当前位置:文档之家› The clinical use of MEG activity associated with brain lesions

The clinical use of MEG activity associated with brain lesions

The clinical use of MEG activity associated with brain lesions
The clinical use of MEG activity associated with brain lesions

The c linical u se of MEG a ctivity a ssociated with b rain l esions J. B. Vieth1,2, H. Kober2,3, O. Ganslandt3, M. M?ller2,3, and K. Kamada2 Departments of 1Biomedical Engineering, and 2Experimental Neuropsychiatry, and 3Clinic of Neurosurgery, University of Erlangen-Nürnberg, Germany

1Introduction

Brain lesions may alter the surrounding brain tissue structurally by moving or compressing it, or by in-filtration or edema. Electrophysiological signs of the deteriorated function in these border zones can be focal slow (and fast) wave and epileptic activity in MEG (and EEG).

Clinically it is of great interest to know the localiza-tion and the extent of these focal sources, but also the location and the extent of the evoked and event related activity of functionally important areas around brain lesions. So we developed, adapted and established clinical applications in neurosurgery and neurology with special reference to clinical rele-vance and acceptance.

2Methods

2.1Magnetic Source Imaging (MSI)

2.1.1 B iomagnetic recording and source localiza-tion: From 1990 to 1994 we used the 37 channel system "Krenikon R" of Siemens, Erlangen, Germany (planar recording surface of 20 cm in diameter), and since 1995 the 2x37 channel system "MAGNES II R" of Biomagnetic Technologies Inc. (BTi), San Diego, CA, USA, (curved recording surface with a 14 cm open diameter). The transfer of the coordinates from the head to the recording device and to the magnetic resonance imaging (MRI) data set was done with our surface fit (edge detection algorithm) of the electrically measured head surface (Isotrack TM 3D-digitizer, Polhemus Navigation Sciences, Colches-ter, Vermont, USA) and the head surface which was reconstructed from the MR images. The transfer er-ror is less than 2 mm. The advantages are: (1) easy scanning of the head surface, (2) no need of fiducial points [19].

We used the sphere as the volume conductor model [22]. The source model was - depending on the task - either the single current dipole model or a current distribution solution. In order to apply the single current dipole model in a more adequate way, the localization procedure is performed only on signal sections where one component predominantly de-scribes the signal. The principle component analysis (PCA) is used to select typically only 1-2 % of the whole recording signal, speeding up the source lo-calization procedure substantially [18].

2.1.2 M EG multisource problem: The electric or magnetic fields of brain activity not only originate from the sources of interest but also from the rest of the brain. In order to reduce this "background activ-ity" we use besides the alpha blocking effect during the recording (eyes open) either one of two proce-dures:

Following the localization of dipoles we use a spa-tial averaging, our Dipole-Density-Plot (DDP), which shows the spatial distribution of dipoles over the recording time. It works by a three dimensional convolution using a three dimensional Gaussian en-velope, that takes into account the localization un-certainty [18,38].

Or we use a current density procedure, the CLSF (Current Localization by Spatial Filtering), which we adapted from Robinson and Rose [32]. Our ana-lyzing space (a sphere) consists of 7000 voxels which is adjusted in size and location to the area of interest [10]. The Current-Density-Plot (CDP) is our corresponding spatial averaging of the CLSF [13].

2.2Functional Magnetic Resonance Imaging (fMRI) and Magnetic Resonance Spectroscopic Imaging (MRSI)

For details of these comparing methods see for the fMRI, (1H MRSI) in [35], and for the MRSI in [16]. 3Results and Discussion

3.1Clinical Applications: Normal activity The tool to localize the spatial relation of tumors and their border zones to the cortical somatosensory, motor, auditory and cortical speech areas are now routinely used in Erlangen for operation planning and intraoperative functional neuronavigation with either the Zeiss microscope neuronavigation system (MKM), or the Stealth pointer neuronavigation sys-tem [7].

3.1.1 S omatosensory evoked and motor event re-lated responses: In neurosurgery the clinical useful-ness of the somatosensory magnetic evoked re-sponses (SEF = somatosensory evoked field) have

been demonstrated [5,9,17,25,26,30,36]. A coupling of MSI results to the neuronavigator in image guided neurosurgery was also described [31,43]. The first motor related MEG response was the so called "Bereitschaftsfeld" of the supplementary motor area [4]. The localization of the directly motor induced MEG activity (MEF = motor evoked field) in the precentral gyrus followed [21].

Up to June 2000 we localized in 137patients with tumors around the central sulcus successfully the somatosensory response in 131 cases (95,6 %) and the motor associated cortical responses in 68 out of 72 cases (94,4%), elicited by selfpaced finger movements (trigger obtained by rectified electro-myogram). The SEF-MEG results coincided in all patients with the intraoperatively evoked phase re-versal of the epicortically obtained evoked potentials [7,8,9].

Figure1: Single dipole MSI source localization in the postcentral gyrus using the somatosensory evoked field (SEF) at 50 ms after the tactile stimulus of the right index finger (200 samples averaged) of a 65 years old female patient (wwa) with a meningeoma. A: display of the Stealth neuronavigator showing in a tangential plane the tumor and the MSI SEF source and the intraoperatively used pointer instru-ment. B: enlarged section of A, the central sulcus is shaded, and marked by CS and the SEF source by a white encircled spot (from [37]).

86 patients out of the 137patients were operated by using the functional neuronavigation. 26 patients have not been operated on the basis of the MSI findings. In figure 1 an example is shown of the SEF dipole source in the postcentral gyrus in a patient with a meningeoma displayed by the Stealth neuro-navigator system (c.f. [7,8,9]).

Figure 2 shows in a patient with a left astrocytoma an example of the MEF and the SEF dipole sources in the pre- and post-central gyrus respectively.

3.1.2 M SI and functional MRI (fMRI): The "blood oxygenation level dependent contrast"(BOLD) [28] enables the functional magnetic reso-nance imaging (fMRI) [1], which is used to localize oxygenation differences caused by evoked or event related brain activity. Some fundamental differences between the MSI and the fMRI may result in misin-terpretations of the fMRI localization results. One of these is the different origin of the recorded signals: In MSI the neuronal areas will be localized. But In fMRI the venous branch of the blood supply indi-cates the oxygen level change [28,33]. Another im-portant difference is the time resolution: In fMRI it is in the order of seconds depending on the tissue diffusion and regulation time of oxygen. In MSI the time resolution is in the order of a millisecond. de-pending on the electric properties of the tissue and the recording equipment. So fMRI interpretations should be done with general caution.

Figure 2: Single dipole MSI source localizations of the motor related source (MEF) in the precentral and of the somatosensory evoked field (SEF) in the postcentral gyrus of a 39 years old female patient (age) with a left astrocytoma. SEF and MEF dipole sources are marked respectively. The central sulcus is marked by CS in A. The SEF protocol was as in figure 1. The MEF source was localized at 100 ms after the movement onset of selfpaced brisk move-ments of the right index finger (100 samples aver-aged) (from [37]).

The consequence of the two different principles of the signal origin is demonstrated in our two com-paring studies with 6 subjects [35] and 15 patients [27]. We found a dislocation of the evoked cortical responses obtained by MSI and fMRI typically by around 1 cm.

3.1.3 E vent related speech responses: The clinical usefulness to localize the speech activated cortical areas was demonstrated [13,23,24,34]. In our ap-proach - similar to the WADA-Test [42] - we acti-vate visually by written words and pictograms of monosyllabic concrete objects via a glass fiber bun-

dle from outside the shielded room. In addition to

the Wernicke area the Broca area can be activated by internally speaking of the prior recognised terms [11]. In order to enhance the average signal of the speech related signals meaningless pictograms were presented in another trial and were subtracted after averaging from the average of the speech related presentation [13,23,24].

In Erlangen up to June 2000 we localized in 44pa-tients(37right and7left handed) with brain tumors the speech related cortical areas by using our aver-aging version of the CLSF, the CDP [23,24]. The handedness was determined by the Edinburgh Handedness Inventory [29]. We had a baseline group of 11 healthy subjects. In right handed people one high activity density was in the posterior part of the left superior temporal gyrus (Wernicke area) around 350 ms and with internal speaking in addi-tion in the left inferior frontal gyrus (Broca area) around 500-600 ms (methods c.f. [13]). 12 out of44 patients suffered preoperatively from transient or permanent speech disturbances.

Figure3: Speech related MSI source localizations in A and somatosensory evoked field (SEF) in B of a 69 years old male patient (jza) with a left temporo-parietal glioma. The speech responses were elicited by presenting pictograms of monosyllabic concrete objects for 800 ms. The task was to recognise the meaning of the object and to speak internally the word of the object. The CLSF was determined of 250 averaged samples and displayed with isocontour lines. The first response appeared 340 ms after the onset of the presentation in the posterior part of the left superior temporal gyrus (Wernicke area) marked by W, and the second response was at 745 ms in the left inferior frontal gyrus (Broca area) marked by B. The SEF protocol was as in figure 1. In B the central sulcus is marked by CS (from [37]). In 43 patients(97,7%) the sensory speech area and in 38 patients (86,4%) also the motor speech area could be localized. 24 patients out of the 44patients were operated. 14 patients were operated by using the functional neuronavigation. None suffered from a postoperative deterioration of speech. 8 patients have not been operated on the basis of the MSI findings [23,24]. Figure 3 shows an example of the localization of the speech areas and the somatosen-sory evoked responses in a patient with a left tem-poro-parietal glioma.

