新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6.
【报告名称】:新药委托开发市场研究－Outsourcing in Drug Discovery - 2010.6.
【报告页数】:176
【报告来源】:Kalorama Information
【报告日期】:2010.6.
【报告价格】:电子版RMB ￥500.00
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【报告摘要】: All4report [报告汇] is an industrial focused team, providing most up-to-date industrial analysis, marketing research reports, consulting reports across sectors. It provides free & sharing-base platform for exchange industrial information & trends.
OVERVIEW
Drug discovery is a high-cost, risky business because only a fraction of the therapeutic targets selected for study will actually yield products that achieve regulatory approval by the Food & Drug Administration (FDA). The average drug can take 10+ years to progress from the discovery phase to the clinic, with only one compound out of 10,000 evolving into a viable product (Exhibit 1-1).
Through outsourcing portions of their drug discovery programs, many pharmaceutical and biotechnology companies have found an effective cost-cutting strategy that can also improve the hit-to-lead conversion and early identification of unsuccessful compounds. In view of the fact that outsourcing can accelerate the drug discovery process, the business of contract drug discovery has evolved from providing low-end research services to more value-added high-end research.
Major trends that have led to an increase in demand for contract services in drug discovery include: ?development of new technologies that continued to increase the number of targets and accelerate the identification of active compounds;
?pressure to develop new lead compounds due to the near-term loss of patent protection for many drug products;
?increased pressure to reduce the time spent in drug discovery and to bring drugs to market sooner;
?increased focus on converting fixed costs to variable costs and streamlining operations by contracting for research and development services;
?heightened regulatory environment and increased complexity that made the internal management of complicated discovery projects more difficult and costly; and
?biotechnology and emerging pharmaceutical companies, in many cases, lacking the required in-house drug discovery and development expertise.
Another major trend that continues to gain momentum is choosing
outsourcing partners in Asia and Eastern Europe. It is not only large pharmaceutical and biopharmaceutical companies that are moving their outsourcing offshore, but smaller biopharmaceutical companies are following this trend as well. Small biopharmaceutical firms, such as virtual companies, that lack the infrastructure to carry out complex chemistry, biology, and lead optimization services are chosing outsourcing partners in India or china, thus expanding the
新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6.
rapidly evolving global drug discovery outsourcing market.
【报告目录】:
TABLE OF CONTENTS
CHAPTER ONE: EXECUTIVE SUMMARY Overview (1)
Scope and Methodology (3)
Introduction (3)
Pharmaceutical Industry Challenges (3)
The Drug Discovery Process (6)
Accelerating the Drug Discovery Process (6)
Bottlenecks Within the Drug Discovery Process (6)
Outsourcing to Increase efficiency (8)
Outsourcing Drug Discovery (10)
The Outsourcing Decision (10)
Developing an Outsourcing Plan (11)
Contract Research Organizations (13)
Strategic Versus Tactical Outsourcing Model (13)
Effective Communication is Essential (13)
Mitigating the Challenges of Protecting IP Rights (13)
Offshoring Contract Drug Discovery (14)
Factors to Consider in Offshore Outsourcing (14)
Benefits of Global Outsourcing (14)
Cost Advantage (14)
Concerns about Global Outsourcing (14)
Outsourcing to China (15)
Chinese Contract Research Organizations (15)
FDA Offices in China (16)
Outsourcing to india (16)
Indian Contract Research Orgnizations (16)
FDA Offices in India (17)
Outsourcing to Eastern Europe (17)
Drug Discovery Outsourcing Market (17)
Current Market and Forecast (18)
Market analysis by Segment (19)
CHAPTER TWO: INTRODUCTION
Introduction To Outsourcing Drug Discovery (21)
Number of NME Approved in Decline While R&D Spending Rising (22)
Ramping up the Pipelines (23)
Factors to Consider in Offshore Outsourcing (28)
Benefits of Global Outsourcing (29)
新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6.
