Sunifiram_314728-85-3_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90–CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose–dependent manner with IC 50 values range from 47 to 73 nM.IC50 & Target: heat shock factor (HSF1)[1]IC50: 47 to 73 nM (MDM2, in ALL cell lines)[2]In Vitro: Triptolide induces apoptosis in cultured and primary Chronic Lymphocytic Leukemia (CLL) B–cells. Treatment of CD19+ B cells with Triptolide, induces a dose–dependent increase in apoptosis in cultured and primary CLL cells. Triptolide is selectively toxic to both high risk (n=5) and low risk CLL (n=12) B cells (10 to 50 nM range) while largely sparing normal B–cells (n=5). Consistent with the inhibition of heat–shock induced HSP transcription, treatment with Triptolide attenuates heat–shock induced expression of HSPs [1]. Triptolide is a natural product derived from the Chinese plant Tripterygium wilfordii , is reported to exhibit antitumor effects in a broad range of cancers. Triptolide inhibits MDM2 expression in a dose–dependent manner, even at low concentrations spanning 20–100 nM in acute lymphoblastic leukemia (ALL) cells. Triptolide exhibits strongly cytotoxic activity in all 8 cell lines having native MDM2 overexpression, with IC 50 values range from 47 to 73 nM. Triptolide exhibits much less cytotoxic effect on EU–4 cells that express very low level of MDM2, while it effectively kill these cells when MDM2 is stably transfected (IC 50 values: 725 nM vs. 88 nM)[2].Differentiated PC12 cells are incubated with different concentrations of Triptolide (0.01, 0.1, and 1 nM) in the presence of 10 μM Aβ25–35 for 24 hours and MTT assay is used to detect the effect of Triptolide. The results show that Aβ25–35 can decrease the cell viability and when treated with Triptolide the viability of differentiated PC12 cells is significantly increased. The results indicate that Triptolide can alleviate cellular damage caused by Aβ25–35, which means that Triptolide has a neuroprotective effect [3].In Vivo: The Triptolide (TP) plasma concentrations are declined rapidly in mice after receive an intravenous dose. After 2h of injection, the Triptolide concentrations are dropped below the lower limit of quantification for all three groups. A comparison of the parameters is made between the control and the treated groups to assess the effect of P–gp inhibition on the Triptolide exposure and elimination. Treatment with the mdr1a–siRNA can significantly enhance the Triptolide plasma exposure, with the C max increases from 413±74 to 510±94 ng/mL (P<0.05) and the AUC from 103.5±9.6 to 154.3±30.2 ng•h/mL (P<0.05). In theconcomitant group with Tariquidar, the significantly increased AUC is also noted, from 103.5±9.6 of the control to 145.9±24.6ng•h/mL of the Triptolide+Tariquidar group (P<0.05). Accordingly, the total body clearance of Triptolide in mice is remarkably decreased, from 9564±1024.2 mL/min/kg of the control to 6576.4±1438.5 (P<0.05) and 5755.4±1200.1 mL/min/kg (P<0.05) for Triptolide+Tariquidar and Triptolide+mdr1a–siRNA groups, respectively [4].PROTOCOL (Extracted from published papers and Only for reference)Cell Assay: Triptolide is dissolved in DMSO (1 mg/mL) and stored, and then diluted with RPMI 1640 medium before use [3].[3]The viability of differentiated PC12 cells treated with different concentrations of Triptolide. After differentiated PC12 cells are culturedProduct Name:Triptolide Cat. No.:HY-32735CAS No.:38748-32-2Molecular Formula:C 20H 24O 6Molecular Weight:360.40Target:HSP; HSP; MDM–2/p53; ADC Cytotoxin Pathway:Metabolic Enzyme/Protease; Cell Cycle/DNA Damage; Apoptosis;Antibody–drug Conjugate/ADC Related Solubility:DMSO: ≥ 33 mg/mLon 96–well plates with RPMI 1640 medium for stabilization, differentiated PC12 cells are incubated with different concentrations of Triptolide (0.01, 0.1, and 1 nM) for 24 hours. The concentrations in this study are chosen. Then cell viability is determined by the MTT assay. Each condition and experiment is repeated three times[3].Animal Administration: Triptolide (TP) is prepared in saline (Mice)[4]. [4]Mice[4]Male BALB/C mice (weight, 18–22 g) are used. For Triptolide (TP) plasma kinetic study and toxicological evaluation, mice are divided into four groups (n=5 each) to collect blood and tissue samples: (1) normal+saline group; (2) 1.0 mg/kg Triptolide+15 nmol negative control (NC) siRNA–siRNA group; (3) 1.0 mg/kg Triptolide+15 nmol mdr1a–siRNA group; (4) 1.0 mg/kg Triptolide+10 mg/kg Tariquidar group. In order to avoid the complication caused by drug absorption or possible intestinal first–pass effect, Triptolide and the inhibitor are intravenously administrated to mice. The siRNA group is intravenously injected with NC–siRNA or mdr1a–siRNA 2 days before Triptolide dose. For Triptolide+Tariquidar group, the mice are received an intravenous Tariquidar dose 20 min prior to the Triptolide injection. Blood samples are collected at 2, 5, 10, 15, 30, 60 and 120 min after Triptolide dosing. To assess the liver exposure of Triptolide, liver tissue samples are collected from another set of mice at 5, 30, 60 and 120 min after dosing. Three Triptolide groups are design for this experiment, including Triptolide+NC–siRNA group, Triptolide+mdr1a–siRNA group and Triptolide+Tariquidar group. The liver tissue samples are weighed and then homogenized in 10 volume (w:v) of ice–cold saline. The concentrations of Triptolide in plasma and liver tissue are measured by a validated LC–MS/MS method.References:[1]. Ganguly S, et al. Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia. Oncotarget. 2015 Oct 13;6(31):31767–79.[2]. Huang M, et al. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53–independent pathway. Mol Cancer Ther. 2013 Feb;12(2):184–94.[3]. Xu P, et al. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid–Beta????? via the Autophagy Pathway. PLoS One. 2015 Nov 10;10(11):e0142719.[4]. Kong LL, et al. Inhibition of P–glycoprotein Gene Expression and Function Enhances Triptolide–induced Hepatotoxicity in Mice. Sci Rep. 2015 Jul 2;5:11747.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

Product Data SheetTrigonox 501-CS301,2,4,5,7,8-Hexoxonane, 3,6,9-trimethyl-3,6,9-tris(Et and Pr) derivs, 30%solution in odorless mineral spiritsTrigonox® 501-CS30 is an initiator for the production of controlled rheology polypropylene (CR-PP) and high-temperature polymerization of ethylene.CAS number1613243-54-1EINECS/ELINCS No.810-295-5TSCA statuslisted on inventorySpecificationsAppearance Clear liquid at 25°CColor40 Pt-Co max.Total active oxygen 5.17-5.48 %CharacteristicsDensity, 20°C0.86 g/cm³ApplicationsTrigonox® 501-CS30 is an efficient peroxide formulation for the production of controlled rheology polypropylene (CR-PP) in an extrusion process. Trigonox® 501-CS30 allows polypropylene producers great flexibility in controlling a polymer’s Melt Flow Index (MFI). Small changes in either peroxide concentration or process temperature can produce significantly different MFI’s. An important advantage of Trigonox® 501-CS30 is that the final CR-PP contains a low content of volatiles originating from peroxide decomposition products. Trigonox® 501-CS30 forms no acetone and no tert-butanol.Half-life dataThe reactivity of an organic peroxide is usually given by its half-life (t1/2) at various temperatures. For Trigonox® 501-CS30 in chlorobenzene half-life at other temperatures can be calculated by using the equations and constants mentioned below:0.1 hr170°C (338°F)1 hr146°C (295°F)10 hr125°C (257°F)Formula 1kd = A·e-Ea/RTFormula 2t½ = (ln2)/kdEa150.60 kJ/moleA 1.09E+15 s-1R8.3142 J/mole·KT(273.15+°C) KThermal stabilityOrganic peroxides are thermally unstable substances, which may undergo self-accelerating decomposition. The lowest temperature at which self-accelerating decomposition of a substance in the original packaging may occur is the Self-Accelerating Decomposition Temperature (SADT). The SADT is determined on the basis of the Heat Accumulation Storage Test.SADT110°C (230°F)Method The Heat Accumulation Storage Test is a recognized test method for thedetermination of the SADT of organic peroxides (see Recommendations on theTransport of Dangerous Goods, Manual of Tests and Criteria - United Nations, NewYork and Geneva).StorageDue to the relatively unstable nature of organic peroxides a loss of quality can be detected over a period of time. To minimize the loss of quality, Nouryon recommends a maximum storage temperature (Ts max. ) for each organic peroxide product.Ts max.40°C (104°F)Ts min.-30°C (-22°F)Note When stored under these recommended storage conditions, Trigonox® 501-CS30 will remain within the Nouryon specifications for a period of at least 12months after delivery.Packaging and transportThe standard packaging is a 770 kg Polyethylene Intermediate Bulk Container (PE IBC). Both packaging and transport meet the international regulations. For the availability of other packed quantities consult your Nouryon representative. Trigonox® 501-CS30 is classified as Organic peroxide type F; liquid, Division 5.2; UN 3109 for land and sea transport and classified as Organic peroxide type C; liquid, Division 5.2; UN 3103 for air transport.Safety and handlingKeep away from open fire, sparks and other sources of heat or ignition. Avoid contact with reducing agents (e.g. amines), acids, alkalis and heavy metal compounds (e.g. accelerators, driers and metal soaps). Please refer to the Safety Data Sheet (SDS) for further information on the safe storage, use and handling of Trigonox® 501-CS30. This information should be thoroughly reviewed prior to acceptance of this product. The SDS is available at /sds-search.Major decomposition productsCarbon dioxide, Methane, Ethane, Propane, Methyl ethyl ketone, Methyl propyl ketone, Methyl acetate, Ethyl acetate, Propyl acetateAll information concerning this product and/or suggestions for handling and use contained herein are offered in good faith and are believed to be reliable.Nouryon, however, makes no warranty as to accuracy and/or sufficiency of such information and/or suggestions, as to the product's merchantability or fitness for any particular purpose, or that any suggested use will not infringe any patent. Nouryon does not accept any liability whatsoever arising out of the use of or reliance on this information, or out of the use or the performance of the product. Nothing contained herein shall be construed as granting or extending any license under any patent. Customer must determine for himself, by preliminary tests or otherwise, the suitability of this product for his purposes.The information contained herein supersedes all previously issued information on the subject matter covered. The customer may forward, distribute, and/or photocopy this document only if unaltered and complete, including all of its headers and footers, and should refrain from any unauthorized use. Don’t copythis document to a website.Trigonox® is a registered trademark of Nouryon Functional Chemicals B.V. or affiliates in one or more territories.Contact UsPolymer Specialties Americas************************Polymer Specialties Europe, Middle East, India and Africa*************************Polymer Specialties Asia Pacific************************2023-6-22© 2023Polymer production Trigonox 501-CS30。