The simultaneous recording on both hemispheres allowed to determine the larger activity of the CLSF strength (= S, after regularization) by using the lat-erality index (LI):

LI = (left S max – right S max) / (left S max + right S max)

In 34 of 35 cases the activity was three to nine times larger on the left side and in 1 case three times larger on the right side [23,24]. Figure 4 shows an example of the CLSF hemispheric dominance.

The invasive WADA-test [42] was used for confir-mation according to clinical needs restrictively only. In the 5 total cases the test agreed with the LI (4 left side, 1 right side). So this part of the WADA-test might be supplemented or replaced by the MSI ap-proach in the presurgical evaluation of patients. More comparing studies are necessary.

Figure 4: CLSF-In-

tensity (used for lat-

erality index (LI))

along lines across

the brain at the sen-

sory speech response

(W=Wernicke at 360

ms), and at the mo-

tor speech response

(B=Broca at 410

ms) of a 44 years old

male patient with a

left temporal low

grade glioma. A: test

lines and CLSF iso-

contourlines. B:

CLSF- Intensity (af-

ter regularization).

3.2Clinical Applications: Abnormal activity 3.2.1 E valuation with structural lesions: The DDP and the CLSF (including the CDP) were tested up to June 2000 in 147 patients in the border zone of tu-mors and infarcts using focal slow wave activity (2-6 Hz)and in 88 cases using fast wave activity (12.5-30 Hz) [12]. 19 cases were additionally investigated using the magnetic resonance spectroscopy imaging

(MRSI). On the basis of our results we can be sure

to localize the center and at least the main portion of the functionally impaired area with or without visi-ble lesions in the MRI [15,16,38,40,41].

3.2.2 E pileptogenic lesion: Normally the epilep-togenic zone is removed to cure the epilepsy. But the removal of the epileptogenic lesion (assumed to be the original cause of a seizure disorder) is also important for the clinical outcome [3]. Thus the functional localization of the epileptogenic lesion is of great interest. An advantage is: the signals of spontaneous interictal activity are easily to obtain compared to the acquisition of spikes or even a sei-zure. It appeared, that the spontaneous slow wave activity can be used to localize the epileptogenic lesion of focal epilepsies. [6,21,38,39,40].

Figure 5: Current-Density-Plot (CDP) during the 10 minutes recording time of focal abnormal spontane-ous interictal activity in the border zone of a right frontal astrocytoma of a 67 years old female patient (ida) with grand mal epileptic seizures. In A: spikes, B: slow (2-6 Hz) and C: fast (12.5-30 Hz) wave ac-tivities. In B and C occurring spike/wave activity was eliminated in order to prevent contamination of the slow and fast wave spontaneous activity (from [37]).

In our studies [39,40] with focal epilepsies we had one group of epileptic patients with structural le-sions (5 adults, 4 children) as the reason of the epi-lepsy, and the other group without any visible structural lesion (4 adults, 2 children). For localiza-tion enhancement both the DDP and the CDP have been used. Occurring spike/wave complexes were disregarded in the slow and fast wave activity analy-sis. The three different signal components (interictal epileptic spikes, slow and fast wave activity) of all patients gave a strong spatial coincidence of the DDP and CDP localizations. In the tumor patients the activity also coincided with the border zone of the tumors [39,40]. Figure 5 shows an example. Focal abnormal lesional activity even could be found associated with the (focal) Rolandic epilepsy of children [14]. We demonstrated that even in these cases an epileptogenic lesion may be present associ-ated with functional (psychopathological) deficits, in spite of that "per definitionem" no (visible struc-tural) lesion is associated with this disease in the MRI.

So the localization of the epileptogenic lesion seems to be a valuable additional tool in the presurgical evaluation of epileptogenic patients, especially when no structural lesion is visible in the MRI. But more (multicenter) studies should be done to compare the localization of the epileptogenic lesion, interictal spikes and the seizure begin.

3.2.3 C erebrovascular accidents: Cerebrovascular accidents account for around a quarter of the total mortality and the bulk rate of the disabled people. Therefore it would be of great value to have diag-nostic measures for an early detection of prestages. In our studies we found that the MSI is able to lo-calize not only the disturbed function around an in-farct (or tumor) but also that of an area without a visible lesion but with a functional and maybe re-versible impairment. These can be either transient ischemic attacks (TIA), or infarcts which are too small to be detected by the standard MRI resolution. Up to now we localized not only the pathological activity associated with brain infarcts in 23 patients, but also in 21 cases the activity associated with the penumbra of transient ischemic attacks (TIA) [16, 20,38,41].

Thus also clinically silent reversible ischemic brain deficits can be localized in accordance to clinically silent brain infarcts [2]. This finding is of clinical importance for the decision, whether an extracranial stenosis of the internal carotid artery has caused deficits or not. And these deficits might be another indication for an endarterectomy [41].

The detection and localization of such clinically si-lent deficits, caused by a carotid stenosis, needs a screening. So our finding is very helpful, that the abnormal activity of TIAs is lasting at least 4 weeks after the accident [20]. The localization of the pe-numbra of infarcts is also very important in relation with new therapeutic approaches (i.e. neuroprotec-tors), that prevent neurons to be damaged irreversi-bly. More clinical studies should verify the value of these diagnostic tools.

3.2.4 B rain functions and metabolism: The ab-normal metabolic function of the brain lesion and the penumbra of infarcts and tumors can be local-ized by using the proton magnetic resonance spec-troscopic imaging (1

H MRSI). So we combined the

slow wave MSI and the MRSI in order to compare their spatial relation.

3.2.

4.1 B rain infarcts: We compared 12 patients with a brain infarct to 12 normal cases using the MEG slow wave dipole density (DDP) and the MRSI signal intensity of N-acetyl (NA) (marker for normal function of the brain) and the lactate (Lac) MRSI signal intensity (indicator of anaerobic me-tabolism) [16]. In the patients at least normal tissue, the border zone, and the bulk of the infarct were in-cluded in the analysis.

Figure 6: Dipole-Density-Plot (DDP) of focal ab-normal spontaneous slow wave (2-6 Hz) activity of a 60 years old male patient (kfa) during the recording time of 10 minutes in the border zone of a left brain infarct in A. In B and C: additional overlay of a separately recorded proton magnetic resonance spectroscopic imaging ( 1H MRSI). In B: signals of lactate (Lac); in C: of N-acetyl (NA). Field of view (FOV) 200x200 mm, in A marked by a white line and indicated partly in C by the outer limit of the NA activity; 16x16 phase encoding; nominal in-plane resolution: 12.5 mm, point resolved spectroscopy (PRESS); TR: 1500 ms; TE 135 and 270 ms. Details in [16] (from [37]).

The signal intensity of NA was significantly reduced in the regions with the highest slow wave activity but was well correlated interindividually with the dipole density (DDP) of the quantified maximum of slow waves. Though Lac was mildly accumulated in these regions, the Lac level had no correlation with slow wave magnetic activity.

Figure 6 shows isocontourlines of the spatial distri-bution of the abnormal slow waves, the Lac and the NA activities of a patient with a brain infarct. Figure 7 shows an example of the same patient with the topographic development of the three activities (MSI, NA, Lac) along a line from normal to patho-logical tissue. It appears that the abnormal activity starts relatively far away from the infarct, typically 3 cm or more. [16].3.2.4.2 B rain tumors: We also compared 7 patients with common invasive and non invasive brain tu-mors (i.e. astrocytic tumor and menigeoma) to 10 healthy subjects [15]. The protocol was the same as in the infarct study.

Figure 7: Intensity of abnormal spontaneous slow wave (2-6 Hz) activity, lactate (Lac) 1H MRSI activ-ity, and N-acetyl (NA) 1H MRSI activity of the same patient (kfa) as in figure 6 (left brain infarct) along a line from normal tissue into the bulk of the brain infarct. Same recording protocol as in figure 6. C: line seen in a T1 image. D: line seen in a T2. Enclo-sure in a white rectangular line marks the enlarged area in B. The line in B is in direct spatial relation to the three different activities in A. Details in [16] (from [37]).

Focally increased slow (and fast) wave activities and epileptic spikes were observed in the neuronal area adjacent to the bulk of the tumor with a mild reduc-tion of NA and a slight accumulation of Lac. Lac intensity was less pronounced than in the infarct study. The bulk of the tumors was magnetically si-lent. The extension of the tumor border zone seems to depend on the invasiveness of the tumor, but it seems to be smaller than that of the infarcts, typi-cally about 2 cm. Figure 8 shows an example of the intensity of the three activities along a line from tis-sue of the border zone of a tumor through the tumor and back to tissue outside the tumor again [15].

