01.
Mitwally et al. Fertil Steril. 2010.
02.
微粒化P，200-300mg/d 黄体酮油剂，100mg/d
肌注和口服黄体酮的药代动力学
肌肉注射孕酮 10mg 25mg 50mg 血浆浓度 7 ng/mL 28 ng/mL 50 ng/mL
地屈孕酮浓度µg/ml
0
10
20
30
40
60
PIBF阳性细胞(%)
50
12
25
50
100
0
dose-dependent
达芙通治疗流产的机理 -地屈孕酮诱导PIBF的作用
Progesterone
Induced Th1 to Th2 shift
+
P-R
PIBF
IL-4 IL-6 IL-10
Cochrane: 2011,ART & 黄体支持 不同给药途径比较
Cochrane: 2011, ART & 黄体支持
Cochrane :2011,ART & 黄体支持
地屈孕酮/黄体酮凝胶/微粒化黄体酮比较 （2011，RCT，F&S）
亚组分组方法 age>37years, FSH >9–12 IU/mL, dense pelvic adhesions, distorted uterine shape and size, basal antral follicular count fewer than six, body mass index (BMI) >25kg/m2, and duration of infertility>7 years. These factors were considered to be unfavorable for IVF outcome. Each factor was given a score of 1 if unfavorable, or 0 otherwise. The subjects were graded depending on the total scores. Grade 0 (score 0), grade I (scores 1–3), and grade II (scores 3–5) orresponded to highly favorable, unfavorable, and highly unfavorable categories, respectively.
