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Sentence Template for Notebook and Report WritingPfizer Project Management TeamApril 12, 2007Part 1: 反应前的装置描述1.1: A 3 L three-necked round bottom flask equipped with mechanical stirrer (or magneticstirrer), addition funnel and thermometer (or Dean-Stock; drying tube)1.2: All flasks used in the reaction were heated under vacuum for 30 minutes and purged withN2 for 10 minutes. (无水反应装置)Part 2: 加料2.1: 不同的顺序和表达2.1.1: A 3 L three-necked round bottom flask equipped with mechanical stirrer (or magneticstirrer), addition funnel and thermometer (or Dean-Stock; drying tube) were charged with A(10 mL, 1 mole), B (2 g, mole) and C (50 mL),2.1.1.1: a solution of D (10 g, 1 mole) in E (20 mL) was added dropwise (via addition funnelor syringe) at 10o C (or while maintaining gentle reflux; while keeping inner temperaturebetween 10o C – 30o C) under N2 （液体滴加到反应液中）2.1.1.2: D (10 g, 1 mole) was added in portions during a period of 1 hr (固体分批加入到反应液中)2.1.1.3: D (10 g, 1 mole) and E (20 mL) were added in turn2.2:To a solution (mixture, suspension or slurry) of A (10 mL, 1 mole) and B (2 g, mole) in C (50mL)2.2.1: was added dropwise a solution of D (10 g, 1 mole) in E (20 mL) with stirring at 10o C(or while maintaining gentle reflux; while keeping inner temperature between 10o C –30o C)under N22.2.2: was added D (10 g, 1 mole) in portions during a period of 1 hrSentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd.Confidential Page 2 of 72.2.3: were added D (10 g, 1 mole) and E (20 mL) in turn2.3:2.3.1: A solution of D (10 g, 1 mole) in E (20 mL) was added dropwise into a solution(mixture or suspension) of A (10 mL, 1 mole) and B (2 g, mole) in C (50 mL) at 10o C (orwhile maintaining gentle reflux; while keeping inner temperature between 10o C –30o C) underN22.3.2: D (10 g, 1 mole) was added into a solution (mixture or suspension) of A(10 mL, 1mole) and B (2 g, mole) in C (50 mL) in portions2.3.3: D (10 g, 1 mole) and E (20 mL) were added into a solution (mixture or suspension) ofA (10 mL, 1 mole) andB (2 g, mole) inC (50 mL) in turn2.4:2.4.1: A solution of BuLi or BH3/THF (10 mL, 1 mole, 2.5 M in hexane) was cannulated intoaddition funnel or into a solution A in solvent B2.4.2: A solution of BuLi or BH3/THF (10 mL, 1 mole, 2.5 M in hexane) was added into asolution of A in solvent B via cannula, dropping funnel or syringe over a period of hrs Part 3: 反应3.1: 无溶剂反应A (1 g, 1 mol) andB (1 g, 1 mol) were dissolved in solvent C, evaporated to dryness andheated for x hours at x o C3.2: 催化量的反应A (20 mL, 142 mmol) and catalytic amount (a trace amount or two drops) ofB were addedinto a solution of C (4.549 g, 46.4 mmol) in D(120mL) at 0 o C3.3: 闷罐反应或封管反应A solution of A(x g, x mol) in methanol (x mL) saturated with NH3 (or other gas such as: CO,CO2, H2S) was stirred under 50 Psi at x o C for x hours in a 50 mL of sealed tube or autoclave.Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd.Confidential Page 3 of 73.4: 有气体参与的反应3.4.1: A solution of A (x g, x mol) in methanol (x mL) saturated with HCl was stirred at x ℃.3.4.2: Ozone was bubbled into a solution of A (x g, x mol) in MeOH (x mL) at x o C for 15minutes. After excess O3 was purged by N2, Me2S (x mL) was added at x o C.3.4.3: Gas was bubbled into a solution of A (x g, x mol) and B (x g, x mol) in solventC (xmL) at x o C for x hours.3.5: 混合溶剂参与的反应3.5.1: To a solution of A (x g, x mol) in a mixture of solvent B (mL) and solvent C (x mL) (ora mixed solvent of B and C) was added D (x g, x mol) at x o C, the reaction mixture wasallowed to stir (reflux or heat) for x hrs.3.5.2: To a solution of A (x g, x mol) in 10: 1 aqueous acetone (x mL) was added B (x g, xmol) followed by addition of C (x g, x mol), the reaction mixture was allowed to stir (refluxor heat) for x hrs.3.6: 分水器分水的反应3.6.1: A (x g, x mol) and B (x g, x mol) in benzene or toluene (x mL) were refluxed for xhours with azeotropical removal of water.3.6.2; A mixture of A, B and TsOH.H2O (56.91 g, 0.3 mol) in toluene (400 mL) was heated toreflux and remove water by Dean-Stark trap.3.7: 氢化反应To a solution of A (x g, x mol) in EtOH (x mL) was added Pd-C or Ra-Ni orPd(OH)2/C (10%,x g) under N2. The suspension was degassed under vacuum and purged with H2 several times.3.7.1: The mixture was stirred under H2 (x psi) at x ℃for x hours. [氢化瓶或高压釜] 3.7.2: The mixture was stirred under H2 balloon at x ℃for x hours. [常压氢化如气球反应]3.7.3: A mixture of A (x g, x mol) and Ra-Ni (x g) in EtOH (x mL) was hydrogenated under50 Psi of hydrogen pressure for x hours at room temperature.Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 4 of 7Part 4: 反应条件或过程描述4.1: The reaction mixture (solution or suspension) was stirred at 5o C for 2 hrs and then kept atroom temperature (or ambient temperature) for another 2 hrs (or overnight)4.2: The reaction mixture (solution or suspension) was refluxed (heated to reflux) or heated at60o C for 2 hrs (or overnight)4.3: The reaction mixture (solution or suspension) was allowed to reflux (or heat to reflux) for2 hrs (or overnight)4.4: The reaction mixture (solution or suspension) was allowed to warm to temperature during2 hrs and reflux (or heat to reflux) for 2 hrs (or overnight)Part 5: 反应监测5.1: Taking sample from the reaction mixture (solution or suspension) by dropping tube orsyringe. After workup, check the reaction via TLC, LC-MS or HPLC etc.. (预处理) 5.2: 反应状态或终点描述5.2.1: The reaction was complete (incomplete or messy) detected (determined or confirmed)by TLC (PE/EtOAc 4:1), LC-MS, HPLC or NMR5.2.2: TLC (PE:EtOAc=1:1) or HPLC (107757-088-1) showed or indicated that the reactionwas complete.5.2.3: TLC (PE:EtOAc=1:1) or HPLC (107757-088-1) showed the starting material wasconsumed completely.5.2.4: TLC (PE:EA=1:1) or HPLC (107757-088-1) showed the reaction didn’t work at all ormost of starting material was still remained.5.2.5: The starting material was consumed completely, but no desired compound was detectedor determined by MS (106657-078-1) or LC-MS (106657-078-1).5.2.6: Several spots were shown on TLC.5.2.7: Only a trace amount of desired compound was detected by MS (106657-078-1) orLC-MS (106657-078-1) or HPLC (106657-078-1) or TLC (PE:EtOAc=1:1).5.2.8: The desired compound could not be isolated, separated or purified by chromatographyor prep. HPLC due to poor yield or poor solubility.Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 5 of 75.2.9:1H NMR (106675-010-2) or MS confirmed the obtained (or isolated) compound is notthe desired compound. The reaction was failed.Part 6: 反应淬灭6.1: An aqueous solution of A (10 mL) was added dropwise into the reaction mixture once thereaction mixture (solution or suspension) was allowed to warm (or cool) to -5o C or roomtemperature (ambient temperature).6.2: The hot (or cold) reaction mixture (solution or suspension) was poured into water (icewater) or poured onto ice.6.3: The reaction mixture (solution or suspension) was concentrated (distilled) under reducedpressure (in vacuum) or evaporated to remove MeOH (THF; DMF etc.) or excess SOCl2(reagent). Then the reaction residue (or the residual) was diluted with solvent and poured intowater (ice water) or poured onto ice.Part 7: 分液提取7.1: The residue was partitioned between ethyl acetate (100 mL) and 1N aq. HCl (50 mL).The separated organic layer was washed with water, dried over (Na2SO4 or MgSO4) andevaporated to dryness.7.2: After quenching the reaction, the reaction mixture was poured into separatory funnel andseparated.7.3: The aqueous layer (or phase) was extracted with organic solvent (40 mL) twice (or Xtimes). The combined organic layers were (or the organic layers were combined and) washedwith an aqueous solution of A (50 mL) or water and dried over Na2SO4 or MgSO4.7.4: The combined aqueous layers were extracted with solvent (40 mL) twice (or X times) toremove neutral impurities. The aqueous phase was acidified (or basified) with aqueous HCl(or NaHCO3) till PH = X and extracted with organic solvent.7.5: The combined organic layers were (or the organic layers were combined and) washedwith an aqueous solution of A (50 mL) or water and dried over Na2SO4 or MgSO4. Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 6 of 7Part 8: 浓缩蒸发8.1: After filtration via filter paper or Celite pad, the organic layer (or extract) was concentrated under reduced pressure (or in vacuum) or evaporated to dryness to provide(afford; give or yield) an oil (or foam) (which solidified on standing) or a white solid.8.2: The organic layer (or extract) was filtered and concentrated under reduced pressure (or invacuum) or evaporated to dryness to provide (afford or give) A (10 g, 0.5 mole) an oil (orfoam) (which solidified on standing) or a white solid.8.3: After removal of solvent by evaporation or concentration, A (10 g, 0.5 mole) was obtained (or prepared) an oil (or foam) (which solidified on standing) or a white solid.8.4: The extract in CH2Cl2 was evaporated to dryness and then swapped with toluene toremove residual CH2Cl2.Part 9: 几种常见的后处理描述9.1: The reaction mixture or solution was concentrated to dryness. [适用于反应液不需要quench]9.2: After the reaction mixture was cooled to 0 ℃, the reaction mixture was quenched byaddition of x mL of H2O, followed by x mL of 15% aqueous NaOH. After being stirred atroom temperature for x hour, the solid was removed by filtration (or the mixture was filteredthroughCelite pad to remove by-product). The filtrate was concentrated to dryness to givecrude product. [LiAlH4 反应的经典后处理]9.3: The mixture was diluted with water (x mL), neutralized with solid K2CO3 until no CO2was evolved. [适用于酸性反应液的后处理]9.4: The suspension was filtered through a pad of Celite or silica gel and the pad or filter cakewas washed with EtOH (x mL×x). The combined filtrates were concentrated to dryness togive product (x g, x%) as. [适用氢化反应的后处理, 或者难于过滤的反应液的后处理, 但要注意的是这里需要的是滤液而不是固体才能添加助滤剂]9.5: The reaction mixture was poured into x mL of ice-water carefully and the organic layer orphase was separated. [产物在有机相里]9.6: The reaction mixture was poured into x mL of ice-water carefully and the aqueous phasewas washed with Et2O (x mL×x) [产品在水相] and acidified with 1N HCl to pH=3. TheSentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 7 of 7resulting precipitate was collected by filtration or the resulting solution was extracted with EA(x mL×x).9.7: The reaction mixture was filtered and the filter cake was washed with x mL of solvent,dried in vacuum to give or afford product. [这里需要的是固体而不是滤液]9.8: The reaction mixture was quenched with x mL of saturated aqueous NH4Cl. The resultingsolution was extracted with EA (x mL×x). [适用于丁基锂等活泼金属有机物的后处理]9.10: The residue was triturated with ether and filtered to afford a white solid. (磨碎) 9.11: The crude product was purified by prep. HPLC to give A as a colorless thick oil whichwas solidified on standing. (静止固化)9.12: After prep. HPLC purification, the eluent was concentrated or evaporated to removeorganic solvents. The residual aqueous solution was lyophilized to give a white solid. (冷冻干燥)9.13: After concentration, the crude product was used directly for the next step withoutpurification.Part 10: 产品的纯化10.1: The crude product was purified by silica gel chromatography eluted with PE: EtOAc=10:1 to give product (x g, x%) as yellow solid.10.2: The crude product was purified by re-crystallization (or re-crystallized) from x solvent(x mL).10.3: The crude product was distilled in vacuum (x o C, x pressure) to afford pure product (x g,x%) as colorless liquid.10.4: The crude product was pre-purified by column chromatography followed by prep.HPLC purification or re-crystallization to afford pure product.__。
英语课外活动记录活动一：英语角英语角是一个学生自发组织的活动，旨在提高学生的英语口语表达能力。
在英语角，学生可以与其他学生自由交流，分享彼此的英语学习体验和技巧。
活动时间和地点每周五下午3点至5点，活动地点为学校图书馆一楼。
活动内容英语角主要以小组讨论的形式进行，每个小组由5到6个学生组成。
学生可以根据自己的兴趣和英语水平选择不同的小组。
小组设有专门的话题，例如旅行、电影、音乐等，并由一个小组负责人引导讨论。
在英语角中，学生需要使用英语进行交流，禁止使用母语。
这样可以有效提高学生的英语口语表达能力和听力能力。
活动收获参加英语角活动后，我的英语口语能力有了明显提高。
通过与其他学生的交流，我学到了很多新的词汇和表达方式。
同时，我也积累了更多的语言环境下的实战经验，从而更加自信地使用英语与他人交流。
活动二：英语电影欣赏为了提高学生的英语听力和理解能力，学校组织了一系列英语电影欣赏活动。
每月一次，在周末上午，学生可以在学校的多媒体教室观看一部英语电影，并进行相关讨论。
活动时间和地点每月的最后一个周六上午9点至11点，在学校多媒体教室。
活动内容活动开始前，学校会提前通知学生本次观影的电影名称和简介，并提供相关英文字幕。
学生可以提前了解电影的背景知识，为观影做准备。
在观影过程中，学生需要全程使用英语听力并尝试理解电影中的对话和情节。
观影后，学生会进行小组讨论，分享对电影的理解和各自的观点。
活动收获通过参加英语电影欣赏活动，我不仅巩固了自己的英语听力能力，还学到了很多地道的口语表达方式。
与其他学生的讨论也让我思考了电影中的深层意义，并提高了我的分析和思考能力。
活动三：英语俱乐部英语俱乐部是由学校的英语教师组织的活动，旨在培养学生对英语的兴趣和学习动力。
活动内容涵盖了英语听说读写的各个方面。
活动时间和地点每周三下午4点至6点，活动地点为学校语音实验室。
活动内容英语俱乐部的活动内容丰富多样，包括英语歌曲欣赏、阅读小组、口语练习等。
描述实验英文作文英文：I remember one of the most interesting experiments I participated in during my high school years. It was a science experiment where we had to test the effects of different types of fertilizers on the growth of plants. The purpose of the experiment was to determine which fertilizer would produce the healthiest and fastest-growing plants.We were divided into groups and each group was given a different type of fertilizer to use on their plants. My group was assigned to use organic fertilizer, while other groups used chemical and natural fertilizers. We planted the same type of seeds in identical pots and began our experiment.Over the course of several weeks, we carefully monitored the growth of our plants, taking note of their height, the number of leaves, and the overall health of theplants. It was fascinating to see how each plant responded differently to the type of fertilizer it was given. The plants that received organic fertilizer seemed to growtaller and had a richer green color compared to the others.In the end, we presented our findings to the class and it was clear that the plants given organic fertilizer had outperformed the others. It was a great learning experience for all of us and it showed the importance of using natural and organic methods for plant growth.中文：我记得在高中时参与的一个最有趣的实验是一个科学实验，我们需要测试不同类型的肥料对植物生长的影响。