3.2.

4.3 C onsequences: From the results of both studies we could assume, that preserved and metab-olically active cortical tissue in the border region of infarcts and tumors with remaining NA signal and the increased slow wave activity under lactic acido-sis (mild accumulation of Lac) could be one of the ischemic "penumbra" states [15,16]. So slow wave

sources can serve as a marker to localize the penum-

bra of infarcts and tumors. The clinical importance is to have a diagnostic tool to find and followup ar-eas of neurons, where in the case of infarcts thera-peutic measures (i.e. neuroprotectors) might prevent neurons to be damaged irreversibly. In the case of tumors an early detection of prestages of tumors can be possible.

Figure 8: Intensity of abnormal spontaneous slow wave (2-6 Hz) activity, lactate (Lac) 1H MRSI activ-ity, and of N-acetyl (NA) 1H MRSI activity of a 53 years old female (mga) with a left meningeoma along a line from tissue in the border zone through one pole of the tumor and back to border zone tissue on the other side of the meningeoma. Same record-ing protocol as in figures 6 and 7. C: line seen in a T1 image. D: line seen in a T2. Enclosure in a white rectangular line marks the enlarged area in B. The line in B is in direct spatial relation to the three dif-ferent activities in A. Details in [15,16] (from [37]). 4Conclusions

In our studies we could demonstrate: the localization of the function of eloquent cortical areas is well ac-cepted in functional image guided neurosurgery. The localization of the epileptogenic lesion is an addi-tional promising tool in the presurgical investigation of epileptic patients. The penumbra of transient is-chemic attacks (TIAs), of infarcts and of tumors can be localized. A possible screening for "asympto-matic TIAs" (clinically silent reversible neuronal deficit) might help in the prevention of strokes. In patients with infarcts the knowledge of the localiza-tion and the extent of the penumbra may serve as a basis to prevent the increase of irreversibly damaged tissue. In patients with tumors the localization of the border zone activity may serve as a tool of early de-tection or prestages of tumors. More clinical studies have to verify the value of these promising tools.References

1.J.W. Belliveau, D.N. Kennedy Jr., R.C. McKin-

stry, B.R. Buchbinder, R.M. Weisskoff, M.S.

Cohen, J.M. Vevea, T.J. Brady, and B.R. Rosen, Functional mapping of the human visual cortex by magnetic resonance imaging, Science, 254, 716-719, 1991.

2.L.R. Caplan, Silent brain infarcts, Cerebrovasc.

Dis., 4 (Suppl 1), 32-40, 1994.

3.G.D. Cascino, P.J. Kelly, F.W. Sharbrough, J.F.

Hulihan, K.A. Hirschorn, and M.R. Trenerry, Longterm followup of stereotactic lesionectomy in partial epilepsy: Predictive factors and elec-troencephalographic results, Epilepsia,33, 639-644, 1992.

4.L. Deecke, P. Weinberg, and P. Brickett, Mag-

netic fields of the human brain accompanying voluntary movement: Bereitschaftsmagnetfeld, Exp. Brain Research,48, 144-148, 1982.

5. C.C. Gallen, D.F. Sobel, T. Waltz, M. Aung, B.

Copeland, B.J. Schwartz, E.C. Hirschkoff, and

F.E. Bloom, Noninvasive presurgical neuro-

magnetic mapping of somatosensory cortex, Neurosurgery, 33, 260-268, 1993.

6. C.C. Gallen, E. Tecoma, V. Iragui, D.F. Sobel,

B.J. Schwartz, and F.E. Bloom, Magnetic source

imaging of abnormal low-frequency magnetic activity in presurgical evaluations of epilepsy, Epilepsia, 38, 452-460, 1997.

7.O. Ganslandt, R. Fahlbusch, C. Nimsky, H. Ko-

ber, M. M?ller, R. Steinmeier, J. Romst?ck, and J. Vieth, Functional neuronavigation with mag-netoencephalography: outcome in 50 patients with lesions around the motor cortex, Neurosur-gical Focus6, Article 3, 1999; and J. Neurosur-gery,91, 73-79, 1999.

8.O. Ganslandt, R. Steinmeier, H. Kober, J. Vieth,

J. Kassubek, J. Romst?ck, C. Strauss, and R.

Fahlbusch, Magnetic source imaging combined with image guided, frameless stereotaxy: a new method in surgery around the motor strip, Neu-rosurgery, 41, 621-627, 1997.

9.O. Ganslandt, D. Ulbricht, H. Kober, J. Vieth,

C. Strauss, and R. Fahlbusch, SEF-MEG lo-

calization of somatosensory cortex as a method for presurgical assessment of functional brain area, Electroenceph. Clin. Neurophysiol., 46(Suppl.), 209-213, 1996.

10.P. Grummich, H. Kober, and J. Vieth, Localiza-

tion of the underlying currents of magnetic brain activity using spatial filtering, Biomed. Engi-neer. (Berlin), 37 (Suppl.2), 158-159, 1992. 11.P. Grummich, H. Kober, J. Vieth, J. Matschke,

and O. Ganslandt, Sensory speech area inves-

tigated by magnetoencephalography, Biomed.

Engineer. (Berlin), 39(Suppl.), 129-130, 1994.

12.P. Grummich, J. Vieth, H. Kober, H. Pongratz,

D. Ulbricht, O. Ganslandt, Localization of focal

spontaneous beta wave activity associated with structural lesions in the brain, in: Biomagnetism: Fundamental Research and Clinical Applica-tions, C. Baumgartner, L. Deecke, G. Stroink, and S.J. Williamson, Eds., Amsterdam: Elsevier Science IOS Press, 1995, pp 75-79.

13.K. Kamada, H. Kober, M. Saguer, M. M?ller,

M. Kaltenh?user, and J. Vieth, Responses to si-lent kanji reading of the native japanese and german in task subtraction magnetoencepha-lography, Cognitive Brain Res., 7, 89-98, 1998.

14.K. Kamada, M. M?ller, M. Saguer, J. Kassubek,

M. Kaltenh?user, H. Kober, M. überall, H.

Lauffer, D. Wenzel, and J. Vieth, Localization analysis of neuronal activities in benign rolandic epilepsy using magnetoencephalography, J.

Neurological Sciences,154, 164-172, 1998. 15.K. Kamada, M. M?ller, M. Saguer, O. Gan-

slandt, M. Kaltenh?user, H. Kober, and J. Vieth,

A combined study of tumor-related brain lesions

using magnetoencephalography and proton MR spectroscopic imaging, J. Neurological Sci-ences, (submitted for publication).

16.K. Kamada, M. Saguer, M. M?ller, K. Wicklow,

M. Kaltenh?user, H. Kober, and J. Vieth, Func-tional and metabolic analysis of cerebral ische-mia using magnetoencephalography and proton magnetic resonance spectroscopy, Annals of Neurology, 42, 554-563, 1997.

17.K. Kamada, F. Takeuchi, S. Kuriki, O. Oshiro,

K. Houkin, and H. Abe, Functional Neuro-surgical Stimulation with Brain Surface Mag-netic Resonance Images and Magneto-encephalography, Neurosurgery,33, 269-273, 1993.

18.H. Kober, J. Vieth, P. Grummich, A. Daun, E.

Weise, and H. Pongratz, The factor analysis used to improve the dipole-density-plot (DDP) to localize focal concentrations of spontaneous magnetic brain activity, Biomed. Engineer. (Ber-lin), 37(Suppl.2), 164-165, 1992

19.H. Kober, P. Grummich, and J. Vieth, Fit of the

digitized headsurface with the surface re-constructed from MRI-Tomography, in: Bio-magnetism: Fundamental Research and Clinical Applications, C. Baumgartner, L. Deecke, G.

Stroink, and S.J. Williamson, Eds., Amsterdam: S.J. Elsevier Science IOS Press, 1995, pp 309-312.20.H. Kober, J.B. Vieth, C. Stippich, J.R. Kassu-

bek, and R. Hopfeng?rtner,. Time course of ab-normal MEG activity associated with transient ischemic attacks, in: Biomag96: Proceedings of the Tenth International Conference on Biomag-netism, C.J. Aine, Y. Okada, G. Stroink, S.J.

Swithenby, and C.C. Wood, Eds.. New York, Berlin, Heidelberg, Tokyo: Springer-Verlag, 2000, pp 1033-1036.

21.J.D. Lewine, and W.W. Orrison, Magnetoen-

cephalography and magnetic source imaging, Functional Brain Imaging, Mosby Year Book Inc., 1995, pp 369-417.

22.J.W.H. Meijs, F.G.C. Bosch, M.J. Peters, and

F.H. Lopes Da Silva, On the magnetic field dis-

tribution generated by a dipolar current source situated in a realistically shaped compartment model of the head, Electroenceph. clin. Neuro-physiol.,66, 268-298, 1987

23.M. M?ller, H. Kober, O. Ganslandt, C. Nimsky,

and R. Fahlbusch,Functional mapping of speech evoked brain activity by magnetoen-cephalography and its clinical application, Bio-med. Engineer. (Berlin),44(Suppl.2), 159-161, 1999.

