Nanorobotic Carriers for Drug Delivery into Brain
曾盼（6101213070自动化133）
When we get sick, there are lots of treatment methods to choose according to the kind of our diseases,the most ordinary way is to take drugs.However,have you tried letting medical nanorobots to deliver the drugs to nidus of cancer inside of your brain.It seems it only happen in fiction story.And scientists have improved it possible(Tabatabaei SN,2012; Pardridge WM,2003).It is found hyperthermia, otherwise known as elevation of body temperature, can lead to intense cellular stress and cause temporal disruption of the Blood Brain Barrier as well as death of cancer cells by enhancing cell sensitivity and vulnerability towards more established forms of cancer therapy, such as radiation and chemotherapy (Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, Felix R, Schlag PM.2002).It means the cancer cells is vulnerable when exposed to certain heat. So scientists created the drugs can generate appropriate heat to kill cancer cells.And created the nanorobots which can deliver the drugs to the place that cancer cells locating on,then,release the drugs. It has tested on the mouses brains,scientists inject the Nanorobotic Carriers into the mouse’s body,the robots searc h cancer cells by a way called Complementary Base Pairs(a kind of gene technology).And then release the drug.It is been tested for many times,but all failed,sometimes it was the matter of robots,sometimes it was the matter of the drug,all in all,the number of cancer cells did not decrease.However without giving up and keeping degrading the tech, eventually it worked(Tabatabaei SN,2012).However,It only tested on mouses,cause it dangerous to do experiments on human. Therefore it is still can not prove that it can works on human though lots of similarities between mouse and man on the brain.And will it do damage to the normal cells remain a mystery.And the security of the drugs is also a problem.And will it have influence on our EQ and IQ also need to research.We need further experiments until those questions to be answered.
References
1.Tabatabaei SN 201
2.IEEE Int Conf Robot Autom.
2.Pardridge WM 200
3. Blood-brain barrier drug targeting: the future of brain drug development. Molecular,Interventions. Mar 1 3:90–105.
3.Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, Felix R, Schlag PM 2002.Hyperthermia in combined treatment of cancer. The Lancet Oncology 3:487–497.
4.Tabatabaei SN 2012 .IEEE Int Conf Robot Autom.