Velcade® (bortezomib)Document Number: IC-0137 Last Review Date: 5/1/2018Date of Origin: 11/28/2011Dates Reviewed: 12/2011, 03/2012, 06/2012, 09/2012, 12/2012, 03/2013, 06/2013, 09/2013, 12/2013, 03/2014, 06/2014, 09/2014, 12/2014, 03/2015, 05/2015, 08/2015, 11/2015, 02/2016, 05/2016, 08/2016, 11/2016, 02/2017, 05/2017, 08/2017, 11/2017, 02/2018, 05/2018I.Length of AuthorizationCoverage will be provided for 6 months and may be renewed.II.Dosing LimitsA.Quantity Limit (max daily dose) [Pharmacy Benefit]:-Velcade 3.5 mg powder for injection: 4 vials per 21 day supplyB.Max Units (per dose and over time) [Medical Benefit]:∙140 billable units every 21 daysIII.Initial Approval CriteriaCoverage is provided in the following conditions:∙Patient aged 18 years or older; ANDMultiple myeloma †Mantle cell lymphoma †∙Used as a single agent or in combination with rituximabSystemic Light Chain Amyloidosis ‡∙Used as a single agent; OR∙Used in combination with dexamethasone with or without melphalan; OR∙Used in combination with dexamethasone and cyclophosphamideWaldenström’s macroglobulinemia/Lymphoplasmacytic Lymphoma‡∙Used as a single agent; OR∙Used in combination with dexamethasone; OR∙Used in combination with rituximab with or without dexamethasoneMulticentric Castleman’s Disease‡∙Must be used as subsequent therapy; AND∙Patient has progressed following treatment for relapsed/refractory or progressive disease;AND∙Used as a single agent or in combination with rituximabPrimary cutaneous CD30+ T-Cell Lymphoproliferative Disorders ‡∙Used as single agent for relapsed or refractory disease; ANDo Patient has primary cutaneous anaplastic large cell lymphoma (pcALCL) with multifocal lesions; ORo Patient has cutaneous ALCL with regional nodes (excludes systemic ALCL) Adult T-Cell Leukemia/Lymphoma ‡∙Must be used as a single agent for non-responders to first-line therapy for acute disease or lymphoma; ANDo Used second-line if intent is to proceed to high-dose therapy with autologous stem cell rescue (HDT/ASCR); ORo Subsequent therapy after HDT/ASCR†FDA Approved Indication(s); ‡Compendia recommended indication(s)IV.Renewal CriteriaCoverage can be renewed based upon the following criteria:∙Patient continues to meet the criteria identified in section III; AND∙Tumor response with stabilization of disease or decrease in size of tumor or tumor spread;AND∙Absence of unacceptable toxicity from the drug. Example of unacceptable toxicity include: peripheral neuropathy, hypotension, cardiac toxicity, pulmonary toxicity, posteriorreversible encephalopathy syndrome, gastrointestinal toxicity, thrombocytopenia,neutropenia, tumor lysis syndrome, hepatic toxicity, etc.V.Dosage/AdministrationVI.Billing Code/Availability InformationJcode:∙J9041– Injection, bortezomib, 0.1 mg; 1 billable unit = 0.1 mgNDC(s):∙Velcade 3.5 mg single-use vial powder for injection: 63020-0049-xxVII.References1.Velcade [package insert]. Cambridge, MA; Millennium Pharmaceuticals, Inc; June 2017.Accessed March 2018.2.Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCNCompendium®) for Bortezomib. National Comprehensive Cancer Network, 2018. The NCCN Compendium® is a derivative work of the NCCN Guidelines®. NATIONALCOMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® aretra demarks owned by the National Comprehensive Cancer Network, Inc.” To view the mostrecent and complete version of the Compendium, go online to . Accessed March2018.3.Boccadoro M, Bringhen S, Gaidano G, et al, “Bortezomib, Melphalan, Prednisone, andThalidomide (VMPT) Followed by Maintenance With Bortezomib and Thalidomide (VT) forInitial Treatment of Elderly Multiple Myeloma Patients,” J Clin Oncol, 2010, 28(7s):8013[abstract 8013 from 2010 ASCO Annual Meeting].4.Palumbo A, Bringhen S, Rossi D, et al, “Bortezomib, Melphalan, Prednisone andThalidomide (VMPT) Followed by Maintenance With Bortezomib and Thalidomide for Initial Treatment of Elderly Multiple Myeloma Patients,” Blood, 2009, 114(22):128 [abstract 128from ASH 2009 Annual Meeting].5.Ghobria l IM, Hong F, Padmanabhan S, et al, “Phase II Trial of Weekly Bortezomib inCombination With Rituximab in Relapsed or Relapsed and Refractory WaldenstromMacroglobulinemia,” J Clin Oncol, 2010, 28(8):1422-8.6.First Coast Service Options, Inc. Local Coverage Determination (LCD): Bortezomib(Velcade®) (L33273) Centers for Medicare & Medicare Services, Inc. Updated on 2/2/2018 with effective date 2/8/2018. Accessed March 2018.7.National Government Services, Inc. Local Coverage Article for Bortezomib – Related to LCDL33394 (A52371). Centers for Medicare & Medicaid Services, Inc. Updated on 1/26/2018 with effective date of 2/1/2018. Accessed March 2018.8.Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCNCompendium®) T-Cell Lymphomas. Version 3.2018. National Comprehensive CancerNetwork, 2018. The NCCN Compendium® is a derivative work of the NCCN Guidelines®.NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCNGUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc.” To view the most recent and complete version of the Compendium, go online to. Accessed March 2018.9.Zinzani PL, Musuraca G, Tani M, et al. Phase II trial of proteasome inhibitor bortezomib inpatients with relapsed or refractory cutaneous T-cell lymphoma. J Clin Oncol 2007;25:4293-4297.Appendix 1 – Covered Diagnosis CodesDual coding requirements:Codes Z85.72 & Z85.79 are secondary codes and must be billed in conjunction with a primary code Appendix 2 – Centers for Medicare and Medicaid Services (CMS)Medicare coverage for outpatient (Part B) drugs is outlined in the Medicare Benefit Policy Manual (Pub. 100-2), Chapter 15, §50 Drugs and Biologicals. In addition, National Coverage Determination (NCD) and Local Coverage Determinations (LCDs) may exist and compliance with these policies is required where applicable. They can be found at: /medicare-coverage-database/search/advanced-search.aspx. Additional indications may be covered at the discretion of the health plan.Medicare Part B Covered Diagnosis Codes (applicable to existing NCD/LCD):。