24.M. M?ller, H. Kober, O. Ganslandt, C. Nimsky,

M. Kaltenh?user, J. Vieth, and R. Fahlbusch, Speech relevant brain areas and their hemi-spheric dominance investigated by magnetoen-cephalography, Brain, (submitted for publica-tion)

25.T. Morioka, T. Yamamoto, T. Katsuta, K. Fujii,

and M. Fukui, Presurgical Three-Dimensional Magnetic Source Imaging of the Somatosensory Cortex in a Patient with a peri-Rolandic Lesion: Technical Note, Neurosurgery,34, 930-934, 1994.

26.N. Nakasato, K. Seki, T. Kawamura, S. Ohtomo,

A. Kanno, S. Fujita, K. Hatanaka, S. Fujiwara,

T. Kayama, A. Takahashi, H. Jokura, T.

Kumabe, H. Ikeda, K. Mizoi, and T. Yoshimoto, Cortical mapping using an MRI-linked whole head MEG system and presurgical decision making, Electroenceph. clin. Neurophysiol., 47(Suppl.), 333-341, 1996.

27.C. Nimsky, C., O. Ganslandt, H. Kober, M.

M?ller, S. Ulmer, B. Tomandl, and R. Fahl-busch, Integration of Functional Magnetic Resonance Imaging Supported by Magnetoen-cephalography in Functional Neuronavigation, Neurosurgery, 44, 1249-1256, 1999.

28.S. Ogawa, T.M. Lee, A.R. Kay, and D.W. Tank,

Brain magnetic resonance imaging with contrast

dependent on blood oxygenation, Proc. Natl.

Acad. Sci. USA, 87, 9868-9872, 1990.

29.E.C. Oldfield, The assessment and analysis of

handedness: the Edinburgh inventory, Neuro-psychologia,9, 97-113, 1971

30.W.W. Orrison Jr., F.R. Douglas, L.H. Blaine,

L.M. Edward, J.A. Sanders, B.K. Willis, E.P.

Marchand, C.C. Wood, and L.E. Davis, Nonin-vasive Preoperative Cortical Localization by Magnetic Source Imaging, Am. J. Neuro. Ra-diol., 13, 1124-1128, 1992.

31.A.R. Rezai, M. Hund, E. Kronberg, M. Zonen-

shayn, J. Cappell, U. Ribary, B. Kall, R. Llinas, and P.J. Kelly, The Interactive Use of Magneto-encephalography in Stereotactic Image-guided Neurosurgery, Neurosurgery,39, 92-102, 1996.

32.S.E. Robinson, and D.F. Rose, Current source

image estimation by spatially filtered MEG, in: Biomagnetism. Clinical Aspects, M. Hoke, S.N.

Erné, Y.C. Okada, and G.L. Romani, Amster-dam, London, New York, Tokyo: Excerpta Medica, Int. Congress Series 988, 1992, pp 761-765.

33.C. Segebarth, V. Belle, C. Delon, R. Masarelli,

J. Decety, J.F. Le Bas, M. Décorps, and A.L.

Benabid, Functional MRI of the human brain: predominance of signals from extracerebral veins, Neuroreport,5, 813-816, 1994.

34.P.G. Simos, J.I. Breier, G. Zouridakis, and A.C..

Papanicolaou, Identification of language-specific brain activity using magnetoencepha-lography, J. Clin. Exp. Neuropsychol., 20, 706-722, 1998.

35.C. Stippich, P. Freitag, J. Kassubek, P. S?r?s, H.

Kober, K. Scheffler, R. Hopfeng?rtner, K. Ka-mada, D. Bilecen, E.W. Radü, and J.B. Vieth, Motor, somatosensory and auditory cortex lo-calization by fMRI and MEG, Neuroreport,9, 1953-1957, 1998.

36.C. Stippich, J. Kassubek, P. S?r?s, O. Gan-

slandt, K. Kamada, H. Kober, R. Hopfeng?rtner,

R. Steinmeier, and J.B. Vieth, Precise pre- and intraoperative assessment of functional cortex by magnetoencephalography (MEG), Biomed.

Engineer. (Berlin),41(Suppl.1), 306-307, 1996.

37.J.B. Vieth, H. Kober, O. Ganslandt, M. M?ller,

and K. Kamada, The clinical use of MEG activ-ity associated with brain lesions, Biomed. Engi-neer. (Berlin), 44(Suppl.2), 61-69, 1999.

38.J.B. Vieth, H, Kober, and P. Grummich, Sources

of spontaneous slow waves associated with brain lesions, localized by using the MEG, Brain Topography,8, 215-221, 1996.

39.J. Vieth, H. Kober, P. Grummich, D. Ulbricht,

C. Brigel,

D. Claus, and P.B.C. Fenwick, Lo-

calization of the epileptogenic lesion by focal slow and beta wave MEG activity, Biomed. En-gineer. (Berlin),39(Suppl.), 133-134, 1994. 40.J.B. Vieth, H. Kober, K. Kamada, and O. Gan-

slandt, Normal and abnormal MEG activity in border zones of brain lesions, in: Brain Topog-raphy Today, Y. Koga, K. Nagata, and K. Hi-rata, Eds., Elsevier, Amsterdam, Lausanne, New York, Oxford, Shannon, Singapore, Tokyo: Ex-cerpta Medica, International Congress Series 1147, 1998, pp 39-46.

41.J. Vieth, H. Kober, E. Weise, H. Daun, A. Moe-

ger, S. Friedrich, and H. Pongratz, Functional 3D localization of cerebrovascular accidents by magnetoencephalography (MEG), Neurological Res., 14, 132-134, 1992.

42.J. Wada, and T. Rasmussen, Intracarotis injec-

tion of sodium amytal for the lateralization of cerebral speech dominance: Experimental and clinical observations, J. Neurosurgery,17, 266-282, 1960.

43.E. Watanabe, Y. Mayanagi, and Y. Kaneko,

Identification of the central sulcus using mag-netoencephalography and neuronavigator, No To Shinkei, 45, 1027-1032, 1993.

初中语文古文赏析曹操《短歌行》赏析(林庚)

教育资料 《短歌行》 《短歌行》赏析(林庚) 曹操这一首《短歌行》是建安时代杰出的名作,它代表着人生的两面,一方面是人生的忧患,一方面是人生的欢乐。而所谓两面也就是人生的全面。整个的人生中自然含有一个生活的态度,这就具体地表现在成为《楚辞》与《诗经》传统的产儿。它一方面不失为《楚辞》中永恒的追求,一方面不失为一个平实的生活表现,因而也就为建安诗坛铺平了道路。 这首诗从“对酒当歌,人生几何”到“但为君故,沉吟至今”,充分表现着《楚辞》里的哀怨。一方面是人生的无常,一方面是永恒的渴望。而“呦呦鹿鸣”以下四句却是尽情的欢乐。你不晓得何以由哀怨这一端忽然会走到欢乐那一端去,转折得天衣无缝,仿佛本来就该是这么一回事似的。这才是真正的人生的感受。这一段如是,下一段也如是。“明明如月,何时可掇?忧从中来,不可断绝。越陌度阡,枉用相存。契阔谈宴,心念旧恩。月明星稀,乌鹊南飞。绕树三匝,何枝可依。”缠绵的情调,把你又带回更深的哀怨中去。但“山不厌高,海不厌深”,终于走入“周公吐哺,天下归心”的结论。上下两段是一个章法,但是你并不觉得重复,你只觉得卷在悲哀与欢乐的旋涡中,不知道什么时候悲哀没有了,变成欢乐,也不知道什么时候欢乐没有了,又变成悲哀,这岂不是一个整个的人生吗?把整个的人生表现在一个刹那的感觉上,又都归于一个最实在的生活上。“我有嘉宾,鼓瑟吹笙”,不正是当时的情景吗?“周公吐哺,天下归心”,不正是当时的信心吗? “青青子衿”到“鼓瑟吹笙”两段连贯之妙,古今无二。《诗经》中现成的句法一变而有了《楚辞》的精神,全在“沉吟至今”的点窜,那是“青青子衿”的更深的解释,《诗经》与《楚辞》因此才有了更深的默契,从《楚辞》又回到《诗经》,这样与《鹿鸣》之诗乃打成一片,这是一个完满的行程,也便是人生旅程的意义。“月明星稀”何以会变成“山不厌高,海不厌深”?几乎更不可解。莫非由于“明月出天山”,“海上生明月”吗?古辞说:“枯桑知天风,海水知天寒”,枯桑何以知天风,因为它高;海水何以知天寒,因为它深。唐人诗“一叶落知天下秋”,我们对于宇宙万有正应该有一个“知”字。然则既然是山,岂可不高?既然是海,岂可不深呢?“并刀如水,吴盐胜雪”,既是刀,就应该雪亮;既是盐,就应该雪白,那么就不必问山与海了。 山海之情,成为漫漫旅程的归宿,这不但是乌鹊南飞,且成为人生的思慕。山既尽其高,海既尽其深。人在其中乃有一颗赤子的心。孟子主尽性,因此养成他浩然之气。天下所以归心,我们乃不觉得是一个夸张。 .