Sentence Template for Notebook and Report WritingPfizer Project Management TeamApril 12, 2007Part 1: 反应前的装置描述1.1: A 3 L three-necked round bottom flask equipped with mechanical stirrer (or magneticstirrer), addition funnel and thermometer (or Dean-Stock; drying tube)1.2: All flasks used in the reaction were heated under vacuum for 30 minutes and purged withN2 for 10 minutes. (无水反应装置)Part 2: 加料2.1: 不同的顺序和表达2.1.1: A 3 L three-necked round bottom flask equipped with mechanical stirrer (or magneticstirrer), addition funnel and thermometer (or Dean-Stock; drying tube) were charged with A(10 mL, 1 mole), B (2 g, mole) and C (50 mL),2.1.1.1: a solution of D (10 g, 1 mole) in E (20 mL) was added dropwise (via addition funnelor syringe) at 10o C (or while maintaining gentle reflux; while keeping inner temperaturebetween 10o C – 30o C) under N2 （液体滴加到反应液中）2.1.1.2: D (10 g, 1 mole) was added in portions during a period of 1 hr (固体分批加入到反应液中)2.1.1.3: D (10 g, 1 mole) and E (20 mL) were added in turn2.2:To a solution (mixture, suspension or slurry) of A (10 mL, 1 mole) and B (2 g, mole) in C (50mL)2.2.1: was added dropwise a solution of D (10 g, 1 mole) in E (20 mL) with stirring at 10o C(or while maintaining gentle reflux; while keeping inner temperature between 10o C –30o C)under N22.2.2: was added D (10 g, 1 mole) in portions during a period of 1 hrSentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd.Confidential Page 2 of 72.2.3: were added D (10 g, 1 mole) and E (20 mL) in turn2.3:2.3.1: A solution of D (10 g, 1 mole) in E (20 mL) was added dropwise into a solution(mixture or suspension) of A (10 mL, 1 mole) and B (2 g, mole) in C (50 mL) at 10o C (orwhile maintaining gentle reflux; while keeping inner temperature between 10o C –30o C) underN22.3.2: D (10 g, 1 mole) was added into a solution (mixture or suspension) of A(10 mL, 1mole) and B (2 g, mole) in C (50 mL) in portions2.3.3: D (10 g, 1 mole) and E (20 mL) were added into a solution (mixture or suspension) ofA (10 mL, 1 mole) andB (2 g, mole) inC (50 mL) in turn2.4:2.4.1: A solution of BuLi or BH3/THF (10 mL, 1 mole, 2.5 M in hexane) was cannulated intoaddition funnel or into a solution A in solvent B2.4.2: A solution of BuLi or BH3/THF (10 mL, 1 mole, 2.5 M in hexane) was added into asolution of A in solvent B via cannula, dropping funnel or syringe over a period of hrs Part 3: 反应3.1: 无溶剂反应A (1 g, 1 mol) andB (1 g, 1 mol) were dissolved in solvent C, evaporated to dryness andheated for x hours at x o C3.2: 催化量的反应A (20 mL, 142 mmol) and catalytic amount (a trace amount or two drops) ofB were addedinto a solution of C (4.549 g, 46.4 mmol) in D(120mL) at 0 o C3.3: 闷罐反应或封管反应A solution of A(x g, x mol) in methanol (x mL) saturated with NH3 (or other gas such as: CO,CO2, H2S) was stirred under 50 Psi at x o C for x hours in a 50 mL of sealed tube or autoclave.Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd.Confidential Page 3 of 73.4: 有气体参与的反应3.4.1: A solution of A (x g, x mol) in methanol (x mL) saturated with HCl was stirred at x ℃.3.4.2: Ozone was bubbled into a solution of A (x g, x mol) in MeOH (x mL) at x o C for 15minutes. After excess O3 was purged by N2, Me2S (x mL) was added at x o C.3.4.3: Gas was bubbled into a solution of A (x g, x mol) and B (x g, x mol) in solventC (xmL) at x o C for x hours.3.5: 混合溶剂参与的反应3.5.1: To a solution of A (x g, x mol) in a mixture of solvent B (mL) and solvent C (x mL) (ora mixed solvent of B and C) was added D (x g, x mol) at x o C, the reaction mixture wasallowed to stir (reflux or heat) for x hrs.3.5.2: To a solution of A (x g, x mol) in 10: 1 aqueous acetone (x mL) was added B (x g, xmol) followed by addition of C (x g, x mol), the reaction mixture was allowed to stir (refluxor heat) for x hrs.3.6: 分水器分水的反应3.6.1: A (x g, x mol) and B (x g, x mol) in benzene or toluene (x mL) were refluxed for xhours with azeotropical removal of water.3.6.2; A mixture of A, B and TsOH.H2O (56.91 g, 0.3 mol) in toluene (400 mL) was heated toreflux and remove water by Dean-Stark trap.3.7: 氢化反应To a solution of A (x g, x mol) in EtOH (x mL) was added Pd-C or Ra-Ni orPd(OH)2/C (10%,x g) under N2. The suspension was degassed under vacuum and purged with H2 several times.3.7.1: The mixture was stirred under H2 (x psi) at x ℃for x hours. [氢化瓶或高压釜] 3.7.2: The mixture was stirred under H2 balloon at x ℃for x hours. [常压氢化如气球反应]3.7.3: A mixture of A (x g, x mol) and Ra-Ni (x g) in EtOH (x mL) was hydrogenated under50 Psi of hydrogen pressure for x hours at room temperature.Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 4 of 7Part 4: 反应条件或过程描述4.1: The reaction mixture (solution or suspension) was stirred at 5o C for 2 hrs and then kept atroom temperature (or ambient temperature) for another 2 hrs (or overnight)4.2: The reaction mixture (solution or suspension) was refluxed (heated to reflux) or heated at60o C for 2 hrs (or overnight)4.3: The reaction mixture (solution or suspension) was allowed to reflux (or heat to reflux) for2 hrs (or overnight)4.4: The reaction mixture (solution or suspension) was allowed to warm to temperature during2 hrs and reflux (or heat to reflux) for 2 hrs (or overnight)Part 5: 反应监测5.1: Taking sample from the reaction mixture (solution or suspension) by dropping tube orsyringe. After workup, check the reaction via TLC, LC-MS or HPLC etc.. (预处理) 5.2: 反应状态或终点描述5.2.1: The reaction was complete (incomplete or messy) detected (determined or confirmed)by TLC (PE/EtOAc 4:1), LC-MS, HPLC or NMR5.2.2: TLC (PE:EtOAc=1:1) or HPLC (107757-088-1) showed or indicated that the reactionwas complete.5.2.3: TLC (PE:EtOAc=1:1) or HPLC (107757-088-1) showed the starting material wasconsumed completely.5.2.4: TLC (PE:EA=1:1) or HPLC (107757-088-1) showed the reaction didn’t work at all ormost of starting material was still remained.5.2.5: The starting material was consumed completely, but no desired compound was detectedor determined by MS (106657-078-1) or LC-MS (106657-078-1).5.2.6: Several spots were shown on TLC.5.2.7: Only a trace amount of desired compound was detected by MS (106657-078-1) orLC-MS (106657-078-1) or HPLC (106657-078-1) or TLC (PE:EtOAc=1:1).5.2.8: The desired compound could not be isolated, separated or purified by chromatographyor prep. HPLC due to poor yield or poor solubility.Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 5 of 75.2.9:1H NMR (106675-010-2) or MS confirmed the obtained (or isolated) compound is notthe desired compound. The reaction was failed.Part 6: 反应淬灭6.1: An aqueous solution of A (10 mL) was added dropwise into the reaction mixture once thereaction mixture (solution or suspension) was allowed to warm (or cool) to -5o C or roomtemperature (ambient temperature).6.2: The hot (or cold) reaction mixture (solution or suspension) was poured into water (icewater) or poured onto ice.6.3: The reaction mixture (solution or suspension) was concentrated (distilled) under reducedpressure (in vacuum) or evaporated to remove MeOH (THF; DMF etc.) or excess SOCl2(reagent). Then the reaction residue (or the residual) was diluted with solvent and poured intowater (ice water) or poured onto ice.Part 7: 分液提取7.1: The residue was partitioned between ethyl acetate (100 mL) and 1N aq. HCl (50 mL).The separated organic layer was washed with water, dried over (Na2SO4 or MgSO4) andevaporated to dryness.7.2: After quenching the reaction, the reaction mixture was poured into separatory funnel andseparated.7.3: The aqueous layer (or phase) was extracted with organic solvent (40 mL) twice (or Xtimes). The combined organic layers were (or the organic layers were combined and) washedwith an aqueous solution of A (50 mL) or water and dried over Na2SO4 or MgSO4.7.4: The combined aqueous layers were extracted with solvent (40 mL) twice (or X times) toremove neutral impurities. The aqueous phase was acidified (or basified) with