SAFETY DATA SHEET1. IdentificationMERCON ULV AUTOMATIC TRANSMISSION FLUIDProduct identifierOther means of identification196825FIR No.Automatic Transmission FluidRecommended useNone known.Recommended restrictionsManufacturer/Importer/Supplier/Distributor informationFord Motor CompanyCompany NameAttention: SDS Information, P.O. Box 1899AddressDearborn, Michigan 48121USA1-800-392-3673Telephone1-800-448-2063 (USA and Canada)SDS InformationEmergency telephonenumbersPoison Control Center: USA and Canada: 1-800-959-3673INFOTRAC (Transportation): USA and Canada 1-800-535-50532. Hazard(s) identificationNot classified.Physical hazardsAspiration hazardCategory 1Health hazardsNot classified.Environmental hazardsNot classified.OSHA defined hazardsLabel elementsSignal word DangerHazard statement May be fatal if swallowed and enters airways.Precautionary statementPrevention Observe good industrial hygiene practices.Response If swallowed: Immediately call a poison center/doctor. Do NOT induce vomiting. Take offcontaminated clothing and wash it before reuse.Storage Store locked up.Disposal Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard(s) not otherwiseNone known.classified (HNOC)Supplemental information None.3. Composition/information on ingredientsMixturesCAS number% Chemical name Common name and synonyms89 - 90Distillates (petroleum), hydrotreated64742-55-8light paraffinicSpecific chemical identity and/or exact percentage (concentration) of composition has been withheld as a trade secret.4. First-aid measuresMove to fresh air. Call a physician if symptoms develop or persist.Inhalation Wash off with soap and water. Get medical attention if irritation develops and persists.Skin contact Rinse with water. Get medical attention if irritation develops and persists.Eye contact Call a physician or poison control center immediately. Rinse mouth. Do not induce vomiting. If vomiting occurs, keep head low so that stomach content doesn't get into the lungs.IngestionAspiration may cause pulmonary edema and pneumonitis.Most importantsymptoms/effects, acute and delayedProvide general supportive measures and treat symptomatically. Keep victim under observation.Symptoms may be delayed.Indication of immediatemedical attention and special treatment needed Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves.General information5. Fire-fighting measuresWater fog. Foam. Dry chemical powder. Carbon dioxide (CO2).Suitable extinguishing media Do not use water jet as an extinguisher, as this will spread the fire.Unsuitable extinguishing mediaDuring fire, gases hazardous to health may be formed. Upon decomposition, this product emits carbon monoxide, carbon dioxide and/or low molecular weight hydrocarbons.Specific hazards arising from the chemicalSelf-contained breathing apparatus and full protective clothing must be worn in case of fire.Special protective equipment and precautions for firefighters Move containers from fire area if you can do so without risk.Fire fightingequipment/instructions Use standard firefighting procedures and consider the hazards of other involved materials.Specific methods No unusual fire or explosion hazards noted.General fire hazards6. Accidental release measuresAvoid contact with eyes, skin, and clothing. Avoid inhalation of vapors and spray mists. Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Keep unnecessarypersonnel away. Local authorities should be advised if significant spillages cannot be contained.Wear appropriate protective equipment and clothing during clean-up. For personal protection, see section 8 of the SDS.Personal precautions,protective equipment and emergency proceduresThe product is immiscible with water and will spread on the water surface.Large Spills: Stop the flow of material, if this is without risk. Dike the spilled material, where this is possible. Absorb in vermiculite, dry sand or earth and place into containers. Following product recovery, flush area with water.Small Spills: Wipe up with absorbent material (e.g. cloth, fleece). Clean surface thoroughly to remove residual contamination.Never return spills to original containers for re-use. For waste disposal, see section 13 of the SDS.Methods and materials for containment and cleaning upAvoid discharge into drains, water courses or onto the ground.Environmental precautions7. Handling and storageAvoid contact with eyes, skin, and clothing. Avoid breathing mist or vapor. Avoid prolongedexposure. Provide adequate ventilation. Observe good industrial hygiene practices. Wash hands thoroughly after handling. Wear appropriate personal protective equipment. For personal protection, see Section 8 of the SDS.Precautions for safe handlingStore locked up. Store in tightly closed container. Store away from incompatible materials (see Section 10 of the SDS).Conditions for safe storage,including any incompatibilities8. Exposure controls/personal protectionOccupational exposure limitsThe following constituents are the only constituents of the product which have a PEL, TLV or other recommended exposure limit.At this time, the other constituents have no known exposure limits.US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000)Form Value Components Type PEL5 mg/m3Mist.Distillates (petroleum),hydrotreated light paraffinic (CAS 64742-55-8)US. ACGIH Threshold Limit Values FormValue ComponentsType TWA5 mg/m3Inhalable fraction.Distillates (petroleum),hydrotreated light paraffinic (CAS 64742-55-8)US. NIOSH: Pocket Guide to Chemical Hazards Form Value Components Type STEL10 mg/m3Mist.Distillates (petroleum),hydrotreated light paraffinic (CAS 64742-55-8)TWA 5 mg/m3Mist.No biological exposure limits noted for the ingredient(s).Biological limit values Use adequate ventilation to control airborne concentrations below the exposure limits/guidelines. If user operations generate a vapor, dust and/or mist, use process enclosure, appropriate local exhaust ventilation, or other engineering controls to control airborne levels below the recommended exposure limits/guidelines.Appropriate engineering controlsIndividual protection measures, such as personal protective equipmentWear safety glasses with side shields (or goggles).Eye/face protectionSkin protectionSuitable chemical protective gloves should be worn when the potential exists for skin exposure.The choice of an appropriate glove does not only depend on its material but also on other quality features and is different from one producer to the other. Nitrile gloves are recommended.Hand protectionWear appropriate chemical resistant clothing if applicable.OtherIf engineering controls do not maintain airborne concentrations to a level which is adequate to protect worker health, an approved respirator must be worn. Respirator selection, use and maintenance should be in accordance with the requirements of OSHA Respiratory Protection Standard 29 CFR 1910.134 and/or Canadian Standard CSA Z94.4.Respiratory protectionWear appropriate thermal protective clothing, when necessary.Thermal hazards Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing and protective equipment to remove contaminants.General hygiene considerations9. Physical and chemical propertiesAppearanceLiquid.Physical state Liquid.Form Red.Color PETROLEUM OdorOdor threshold Not available.pHNot available.Melting point/freezing point Not available.Initial boiling point and boiling range Not available.Flash point > 314.6 °F (> 157.0 °C) Pensky-Martens Closed Cup Evaporation rate Not available.Not applicable.Flammability (solid, gas)Upper/lower flammability or explosive limits Explosive limit - lower (%)Not available.Explosive limit - upper (%)Not available.Vapor pressure< 1 mm HgVapor density > 1 (Air=1)Relative density0.83 - 0.85 (Water=1)Relative density temperature 60.08 °F (15.6 °C)Solubility(ies)Solubility (water)Negligible Partition coefficient (n-octanol/water)Not available.Auto-ignition temperature Not available.Decomposition temperature Not available.Viscosity19 - 20 cSt Viscosity temperature104 °F (40 °C)10. Stability and reactivityThe product is stable and non-reactive under normal conditions of use, storage and transport.Reactivity Material is stable under normal conditions.Chemical stability No dangerous reaction known under conditions of normal use.Possibility of hazardous reactionsContact with incompatible materials.Conditions to avoid Strong oxidizing agents.Incompatible materials Upon decomposition, this product emits carbon monoxide, carbon dioxide and/or low molecular weight hydrocarbons.Hazardous decomposition products11. Toxicological informationInformation on likely routes of exposureInhalationBased on available data, the classification criteria are not met. Prolonged inhalation may be harmful.Skin contact Based on available data, the classification criteria are not met.Eye contact Based on available data, the classification criteria are not met.IngestionDroplets of the product aspirated into the lungs through ingestion or vomiting may cause a serious chemical pneumonia.Symptoms related to the physical, chemical andtoxicological characteristics Aspiration may cause pulmonary edema and pneumonitis.Information on toxicological effectsAcute toxicityMay be fatal if swallowed and enters airways.Prolonged skin contact may cause temporary irritation.Skin corrosion/irritation Direct contact with eyes may cause temporary irritation.Serious eye damage/eye irritationRespiratory or skin sensitizationRespiratory sensitizationNot a respiratory sensitizer.This product is not expected to cause skin sensitization.Skin sensitization No data available to indicate product or any components present at greater than 0.1% are mutagenic or genotoxic.Germ cell mutagenicity CarcinogenicityNot classifiable as to carcinogenicity to humans.IARC Monographs. Overall Evaluation of CarcinogenicityNot listed.OSHA Specifically Regulated Substances (29 CFR 1910.1001-1053)Not listed.This product is not expected to cause reproductive or developmental effects.Reproductive toxicitySpecific target organ toxicity -single exposureNot classified.Specific target organ toxicity -repeated exposureNot classified.Aspiration hazard May be fatal if swallowed and enters airways.Chronic effectsProlonged inhalation may be harmful.12. Ecological informationThe product is not classified as environmentally hazardous. However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment.EcotoxicityNo data is available on the degradability of any ingredients in the mixture. Persistence and degradabilityBioaccumulative potential No data available.Mobility in soil Other adverse effectsNo other adverse environmental effects (e.g. ozone depletion, photochemical ozone creationpotential, endocrine disruption, global warming potential) are expected from this component.13. Disposal considerationsCollect and reclaim or dispose in sealed containers at licensed waste disposal site. Dispose of contents/container in accordance with local/regional/national/international regulations. Don't pollute. Conserve resources. Return used oil to collection centers.Disposal instructionsDispose in accordance with all applicable regulations.Local disposal regulations The waste code should be assigned in discussion between the user, the producer and the waste disposal company.Hazardous waste code Dispose of in accordance with local regulations. Empty containers or liners may retain some product residues. This material and its container must be disposed of in a safe manner (see:Disposal instructions).Waste from residues / unused productsSince emptied containers may retain product residue, follow label warnings even after container is emptied. Empty containers should be taken to an approved waste handling site for recycling or disposal.Contaminated packaging14. Transport informationDOTNot regulated as dangerous goods.IATANot regulated as dangerous goods.IMDGNot regulated as dangerous goods.Not established.Transport in bulk according toAnnex II of MARPOL 73/78 and the IBC Code15. Regulatory informationThis product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication Standard, 29 CFR 1910.1200.US federal regulationsToxic Substances Control Act (TSCA)TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D)Not regulated.CERCLA Hazardous Substance List (40 CFR 302.4)Not listed.SARA 304 Emergency release notificationNot regulated.OSHA Specifically Regulated Substances (29 CFR 1910.1001-1053)Not listed.SARA 302 Extremely hazardous substanceSuperfund Amendments and Reauthorization Act of 1986 (SARA)Not listed.YesSARA 311/312 Hazardous chemicalAspiration hazardClassified hazard categoriesSARA 313 (TRI reporting)Not regulated.Other federal regulationsClean Air Act (CAA) Section 112 Hazardous Air Pollutants (HAPs) ListNot regulated.Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130)Not regulated.Not regulated.Safe Drinking Water Act(SDWA)International InventoriesAll components are listed or are exempt from listing on the Toxic Substances Control Act Inventory.16. Other information, including date of preparation or last revision08-20-2021Issue date Version 01Health: 0Flammability: 1Physical hazard: 0HMIS® ratingsHealth: 0Flammability: 1Instability: 0NFPA ratingsThis document was prepared by FCSD-Toxicology, Ford Motor Company, Diagnostic Service Center II, 1800 Fairlane Drive, Allen Park, MI 48101, USA, based in part on information provided by the manufacturer. The information on this data sheet represents our current data and is accurate to the best of our knowledge as to the proper handling of this product under normal conditions and in accordance with the application specified on the packaging and/or technical guidance literature. Any other use of the product which involves using the product in combination with any other product or any other process is the responsibility of the user. To the extent that there are any differences between this product’s Safety Data Sheet (SDS) and the consumer packaged product labels, the SDS should be followed.Preparation Information and DisclaimerXT-12-QULV, XT-12-QULV1Part number(s)。

Santoprene™ 8281-45MEDThermoplastic Vulcanizate产品说明关键特性它是热塑性弹性体（TPE ）• 基于对代表性牌号进行的一系列生物适应性测试,此牌号符合USP(美国药典)针对塑料制品的 VI 级要求。