The way常见用法

The way 的用法 Ⅰ常见用法: 1)the way+ that 2)the way + in which(最为正式的用法) 3)the way + 省略(最为自然的用法) 举例:I like the way in which he talks. I like the way that he talks. I like the way he talks. Ⅱ习惯用法: 在当代美国英语中,the way用作为副词的对格,“the way+ 从句”实际上相当于一个状语从句来修饰整个句子。 1)The way =as I am talking to you just the way I’d talk to my own child. He did not do it the way his friends did. Most fruits are naturally sweet and we can eat them just the way they are—all we have to do is to clean and peel them. 2)The way= according to the way/ judging from the way The way you answer the question, you are an excellent student. The way most people look at you, you’d think trash man is a monster. 3)The way =how/ how much No one can imagine the way he missed her. 4)The way =because

The use of force

孩子。 Does your throat hurt you? Added the mother to the child. 女孩的表情没有任何变化,而她的目光却一直没有从我的脸上移开。 But the little girl’s expression didn’t change nor did she move her eyes from my face. 你看过她的嗓子了吗? Have you looked? 我想看,孩子的母亲说,但看不见。 I tried to, said the mother but II couldn’t see. 这个月碰巧她上学的那个学校已经有好几例白喉病。虽然到目前为止没有人说出这件事,但很显然,我们心里都想到了。 As it happens we had been having a number of cases of diphtheria in the school to which this child went during that month and we were all, quite apparently, thinking of that, though no one had as yet spoken of the thing. 好了,我说,我们先看看嗓子吧。 Well, I said, suppose we take a look at the throat first. 我以医生特有的职业方式微笑着,叫着孩子的名字。我说,来吧,玛蒂尔达,张开嘴,让我看一下你的嗓子。 I smiled in my best professional manner and asking for the child’s first name I said, come on, Mathilda, open your mouth and let’s take a look at your throat.没有任何反应。 Nothing doing. 哦,来吧,我劝道,张大你的嘴,让我看看。看,我说着把两只手伸开,我的手里没有东西,张大嘴,让我看看。 Aw, come on, I coaxed, just open your mouth wide and let me take a look. Look, I said opening both hands wide, I haven’t anything in my hands. Just open up and let me see.

高中语文文言文曹操《短歌行(对酒当歌)》原文、翻译、赏析

曹操《短歌行【对酒当歌】》原文、翻译、赏析译文 原文 面对美酒应该高歌,人生短促日月如梭。对酒当歌,人生几何? 好比晨露转瞬即逝,失去的时日实在太多!譬如朝露,去日苦多。 席上歌声激昂慷慨,忧郁长久填满心窝。慨当以慷,忧思难忘。 靠什么来排解忧闷?唯有狂饮方可解脱。何以解忧?唯有杜康。 那穿着青领(周代学士的服装)的学子哟,你们令我朝夕思慕。青青子衿,悠悠我心。 正是因为你们的缘故,我一直低唱着《子衿》歌。但为君故,沉吟至今。 阳光下鹿群呦呦欢鸣,悠然自得啃食在绿坡。呦呦鹿鸣,食野之苹。 一旦四方贤才光临舍下,我将奏瑟吹笙宴请宾客。我有嘉宾,鼓瑟吹笙。 当空悬挂的皓月哟,你运转着,永不停止;明明如月,何时可掇? 我久蓄于怀的忧愤哟,突然喷涌而出汇成长河。忧从中来,不可断绝。 远方宾客踏着田间小路,一个个屈驾前来探望我。越陌度阡,枉用相存。 彼此久别重逢谈心宴饮,争着将往日的情谊诉说。契阔谈讌,心念旧恩。 明月升起,星星闪烁,一群寻巢乌鹊向南飞去。月明星稀,乌鹊南飞。 绕树飞了三周却没敛绕树三匝,何枝

翅,哪里才有它们栖身之 所? 可依? 高山不辞土石才见巍 峨,大海不弃涓流才见壮阔。(比喻用人要“唯才是举”,多多益善。)山不厌高,水不厌深。 只有像周公那样礼待贤 才(周公见到贤才,吐出口 中正在咀嚼的食物,马上接 待。《史记》载周公自谓: “一沐三握发,一饭三吐哺, 犹恐失天下之贤。”),才 能使天下人心都归向我。 周公吐哺,天 赏析 曹操是汉末杰出的政治家、军事家和文学家,他雅好诗章,好作乐府歌辞,今存诗22首,全是乐府诗。曹操的乐府诗多描写他本人的政治主张和统一天下的雄心壮志。如他的《短歌行》,充分表达了诗人求贤若渴以及统一天下的壮志。 《短歌行》是政治性很强的诗作,主要是为曹操当时所实行的政治路线和政策策略服务的,但是作者将政治内容和意义完全熔铸在浓郁的抒情意境之中,全诗充分发挥了诗歌创作的特长,准确而巧妙地运用了比兴手法,寓理于情,以情感人。诗歌无论在思想内容还是在艺术上都取得了极高的成就,语言质朴,立意深远,气势充沛。这首带有建安时代"志深比长""梗概多气"的时代特色的《短歌行》,读后不觉思接千载,荡气回肠,受到强烈的感染。 对酒当歌,人生几何? 譬如朝露,去日苦多。 慨当以慷,幽思难忘。 何以解忧,唯有杜康。 青青子衿,悠悠我心。 但为君故,沈吟至今。 呦呦鹿鸣,食野之苹。 我有嘉宾,鼓瑟吹笙。 明明如月,何时可掇? 忧从中来,不可断绝。 越陌度阡,枉用相存。 契阔谈,心念旧恩。 月明星稀,乌鹊南飞, 绕树三匝,何枝可依? 山不厌高,海不厌深, 周公吐哺,天下归心。 《短歌行》是汉乐府的旧题,属于《相和歌?平调曲》。这就是说它本来是一个乐曲的名称,这种乐曲怎么唱法,现在当然是不知道了。但乐府《相和歌?平调曲》中除了《短歌行》还有《长歌行》,唐代吴兢《乐府古题要解》引证古诗“长歌正激烈”,魏文帝曹丕《燕歌行》“短歌微吟不能长”和晋代傅玄《艳歌行》“咄来长歌续短歌”等句,认为“长歌”、“短

外国文学名著鉴赏期末论文

外国文学名著鉴赏期末论文院—系:数学学院 科目:外国文学名著鉴赏(期末论文)班级: 08级数学与应用数学A班 姓名:沈铁 学号: 200805050149 上课时段:周五晚十、十一节课

奋斗了,才有出路 ——读《鲁宾逊漂游记》有感小说《鲁宾逊漂游记》一直深受人们的喜爱。读完这篇小说,使我对人生应该有自己的一个奋斗历程而受益匪浅。当一个人已经处于绝境的时候,还能够满怀信心的去面对和挑战生活,实在是一种可贵的精神。他使我认识到,人无论何时何地,不管遇到多大的困难,都不能被困难所吓倒,我们要勇敢的面对困难,克服困难,始终保持一种积极向上、乐观的心态去面对。在当今社会只有努力去奋斗,才会有自己的出路! 其实现在的很多人都是那些遇到困难就退缩,不敢勇敢的去面对它。不仅如此,现在很多人都是独生子女,很多家长视子女为掌上明珠,不要说是冒险了,就连小小的家务活也不让孩子做,天天总是说:“我的小宝贝啊,你读好书就行了,其它的爸爸妈妈做就可以了。”读书固然重要,但生活中的小事也不能忽略。想一想,在荒无人烟的孤岛上,如果你连家务活都不会做,你能在那里生存吗?读完这部著作后,我不禁反问自己:“如果我像书中的鲁宾逊那样在大海遭到风暴,我能向他那样与风暴搏斗,最后逃离荒岛得救吗?恐怕我早已经被大海所淹没;如果我漂流到孤岛,能活几天?我又能干些什么?我会劈柴吗?会打猎做饭吗?我连洗洗自己的衣服还笨手笨脚的。”我们应该学习鲁宾逊这种不怕困难的精神,无论何时何地都有坚持地活下去,哪怕只有一线希望也要坚持到底,决不能放弃!我们要像鲁宾