aqueous HCl(or NaHCO3) till PH = X and extracted with organic solvent.7.5: The combined organic layers were (or the organic layers were combined and) washedwith an aqueous solution of A (50 mL) or water and dried over Na2SO4 or MgSO4. Sentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 6 of 7Part 8: 浓缩蒸发8.1: After filtration via filter paper or Celite pad, the organic layer (or extract) was concentrated under reduced pressure (or in vacuum) or evaporated to dryness to provide(afford; give or yield) an oil (or foam) (which solidified on standing) or a white solid.8.2: The organic layer (or extract) was filtered and concentrated under reduced pressure (or invacuum) or evaporated to dryness to provide (afford or give) A (10 g, 0.5 mole) an oil (orfoam) (which solidified on standing) or a white solid.8.3: After removal of solvent by evaporation or concentration, A (10 g, 0.5 mole) was obtained (or prepared) an oil (or foam) (which solidified on standing) or a white solid.8.4: The extract in CH2Cl2 was evaporated to dryness and then swapped with toluene toremove residual CH2Cl2.Part 9: 几种常见的后处理描述9.1: The reaction mixture or solution was concentrated to dryness. [适用于反应液不需要quench]9.2: After the reaction mixture was cooled to 0 ℃, the reaction mixture was quenched byaddition of x mL of H2O, followed by x mL of 15% aqueous NaOH. After being stirred atroom temperature for x hour, the solid was removed by filtration (or the mixture was filteredthroughCelite pad to remove by-product). The filtrate was concentrated to dryness to givecrude product. [LiAlH4 反应的经典后处理]9.3: The mixture was diluted with water (x mL), neutralized with solid K2CO3 until no CO2was evolved. [适用于酸性反应液的后处理]9.4: The suspension was filtered through a pad of Celite or silica gel and the pad or filter cakewas washed with EtOH (x mL×x). The combined filtrates were concentrated to dryness togive product (x g, x%) as. [适用氢化反应的后处理, 或者难于过滤的反应液的后处理, 但要注意的是这里需要的是滤液而不是固体才能添加助滤剂]9.5: The reaction mixture was poured into x mL of ice-water carefully and the organic layer orphase was separated. [产物在有机相里]9.6: The reaction mixture was poured into x mL of ice-water carefully and the aqueous phasewas washed with Et2O (x mL×x) [产品在水相] and acidified with 1N HCl to pH=3. TheSentence Template for Notebook and Report Writing WuXiPharmaTech Co., Ltd. Confidential Page 7 of 7resulting precipitate was collected by filtration or the resulting solution was extracted with EA(x mL×x).9.7: The reaction mixture was filtered and the filter cake was washed with x mL of solvent,dried in vacuum to give or afford product. [这里需要的是固体而不是滤液]9.8: The reaction mixture was quenched with x mL of saturated aqueous NH4Cl. The resultingsolution was extracted with EA (x mL×x). [适用于丁基锂等活泼金属有机物的后处理]9.10: The residue was triturated with ether and filtered to afford a white solid. (磨碎) 9.11: The crude product was purified by prep. HPLC to give A as a colorless thick oil whichwas solidified on standing. (静止固化)9.12: After prep. HPLC purification, the eluent was concentrated or evaporated to removeorganic solvents. The residual aqueous solution was lyophilized to give a white solid. (冷冻干燥)9.13: After concentration, the crude product was used directly for the next step withoutpurification.Part 10: 产品的纯化10.1: The crude product was purified by silica gel chromatography eluted with PE: EtOAc=10:1 to give product (x g, x%) as yellow solid.10.2: The crude product was purified by re-crystallization (or re-crystallized) from x solvent(x mL).10.3: The crude product was distilled in vacuum (x o C, x pressure) to afford pure product (x g,x%) as colorless liquid.10.4: The crude product was pre-purified by column chromatography followed by prep.HPLC purification or re-crystallization to afford pure product.__。
实验报告英语作文模板英文回答：Introduction。
The purpose of this experiment was to investigate the effect of temperature on the rate of a chemical reaction. The reaction studied was the decomposition of hydrogen peroxide (H2O2) into water (H2O) and oxygen (O2). The hypothesis was that the rate of the reaction would increase as the temperature increased.Methods。
The experiment was conducted by measuring the volume of oxygen produced over time at different temperatures. The following materials were used:100 mL of 3% hydrogen peroxide solution。
10 mL of catalase enzyme solution。
250 mL graduated cylinder。
Thermometer。
Stopwatch。
The procedure was as follows:1. The hydrogen peroxide solution was poured into the graduated cylinder.2. The catalase enzyme solution was added to the hydrogen peroxide solution.3. The stopwatch was started.4. The volume of oxygen produced was recorded every minute for 10 minutes.5. The temperature of the solution was recorded everyminute for 10 minutes.Results。
No. Date: Student number:Name:Title:Freefall【Aim】请参考讲义，内容用英文手写。
拍照后截图插入此处，要求拍照内容清晰，窗口大小可自行调整。
【Theory】请参考讲义，内容用英文手写。
拍照后截图插入此处，要求拍照内容清晰，窗口大小可自行调整。
一、作图要求：1、描绘出自由落体运动的原理图；2、原理图需要手工描绘。
二、内容要求：1、重力加速度的含义；2、重力加速度的影响因素；3、自由落体运动公式。
1【Table】【Results】数据分析及结果撰写要求（英文撰写）：1、利用作图求得的斜率求出重力加速度大小，查找自己所在地的纬度值，按照讲义中的公式（4）计算自己所在地的重力加速度大小，并与测量值进行比较，计算百分偏差大小，百分偏差在±5.0%以内的都是合理的。
2、百分偏差计算例子：测量值：g测量=9.56 m/s2；福州地区重力加速度g理论=9.78 m/s2 ；g的相对误差值为：%3.2%10078.978.956.9%100--=⨯-=⨯=理论理论测量gggB【Conclusions】请对本实验测量做个总结，内容用英文手写。
拍照后截图插入此处，要求拍照内容清晰，窗口大小可自行调整。
总结示例：在本实验中，我们利用手机软件Phyphox的声学秒表功能来测量小重物自由落体的时间。
测量时通过多次重复测量的方法来减小偶然误差，利用作图的方法求出高度与时间平方的比值大小，最终计算得到**地区（例如：福州地区）的重力加速度大小。
实验测量值与当地的重力加速度的理论值还是比较接近的。
Score: T A: Date :附录：1、演示视频文件：用手机Phyphox做自由落体实验.mp4，文件已经上传至群文件。
2、手机Phyphox APP：3、实验示例：自由落体测重力加速度实验仪器：米尺，空的纸盒子，小重物（如小球，小核桃等），手机（需要安装Phyphox）实验步骤：（1）从手机应用或网页下载Phyphox；（2）将纸盒放于桌上，用米尺标定离纸盒正上方0.500 m高度，手拿小重物悬在标定高度上，将手机放在空的纸盒附近，打开Phyphox中的声学秒表，如下图所示。
2023新教科版三年级上册英语学生实验
报告单范本
实验信息
- 实验名称：英语单词拼写实验
- 实验日期：2023年3月15日
- 实验地点：三年级三班
实验目的
本次实验的目的是通过进行英语单词拼写练，帮助学生巩固和提高他们的英语单词拼写能力，并培养他们的语言研究兴趣。
实验材料
- 实验记录本
- 班级名单
- 英语课本
实验步骤
1. 给每个学生分发实验记录本和铅笔。
2. 将英语课本中的10个单词写在黑板上，并读出每个单词的音标和中文翻译。
3. 学生们读出每个单词，并尝试用英语拼写在实验记录本上。
4. 学生们相互检查对方的拼写，并提供建议和讨论。
5. 教师对每个学生的拼写进行评估和反馈。
实验结果
学生们在本次实验中表现出色，大部分学生都能正确拼写出给定的单词，并通过相互检查和讨论进一步提高了拼写能力。
实验总结
通过这个实验，学生们不仅巩固了对英语单词的拼写能力，还培养了合作与交流的能力。
学生们在实验过程中表现出积极的研究态度，展现出对英语研究的兴趣和热情。
实验改进
为了进一步提升实验效果，可以考虑增加实验的难度，增加更多的单词和句子拼写练，并引入一些游戏元素，激发学生们的研究兴趣。
有机化学英文实验记录Alright, here's a sample of an organic chemistry experiment record in an informal, conversational English style:Just started the experiment. Got all the glassware set up and the reagents ready. Feeling a bit nervous, but excited too. This could be interesting.Man, the smell of that solvent is intense! It's like a punch in the nose. Gotta be careful not to breathe it in too much.Hey, the reaction is kicking off! I can see the colors changing already. It's so cool to watch the magic happen.Uh-oh, looks like I overheated the mixture a bit. Hope it didn't mess up the whole experiment. Gotta be more careful next time.Alright, time to separate the products. Thisdistillation setup is a bit tricky, but I think I've got it. Just gotta keep an eye on the temperature.Wow, the yield is pretty good! I didn't expect to get this much product. Feels like all that hard work paid off.Now for the purification step. This recrystallization process is tedious, but it's gotta be done right. Don'twant any impurities in my final sample.Okay, so I think I've got it now. The product iscrystal clear and looks great. Just gotta do some final testing to confirm everything is as expected.Well, that's it for today. The experiment is done andI'm pretty happy with the results. Just gotta write up the report now and submit it. Hopefully, my professor will be impressed!。