- 此外还进行了一些ISO 10993 测试。

-每种医疗牌号都会经过细胞毒性和重金属的年度测试。

- 药物主文件在FDA 备案。

- 符合 RoHS 规范。

系列中的一种软质、可着色、特种非吸湿性热塑性硫化弹性体 （TPV ）。

它适用于医疗保健领域。

这一牌号的山都平 TPV 是剪切速率依赖型产品，可在常规热塑性注塑成型设备上加工。

它是聚烯烃基产品， 可以完全回收利用。

总体 供货地区 1 • 北美洲 • 非洲和中东 • 拉丁美洲 • 南美洲 • 欧洲 • 亚太地区应用 • 医药 - 软质手柄，USP VI 类密封件和垫片 • 医疗/护理领域的应用用途 机构评级 • EU Annex XVII of Regulation • USP 第VI 类(EC) No 1907/2006RoHS 合规性 外观 • RoHS 合规 • 自然色 形式 • 颗粒料 加工方法 修订信息 • 多次注射成型 • 06/16/2011• 注射成型物理性能 比重 典型数值 (英制 ) 典型数值 (公制 ) 测试依据 0.910 0.910 ASTM D792ISO 1183 密度 0.910 g/cm³ 0.910 g/cm³ 硬度 典型数值 (英制 )49典型数值 (公制 )49测试依据 ISO 868支撐硬度邵氏 A, 15 秒, 73°F (23°C), 0.0787 in (2.00 mm) 弹性体典型数值 (英制 )189 psi 典型数值 (公制 )1.30 MPa 测试依据 拉伸应力（在100％时） - 横向流量 (73°F (23°C)) ASTM D412 拉伸应力（在100％时） - 横向流量 (73°F (23°C)) 189 psi 1.30 MPa ISO 37 拉伸断裂强度 - 横向流量 (73°F (23°C)) 拉伸断裂应力 - 横向流量 (73°F (23°C)) 522 psi 522 psi 380 % 3.60 MPa 3.60 MPa 380 % ASTM D412 ISO 37 伸长率（在断裂伸长时） - 横向流量 (73°F (23°C)) ASTM D412 拉伸断裂应变 - 横向流量 (73°F (23°C)) 撕裂强度 - 横向流量 380 % 380 % ISO 37 ASTM D62473°F (23°C), C 模具 68.5 lbf/in 22.8 lbf/in12.0 kN/m 4.00 kN/m212°F (100°C), C 模具ExxonMobil Chemical Santoprene™ 8281-45MEDThermoplastic Vulcanizate弹性体典型数值 (英制 ) 典型数值 (公制 ) 测试依据ISO 34-1 撕裂强度 - 横向流量73°F (23°C), B方法，直角形试样（割口）69 lbf/in23 lbf/in 12 kN/m 4.0 kN/m212°F (100°C), B方法，直角形试样（割口）压缩永久变形 (73°F (23°C), 168 hr, 类型 1) 12 %12 % 12 %12 %ASTM D395BISO 815压缩永久变形 (73°F (23°C), 168 hr, 类型A)注射典型数值 (英制 )0.080 % 典型数值 (公制 )0.080 %建议的最大水分含量建议的最大回制料比例螺筒后部温度螺筒中部温度螺筒前部温度射嘴温度20 % 20 % 350 到 375 °F355 到 380 °F365 到 390 °F365 到 410 °F290 到 420 °F75.0 到 125 °F快速177 到 191 °C179 到 193 °C185 到 199 °C185 到 210 °C143 到 216 °C23.9 到 51.7 °C快速加工（熔体）温度模具温度注射速度背压50.0 到 100 psi100 到 200 rpm3.0 到 5.0 tons/in²0.125 到 0.250 in 0.345 到 0.689 MPa100 到 200 rpm41 到 69 MPa 3.18 到 6.35 mm螺杆转速合模力垫层螺杆长径比16.0:1.0 至20.0:1.0 16.0:1.0 至20.0:1.0螺杆压缩比排气孔深度2.0:1.0 至 2.5:1.00.0010 in2.0:1.0 至 2.5:1.00.025 mm注射说明Santoprene TPV与乙缩醛和PVC不相容。

注意事项请在操作使用前，首先仔细阅读以下内容 。

请将本使用手册妥善保管，以便将来随时查阅。

电源当从电源插座中拔出电源线插头时，请务必抓住插头。

请不要直接拽拉电源线可能会导致损坏。

只能使用本设备背部面板铭牌上所规定的额定电压。

请勿用多路连接器将设备连接到电源插座上，否则可能会使插座过热。

设备不使用时，或者在雷雨暴风期间，请从插座上拔下电源插头。

连接在将本设备连接到其他设备之前，请关闭所有设备的电源开关。

这将有效防止设备故障或防止损坏其他设备。

位置请勿将设备放置于以下环境中，以免设备发生变形、变色或其他更严重的损害：阳光直射处、暖气旁多尘土、高温、高湿、可能产生强烈震动或冲击的位 置接近磁场处对其他设备的干扰将此设备放置在电视机、收音机的周围可能引起干扰。

使用此设备时，请与电视机和收音机保持适当的距离。

维护保养只能使用柔软的干布清洁此设备。

请勿使用涂料稀释剂、溶剂、清洁液或浸了化学物质的抹布。

处理请勿对开关或控制按钮用力过猛。

避免纸张、金属或其他杂物进入设备内部。

如果发生此类情况，请拔掉墙上电源插座中的插头。

然后请具有资格的维修人员对设备进行检查。

在移动设备之前，请断开所有的电源。

警告该产品的正常功能可能会遭受强电磁干扰。

如果出现这种情况，只需简单地按照用户手册将产品恢复初始设置。

当产品的功能无法恢复时，请在其他位置使用本产品。

装箱单尊敬的用户，当您选购本乐器后，请检查以下物品是否齐全： 琴体 左支撑板 右支撑板 后面板踏板组件（包括踏板连接线） 一包螺母 用户说明书 售后保修证书调音台23踏板功能..................................................................23功能菜单音调设置....................................................................24键盘分离点设置.........................................................25节拍种类设置.............................................................25节拍器音量设置.........................................................25踏板定义设置.............................................................25混响深度设置.............................................................26合唱深度设置.............................................................26和声类型设置.............................................................26和声速度设置.............................................................27MIDI接收设置............................................................27MIDI发送设置............................................................27定时关机设置.............................................................27演奏帮助节拍设置.. (27)恢复出厂设置..........................................................28面板注册记忆设置将设置保存到注册记忆..............................................28调出注册记忆.............................................................28选择记忆库................................................................28伴奏锁定.. (29)歌本功能..................................................................29录制自己的歌曲 (30)开始录音....................................................................30停止录音....................................................................31回放已录制的歌曲.....................................................31删除已录制的歌曲.. (31)播放及控制歌曲欣赏歌曲....................................................................32歌曲控制....................................................................32歌曲学习模式. (32)和弦字典..................................................................34MIDI功能什么是MIDI?..............................................................35上传数据到电脑/下载数据到设备. (35)故障排除..................................................................36规格..........................................................................36附录音色列表....................................................................37节奏列表....................................................................42歌曲列表....................................................................44歌本列表....................................................................44和弦类型表................................................................46MIDI应用表................................................................47音律 (48)......................................................................面板控制与显示说明前面板.........................................................................4LCD液晶显示...............................................................4后面板.........................................................................5踏板.. (5)安装安装指南......................................................................6电源供电. (8)外部连接连接耳机......................................................................9连接到音频设备...........................................................9连接到MP3/CD机等播放器..........................................9连接到电脑..................................................................9连接到其它设备.. (9)调节主音量..............................................................10调节声音亮度..........................................................10播放示范曲..............................................................10演奏各种乐器音色选择并演奏音色(主音色)............................................11演奏两种音色(双音色)...............................................11下音色.......................................................................12力度响应....................................................................12移调...........................................................................12钢琴演奏模式.............................................................13节拍器.......................................................................13双钢琴功能................................................................13古典音律.. (14)演奏各种风格伴奏演奏自动伴奏(只演奏打击乐声部).............................15演奏自动伴奏(所有声部)............................................15伴奏段落....................................................................16演奏不同的伴奏段落..................................................16伴奏音量控制.............................................................17和弦演奏指法.............................................................17速度...........................................................................18单触键设置. (18)和声设置操作....................................................................19使用和声演奏. (19)演奏帮助什么是“演奏帮助”?................................................20进入演奏帮助功能.....................................................20吉他模式....................................................................20在吉他模式中演奏.....................................................21钢琴模式....................................................................21民乐模式....................................................................22在民乐模式中演奏.....................................................22退出演奏帮助功能.. (22)前面板在松开 【切换】按钮时3～8.节奏直选按钮 快速选择预设节奏9.【速度+/-】按钮 调节当前速度16.【插入C 】按钮 插入变奏C 17.【插入D 】按钮 插入变奏D19.【左手】按钮选择学习歌曲的左手声部20.【右手】按钮选择学习歌曲的右手声部在伴奏模式下11.【启动/停止】按钮 启动或停止播放伴奏12.【同步启动】按钮打开/关闭同步启动功能13.【前奏/尾奏】按钮播放自动伴奏的前奏/尾奏14.【插入A】按钮 插入变奏A 15.【插入B】按钮 插入变奏B在歌曲模式下11.【启动/停止】按钮 启动或停止播放歌曲12.【暂停】暂停播放或继续播放歌曲13.【重复 A/B】按钮设定歌曲段落循环起始和 结束的位置14.【快退】按钮 快退播放歌曲15.【快进】按钮 快进播放歌曲1.【音量】旋钮调节主音量的大小2.【明亮度】旋钮 调节音色的明亮度LCD显示1. 伴奏音轨2. 旋律音轨13. 旋律音轨24. 旋律音轨35. 旋律音轨46. 旋律音轨57. 音色/节奏/示范曲/歌曲/歌本8. 数字序号9. 自动低音和弦/全键盘模式/伴奏段落10. 和弦显示21. 双钢琴22. 演奏帮助23. 演奏帮助 高24. 歌本25. 和声26. 古典音律27. 数码效果28. 双音色29. 下音色30. 力度11. 低音谱表音符12. 高音谱表音符13. USB连接14. 字符显示区15. 小节计数16. 拍点显示17. 速度18. 录音19. 记忆/锁定/单触设置/记忆库20. 学习模式/左手/右手1234562122232426在按住按钮时3.伴奏音量按钮 调节伴奏音量4.【打击乐】按钮调节打击乐通道音量5.【贝司】按钮 调节贝司音量6.【和弦】按钮调节和弦通道音量7.【左手音色】按钮调节左手音色通道音量8.【右手音色】按钮调节右手音色通道音量9.【功能+/-】按钮 调节功能参数20.【和弦字典】按钮 进入和弦字典【切换】【】10.【切换】按钮切换部分功能按钮的 功能定义18.【和弦模式】按钮 选择和弦的模式21.【学习】按钮 进入学习模式22. LCD 显示屏幕显示关于此设备所有的 重要设定信息后面板49. 辅助输入接口连接到MP3或CD机等播放器。