逊那样有志气、有毅力、爱劳动,凭自己的双手创造财富,创造奇迹,取得最后的胜利。这样的例子在我们的生活中屡见不鲜。 《史记》的作者司马迁含冤入狱,可它依然在狱中完成《史记》一书,他之所以能完成此书,靠的也是他心中那顽强的毅力,永不放弃的不断努力的精神。著名作家爱迪生从小就生活在一个贫困的家庭中,可是他从小就表现出了科学方面的天赋。长大后爱迪生着力于电灯的发明与研究,他经过了九百多次的失败,可它依然没有放弃,不断努力,最后终于在第一千次实验中取得了成功。 鲁宾逊在岛上生活了二十八年,他面对了各种各样的困难和挫折,克服了许多常人无法想象的困难,自己动手,丰衣足食,以惊人的毅力,顽强的活了下来。他自从大船失事后,找了一些木材,在岛上盖了一间房屋,为防止野兽,还在房子周围打了木桩,来到荒岛,面对着的首要的就是吃的问题,船上的东西吃完以后,鲁宾逊开始打猎,有时可能会饿肚子,一是他决定播种,几年后他终于可以吃到自己的劳动成果,其实学习也是这样,也有这样一个循序渐进的过程,现在的社会,竞争无处不在,我们要懂得只有付出才会有收获,要勇于付出,在战胜困难的同时不断取得好成绩。要知道只有付出,才会有收获。鲁宾逊在失败后总结教训,终于成果;磨粮食没有石磨,他就用木头代替;没有筛子,就用围巾。鲁宾逊在荒岛上解决了自己的生存难题,面对人生挫折,鲁宾逊的所作所为充分显示了他坚毅的性格和顽强的精神。同样我们在学习上也可以做一些创新,养成一种创新精神,把鲁宾逊在荒岛,不畏艰险,不怕失败挫折,艰苦奋斗的精

The way的用法及其含义(二)

The way的用法及其含义(二) 二、the way在句中的语法作用 the way在句中可以作主语、宾语或表语: 1.作主语 The way you are doing it is completely crazy.你这个干法简直发疯。 The way she puts on that accent really irritates me. 她故意操那种口音的样子实在令我恼火。The way she behaved towards him was utterly ruthless. 她对待他真是无情至极。 Words are important, but the way a person stands, folds his or her arms or moves his or her hands can also give us information about his or her feelings. 言语固然重要,但人的站姿,抱臂的方式和手势也回告诉我们他(她)的情感。 2.作宾语 I hate the way she stared at me.我讨厌她盯我看的样子。 We like the way that her hair hangs down.我们喜欢她的头发笔直地垂下来。 You could tell she was foreign by the way she was dressed. 从她的穿著就可以看出她是外国人。 She could not hide her amusement at the way he was dancing. 她见他跳舞的姿势,忍俊不禁。 3.作表语 This is the way the accident happened.这就是事故如何发生的。 Believe it or not, that's the way it is. 信不信由你, 反正事情就是这样。 That's the way I look at it, too. 我也是这么想。 That was the way minority nationalities were treated in old China. 那就是少数民族在旧中

曹操《短歌行》其二翻译及赏析

曹操《短歌行》其二翻译及赏析 引导语:曹操(155—220),字孟德,小名阿瞒,《短歌行 二首》 是曹操以乐府古题创作的两首诗, 第一首诗表达了作者求贤若渴的心 态,第二首诗主要是曹操向内外臣僚及天下表明心迹。 短歌行 其二 曹操 周西伯昌,怀此圣德。 三分天下,而有其二。 修奉贡献,臣节不隆。 崇侯谗之,是以拘系。 后见赦原,赐之斧钺,得使征伐。 为仲尼所称,达及德行, 犹奉事殷,论叙其美。 齐桓之功,为霸之首。 九合诸侯,一匡天下。 一匡天下,不以兵车。 正而不谲,其德传称。 孔子所叹,并称夷吾,民受其恩。 赐与庙胙,命无下拜。 小白不敢尔,天威在颜咫尺。 晋文亦霸,躬奉天王。 受赐圭瓒,钜鬯彤弓, 卢弓矢千,虎贲三百人。 威服诸侯,师之所尊。 八方闻之,名亚齐桓。 翻译 姬昌受封为西伯,具有神智和美德。殷朝土地为三份,他有其中两分。 整治贡品来进奉,不失臣子的职责。只因为崇侯进谗言,而受冤拘禁。 后因为送礼而赦免, 受赐斧钺征伐的权利。 他被孔丘称赞, 品德高尚地位显。 始终臣服殷朝帝王,美名后世流传遍。齐桓公拥周建立功业,存亡继绝为霸 首。

聚合诸侯捍卫中原,匡正天下功业千秋。号令诸侯以匡周室,主要靠的不是 武力。 行为磊落不欺诈,美德流传于身后。孔子赞美齐桓公,也称赞管仲。 百姓深受恩惠,天子赐肉与桓公,命其无拜来接受。桓公称小白不敢,天子 威严就在咫尺前。 晋文公继承来称霸,亲身尊奉周天王。周天子赏赐丰厚,仪式隆重。 接受玉器和美酒,弓矢武士三百名。晋文公声望镇诸侯,从其风者受尊重。 威名八方全传遍,名声仅次于齐桓公。佯称周王巡狩,招其天子到河阳,因 此大众议论纷纷。 赏析 《短歌行》 (“周西伯昌”)主要是曹操向内外臣僚及天下表明心 迹,当他翦灭群凶之际,功高震主之时,正所谓“君子终日乾乾,夕惕若 厉”者,但东吴孙权却瞅准时机竟上表大说天命而称臣,意在促曹操代汉 而使其失去“挟天子以令诸侯”之号召, 故曹操机敏地认识到“ 是儿欲据吾著炉上郁!”故曹操运筹谋略而赋此《短歌行 ·周西伯 昌》。 西伯姬昌在纣朝三分天下有其二的大好形势下, 犹能奉事殷纣, 故孔子盛称 “周之德, 其可谓至德也已矣。 ”但纣王亲信崇侯虎仍不免在纣王前 还要谗毁文王,并拘系于羑里。曹操举此史实,意在表明自己正在克心效法先圣 西伯姬昌,并肯定他的所作所为,谨慎惕惧,向来无愧于献帝之所赏。 并大谈西伯姬昌、齐桓公、晋文公皆曾受命“专使征伐”。而当 今天下时势与当年的西伯、齐桓、晋文之际颇相类似,天子如命他“专使 征伐”以讨不臣,乃英明之举。但他亦效西伯之德,重齐桓之功,戒晋文 之诈。然故作谦恭之辞耳,又谁知岂无更讨封赏之意乎 ?不然建安十八年(公元 213 年)五月献帝下诏曰《册魏公九锡文》,其文曰“朕闻先王并建明德, 胙之以土,分之以民,崇其宠章,备其礼物,所以藩卫王室、左右厥世也。其在 周成,管、蔡不静,惩难念功,乃使邵康公赐齐太公履,东至于海,西至于河, 南至于穆陵,北至于无棣,五侯九伯,实得征之。 世祚太师,以表东海。爰及襄王,亦有楚人不供王职,又命晋文登为侯伯, 锡以二辂、虎贲、斧钺、禾巨 鬯、弓矢,大启南阳,世作盟主。故周室之不坏, 系二国是赖。”又“今以冀州之河东、河内、魏郡、赵国、中山、常 山,巨鹿、安平、甘陵、平原凡十郡,封君为魏公。锡君玄土,苴以白茅,爰契 尔龟。”又“加君九锡,其敬听朕命。” 观汉献帝下诏《册魏公九锡文》全篇,尽叙其功,以为其功高于伊、周,而 其奖却低于齐、晋,故赐爵赐土,又加九锡,奖励空前。但曹操被奖愈高,心内 愈忧。故曹操在曾早在五十六岁写的《让县自明本志令》中谓“或者人见 孤强盛, 又性不信天命之事, 恐私心相评, 言有不逊之志, 妄相忖度, 每用耿耿。

