• PTMs involving addition include:
• Acetylation - the addition of an acetyl group, usually at the N-terminus of the protein
• Alkylation - the addition of an alkyl group (e.g. methyl, ethyl)
• Or - A complete description of proteins expressed in any given cell at any given time
Proteomics
• A cellular proteome is the collection of proteins found in a particular cell type under a particular set of environmental conditions such as exposure to hormone stimulation
• This is due to:
• alternative splicing of genes
• post-translational modifications like glycosylation or Phosphorylation.
alternative splicing of genes
• PTMs involving addition include:
• Phosphopantetheinylation - the addition of a 4'phosphopantetheinyl moiety from coenzyme A, as in fatty acid, polyketide, non-ribosomal peptide and leucine biosynthesis