安全技术说明书Insulcure 24 PT B产品标识产品名称Insulcure 24 PT B物质或混合物的推荐用途及限制用途推荐用途Casting compound供应商的详细情况供应商ITW Performance PolymersBay 150Shannon Industrial EstateCo. ClareIrelandV14 DF82353(61)771500353(61)471285应急电话应急电话+44(0)1235 239 670 (24h)物质或混合物的分类物理危险非此类健康危害急性毒性类别4 - H302 急性毒性类别4 - H312 皮肤刺激类别2 - H315 眼损伤类别1 - H318 皮肤致敏物类别1A - H317环境危害危害水生环境-长期危险类别2 - H411标签要素象形图警示词危险危险性说明H302+H312 吞咽或皮肤接触有害。

H315 造成皮肤刺激。

H317 可能造成皮肤过敏反应。

H318 造成严重眼损伤。

H411 对水生生物有毒并具有长期持续影响。

防范说明P261 避免吸入蒸气/ 喷雾。

P264 作业后彻底清洗沾染的皮肤。

P280 戴防护手套/ 穿防护服/ 戴防护眼罩/ 戴防护面具。

P302+P352 如皮肤沾染：用大量水清洗。

P305+P351+P338 如进入眼睛： 用水小心冲洗几分钟。

如戴隐形眼镜并可方便地取出，取出隐形眼镜。

继续冲洗。

P333+P313 如发生皮肤刺激或皮疹：求医/ 就诊。

含有POLYAMINOAMIDE, TRIETHYLENETETRAMINE所有危险性说明的全文会显示在第16部分。

急救措施说明吸入转移受影响的人员远离污染源。

将受影响的人员转移至新鲜空气处，并注意保暖和呼吸舒适的体位休息。

如果不适感持续，就医。

食入立即就医。

不要催吐。

漱口。

皮肤接触立即脱去污染的衣着，并用肥皂和水清洗皮肤。

连续用水冲洗至少15分钟。

SIGMA-ALDRICHMaterial Safety Data SheetVersion 4.2Revision Date 12/18/2012Print Date 05/07/20131. PRODUCT AND COMPANY IDENTIFICATIONProduct name :1-PropanolProduct Number : 402893Brand : Sigma-AldrichSupplier: Sigma-Aldrich3050 Spruce StreetSAINT LOUIS MO 63103 USATelephone : +1 800-325-5832 Fax: +1 800-325-5052 Emergency Phone # (For both supplier and manufacturer): (314) 776-6555Preparation Information: Sigma-Aldrich CorporationProduct Safety - Americas Region 1-800-521-89562. HAZARDS IDENTIFICATIONEmergency OverviewOSHA HazardsFlammable liquid, Target Organ Effect, Irritant Target Organs Nerves., LiverGHS ClassificationFlammable liquids (Category 2)Acute toxicity, Inhalation (Category 5) Skin irritation (Category 3)Serious eye damage (Category 1)Specific target organ toxicity - single exposure (Category 3)GHS Label elements, including precautionary statements PictogramSignal word DangerHazard statement(s) H225 Highly flammable liquid and vapour. H316 Causes mild skin irritation. H318 Causes serious eye damage. H333 May be harmful if inhaled. H336 May cause drowsiness or dizziness.Precautionary statement(s) P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, ifpresent and easy to do. Continue rinsing.HMIS ClassificationHealth hazard:2Chronic Health Hazard:*Flammability:3Physical hazards:0NFPA RatingHealth hazard:2Fire:3Reactivity Hazard:0Potential Health EffectsInhalation May be harmful if inhaled. Causes respiratory tract irritation.Vapours may causedrowsiness and dizziness.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes Causes eye irritation.Ingestion May be harmful if swallowed.3. COMPOSITION/INFORMATION ON INGREDIENTSSynonyms : Propyl alcoholFormula : C3H8OMolecular Weight : 60.10 g/mol4. FIRST AID MEASURESGeneral adviceConsult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.In case of skin contactWash off with soap and plenty of water. Consult a physician.In case of eye contactRinse thoroughly with plenty of water for at least 15 minutes and consult a physician.If swallowedDo NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.5. FIREFIGHTING MEASURESConditions of flammabilityFlammable in the presence of a source of ignition when the temperature is above the flash point. Keep away from heat/sparks/open flame/hot surface. No smoking.Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Special protective equipment for firefightersWear self contained breathing apparatus for fire fighting if necessary.Hazardous combustion productsHazardous decomposition products formed under fire conditions. - Carbon oxidesFurther informationUse water spray to cool unopened containers.6. ACCIDENTAL RELEASE MEASURESPersonal precautionsUse personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove allsources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosiveconcentrations. Vapours can accumulate in low areas.Environmental precautionsPrevent further leakage or spillage if safe to do so. Do not let product enter drains.Methods and materials for containment and cleaning upContain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place incontainer for disposal according to local regulations (see section 13).7. HANDLING AND STORAGEPrecautions for safe handlingAvoid inhalation of vapour or mist.Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.Conditions for safe storageKeep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONComponents with workplace control parametersPersonal protective equipmentRespiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If therespirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and componentstested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).Hand protectionHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use inaccordance with applicable laws and good laboratory practices. Wash and dry hands.Full contactMaterial: Nitrile rubberMinimum layer thickness: 0.4 mmBreak through time: > 480 minMaterial tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)Splash protectionMaterial: Nitrile rubberMinimum layer thickness: 0.2 mmBreak through time: 72 minMaterial tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M)datasource:KCLGmbH,D-36124Eichenzell,phone+49(0)665987300,******************,testmethod:EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact thesupplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our customers. It should not be construed asoffering an approval for any specific use scenario.Eye protectionTightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin and body protectionComplete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protectiveequipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.Hygiene measuresHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.9. PHYSICAL AND CHEMICAL PROPERTIESAppearanceForm clear, liquidColour colourlessSafety datapH 8.5 at 200 g/l at 20 °C (68 °F)Melting point/range: -127 °C (-197 °F) - lit.Meltingpoint/freezing pointBoiling point 97 °C (207 °F) - lit.Flash point 22 °C (72 °F) - closed cupIgnition temperature 395 °C (743 °F)Auto-ignitionno data availabletemperatureLower explosion limit 2.1 %(V)Upper explosion limit 13.7 %(V)Vapour pressure 19.3 hPa (14.5 mmHg) at 20 °C (68 °F) Density 0.804 g/cm3 at 25 °C (77 °F)Water solubility completely solublePartition coefficient:n-octanol/waterlog Pow: 0.25 - 0.34Relative vapor density 2.07- (Air = 1.0)Odour no data availableOdour Threshold no data availableEvaporation rate 110. STABILITY AND REACTIVITYChemical stabilityStable under recommended storage conditions.Possibility of hazardous reactionsVapours may form explosive mixture with air.Conditions to avoidHeat, flames and sparks. Extremes of temperature and direct sunlight.Materials to avoidStrong oxidizing agentsHazardous decomposition productsHazardous decomposition products formed under fire conditions. - Carbon oxidesOther decomposition products - no data available11. TOXICOLOGICAL INFORMATIONAcute toxicityOral LD50LD50Oral - rat - 8,038 mg/kgInhalation LC50LC50Inhalation - rat - 1 h - 20000 ppmDermal LD50LC50Dermal - rabbit - 4,000 mg/kgOther information on acute toxicityno data availableSkin corrosion/irritationSkin - rabbit - Mild skin irritationSerious eye damage/eye irritationEyes - rabbit - Severe eye irritationRespiratory or skin sensitizationno data availableGerm cell mutagenicityno data availableCarcinogenicityIARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.NTP: No component of this product present at levels greater than or equal to 0.1% is identified as aknown or anticipated carcinogen by NTP.OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.Reproductive toxicityno data availableTeratogenicityno data availableSpecific target organ toxicity - single exposure (Globally Harmonized System)May cause drowsiness or dizziness.Specific target organ toxicity - repeated exposure (Globally Harmonized System)no data availableAspiration hazardno data availablePotential health effectsInhalation May be harmful if inhaled. Causes respiratory tract irritation.Vapours may causedrowsiness and dizziness.Ingestion May be harmful if swallowed.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes Causes eye irritation.Signs and Symptoms of ExposureCentral nervous system depression, prolonged or repeated exposure can cause:, narcosis, Skin irritation Synergistic effectsno data availableAdditional InformationRTECS: UH822500012. ECOLOGICAL INFORMATIONToxicityToxicity to fish LC50 - Pimephales promelas (fathead minnow) - 1,000 mg/l - 96 hToxicity to daphniaEC50 - Daphnia magna (Water flea) - 3,642 mg/l - 48 hand other aquaticinvertebratesPersistence and degradabilityBiodegradabilityBioaccumulative potentialno data availableMobility in soilno data availablePBT and vPvB assessmentno data availableOther adverse effectsno data available13. DISPOSAL CONSIDERATIONSProductBurn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.Contaminated packagingDispose of as unused product.14. TRANSPORT INFORMATIONDOT (US)UN number:1274 Class: 3 Packing group: IIProper shipping name: n-PropanolMarine Pollutant: NoPoison Inhalation Hazard: NoIMDGUN number: 1274 Class: 3 Packing group: II EMS-No: F-E, S-DProper shipping name: n-PROPANOLMarine Pollutant: NoIATAUN number:1274 Class: 3 Packing group: IIProper shipping name: n-Propanol15. REGULATORY INFORMATIONOSHA HazardsFlammable liquid, Target Organ Effect, IrritantSARA 302 ComponentsSARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 ComponentsSARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312HazardsFire Hazard, Acute Health Hazard, Chronic Health HazardMassachusetts Right To Know Componentsn-Propanol CAS-No.71-23-8Revision Date1993-04-24Pennsylvania Right To Know Componentsn-Propanol CAS-No.71-23-8Revision Date1993-04-24New Jersey Right To Know Componentsn-Propanol CAS-No.71-23-8Revision Date1993-04-24California Prop. 65 ComponentsThis product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.16. OTHER INFORMATIONFurther informationCopyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to theproduct with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.。

