Different fatty acid metabolism effects of (?)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer
Results
Treating lung cancer cells with EGCG or C75 induced apoptosis and affected EGFR-signaling. While EGCG abolished p-EGFR, p-AKT, p-ERK1/2 and p-mTOR, C75 was less active in decreasing the levels of EGFR and p-AKT. In vivo, EGCG and C75 blocked the growth of lung cancer xenografts but C75 treatment, not EGCG, caused a marked animal weight loss.
L-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways
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Novel indoloquinoline derivative, IQDMA, induces G2/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation
时间点：0 8 16 24h
MRC-5(胚肺细胞)株（ATCC）-正常的肺细胞株。
Organ: lung
Cell type: fibroblast
Disease: normal
ERK i nhibito r (PD9805 9), inhibitors of JNK (SP6 00125)
inhibitors p 38 MAPK (SB2035 80)