2008年浙师大《外国文学名著鉴赏》期末考试答案

(一)文学常识 一、古希腊罗马 1.(1)宙斯(罗马神话称为朱庇特),希腊神话中最高的天神,掌管雷电云雨,是人和神的主宰。 (2)阿波罗,希腊神话中宙斯的儿子,主管光明、青春、音乐、诗歌等,常以手持弓箭的少年形象出现。 (3)雅典那,希腊神话中的智慧女神,雅典城邦的保护神。 (4)潘多拉,希腊神话中的第一个女人,貌美性诈。私自打开了宙斯送她的一只盒子,里面装的疾病、疯狂、罪恶、嫉妒等祸患,一齐飞出,只有希望留在盒底,人间因此充满灾难。“潘多拉的盒子”成为“祸灾的来源”的同义语。 (5)普罗米修斯,希腊神话中造福人间的神。盗取天火带到人间,并传授给人类多种手艺,触怒宙斯,被锁在高加索山崖,受神鹰啄食,是一个反抗强暴、不惜为人类牺牲一切的英雄。 (6)斯芬克司,希腊神话中的狮身女怪。常叫过路行人猜谜,猜不出即将行人杀害;后因谜底被俄底浦斯道破,即自杀。后常喻“谜”一样的人物。与埃及狮身人面像同名。 2.荷马,古希腊盲诗人。主要作品有《伊利亚特》和《奥德赛》,被称为荷马史诗。《伊利亚特》叙述十年特洛伊战争。《奥德赛》写特洛伊战争结束后,希腊英雄奥德赛历险回乡的故事。马克思称赞它“显示出永久的魅力”。 3.埃斯库罗斯,古希腊悲剧之父,代表作《被缚的普罗米修斯》。6.阿里斯托芬,古希腊“喜剧之父”代表作《阿卡奈人》。 4.索福克勒斯,古希腊重要悲剧作家,代表作《俄狄浦斯王》。5.欧里庇得斯,古希腊重要悲剧作家,代表作《美狄亚》。 二、中世纪文学 但丁,意大利人,伟大诗人,文艺复兴的先驱。恩格斯称他是“中世纪的最后一位诗人,同时又是新时代的最初一位诗人”。主要作品有叙事长诗《神曲》,由地狱、炼狱、天堂三部分组成。《神曲》以幻想形式,写但丁迷路,被人导引神游三界。在地狱中见到贪官污吏等受着惩罚,在净界中见到贪色贪财等较轻罪人,在天堂里见到殉道者等高贵的灵魂。 三、文艺复兴时期 1.薄迦丘意大利人短篇小说家,著有《十日谈》拉伯雷,法国人,著《巨人传》塞万提斯,西班牙人,著《堂?吉诃德》。 2.莎士比亚,16-17世纪文艺复兴时期英国伟大的剧作家和诗人,主要作品有四大悲剧——《哈姆雷特》、《奥赛罗》《麦克白》、《李尔王》,另有悲剧《罗密欧与朱丽叶》等,喜剧有《威尼斯商人》《第十二夜》《皆大欢喜》等,历史剧有《理查二世》、《亨利四世》等。马克思称之为“人类最伟大的戏剧天才”。 四、17世纪古典主义 9.笛福,17-18世纪英国著名小说家,被誉为“英国和欧洲小说之父”,主要作品《鲁滨逊漂流记》,是英国第一部现实主义长篇小说。10.弥尔顿,17世纪英国诗人,代表作:长诗《失乐园》,《失乐园》,表现了资产阶级清教徒的革命理想和英雄气概。 25.拉伯雷,16世纪法国作家,代表作:长篇小说《巨人传》。 26.莫里哀,法国17世纪古典主义文学最重要的作家,法国古典主义喜剧的创建者,主要作品为《伪君子》《悭吝人》(主人公叫阿巴公)等喜剧。 五、18世纪启蒙运动 1)歌德,德国文学最高成就的代表者。主要作品有书信体小说《少年维特之烦恼》,诗剧《浮士德》。 11.斯威夫特,18世纪英国作家,代表作:《格列佛游记》,以荒诞的情节讽刺了英国现实。 12.亨利·菲尔丁,18世纪英国作家,代表作:《汤姆·琼斯》。 六、19世纪浪漫主义 (1拜伦, 19世纪初期英国伟大的浪漫主义诗人,代表作为诗体小说《唐璜》通过青年贵族唐璜的种种经历,抨击欧洲反动的封建势力。《恰尔德。哈洛尔游记》 (2雨果,伟大作家,欧洲19世纪浪漫主义文学最卓越的代表。主要作品有长篇小说《巴黎圣母院》、《悲惨世界》、《笑面人》、《九三年》等。《悲惨世界》写的是失业短工冉阿让因偷吃一片面包被抓进监狱,后改名换姓,当上企业主和市长,但终不能摆脱迫害的故事。《巴黎圣母院》 弃儿伽西莫多,在一个偶然的场合被副主教克洛德.孚罗洛收养为义子,长大后有让他当上了巴黎圣母院的敲钟人。他虽然十分丑陋而且有多种残疾,心灵却异常高尚纯洁。 长年流浪街头的波希米亚姑娘拉.爱斯梅拉达,能歌善舞,天真貌美而心地淳厚。青年贫诗人尔比埃尔.甘果瓦偶然同她相遇,并在一个更偶然的场合成了她名义上的丈夫。很有名望的副教主本来一向专心于"圣职",忽然有一天欣赏到波希米亚姑娘的歌舞,忧千方百计要把她据为己有,对她进行了种种威胁甚至陷害,同时还为此不惜玩弄卑鄙手段,去欺骗利用他的义子伽西莫多和学生甘果瓦。眼看无论如何也实现不了占有爱斯梅拉达的罪恶企图,最后竟亲手把那可爱的少女送上了绞刑架。 另一方面,伽西莫多私下也爱慕着波希米亚姑娘。她遭到陷害,被伽西莫多巧计救出,在圣母院一间密室里避难,敲钟人用十分纯朴和真诚的感情去安慰她,保护她。当她再次处于危急中时,敲钟人为了援助她,表现出非凡的英勇和机智。而当他无意中发现自己的"义父"和"恩人"远望着高挂在绞刑架上的波希米亚姑娘而发出恶魔般的狞笑时,伽西莫多立即对那个伪善者下了最后的判决,亲手把克洛德.孚罗洛从高耸入云的钟塔上推下,使他摔的粉身碎骨。 (3司汤达,批判现实主义作家。代表作《红与黑》,写的是不满封建制度的平民青年于连,千方百计向上爬,最终被送上断头台的故事。“红”是将军服色,指“入军界”的道路;“黑”是主教服色,指当神父、主教的道路。 14.雪莱,19世纪积极浪漫主义诗人,欧洲文学史上最早歌颂空想社会主义的诗人之一,主要作品为诗剧《解放了的普罗米修斯》,抒情诗《西风颂》等。 15.托马斯·哈代,19世纪英国作家,代表作:长篇小说《德伯家的苔丝》。 16.萨克雷,19世纪英国作家,代表作:《名利场》 17.盖斯凯尔夫人,19世纪英国作家,代表作:《玛丽·巴顿》。 18.夏洛蒂?勃朗特,19世纪英国女作家,代表作:长篇小说《简?爱》19艾米丽?勃朗特,19世纪英国女作家,夏洛蒂?勃朗特之妹,代表作:长篇小说《呼啸山庄》。 20.狄更斯,19世纪英国批判现实主义文学的重要代表,主要作品为长篇小说《大卫?科波菲尔》、《艰难时世》《双城记》《雾都孤儿》。21.柯南道尔,19世纪英国著名侦探小说家,代表作品侦探小说集《福尔摩斯探案》是世界上最著名的侦探小说。 七、19世纪现实主义 1、巴尔扎克,19世纪上半叶法国和欧洲批判现实主义文学的杰出代表。主要作品有《人间喜剧》,包括《高老头》、《欧也妮·葛朗台》、《贝姨》、《邦斯舅舅》等。《人间喜剧》是世界文学中规模最宏伟的创作之一,也是人类思维劳动最辉煌的成果之一。马克思称其“提供了一部法国社会特别是巴黎上流社会的卓越的现实主义历史”。

(完整版)the的用法

定冠词the的用法: 定冠词the与指示代词this ,that同源,有“那(这)个”的意思,但较弱,可以和一个名词连用,来表示某个或某些特定的人或东西. (1)特指双方都明白的人或物 Take the medicine.把药吃了. (2)上文提到过的人或事 He bought a house.他买了幢房子. I've been to the house.我去过那幢房子. (3)指世界上独一无二的事物 the sun ,the sky ,the moon, the earth (4)单数名词连用表示一类事物 the dollar 美元 the fox 狐狸 或与形容词或分词连用,表示一类人 the rich 富人 the living 生者 (5)用在序数词和形容词最高级,及形容词等前面 Where do you live?你住在哪? I live on the second floor.我住在二楼. That's the very thing I've been looking for.那正是我要找的东西. (6)与复数名词连用,指整个群体 They are the teachers of this school.(指全体教师) They are teachers of this school.(指部分教师) (7)表示所有,相当于物主代词,用在表示身体部位的名词前 She caught me by the arm.她抓住了我的手臂. (8)用在某些有普通名词构成的国家名称,机关团体,阶级等专有名词前 the People's Republic of China 中华人民共和国 the United States 美国 (9)用在表示乐器的名词前 She plays the piano.她会弹钢琴. (10)用在姓氏的复数名词之前,表示一家人 the Greens 格林一家人(或格林夫妇) (11)用在惯用语中 in the day, in the morning... the day before yesterday, the next morning... in the sky... in the dark... in the end... on the whole, by the way...