BeyoPure™ Ultrapure Water (PCR 级, Sterile)产品编号 产品名称包装 ST873-100mlBeyoPure™ Ultrapure Water (PCR 级, Sterile)100ml产品简介：碧云天的BeyoPure™ Ultrapure Water (PCR 级, Sterile)，BeyoPure™ Ultrapure Water (PCR grade, Sterile)，即用于普通PCR 、qPCR 、RT-PCR 等分子生物学级别的无菌、无核酸酶的超纯水，是采用了Merck Millipore 先进的反渗透技术，辅以核子级离子交换树脂、高能量双波长紫外灯和Q-Gard ®超纯水柱，并配合BioPak ®终端超滤器而生产出的无热原(pyrogen-free)、无核酸酶(DNase/RNase-free)、无蛋白酶(Protease-free)、无细菌(bacteria-free)的超纯水。

主要用于PCR 等分子生物学实验中各种缓冲液和溶液的配制。

实验室常用的水有：超纯水(ultrapure water)也称为UPW 或高纯水(high-purity water)、去离子水(deionized water)、反渗透水(reverse osmosis water ，即RO 水，也常称为纯水)、蒸馏水(distilled water)、双蒸水(double-distilled water/dd H 2O)和三蒸水(triple-distilled water)。

其中超纯水是纯度非常高的水，可以满足绝大部分实验用水要求，特别是高灵敏度ICP/MS(电感耦合等离子体质谱)、同位素分析、以及疾控中心、药检所、质检所、环监站、高校和科研院所等实验室及各种高端精密仪器用水。

实验室常用水的特征、制备工艺及比较参考下表。

除超纯水外，其它水的最终水质和制备用水源的质量关系极大。

Data Sheet 3M™ Emphaze™ AEXHybrid PurifierThe 3M™ Emphaze™ AEX Hybrid Purifier is improving biopharmaceutical manufacturing processes, including recombinant protein and especially monoclonal antibody (mAB).The 3M Emphaze AEX Hybrid Purifier is a synthetic, multi-mechanism single-use purifier used for biopharmaceutical clarification. It delivers consistent, high-purity clarified process fluid by reducing negatively charged DNA, HCP, endotoxin, and cell debris through a combination of chromatographic and size exclusion mechanisms.PerformanceIn a representative monoclonal antibody (mAb) manufacturing process, when used in combination at the clarification stage with Zeta Plus™ depth filters and LifeASSURE™ membrane filters, the Emphaze AEX Hybrid Purifier increases process efficiency and protein purity post Protein A.Customers experience benefits in typical monoclonal antibody purification processes using the Emphaze AEX Hybrid Purifier.•Nominal 20-40% HCP and greater than 4 log DNA reduction •Consistent output turbidity(<5NTU)•Increase product purity post-protein A •Downsizing of the sterilizing grade membrane •Reduce turbidity post viral inactivation/ neutralization step•Reduce impurities load on downstream AEX column Sterilization/SanitizationEmphaze AEX Hybrid Purifier products, listed in Table 1, can be sterilized or sanitized. Refer to Table 1 on page 3 for more information.As we worked with customers to qualify the Emphaze AEX Hybrid Purifier, we heard that sterilization/ sanitization compatibility is an important feature.We announced that 3M Emphaze AEX Hybrid Purifier, with part and model numbers that end in an R, canbe sterilized/sanitized across various aqueous-based biopharmaceutical processes, including vaccine purification. See Table 1 for the product namesand numbers.Note: Only these products can be sterilized and sanitized.Layer 3Layer 4Zone 4-6100μmProduct Selection/Specification(NOTE:R after product and model name indicates the sterilization/sanitization compatible products)A full support package is available for the 3M™ Emphaze™ AEX Hybrid Purifier. This package includes Installation and Operation Instructions, Certificate of Quality or Certificate of Lot Conformance, and a Regulatory Support File.1.Capsule Fill Volume is defined as the volume of liquid that is required to fill the capsule.2.Post Blow-Down Hold-Up Volume is defined as the volume of the residual liquid after air/gas blow down.3.Do not use this product for continuous service with compressed gasses. The use of compressed gas is permissible for integrity testing and blowdown purposes.4.A Preconditioning Flush is required for the product to be compliant with USP Biological Reactivity Tests, including USP <87> and <88> Class VI.The flush solution can be a buffer or 25–150mM sodium chloride solution. Refer to Installation and Operation Instructions for complete instructions on how to perform the preconditioning flush.Compliance•U SP <87> Biological Reactivity Tests, In Vitro: All wetted component materials of the 3M™ Emphaze™ AEX Hybrid Purifier products were tested and met the requirements of USP <87> Biological Reactivity Tests, In Vitro. The media was subjected to the required preconditioning flush prior to testing.•U SP <88> VI Biological Reactivity Tests, In Vivo: All wetted component materials of the 3M™ Emphaze™ AEX Hybrid Purifier products were tested and met the requirements of USP <88> Biological Reactivity Tests, In Vivo. The media was subjected to the required preconditioning flush prior to testing.Animal-Derived Material Statement:In order to assess the BSE/TSE risk associated with the 3M Emphaze AEX Hybrid Purifier products, we have contacted our suppliers of raw materials and performed an evaluation of our production processes to determineif any of the materials used are of animal origin. The result of our survey and inquiries of our raw material suppliers has revealed thatthe polypropylene resins used in the nonwovens and the glass-filled polyphenylene oxide/polystyrene resin used in molded parts may contain tallow. Our suppliers have indicated that these parts that use tallow derivatives are processed at conditions conforming to the requirements of the European Medicines Agency note for guidance EMEA/410/01 rev.3.Intended Use: Single-use processing of aqueous based biological pharmaceuticals (drugs) and vaccines strictly following the product operating instructions and cGMP requirements, where applicable.Prohibited Use: As a component in a medical device that is regulated by any agency, and/or globally exemplary agencies, including but not limited to: a) FDA, b) European Medical Device Directive (MDD), c) Japan Pharmaceuticals and Medical Devices Agency (PMDA); Applications involving permanent implantation into the body; Life-sustaining medical applications; Applications requiring food contact compliance.Product Selection and Use: Many factors beyond 3M’s control and uniquely within user’s knowledge and control can affect the useand performance of a 3M product in a particular application. As a result, end-user is solely responsible for evaluating the product and determining whether it is appropriate and suitable for end-user’s application, including completing a risk assessment that considers the product leachable characteristics and its impact on drug safety conducting a workplace hazard assessment and reviewing all applicable regulations and standards (e.g., OSHA, ANSI, etc.). Failure to properly evaluate, select, and use a 3M product and appropriate safety products, or to meet all applicable safety regulations, may result in injury, sickness, death, and/or harm to property.Warranty, Limited Remedy, and Disclaimer: Unless a different warranty is specifically stated on the applicable 3M product packaging or product literature (in which case such warranty governs), 3M warrants that each 3M product meets the applicable 3M product specification at the time 3M ships the product. 3M MAKES NO OTHER WARRANTIES OR CONDITIONS, EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, ANY IMPLIED WARRANTY OR CONDITION OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR ARISING OUT OF A COURSE OF DEALING, CUSTOM, OR USAGE OF TRADE. If a 3M product doesnot conform to this warranty, then the sole and exclusive remedy is, at 3M’s option, replacement of the 3M product or refund of the purchase price.Limitation of Liability: Except for the limited remedy stated above, and except to the extent prohibited by law, 3M will not be liable for any loss or damage arising from or related to the 3M product, whether direct, indirect, special, incidental, or consequential (including,but not limited to,lost profits or business opportunity), regardless of the legal or equitable theory asserted, including, but not limited to, warranty, contract, negligence, or strict liability.3M Purification Inc.3M, Emphaze, LifeASSURE and Zeta Plus are3M Separation and Purification Sciences Division trademarks of 3M Company. All other trademarks 400 Research Parkway, Meriden, CT 06450 USA are property of their respective owners.Phone 1-203-237-5541Please recycle. Printed in USA © 3M 2019.Web /bioprocessing All rights reserved. 70201600056 REV 07/2019。

