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结直肠上皮内瘤变病理临床诊断研究

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结直肠上皮内瘤变病理临床诊断研究

作者:杨应益

来源:《健康之路(医药研究)》2014年第04期

【摘要】目的:分析结直肠上皮内瘤变采用病理诊断的临床价值。方法:共121例上皮内瘤变患者,其中63例属于低级别,58例属于高级别。患者均实施手术,对术后患者病理切片结果同手术前活检结果进行对比。结果:63例术前低级别患者,手术后检查,23例患者为浸润性腺癌,40例患者为腺瘤;58例术前高级别患者,手术后检查,50例患者为浸润性腺癌,8例患者为腺瘤。浸润性腺癌共73例,其中2例出现肝脏病灶转移,4例出现组织病灶转移,9例出现淋巴结病灶转移。结论:结直肠上皮内瘤变诊断结果在手术前后具有明显差异,并且诊断过程中还要提防患者出现浸润性癌变,要对可疑病例进行细致的分析,防止出现误诊。

【关键词】结直肠上皮内瘤变;浸润性腺癌;临床诊断

Abstract Objective: To analyze the clinical value of the pathologic diagnosis in colorectal intraepithelial neoplasia. Methods: Choosed 121 patients to divide into high-grade group and low-grade group. All patients were actualized operation, compared the results of tissue sections before and after operation. Results: In low-grade group with 63 patients, there were 23 cases of invasive adenocarcinoma and 40 cases of adenoma. In high-grade group with 58 patients, there were 50 cases of invasive adenocarcinoma and 8 cases of adenoma. In total 73 cases were invasive adenocarcinoma, including 2 cases of liver metastatic lesions, 4 cases of tissue metastatic lesions and 9 cases of lymph node metastatic lesions. Conclusion: There is a significant difference between the diagnosis results of colorectal intraepithelial neoplasia before and after operation. Notice the invasive adenocarcinoma and reduce misdiagnosis.

Key words: colorectal intraepithelial neoplasia, invasive adenocarcinoma, clinical diagnosis

【中图分类号】R4 【文献标识码】A 【文章编号】1671-8801(2014)04-0016-02

国际癌症研究部门在2000年规定,对结直肠癌实施诊断时,当肿瘤组织经过粘膜肌层到达粘膜下部时才能确定为浸润性癌;没有到达粘膜下层的肿瘤,依据不同的结构以及细胞变异程度,分为上皮内瘤变低级别和高级别两种类型。我院对121例手术前确诊为上皮内瘤变患者进行病理诊断,分析如下。

1资料和方法

1.1一般资料我院2006年6月到2012年11月收治121例上皮内瘤变手术前确诊患者,其中63例属于低级别,58例属于高级别。男63例,女58例,平均为49岁。17例患者升结肠

出现肿瘤,3例患者横结肠出现肿瘤,13例患者降结肠发现肿瘤,23例患者乙状结肠发现肿瘤,65例患者直肠发现肿瘤。

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