Cost Advantage (29)
Access to talent and technologies (29)
Compress timeline (29)
Increase Production (29)
Concerns about Global Outsourcing (29)
Intellectual property protection (IP) (29)
Confidential Information and Trade Secrets (30)
Fraud and Corruption (30)
Meeting Regulatory Compliance Demands (30)
Long distance (30)
Introduction (30)
Choosing the Right CRO (31)
Experience is Paramount (31)
Facility Standards (31)
Excellent Track Record (31)
Contract Pharma’s Outsourcing Survey (32)
Global Outsourcing (33)
CHAPTER THREE: THE DRUG DISCOVERY PROCESS Introduction (37)
Drug Discovery Stages (39)
Target Identification (39)
Target Validation (39)
High Throughput Screening (40)
Lead Optimization (40)
Accelerating the Drug Discovery Process (41)
Technologies Utilized in Drug Discovery (41)
Combinatorial Chemistry (42)
Bioinformatics/Pharmacogenomics (43)
ADME/Tox Screening (45)
High Throughput Screening (47)
Computational Modeling and Bioinformatics (47)
Outsourcing to increase efficiency (48)
Outsourcing to access novel technologies (50)
Bioinformatics (50)
Lab-on-a-chip: Microfluidics in Drug Discovery (51)
CHAPTER FOUR: OUTSOURCING TRENDS
Overview (53)
Contract Research Organizations (55)
新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6. Introduction (55)
Role of a CRO (56)
Strategic Versus Tactical Outsourcing Model (57)
The Tactical Model (57)
The Strategic Model (57)
Mitigating the Challenges of Protecting IP Rights (59)
Offshoring Contract Drug Discovery (60)
Introduction (60)
Center of Gravity for the Pharmaceutical Industry Shifting from West to East (62)
Evolution of Contract Drug Discovery in Asia (63)
Outsourcing to China (63)
Introduction (63)
Multi-National Pharmaceutical Companies Establish Drug Discovery Facilities in China (64)
Chinese Contract Research Organizations (65)
WuXi AppTec China’s Largest CRO (66)
First Chinese CRO Alliance (67)
FDA Offices in China (68)
China's Management of Counterfeit Pharmaceuticals and IP Rights and Laws (68)
IP Rights Enforcement System (69)
Outsourcing to India (70)
Introduction (70)
AstraZeneca Sets up Drug Discovery Facility in Bangalore (70)
Drug Discovery Services in India (71)
India’s Handling of IP Rights and Laws (73)
Patent Filing Considerations (73)
Limitations on Patentability (73)
Compulsory Licenses (74)
FDA Offices in India (74)
Outsourcing to Eastern Europe (75)
Introduction (75)
Russian and Ukraine CROs (75)
CHAPTER FIVE: MARKET ANALYSIS
Drug Discovery Outsourcing Market (78)
Unfavorable Global Economic Market Conditions (78)
Current Market and Forecast (79)
Contract Drug Discovery Competitors (81)
Market Analysis by Segment (83)
Chemistry Services Market (84)
Current Market and Forecast (85)
Biology Services Market (88)
Current Market and Forecast (89)
新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6.
High Throughput Screening Services Market (91)
Current Market and Forecast (93)
Lead Optimization Services Market (95)
Current Market and Forecast (96)
CHAPTER SIX: COMPETITOR PROFILES
Competitor Profiles (101)
Albany Molecular Research, Inc. (101)
History and Lines of Business (101)
Drug Discovery Services (102)
Financial Information (103)
Argenta Discovery, Ltd (103)
History and Lines Business (103)
Drug Discovery Services (104)
Biology (105)
Chemistry (105)
Asinex Ltd (106)
History and Lines of Business (106)
Drug Discovery Services (106)
BioDuro, Inc. (108)
History and Lines of Business (108)
Drug Discovery Services (108)
Chemistry Services (108)
Biology Services (109)
BioFocus DPI (110)
History and Lines of Business (110)
Drug Discovery Services (110)
Integrated drug discovery (111)
ADME/PK (111)
Target discovery (111)
Assay development & screening (111)
Additional drug discovery services include: (111)
Caliper Life Sciences (112)
History and Lines of Business (112)
Drug Discovery Services (113)
Financial Information (113)
Charles River Laboratories, Inc. (115)
History and Lines of Business (115)
Drug Discovery Services (116)
Financial Information (117)
ChemBridge Corp. (118)
History and Background (118)
Drug Discovery Services (119)
新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6.