ApplicationThe sensor measures the spectral absorption of process liquids in the ultraviolet region of the electromagnetic spectrum.•Measurement of protein concentrations •Chromatography monitoring •Filtration monitoring •Concentration measurement of organic compounds •Detection of aromatesYour benefits•Improved process control and easier quality control thanks to quick and reliable monitoring of product concentration –Measuring range up to 2.5 AU or 50 OD (depending on optical path length)–Measurement of UV absorption at discrete wavelengths between 254 nm and 365 nm –Outstanding filter properties for highest linearity –Direct concurrence with laboratory values –Integrated reference detector for lamp compensation –Gas discharge lamp for long service life and stable measured values •Patented Easycal system (optional)–Cost-effective, time-efficient calibration –Easy, in-line calibration which is traceable to NIST without any liquid standards •FM- and ATEX-approved lamps for applications in the hazardous area •Compliance with life sciences sector thanks to hygienic design and FDA- and USP-compliant sealing materials •High degree of product safety as SIP/CIP-resistant •High product yield thanks to low volume requirements •Maximum durability in all applications owing to wide range of materials and process connections •Can be adapted to process requirements:–Optional air purge ports to prevent the formation of condensate on the optical windows –Optional adjuster for optical path lengthProducts Solutions ServicesTechnical Information OUSAF44Optical sensor combined with the OUA260 flow assembly for the measurement of UV absorptionTI00416C/07/EN/13.1671316935OUSAF442Endress+HauserFunction and system designMeasuring principle Light absorption The measuring principle is based on the Lambert-Beer law.There is a linear dependency between the absorption of light and the concentration of the absorbing substance:A = -logA m = ε . c . OPLA ... absorption, A m ... absorption measured by detector ε ... Extinction coefficient c ... Concentration OPL ... Optical path lengthA light source emits radiation through the medium and the incident radiation is measured on the detector side.Once the light has passed through a filter for wavelength selection, the intensity of the light is determined by a photodiode and converted to a photocurrent.The subsequent conversion to transmission (%) or absorbance units (AU, OD) is performed in the associated transmitter.1Absorption measurement with reference 1Light source 2Optical windows 3Measurement filter 4Measuring detector 5Lens 6Medium flow 7Reference filter 8Reference detectorMeasuring system An optical measuring system comprises:•Sensor (photometer) OUSAF44•Liquiline CM44P transmitter •Cable set CUK80•Assembly to suit the sensor, e.g. OUA260OUSAF44Endress+Hauser 31pipe 5Flow assembly OUA2602Transmitter CM44P 6Sensor: light source (lamp)3Cable set CUK807Cable set CUK804Sensor: detector InputMeasured variableUV absorption Measuring range •0 to 2.5 AU •Max. 50 OD (depending on the optical path length)WavelengthDiscrete wavelength at 254, 280, 295, 302, 313 or 365 nmMore available on request Power supplyElectrical connection The sensor is connected to the transmitter using the pre-terminated or labeled cable set CUK80 (for connection to CM44P) or OUK40 (for connection to CVM40). The terminals and labeling may vary depending on the transmitter in use. The cable set must be ordered separately.OUSAF444Endress+Hauser3OUSAF44 connecting cable ALight source (lamp) power supply B Signals of measurement and reference detectorCable lengthMaximum 100 m (330 ft)Versions for use in hazardous areas Safety instructions for electrical apparatus in explosion-hazardous areas, XA01403CConnecting the detector using a safety barrierThe photometer sensors use silicon photovoltaic cells as detectors which are operated in the current mode. The detectors are intrinsically safe and can be deployed in Zone 1 environments.The safe area is separated from the hazardous area by one safety barrier MTL7760AC.OUSAF44Endress+Hauser 5The safety barrier may only have a very low leak current since the optical signals from the sensor can be in the nanoampere range. Therefore, the sensor cable shield is connected to the ground terminal of the barrier.On delivery, the CUK80 detector cable is permanently wired to the safety barrier. All you have to do is simply connect the individual cable ends to the detector and transmitter.Connecting the hazardous area lamp using a junction boxThe hazardous area lamp (EXP-1) must be connected to the transmitter using a certified junction box.For versions with FM approval, the junction box is included in the delivery and already pre-terminated on the lamp side. You simply have to connect the cable of the transmitter (CUK80)to the terminals of the junction box.For versions with ATEX approval, the junction box is not included in the delivery and it and the cable glands required must be provided by the customer at the place of installation. You must connect the cables entirely on your own (CUK80 of transmitter and lamp cable of photometer sensor).OUSAF446Endress+Hauser5Connecting the hazardous area lamp to CM44P using a junction boxInstallationInstallation instructions6Mounting angles. The arrows indicate the direction of medium flow in the pipe.APreferred mounting angle BOptimum mounting angle CAcceptable mounting angle DMounting angle to be avoided E Forbidden mounting angleOUSAF44Endress+Hauser 7EnvironmentAmbient temperature range 0 to 55 °C (32 to 130 °F)Storage temperature -10 to +70 °C (+10 to +160 °F)Humidity 5 to 95 %Degree of protection IP 65 (NEMA 4) for all optical partsProcessProcess temperature 0 to 90 °C (32 to 194 °F) continuous Max. 130 °C (266 °F) for 2 hoursProcess pressure Max. 100 bar (1450 psi) absolute, depending on the material, pipe size and process connection of the flow assemblyMechanical construction7Sensor module ADimension of lamp, depends on lamp type, see table BDimension of detector, see table C Assembly, see Technical Information for assemblyThe total length of the sensor module is derived from the lengths of the lamp, the detector and the assembly.The dimensions of the OUA260 assembly are provided in Technical Information, TI00418C.‣When connecting the sensor cable, make sure you maintain an additional distance of 5 cm (2")on both the lamp side and the detector side of the sensor.OUSAF448Endress+HauserWeight SensorUV lamp0.58 kg (1.28 lbs)UV lamp with wire-braided cable (1.2 m (4 ft)) and junction box (sensor for hazardous area)3.2 kg (6.66 lbs)Easycal detector0.65 kg (1.43 lbs)Standard detector0.36 kg (0.794 lbs)OUA260 assemblyTC ¼"1.14 kg (2.51 lbs)TC 1"1.39 kg (3.07 lbs)TC 2"1.88 kg (4.15 lbs)TC 4" 3.38 kg (7.45 lbs)MaterialsSensor housingStainless steel 316OUA260 assembly Stainless steel 316, 316L or Kynar or customer-specific material Depends on version Cable connection ends Nickel-plated brassLight source Pre-set, low-pressure mercury lamp Lamp operating life: typically 3000 h, at least 1000 hDetector UV silicon detectors, hermetically sealed Filter Multilayer interference filter, designed for extreme UV conditionsCertificates and approvalsmark Declaration of ConformityThe product meets the requirements of the harmonized European standards. As such, it complies with the legal specifications of the EC directives. The manufacturer confirms successful testing of the product by affixing to it the mark.Ex approvals •ATEX II 2G Ex db IIC T5 Gb •FM Cl.1, Div. 1, Groups B, C, DFDA conformityAll non-metal parts in contact with medium, such as rubber and plastic parts, meet the requirements of FDA 21 CFR 177.2600. The plastic and elastomer parts of the sensor in contact with medium have passed the biological reactivity tests according to USP <87> and <88> Class VI.Ordering informationProduct page /ousaf44Product Configurator On the product page there is a "Configuration" button to the right of the product image.1.Click this button. The Configurator opens in a separate window.2.Select all the options to configure the device in line with your requirements.In this way, you receive a valid and complete order code for the device.OUSAF44Endress+Hauser 93.Export the order code as a PDF or Excel file. To do so, click the appropriate button on the rightabove the selection window.For many products you also have the option of downloading CAD or 2D drawings of the selected product version. To do so, click the "CAD" tab and select the desired file type using drop-down lists.Scope of delivery The scope of delivery consists of the following depending on the version ordered:•sensor •Detector and lamp module without flow assembly or •Detector and lamp module mounted on OUA260 flow assembly •Operating InstructionsIf the sensor is ordered with a transmitter, the complete measuring system is factory-calibrated and shipped as one package.If you have any questions, please contact your supplier or your local sales center.AccessoriesThe following are the most important accessories available at the time this documentation was issued. For accessories not listed here, please contact your service or sales office.Flow assembly OUA260•Flow assembly for hygienic sensors •For sensor installation in pipes •Materials: stainless steel 316, 316L or Kynar (other materials available on request)•Wide variety of process connections and path lengths available •Product Configurator on the product page: /oua260Technical Information TI00418CCable CUK80 cable set •Pre-terminated and labeled cables for connecting analog photometer sensors •Product Configurator on the product page: /cuk80CalibrationOUSAF44 EasyCal retrofit kit •Patented system traceable to NIST for the online calibration of UV absorption sensors •Order numbers:–254 nm: 71210149–280 nm: 71210150–295 nm: 71210156–302 nm: 71210153–313 nm: 71210151–365 nm: 71210152Reference rod Order number: 71108543。

收稿日期：2018-08-01作者简介：张雪梅（1988-），女，研究生，主要从事榛树育种与栽培研究，E-mail:286856531@ 。

2018年第5期辽宁林业科技Journal of Liaoning Forestry Science ＆Technology4种榛树中紫杉醇含量研究张雪梅，李志军，尤文忠（辽宁省经济林研究所，辽宁大连116031）摘要：以欧榛、平榛、毛榛和平欧杂交榛（达维）1年生幼苗为试材，采用高效液相色谱技术对各组织器官中的紫杉醇含量进行取样分析，结果表明：4种榛树中均含有紫杉醇，含量差异显著，其顺序为欧榛（2.71～9.83μg ·g -1）>平欧杂交榛（1.86～4.13μg ·g -1）>平榛（0.21～0.62μg ·g -1）>毛榛（0.23～0.59μg ·g -1）。

在同种榛树中，不同组织器官紫杉醇含量差异不显著，4种榛树间组织器官都表现出相同的含量分布规律，为根系>枝条>叶片。

平欧杂交榛（达维）提取紫杉醇具有较大的开发潜力。

关键词：榛树；紫杉醇；含量与分布中图分类号：S664.4；R284.2文献标识码：A文章编号：1001-1714（2018）05-0021-032018№5美国俄勒冈州波特兰大学研究小组（Robert F.，2000）在探究美国抗东方枯萎病榛子品种时，应用HPLC-MS 技术在欧榛Corylus avellana 提取液中首次发现紫杉醇的存在[1]。