实验记录英文作文开头Experiment Record。
Experiment 1。
So, I was in the lab yesterday, trying to mix these two chemicals together, and BAM! The whole thing just exploded in my face. It was crazy, but also kind of exciting.Experiment 2。
Today, I decided to test the effects of different temperatures on plant growth. I set up three different environments – hot, cold, and room temperature – and I'm curious to see how they'll all turn out.Experiment 3。
I've been working on this new project for a while now, and I think I finally made a breakthrough. I can't wait tosee the results of this experiment and see if my hypothesis was correct.Experiment 4。
I tried to replicate an experiment that I read about ina scientific journal, but it didn't go as planned. I'm not sure what went wrong, but I'll have to go back and figureit out.Experiment 5。
通水实验记录ty-005填表指南英文回答：Ty-005 Flood Test Record Completion Guide.The Ty-005 Flood Test Record is an important document that provides a record of the flood test conducted at a facility. It is used to ensure that the facility is meeting the required standards for flood protection. The record should be filled out accurately and completely by the person conducting the test.The following are the steps that should be followed when completing the Ty-005 Flood Test Record:1. Enter the date of the test.2. Enter the name of the facility.3. Enter the location of the facility.4. Enter the name of the person conducting the test.5. Enter the type of flood test being conducted.6. Enter the duration of the flood test.7. Enter the water level reached during the flood test.8. Enter any observations made during the flood test.9. Enter any recommendations that were made as a result of the flood test.Once the Ty-005 Flood Test Record has been completed,it should be submitted to the appropriate authority. The record will be used to evaluate the facility's flood protection measures and to make any necessary improvements.中文回答：通水实验记录ty-005填表指南。
实验记录英文作文范文Experiment Record。
Experiment 1:So, like, I was mixing the chemicals together and then suddenly there was this crazy reaction! It was like a mini explosion in the beaker, and I was like, "Whoa, that was unexpected!" But it was super cool to see the chemical reaction in action.Experiment 2:I was observing the growth of the plants in different environments. It was really interesting to see how the plants responded to the changes in light and water. Some of them grew so much faster than the others, and it was kind of surprising to see the difference.Experiment 3:I was testing the conductivity of different materials, and let me tell you, some of them were total duds. Like, I thought for sure that metal would be the most conductive, but it turns out that some other materials were way better at conducting electricity. It was pretty eye-opening.Experiment 4:I was studying the behavior of the animals in the lab, and it was so funny to see how they reacted to different stimuli. Like, when I introduced a new toy to the mice, they went crazy exploring it. It was really cool to see their natural curiosity in action.Experiment 5:I was conducting an experiment on the effects of temperature on the rate of chemical reactions. It wasreally cool to see how the reactions sped up or slowed down depending on the temperature. It made me realize how much the environment can impact chemical processes.Experiment 6:I was testing the pH levels of different substances, and let me tell you, some of them were way more acidic or basic than I expected. It was pretty surprising to see how different everyday substances can have such extreme pH levels.Experiment 7:I was conducting a psychology experiment on memory, and it was really interesting to see how different people remembered the same information. Some of them had really sharp memories, while others struggled to recall even simple details. It was a real eye-opener.Experiment 8:I was studying the effects of music on plant growth, and it was so cool to see how the plants responded to different types of music. It was kind of surprising to seethat some plants actually grew better when exposed tocertain genres of music. It was a fun experiment to conduct.。
简单的小实验流程英文流程English:For a simple experimental procedure, begin by clearly defining the objective or hypothesis you aim to test. Next, gather all necessary materials and equipment, ensuring they are properly calibrated and ready for use. Prepare a detailed step-by-step protocol outlining each action required to execute the experiment, including measurements, observations, and any specific procedures. Prioritize safety by identifying potential hazards and implementing appropriate precautions, such as wearing protective gear or working in a controlled environment. Once the protocol is established, conduct a trial run to familiarize yourself with the procedure and identify any potential issues or areas for improvement. Adjust the protocol as needed based on the trial run results. When ready, proceed with the actual experiment, carefully following the established protocol and recording all data accurately. After completing the experiment, analyze the results to draw conclusions and evaluate whether they support or refute the initial hypothesis. Finally, document the entire process, including any modifications made during the experiment, for future reference and replication.Translated content:对于一个简单的实验流程，首先要明确定义您想要测试的目标或假设。
简易电动机现象记录【中英文版】英文文档内容：Simple Electric Motor Phenomenon RecordThe simple electric motor phenomenon recorded in this experiment involves the conversion of electrical energy into mechanical energy.When a current-carrying conductor, such as a wire, is placed in a magnetic field, it experiences a force known as the magnetic force.This force causes the conductor to move, thus generating mechanical work.To conduct this experiment, a simple electric motor circuit was set up using a battery, a coil of wire, and a magnet.The wire was connected to the battery, creating an electric current.As the current flowed through the wire, it entered the magnetic field created by the magnet.According to Faraday"s law of electromagnetic induction, the changing magnetic field induced an electromotive force (emf) in the wire, causing a current to flow.Observations:- As the current flowed through the wire, it experienced a force in the direction perpendicular to both the magnetic field and the current direction, as predicted by Fleming"s left-hand rule.- The wire began to rotate around the axis perpendicular to the magnetic field, demonstrating the conversion of electrical energy intomechanical energy.- The rotation speed of the wire increased with the increase in current or the strength of the magnetic field.Conclusion:The experiment confirmed the phenomenon of electromagnetic induction and demonstrated the basic principle of an electric motor.The rotation of the wire resulted from the interaction between the magnetic field and the current-carrying conductor, showcasing the conversion of electrical energy into mechanical energy.This simple electric motor phenomenon has numerous applications in various devices and technologies, highlighting the significance of understanding and harnessing electromagnetic forces.中文文档内容：简易电动机现象记录本次实验记录的简易电动机现象涉及电能转化为机械能的过程。