Chemical Diversity Inc. (120)
History and Lines of Business (120)
Drug Discovery Services (120)
Lead Optimization Services (120)
High throughput Services (121)
Biologically Annotated Libraries (121)
Focused Diversity (121)
Emerald Biostructures (122)
History and Lines of Business (122)
Drug Discovery Services (122)
Gene to Structure (123)
Fragment Screening (123)
Enamine Ltd. (124)
History and Lines of Business (124)
Drug Discovery Services (124)
Screening Compounds (125)
Screening Compounds From REAL Database? (125)
Lead Optimization (125)
Discovery Chemistry and Custom Synthesis (125)
Research (126)
Evotec OAI (127)
History and Lines of Business (127)
Drug Discovery Services (128)
Assay Development Services (128)
High throughput Screening (128)
Medicinal Chemistry Services (129)
Compound Library Services (129)
Financial Information (130)
History and Lines of Business (131)
Drug Discovery Services (131)
Bioinformatics (131)
Chemoinformatics (132)
Structural Biology (132)
Biology Services (132)
GenScript USA Inc. (133)
History and Lines of Business (133)
Drug Delivery Services (134)
Bio-Reagent Center (134)
Molecular Biology Services (134)
Peptide Services (134)
Protein Services (134)
Antibody Services (134)
Cell Line Services (134)
新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6.
Bio-Assay Center (134)
Lead Optimization Center (134)
Antibody Drug Development (134)
hERG testing for drug candidates (134)
Bioprocess Services (135)
Hutchison MediPharma Ltd. (136)
History and Lines of Business (136)
Drug Discovery Services (137)
Discovery Chemistry (137)
Discovery Biology (137)
Discovery Pharmacology (137)
Drug Metabolism and Pharmacokinetics (DMPK) (138)
Jubilant Biosys Ltd. (139)
History and Lines of Business (139)
Drug Discovery Services (139)
Discovery Informatics (140)
Discovery Research (140)
Drug Development (141)
IT Services (142)
Ligand Pharmaceuticals, Inc. (143)
History and Lines of Business (143)
Drug Discovery Services (143)
Pharmaron inc (145)
History and Lines of Business (145)
Drug Discovery Services (145)
Ricerca Biosciences, LLC (147)
History and Lines of Business (147)
Drug Discovery Services (148)
Scynexis, Inc. (149)
History and Lines Business (149)
Drug Discovery Services (149)
Medicinal Chemistry (149)
Custom Synthesis (150)
High Throughput Purification & Analysis (150)
ADMET & Bioanalytical Services (150)
Bioanalytical Capabilities (151)
Data Management And Collaboration (151)
Shanghai ChemPartner Co.,Ltd. (152)
History and Lines of Business (152)
Drug Discovery Services (152)
Discovery Chemistry (152)
Library Generation (153)
Analytical Chemistry (153)
新药委托开发市场研究- Outsourcing in Drug Discovery - 2010.6. Medicinal Chemistry (153)
ADME Studies (154)
Natural Product Chemistry (154)
Computational Chemistry And Drug Design (155)
Shanghai Medicilon Inc. (156)
History and Lines of Business (156)
Drug Discovery Services (156)
Custom Chemical Synthesis (156)
Pharmacokinetics (157)
Metabolism Services (157)
Bioanalytical Services (157)
Structural Biology Services (157)
Other Biological Services (157)
TCG Lifesciences Ltd. (158)
History and Lines of Business (158)
Drug Development Services (158)
WuXI AppTec Co. Ltd. (160)
History and Lines of Buisness (160)
Drug Discovery Services (161)
Discovery Chemistry Services (161)
Analytical Services (162)
Biological Services (162)
Financial Information (163)