为交联剂，这种方法在商业中得到验证。本项研究的目的就是探讨过氧化氢酶的固定化动力学，及其稳定性和工艺条件，这将使我们能够应用此系统，以处理可能被用于清洗染色的反复使用的酒。 2 材料和方法 2.1 酶 Terminox（EC1.11.1.6），50L以上，由AQUITEX- Maia提供，葡萄牙产。 2.2 过氧化氢酶的固定化 取Al2O3颗粒或薄片（Aldrich），直径分别为3和7毫米，在45摄氏度下，先经浓度4%的γ-氨丙基三乙氧基硅烷(Sigma)烷基化，再放入丙酮中浸泡24小时。用蒸馏水洗涤硅烷化载体后，放入浓度为2％戊二醛水溶液中室温下浸泡2小时（Aldrich），重复清洗一次并在60?C下干燥1小时。取五克的烷基化载体，室温24?C下浸泡在25毫升粗酶制剂中（Costa et al. 2001）。得出，每克Al2O3
毕业设计(论文)外文资料翻译 系别光电信息系 专业测控技术与仪器 班级 B090102 姓名马丽娜 学号 36 外文出处 Spriger Link 附件 1. 原文； 2. 译文 2013年3月
Based on single chip microcomputer intelligent street light control system 【abstract 】 A street light automatic control system design, combined with the control, electric lamp switch control function; And street lamp fault detection and fault street lamp according to the function of the number. Use on STC 89C51 as the core Control unit; Using DS1302 clock chip to control the point open to turn off the lights when street lamps; By a photosensor complete collection of ambient light and street light fault detection, so as to realize the number of optically controlled open to turn off the lights and fault street lamp display. This system Can through the RS - 232 communication port with the street light control room of the upper machine communication. 【key words】STC 89C51; Clock chip DS1302; photosensor Introduction For the most part at present domestic cities and regions of the street lamp Lighting adopts electric control, time control and single point of electrons Control, maintenance management and manual inspections and the masses The traditional way, because of the lack of scientific and effective monitoring Means, large area lighting during the day, night not large area Light phenomenon occurs frequently, often can't find and in a timely manner Processing, not only caused power resources, human resources Cost, improve the operating costs of the system and to citizens Life bring inconvenience. Intelligent road lighting system can according to different area Domain of different functional requirements, at different times and different every day Natural light or under different traffic flow conditions, the press According to a specific setting, realize dynamic wisdom of road lighting Can management, namely the TPO management (TIME/PLACE, TIME Location/OCCASION occasions). Intelligent road lighting Control system, through the comprehensive consideration and analysis and road Ming is closely related to the intensity of illumination time, road, environment and hand it in Scene control methods of factors such as flow rate, in the
数据库外文参考文献及翻译 数据库外文参考文献及翻译数据库管理系统——实施数据完整性一个数据库，只有用户对它特别有信心的时候。这就是为什么服务器必须实施数据完整性规则和商业政策的原因。执行SQL Server的数据完整性的数据库本身，保证了复杂的业务政策得以遵循，以及强制性数据元素之间的关系得到遵守。因为SQL Server的客户机/服务器体系结构允许你使用各种不同的前端应用程序去操纵和从服务器上呈现同样的数据，这把一切必要的完整性约束，安全权限，业务规则编码成每个应用，是非常繁琐的。如果企业的所有政策都在前端应用程序中被编码，那么各种应用程序都将随着每一次业务的政策的改变而改变。即使您试图把业务规则编码为每个客户端应用程序，其应用程序失常的危险性也将依然存在。大多数应用程序都是不能完全信任的，只有当服务器可以作为最后仲裁者，并且服务器不能为一个很差的书面或恶意程序去破坏其完整性而提供一个后门。SQL Server使用了先进的数据完整性功能，如存储过程，声明引用完整性（DRI），数据类型，限制，规则，默认和触发器来执行数据的完整性。所有这些功能在数据库里都有各自的用途;通过这些完整性功能的结合，可以实现您的数据库的灵活性和易于管理，而且还安全。声明数据完整性声明数据完整原文请找腾讯3249114六,维-论'文.网 https://www.doczj.com/doc/9c4095754.html, 定义一个表时指定构成的主键的列。这就是所谓的主键约束。SQL Server使用主键约束以保证所有值的唯一性在指定的列从未侵犯。通过确保这个表有一个主键来实现这个表的实体完整性。有时，在一个表中一个以上的列（或列的组合）可以唯一标志一行，例如，雇员表可能有员工编号（ emp_id ）列和社会安全号码（ soc_sec_num ）列，两者的值都被认为是唯一的。这种列经常被称为替代键或候选键。这些项也必须是唯一的。虽然一个表只能有一个主键，但是它可以有多个候选键。 SQL Server的支持多个候选键概念进入唯一性约束。当一列或列的组合被声明是唯一的， SQL Server 会阻止任何行因为违反这个唯一性而进行的添加或更新操作。在没有故指的或者合适的键存在时，指定一个任意的唯一的数字作为主键，往往是最有效的。例如，企业普遍使用的客户号码或账户号码作为唯一识别码或主键。通过允许一个表中的一个列拥有身份属性，SQL Server可以更容易有效地产生唯一数字。您使用的身份属性可以确保每个列中的值是唯一的，并且值将从你指定的起点开始，以你指定的数量进行递增（或递减）。（拥有特定属性的列通常也有一个主键或唯一约束，但这不是必需的。）第二种类型的数据完整性是参照完整性。 SQL Server实现了表和外键约束之间的逻辑关系。外键是一个表中的列或列的组合，连接着另一个表的主键（或着也可能是替代键）。这两个表之间的逻辑关系是关系模型的基础;参照完整性意味着这种关系是从来没有被违反的。例如，一个包括出版商表和标题表的简单的select例子。在标题表中，列title_id （标题编号）是主键。在出版商表，列pub_id （出版者ID ）是主键。 titles表还包括一个pub_id列，这不是主键，因为出版商可以发布多个标题。相反， pub_id是一个外键，它对应着出版商表的主键。如果你在定义表的时候声明了这个关系， SQL Server由双方执行它。首先，它确保标题不能进入titles表，或在titles表中现有的pub_id无法被修改，除非有效的出版商ID作为新pub_id出现在出版商表中。其次，它确保在不考虑titles表中对应值的情况下，出版商表中的pub_id的值不做任何改变。以下两种方法可