Experiment 1PH standard solution preparation and concentration comparisonA Purpose of the experiment1.Learning to master the instrument commonly used in titration of washing and proper use.2.Titration analysis of practice operations through an initial grasp of methyl orange, phenolphthalein indicator end point determination.3.Grasp the pH standard solution preparation method.Two Experimental principle0.1 mol / L HCl solution (strong acid) and0.1 mol / L NaOH solution (alkaline) when each titration, pHsp 7.0, the pH titration jump range of 4.3- 9.7, select the color range in jump indicator ( such as methyl orange, phenolphthalein), can be measured to ensure sufficient accuracy.In the case of the same indicator, a certain concentration of HCl solution and NaOH solution each titration, the ratio of the volume consumed by V HCl / V NaOH should be certain, to, you can test titration technique and the ability to judge the end .Three Main reagents and instruments1. HCl solution of 6 mol / L.2.Saturated NaOH solution (concentration of about15-19 mol /L).3.Methyl orange solution1g / L.4.Phenolphthalein solution of 2 g / L ethanol.Four Experimental procedure1.Solution preparation(1) 0.1 mol / L HCl solution in a clean graduated cylinder to measure small-about8.3 mL 6 mol / L HCl solution was poured into480 mL of water containing about500 mL reagent bottle, add water, diluted to500 mL,covered with glass Cyprus, shaking.(2) 0.1 mol / L NaOH solution in a clean graduated cylinder to measure small about3.3 mL saturated NaOH,poured into480 mL of water containing about500 mL reagent bottle, add water, diluted to500 mL,covered with rubber plug, shake uniform.2.Titration between pH solution(1) with0.1 mol / L NaOH alkaline solution rinse buret2-3times, each time with 5-10 mL solution rinse.And then directly into the alkaline titrant buret in the buret liquid level adjusted to0.00scale.(2) with0.1 mol / L HCl solution, rinse Acid Burette2-3times, each time with5-10 mL solution rinse.And then directly into the acidic titrant in the buret, buret liquid level adjusted to0.00scale.(3)from the buret in the release of alkaline NaOH solution20.00 mL in250 mL conical flask, add2drops of methyl orange indicator, with0.1 mol / L HCl titration to change from yellow to orange.Note reading, parallel to the determination of three.Data record in Table 1, calculate the volume ratio V HCl / V NaOH.(4)from the buret in the release of acidic solution of20.00 mL HCl in250 mL conical flask, add2drops of phenolphthalein indicator, with0.1 mol / L NaOH solution titration to change from colorless to reddish, the red does not maintain the30s fade to end. Note reading, parallel to the determination of three.Data recorded in Table 2, calculate the volume ratio V HCl / V NaOH,and compare the Table1and Table 2, the volume ratio V HCl / V NaOH.Five Data ProcessingIn this study, the data recording and processing are shown in Table1and Table 2..Table 1 HCl NaOH solution titration(using methyl orange as indicator)Table 2 NaOH titration of HCl solution (phenolphthalein as indicator)Six Thinking problems1. HCl and NaOH solution concentration can be accurately prepared me directly?Why?2.Titration analysis in the experiment, buret, pipet titrator and why the need to take to move the solution washed several times Run?Titration flask used have to apply the titrant Run wash?Why?3.Why NaOH titration with HCl using methyl orange as an indicator when, while titration of HCl with NaOH using phenolphthalein as an indicator of when (or other appropriate indicator)?Experiment 2NaOH solution calibration and the determination of total acidity in vinegarA Purpose of the experiment1. To understand base material and potassium dihydrogen phthalate (KHP)the nature of its application.2.Master NaOH standard solution of the preparation, standardization and save points.3.Titration weak acid strong base titration to master the process of jump range and choice of indicator principle.4.To understand the analysis of total acidity of vinegar.Two Experimental principleAcetic acid is an organic weak acid(Ka = 1.8 × 10- 5), and NaOH in the reaction isHAc + NaOH = NaAc + H 2 OReaction product was weak alkali salt, alkaline titration jump in the context of such optional alkaline range of phenolphthalein indicator color.Consumption of acetic acid in vinegar is about30-50 g / L (3- 5%).NaOH standard solution prepared with the calibration method, commonly used potassium dihydrogen phthalate (KHP)as the base material and calibration of its concentration. Calibration reaction is:KHC 8 H 4 O 4 + NaOH = NaKC 8 H 4 O 4 + H 2 OThree Main reagents and instruments1.Saturated NaOH solution (concentration of about15-19 mol /L).2.Phenolphthalein solution of 2 g / L ethanol.3.Potassium dihydrogen phthalate (KHP) standard substance1h at100-125℃ after drying, placed in a desiccator spare.Four Experimental procedure1. 0.1 mol / L NaOH standard solution in the preparation and calibration(1) 0.1 mol / L NaOH solution prepared in a clean small graduated cylinder to measure about 3.3 mL saturated NaOH, poured into480 mL of water containing about500 mL reagent bottle, add water, diluted to500 mL,covered with rubber plug , shake well.(2) 0.1 mol / L NaOH solution to poor calibration of the weighing bottle, weighed KHP three subtraction, each0.4-0.6 g,were poured into250 mL conical flask, adding25-35 mL of water, heating to KHP to dissolve completely.Coolish after blowing flask with distilled water (why?).When completely cooled solution by adding2-3drops of phenolphthalein indicator, calibrated with NaOH solution to be titrated to maintain the30s reddish and shall end not fade.Note the reading, the data records shown in Table 1, calculate the concentration of NaOH solution.2.Determination of total acidity in vinegarPipet25.00 mL of vinegar solution in250 mL conical flask, add2drops of phenolphthalein indicator, titrated with NaOH standard solution changed from colorless to reddish, the red does not fade as the end to keep 30s.Note reading, parallel to the determination of three.Data recorded in Table 2, calculate the total acidity of vinegar, the result in g/100 mL said.Five Data ProcessingIn this study, the data recording and processing are shown in Table1and Table 2..Table 1 NaOH standard solution calibrationTable2Determination of total acidity in vinegarSix Thinking problems1.Calibration standard solution of NaOH the base material used is what?Compared with other benchmark materials, it has any significant advantage?2.Determination of vinegar content, why use phenolphthalein as the indicator? Whether the use of methyl orange or methyl red as indicator?3.Phenolphthalein indicator from colorless to reddish, the solution pH,how many?Red solution in the air, then placed into a colorless why?Experiment 3HCl solution, calibration and determination of total alkalinity