The use of force

The use of force 大意: Mathilda had been ill for three days. Her mother had given her some medicine, but it didn’t do any good. So they had to ask the doctor to come. There had been a number of cases of diphtheria in Mathilda School and two of them had been dead. When the doctor arrived at Olson’s home, he wanted to examine Mathilda throat first. But no matter how he coaxed, She wouldn’t open her mouth. So the doctor had to get the tongue depressor into her mouth. But Mathilda reduced it to splinters. In orde r to protect Mathilda herself and other children, the doctor had to make sure whether she had diphtheria or not, so that he could treat her in time. Letting Mathilda‘s father hold her wrists he tried his best to open her mouth and found she really had diphtheria. This story made us can think such a question that something in life can’t only depend on self-willingness. Under some circumstances, certain force seems necessary. 对医生的评价:After the doctor arrived at the girl’s home, he wanted to see her throat. As there had been a number of cases of diphtheria in the school to which the girl went during that month, the doctor also thought that of the girl. So he smiled to the girl and asked her to open her mouth and let him have a look at her throat. No matter how the doctor coaxed, the girl shut her mouth firmly. Thinking that the girl might have diphtheria and possibly die of it, the doctor decided to use force to open her mouth. He had seen at least two children lying dead in bed of neglect in such cases. He felt that he must get a diagnosis now. So he grasped the girl’s head with his left hand and tried to get the wooden tongue depressor between her teeth. But when the doctor got the wooden spatula behind her last teeth. She gripped the blade between her molars and reduced it to splinters. In the final unreasoning assault the doctor outer powered the girl. He forced the heavy silver spoon back of her teeth and down her throat till she gagged. Her both tonsils were covered with membrane. From that the doctor had done, I thought he was a responsible person. In order to save the lives of the patients, especially those children who did not know how to co-operate with the doctor, he had to take some measure. Otherwise a good or suitable time of treatment would be missed. The doctor appears to be compassionate and keen to human behavior, characteristic of a good doctor, though he is also undeniably blunt and slightly prejudiced. 思想: Though there are reasons often justifiable, what compels the use of force against others isn't simply altruism alone. The overall theme of the story revolves around power and submission and the doctor's unnerved feeling following the forceful encounter. 作者如何写的: The story is narrated in first person by a doctor, who is answering a house visit to see a sick girl. Williams uses interior monologue as a "stream-of-consciousness" tool reflects the narrator's experience of dialogue and gives insight into the character and his appraisal of the situations he encounters. The story is written without the use of quotation marks, and the dialogue is not distinguished from the narrator's comments. The story is rendered from the subjective point of view of the doctor, and explores his subdued enjoyment of forcefully subduing the stubborn child in an attempt to acquire the throat sample.

外国名著赏析论文

题目:浅析从简爱到女性的尊严和爱 学院工商学院 专业新闻学3 学号 姓名闫万里 学科外国文学名着赏析 [摘要] 十九世纪中期,英国伟大的女性存在主义先驱,着名作家夏洛蒂勃朗特创作出了她的代表作--《简爱》,当时轰动了整个文坛,它是一部具有浓厚浪漫主义色彩的现实主义小说,被认为是作者"诗意的生平"的写照。它在问世后的一百多年里,它始终保持着历史不败的艺术感染力。直到现在它的影响还继续存在。在作品的序幕、发展、高潮和结尾中,女主人公的叛逆、自由、平等、自尊、纯洁的个性都是各个重点章节的主旨,而这些主旨则在女主人公的爱情观中被展露的淋漓尽致,它们如同乌云上方的星汉,灼灼闪耀着光芒,照亮着后来的女性者们追求爱情的道路。? [关键词] 自尊个性独特新女性主义自由独立平等 《简爱》是一部带有自转色彩的长篇小说,它阐释了这样一个主题:人的价值=尊严+爱。从小就成长在一个充满暴力的环境中的简爱,经历了同龄人没有的遭遇。她要面对的是舅妈的毫无人性的虐待,表兄的凶暴专横和表姐的傲慢冷漠,尽管她尽力想“竭力赢得别人的好感”,但是事实告诉她这都是白费力气的,因此她发出了“不公平啊!--不公平!”的近乎绝望的呼喊。不公平的生长环境,使得简爱从小就向往平等、自由和爱,这些愿望在她后来的成长过程中表现无疑,

譬如在她的爱情观中的种种体现。? 1.桑菲尔德府? 谭波儿小姐因为出嫁,离开了洛伍德学校,同时也离开了简爱,这使简爱感觉到了“一种稳定的感觉,一切使我觉得洛伍德学校有点像我家的联想,全都随着她消失了”,她意识到:真正的世界是广阔的,一个充满希望和忧虑、激动和兴奋的变化纷呈的天地,正等待着敢于闯入、甘冒风险寻求人生真谛的人们。意识形态的转变促使着简爱走向更广阔的社会,接受社会的挑战,尽管她才只有十八岁。于是,简爱来到了桑菲尔德府,当了一名在当时地位不高的家庭教师。?桑菲尔德府使简爱感受到“这儿有想象中的完美无缺的家庭安乐气氛”,事实证明了她的预感的正确性,。从和简爱相见、相识到相爱的过程当中,简爱的那种叛逆精神、自强自尊的品质深深地征服了罗切斯特,而罗切斯特的优雅风度和渊博知识同样也征服了简爱。最初开始,简爱一直以为罗切斯特会娶高贵漂亮的英格拉姆为妻,她在和罗切斯特谈到婚姻时,曾经义正言辞的对罗切斯特说:“你以为因为我穷,低微,不美,矮小,就没有灵魂了吗?你想错了!我跟你一样有灵魂—也同样有一颗心!我现在不是凭着肉体凡胎跟你说话,而是我的心灵在和你的心灵说话,就好像我们都已经离开人世,两人平等地站在上帝面前—因为我们本来就是平等的。”这充分表现出简爱的叛逆,她这种维护妇女独立人格、主张婚姻独立自主以及男女平等的主张可以看成是他对整个人类社会自由平等的向往追求,罗切斯特正是爱上了她这样的独特个性,同时他也同样重复道:我们本来就是平等的。罗切斯特自始自终爱的是简爱的心灵—有着意志的力量,美德和纯洁的心灵,正是基于如此,简爱才真正的爱着罗切斯特。因为爱情是来不得半点虚假的,一方为另一方付出了真情的爱,假如得到对方的是虚情假意,那么这份爱

“the way+从句”结构的意义及用法

“theway+从句”结构的意义及用法 首先让我们来看下面这个句子: Read the followingpassageand talkabout it wi th your classmates.Try totell whatyou think of Tom and ofthe way the childrentreated him. 在这个句子中,the way是先行词,后面是省略了关系副词that或in which的定语从句。 下面我们将叙述“the way+从句”结构的用法。 1.the way之后,引导定语从句的关系词是that而不是how,因此,<<现代英语惯用法词典>>中所给出的下面两个句子是错误的:This is thewayhowithappened. This is the way how he always treats me. 2.在正式语体中,that可被in which所代替;在非正式语体中,that则往往省略。由此我们得到theway后接定语从句时的三种模式:1) the way+that-从句2)the way +in which-从句3) the way +从句 例如:The way(in which ,that) thesecomrade slookatproblems is wrong.这些同志看问题的方法

不对。 Theway(that ,in which)you’re doingit is comple tely crazy.你这么个干法,简直发疯。 Weadmired him for theway inwhich he facesdifficulties. Wallace and Darwingreed on the way inwhi ch different forms of life had begun.华莱士和达尔文对不同类型的生物是如何起源的持相同的观点。 This is the way(that) hedid it. I likedthe way(that) sheorganized the meeting. 3.theway(that)有时可以与how(作“如何”解)通用。例如: That’s the way(that) shespoke. = That’s how shespoke.

短歌行赏析介绍

短歌行赏析介绍 说道曹操, 大家一定就联想到三国那些烽火狼烟岁月吧。 但是曹操其实也是 一位文学 大家,今天就来分享《短歌行 》赏析。 《短歌行》短歌行》是汉乐府旧题,属于《相和歌辞·平调曲》。这就是说 它本来是一个乐曲名称。最初古辞已经失传。乐府里收集同名诗有 24 首,最早 是曹操这首。 这种乐曲怎么唱法, 现在当然是不知道。 但乐府 《相和歌·平调曲》 中除《短歌行》还有《长歌行》,唐代吴兢《乐府古题要解》引证古诗 “长歌正激烈”, 魏文帝曹丕 《燕歌行》 “短歌微吟不能长”和晋代傅玄 《艳 歌行》 “咄来长歌续短歌”等句, 认为“长歌”、 “短歌”是指“歌声有长短”。 我们现在也就只能根据这一点点材料来理解《短歌行》音乐特点。《短歌行》这 个乐曲,原来当然也有相应歌辞,就是“乐府古辞”,但这古辞已经失传。现在 所能见到最早《短歌行》就是曹操所作拟乐府《短歌行》。所谓“拟乐府”就是 运用乐府旧曲来补作新词,曹操传世《短歌行》共有两首,这里要介绍是其中第 一首。 这首《短歌行》主题非常明确,就是作者希望有大量人才来为自己所用。曹 操在其政治活动中,为扩大他在庶族地主中统治基础,打击反动世袭豪强势力, 曾大力强调“唯才是举”,为此而先后发布“求贤令”、“举士令”、“求逸才 令”等;而《短歌行》实际上就是一曲“求贤歌”、又正因为运用诗歌 形式,含有丰富抒情成分,所以就能起到独特感染作用,有力地宣传他所坚 持主张,配合他所颁发政令。 《短歌行》原来有“六解”(即六个乐段),按照诗意分为四节来读。 “对酒当歌,人生几何?譬如朝露,去日苦多。慨当以慷,忧思难忘。何以 解忧,唯有杜康。” 在这八句中,作者强调他非常发愁,愁得不得。那么愁是什么呢?原来他是 苦于得不到众多“贤才”来同他合作, 一道抓紧时间建功立业。 试想连曹操这样 位高权重人居然在那里为“求贤”而发愁, 那该有多大宣传作用。 假如庶族地主 中真有“贤才”话, 看这些话就不能不大受感动和鼓舞。 他们正苦于找不到出路

相关主题
文本预览
相关文档 最新文档