张丽华等（2003）[2]参照前人的实验条件和榛树中紫杉醇谱图，进行了大量研究确认鞍山地区平榛C.heterophylla 含有紫杉醇。

相关研究者通过进一步的研究证实榛属中紫杉醇的存在并建议将其作为生产紫杉醇的植物源（赵广河2009）[3]。

罗凡等（2011）[4]利用HPLC-MS 技术对毛榛C.mandshurica 醇类物质的化学成分进行了初步研究，结果发现其与红豆杉中紫杉醇类物质基本相同[4]，这也为榛属植物作为红豆杉的替代品种提取紫杉醇类药物进一步提供了科学依据。

F -S T O P ™ F o r P i c t u r e -P e r f e c t , D i s e a s e -F r e e T u r f g r a s s 12770• Provides Systemic Prevention And Control Of Turfgrass Diseases• Prevents Over 15 Major Lawn Diseases • For Use On All Types Of Home Lawns • One Application Protects For Up To 4 WeeksKEEP OUT OF REACH OF CHILDRENCAUTIONBUYER ASSUMES ALL RISKS OF USE, STORAGE OR HANDLING OF THIS MATERIALNOT IN STRICT ACCORDANCE WITH DIRECTIONS GIVEN HEREWITH.NET WEIGHT 10 LBS. (4.53 KG)ACTIVE INGREDIENT:myclobutanil: a-butyl-a-(4-chlorophenyl)-1-H-1,2,4 triazole-propanenitrile: ...............0.39%OTHER INGREDIENTS: .............................................................................................99.61%TOTAL .....................................................................................................................100.00%This product contains 0.195 lb.. of myclobutanil per 50 lb. bag.C o v e r s U p T o 2,500 S q . F t .F-STOP ™ For Picture-Perfect, Disease-Free TurfgrassF -S T O P ™F o r P i c t u r e -P e r f e c t , D i s e a s e -F r e e T u r f g r a s sF-STOP ™For Picture-Perfect, Disease-Free TurfgrassPRECAUTIONARY STATEMENTSHAZARDS TO HUMANS AND DOMESTIC ANIMALSCauses Moderate Eye Irritation.Avoid contact with eyes or clothing. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet.Notice: Read the entire label. Use only according to label directions. Before using this product, read “Warranty Disclaimer,” “Inherent Risks of Use,” and “Limitation of Remedies” at end of Directions for Use. If terms are unacceptable, return at once unopened.In case of emergency endangering health or the environment involving this product,call 1-800-992-5994Agricultural Chemical: Do not ship or store with food, feeds, drugs, or clothing.FIRST AIDIf in eyes: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a Poison Control Center or doctor for treatment advice. Have the product container or label with you when calling a Poison Control Center or doctor, or going for treatment. You may also contact 1-800-992-5994 for emergency treatment information.ENVIRONMENTAL HAZARDSThis pesticide is toxic to fish. To protect the environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or surface waters. Applying this product in calm weather when rain is not predicted for the next 24 hours will help ensure that wind or rain does not blow or wash pesticide off the treatment area. Sweeping any product that lands on a driveway, sidewalk, or street, back onto the treated area of the lawn or garden will help to prevent runoff to water bodies or drainage systems.DIRECTIONS FOR USEIt is a violation of Federal law to use this product in a manner inconsistent with its labeling. Read all directions carefully before applying this product.Not for use on turfgrass being grown for sale or other commercial use as sod, or for commercial seed productions, or for research purposes.STORAGE AND DISPOSALDo not contaminate water, food or feed by storage and disposal.PESTICIDE STORAGE: Keep away from fire and sparks. Store in a cool, dry, well-ventilated area. CONTAINER HANDLING: Nonrefillable container. Do not reuse or refill this container.If empty: Place in trash or offer for recycling if available.If partly filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain.HOW THIS PRODUCT WORKSferti•lome® F-STOP™is a systemic, protectant and curative fungicide for the control of listed diseases in established home lawns and ornamental turfgrass. Optimum disease control is achieved when this product is applied to established turfgrass in a regularly scheduled preventative program. Use this product in conjunction with turf management practices that promote good plant health and optimum disease control. The key to selecting a fungicide is the proper diagnosis of the organism causing the disease. Diagnostic kits, extension experts, or other identification methods should be used when developing disease control strategies.HOW TO APPLYApply ferti•lome® F-STOP™ uniformly over the turfgrass area using a properly calibrated drop or rotary-type spreader designed to apply granules. Before each application, calibrate the spreader according to the equipment manufacturer’s directions. Check frequently to make sure equipment is operating properly and distributing product uniformly. A more uniform application may be achieved by spreading half of the required amount of product over the area and then applying the remaining half in swaths at a right angle to the first. Avoid skips and excessive overlaps during application. Avoid the use of spreaders that apply this product in narrow rows or concentrated bands.Wash hands with soap and water promptly after use.Do not allow people or pets to contact treated area until after product dust has settled into the turfgrass, or if watered in, after the turfgrass surface in the treated area has dried.WHEN TO APPLYReduce the interval between applications of this product when conditions are favorable for disease development. Unless otherwise specified, when disease pressure is high or when used as a curative, use higher rates of ferti•lome® F-STOP™ and shorter application interval. Under light to moderate disease pressure apply this product at the low use rate and/or longer application intervals. To avoid pick-up, lightly irrigate treated areas soon after application. On short cut bentgrass (1/2 inch or less) when temperatures are above 80°F, apply only to dry foliage.HOW MUCH TO APPLYOptimum disease control is achieved when ferti•lome® F-STOP™ is applied in a preventative disease control program at a rate of 4 lb per 1,000 sq. ft. See the following table for specific application rates for various diseases. Under any circumstances, do not apply more than 46 lb of this product per1,000 sq. ft. per year.SPREADER GUIDEONE BAG WILL COVER UP TO 2,500 SQUARE FEETSPREADER SPREADER SETTINGS Scotts®/Republic Accugreen (Drop) 4 1/4Scotts®/Republic Speedy Green (Broadcast) 3 3/4 ferti•lome® /EarthWay Ev-N-Spred (Broadcast)14TERMS AND CONDITION OF USEIf terms of the following Warranty Disclaimer, Inherent Risks of Use, and Limitation of Remedies are not acceptable, return unopened package at once to the Seller for a full refund of purchase price paid. Otherwise, use by the Buyer or any other user constitutes acceptance of the terms under Warranty Disclaimer, Inherent Risks of Use, and Limitations of Remedies.WARRANTY DISCLAIMERSeller warrants that this product conforms to the chemical description of the label and is reasonably fit for the purposes stated on the label when used in strict accordance with the directions, subjectto the Inherent Risks set forth below. Seller MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER EXPRESS OR IMPLIED WARRANTY.INHERENT RISKS OF USEIt is impossible to eliminate all risks associated with use of this product. Plant injury, lack of performance, or other unintended consequences may result because of such factors as use of the product contrary to label instructions (including conditions noted on the label, such as unfavorable temperature, soil conditions, etc.), abnormal conditions (such as excessive rainfall, drought, tornadoes, hurricanes), presence of other materials, the manner of application, or other factors, allof which are beyond the control of the Seller. To the extent allowed by law, all such risks shall be assumed by the Buyer.LIMITATION OF REMEDIESTo the extent consistent with applicable law, the exclusive remedy for losses or damages resulting from this product (including claims based on contract, negligence, strict liability, or other legal theories), shall be limited to, at Seller’s election, one of the following:1. Refund of purchase price paid by Buyer or user for product bought, or2. Replacement of amount of product used.To the extent allowed by law, Seller shall not be liable for the losses of damages resulting from the handling or use of this product unless Seller is promptly notified of such loss or damage in writing. In no case shall Seller be liable for consequential or incidental damages or losses.The terms of the Warranty Disclaimer and Inherent Risks of Use above and this Limitation of Remedies cannot be varied by any written or verbal statements or agreements. No employee or sales agent of Seller or the Seller is authorized to vary or exceed the terms of the Warranty Disclaimer or this Limitation of Remedies in any manner.Disease ferti•lome® F-STOP™(lb/1,000 sq ft)ApplicationInterval/Timing(Days)Directions RestrictionsAnthracnose Red Thread Septoria Leaf Spot 414 - 21Apply when conditions are favorable for disease development.Do not apply more than 46pounds of product per 1,000sq. ft. per year.For Nassau and Suffolkcounties in New York State,do not apply more than 11.5lb of this product per 1,000sq ft per year.Brown Patch14Begin applications when conditions are favorable for disease development andb efore disease symptoms are apparentCopper SpotZonate Leaf SpotApply when conditions are favorable for disease development.Crown Rot Leaf Spot Melting-Out Apply when conditions are favorable for disease development. For crown rot, water in with 3 to 4 gallons of water per 1,000 sq. ft. to increase penetration to crown a nd roots.Dollar Spot14 - 28Apply when conditions are favorable for disease development. Make no morethan 3 consecutive applications for Dollar Spot control before rotating to aregistered fungicide with a diiferent mode of actionFusarium Blight14 - 21Apply when conditions are favorable for disease development.Fusarium Patch(Pink Snow Mold)21 - 28Apply when conditions are favorable for disease development.Gray Leafspot14Apply prior to snow cover.Leaf Spot Apply in the fall after turfgrass enters dormancy and/or in the spring prior to theinitiation of growth.Necrotic Ring Spot Spring: 28Make applications on a preventative basis in early to mid-spring.Necrotic Ring Spot Fall: 28Make 2 applications beginning in August before the turfgrass goes dormant.Powdery MildewRusts14 - 28Apply when conditions are favorable for disease development.Summer Patch Begin applications in the spring when conditions are favorable for disease de-velopment. Make 2 to 4 applications depending on recommendations from localTurfgrass Extension Experts.Water in with at least 3 to 4 gallons of water per 1,000 sq. ft. to increase penetra-tion to crown and roots.Manufactured by:230 FM 87 • BONHAM, TEXAS 75418EPA Reg. No. 62719-461-7401 EPA Est. No. 7401-TX-01Visit Us At: Product Questions? 855-270-477612770-0515-TP。