of alkali dustA Purpose of the experiment1.Learn anhydrous sodium carbonate and borax base material and the nature of its application.2.Master HCl standard solution of the preparation and calibration procedure.3.To master the dual bases, titration acid titration process of jump range and choice of indicator principle.4.To master the basic elements of quantitative transfer operation.Two Experimental principleAlkaline ash (that is, industrial soda ash) is mainly composed of sodium carbonate, soda brand name, which may also contain a small amount of NaCl, Na 2 SO 4,NaOH and NaHCO and other ingredients.Often HCl standard solution for the determination of total 3alkalinity titrant to measure the quality of the product.Titration reactionNa 2 CO 3 + 2HCl = 2NaCl + H 2 CO 3H 2 CO 3 = H 2 O + CO 2↑Reaction H 2 CO 3is easy to form the supersaturated solution and decomposes to COand escape.Stoichiometric point,pH value of 3.8- 3.9, can be used methyl orange 2as indicator, titrated with HCl standard solution, the solution changed from yellow to orange to end.Sample of NaHCO 3were in the same time and.As the sample is easy to absorb moisture and CO 2,the sample should be dried at270-300℃ 2 h, to remove adsorbed water and to all of NaHCO 3into Na 2 CO 3,alkali dust of the total alkalinity is usually Or Said that as the poor uniformity of samples, moresamples should be weighed to make it more representative.Determination of allowable error may be relaxed.Calibration method using HCl standard solution preparation, often with methyl orange as indicator, with anhydrous Na 2 CO 3as the base material and calibration concentration. Calibration reaction is:Na 2 CO 3 + 2HCl = 2NaCl + H 2 CO 3Can also be used borax(Na 2 B 4 O 7 · 10H 2 O)as the base material, using methyl red as indicator, calibration standard solution of HCl concentration.Calibration reaction is:Na 2 B 4 O 7 · 10H 2 O + 2HCl = 2NaCl + 4H 3 BO 3 + H 2 OThree Main reagents and instruments1. HCl solution of 6 mol / L.2.Anhydrous Na 2 CO 3base material Drying at180℃ for2-3 h later, placed ina desiccator spare.3.Methyl orange solution1g / L.Four Experimental procedure1. 0.1 mol / L HCl standard solution for preparation and calibration(1) 0.1 mol / L HCl solution prepared in a clean graduated cylinder to measuresmall-about8.3 mL 6 mol / L HCl solution was poured into480 mL of water containing about500 mL reagent bottle, add water, diluted to500 mL,cover the glass stopper, shake.(2) 0.1 mol / L HCl solution to poor calibration of the weighing bottle, subtraction, said anhydrous Na 2 CO 3three, each of0.15-0.20 g,respectively, into250 mL conical flask, adding25-35 mL water, heated to completely dissolve Na 2 CO 3.Coolish after blowing flask with distilled water (why?).When completely cooled solution, add2drops of methyl orange indicator to be calibrated with HCl titration solution from yellow to orange as the end point exactly.Note the reading, the data records shown in Table 1, calculate the concentration of HCl solution.2.Alkaline ash Determination of total alkalinityAccurately weighed sample 1.8-2 g and the beaker, add appropriate amount of water, heated to dissolve the sample completely.After cooling, quantitatively transfer the solution to250 mL volumetric flask with water set to the mark, shake it well.Pipet25.00 mL test solution three in250 mL conical flask, adding20 mL water and2drops of methyl orange indicator, titrated with HCl standard solution from yellow to orange as the end point exactly.Note the reading.Data recorded in Table 2, calculate the total alkalinity of the sample, the results indicated by Na 2O%.Five Data ProcessingIn this study, the data recording and processing are shown in Table1and Table 2..Table 1 HCl standard solution for calibrationTable2Determination of total alkalinity of alkali dust (m alkali gray= g)Six Thinking problems1.Why are prepared0.1 mol / L HCl solution,500 mL requirements take 6 mol / L HCl solution of8.3 mL?Write a calculation formula.2.Anhydrous Na 2 CO 3kept properly, absorb the1%water, with this reference material and calibration of the concentration of HCl solution, what the impact on its results?3. When titrated with HCl solution, the use of methyl orange and phenolphthalein indicator to distinguish the two samples are from the Na 2 CO 3-NaOH or Na 2 CO 3-NaHCO 3 composition?4.Demarcation of the two reference substances HCl,Na 2 CO 3and anhydrous borax(NaB 4 O 7 · 10H 2 O)is what advantages and disadvantages of each?2Experiment 4EDTA solution calibration and determination of water hardnessA Purpose of the experimentplexometric titration study the theory and application.2.Grasp the complexometric titration of the direct titration.3.Master EDTA solution preparation and calibration.Two Experimental principleDetermination of water hardness and total hardness of water into calcium - magnesium hardness of the former is to measure the total calcium and magnesium, the latter were measured concentration of calcium and magnesium.Countries in the world that the method of water hardness varies, generally use the degrees (°) said,1°= 10 mg CaO / L.Less than16° for the soft water, greater than16° for the hard water.The total hardness of tap water generally is less than 16°.In addition, China also uses mmol / L or mg / L (CaCO 3)as the unit of water hardness.In this study EDTA complexometric titration of total water hardness.The ammonia in pH10buffer to chrome black T as indicator, with triethanolamine, and Na 2 S masking Fe 3 +, Al 3 +, Cu 2 +, Pb 2 +, Zn 2 +and other ions, with EDTA standard solution titration, can be directly measured total water hardness.Titration reactionCa 2 + + Mg 2 + +Y → CaY + MgYEDTA standard solution prepared with the calibration.In this experiment, chrome black T (EBT)as indicator, as the base material with CaCO 3concentration of calibration.Chrome black T indicator to improve the color of sensitivity, can be added to an appropriate amount of MgY.Calibration reaction is:CaCO 3 + 2HCl = 2CaCl + H 2 CO 3Ca 2 + + MgY +Y → CaY + MgYThree Main reagents and instruments1. EDTA solution0.01 mol / L.2. NH 3-NH 4 Cl buffer solution of pH = 10.CaCO 3reference material dried at110℃, 2 h,coolish placed in the desiccator 3.after cooling to room temperature and set aside.4.Eriochrome Black T indicator 5 g / L (containing 25%triethanolamine and20% Na 2 S).5. HCl solution6mol / L.Four Experimental procedure1. 0.01 mol / L EDTA standard solution for calibrationSubtraction Method in the weighing bottle to accurately weigh0.2-0.3 g CaCO 3,poured into250 mL beaker, add a little water before wetting, cover the surface of dish, from beaker to beaker mouth Department dropping about 5 mL 6 mol / L HCl solution, so that CaCO 3is completely dissolved.Water50 mL,micro boiling a few minutes to remove CO 2.After cooling, rinse the beaker and watch glass, quantitative transfer of CaCOsolution in250 mL volumetric flask with water set to the mark, shake well.Pipet 325.00 mL Ca 2 +solution in the250 mL conical flask, adding20-25 mL water and5-10 mL MgY(obtained from the experiment in step 2), and then adding10 mL NH 3-NHCl buffer solution ,3drops of Eriochrome Black T indicator, immediately EDTA4titration, when the solution stabilized by a wine red to blue purple and then just end shall be.Note reading, measured three times in parallel, the data record shown in Table 1, calculate the concentration of EDTA solution.2.Determination of water hardnessGraduated cylinder to measure water with100 mL in250 mL conical flask, (adding1 -2drops of acid to sample solution, boil a few minutes to remove CO 2.Cooling), by adding10 mL NH 3-NH 4 Cl buffer solution,3drops of Eriochrome Black T indicator, immediately with EDTA titration, when the solution stabilized by a wine red to blue purple and then just shall end.Note reading, measured three times in parallel, the data record shown in Table 2,calculate the total water hardness, results in (°) said. Five Data ProcessingIn this study, the data recording and processing are shown in Table1and Table 2.Table 1 EDTA standard solution for calibrationTable2Determination of water hardnessSix Thinking problems1. EDTA used in this experiment with what indicator should be calibrated? The most appropriate benchmark for material that?2.In the calibration process, adding MgY What is the role?MgY it should be accurate to join?3.In this study, the total hardness in tap water (°) that should be reserved several significant figures? A brief explanation.Five calibration experiments EDTA solution and Bi 3+, Pb2+ content of DeterminationA Purpose of the experiment1.Control the acidity increase by the control theory and application of selective EDTA.2.To master continuous titration with EDTA method.3.Master EDTA solution preparation and calibration.Two Experimental principleMixed ions were commonly used control acidity titration method, masking method can be demonstrated according to the side reaction coefficient of the possibility of their titration, respectively.Bi 3+,Pb2+and EDTA can form a stable1: 1complex,lgK 27.94and 18.04,respectively. Because of the difference lgK vary widely, it can make use of pH effect, control of different acidity, for each titration.At pH ≈ 1时titration Bi 3+, at pH ≈ 5-6时titration of Pb 2+.EDTA standard solution prepared with the calibration.In this experiment, xylenol orange (XO)as indicator, calibrated with ZnO as the base material and its concentration. Calibration reaction is:ZnO + 2HCl = ZnCl 2 + H 2 OZn 2 + +Y → ZnYThree Main reagents and instruments1. EDTA solution0.01 mol / L.2.Hexamethylenetetramine solution of200 g / L.3. ZnO base material and dried at300℃ for 2 h,coolish placed in the desiccator after cooling to room temperature and set aside.4.Xylenol orange (XO) indicator 2 g / L.5. HCl solution of 6 mol / L.Four Experimental procedure1. 0.01 mol / L EDTA standard solution for calibrationSubtraction Method in the weighing bottle to accurately weigh0.16-0.24 g ZnO,into 250 mL beaker, add a little water before wetting, cover the surface of dish, from beaker to beaker mouth Department dropping about5 mL 6 mol / L HCl solution to ZnO completely dissolved.Water20 mL,micro boiling a few minutes.After cooling, rinse the beaker and watch glass, quantitative transfer of Zn 2 +solution in250 mL volumetric flask with water set to the mark, shake well.Pipet25.00 mL solution of the Zn 2 +in250 mL conical flask, dropping hexamethylenetetramine solution to a stable red solution was then over3 mL,then add2drops of xylenol orange indicator immediately with EDTA titration, when the solution stabilized by the purple into a bright yellow orange and then just end shall be.Note reading, three parallel determination, calculated the concentration of EDTA solution.2. Bi 3+, Pb2+ content of DeterminationAccurately pipet Bi 3+,Pb2+test solution was10.0 mL in250 mL three conical flask, add2drops of xylenol orange indicator, titration with EDTA, (adding1-2drops to test solution acidification, boiling minutes to remove CO 2.cooling), by adding10 mL NH 3-NH 4 Cl buffer solution, when the solution from purple through orange and then just turned into a stable bright yellow shall be Bi 3+ in the end.Note reading, calculating mixture of Bi 3+ content results in g / L,said.In the titration of Bi 3+ solution after the adding hexamethylenetetramine solution to a stable red solution was then over3 mL,then add2drops of xylenol orange indicator, and immediately titrated with EDTA,when solution stabilized by the purple into a bright yellow orange and then just shall Pb2+in the end.Note reading, calculating mixture of Pb2+ content, results in g / L,said.Five Data ProcessingIn this study, data records and forms from the column.Six Thinking problems1. EDTA used in this experiment with what indicator should be calibrated? The most appropriate benchmark for material that?2.Why not NaOH, NaAc or ammonia, but with hexamethylenetetramine adjust pH to5 - 6?experiment six Back titration samples of aluminum content in aluminumA Purpose of the experiment1.Grasp the back titration.2.Learn replacement titration.3.Mental and physical, hands-on experimental design.Two Experimental principleAl 3 +is easy to form a series of polynuclear hydroxy complexes, the polynuclear hydroxyl complexes with EDTA complex and slow; the same time,Al 3 +closed indicator xylenol orange, it is usually determined by back titration of aluminum.Quantitative and adding excess EDTA standard solution, boil a few minutes at pH≈ 3.5,so that Al 3 +and EDTA complex completely, then at pH 5- 6, with xylenol orange as indicator, with Zn 2 +salt standard excess of EDTA solution and back titration of aluminum content.Reactive as follows:Al 3 + + Y = AlY (pH≈ 3.5)Zn 2 + + Y = ZnY (pH5- 6)(Indicator has just changed from yellow to purple XO)Three Main reagents and apparatusAluminum nitrate samples; ZnO; HCl (1 +1),(1+3); EDTA (0.01mol / L);xylenol orange(2 g / L);Hexamethylenetetramine(200 g / L);ammonia(1 +1).Four Experimental procedure1 Zn2 + salt standard solution preparationWeigh accurately0.20-0.21 g ZnO in a small beaker, dropping(1 +1) HCl to ZnO completely dissolved, then supplement of1drop (1 +1) HCl, heating, cooling, into250 mL volumetric flask , set the volume, shake and set aside.ZnO calculated according to the quality of the material in the amount of standard solution concentration (in Zn 2 +dollars).2 0.01mol / L EDTA standard solution for preparation and calibrationMeasure out50 mL EDTA solution(0.1mol / L)in the reagent bottle, diluted to500 mL with distilled water around, shake and set aside.Dispense25 mL Zn 2 +standard solution (three) in the conical flask, add2drops of xylenol orange, was added dropwise to the solution of hexamethylenetetramine just become purple, then over 3 mL;with homemade The EDTA titration to the solution just becomes bright yellow for the end, record the volume consumed EDTA solution.According to the data of the exact concentration of EDTA solution.3 Determination of aluminum in aluminum-containing samplesWeigh accurately0.53-0.55 g aluminum nitrate samples in small beaker, add3drops (1 +3) HCl, add the appropriate amount of water dissolved, transferred to a250 mL volumetric flask, volume, shaking.Dispense the Al test solution25 mL(three) in the conical flask, were added50 mL EDTA solution accuracy(about 0.01mol / L), 2drops of xylenol orange, then yellow test solution, add ammonia to the solution was purple, together with(1 +3) HCl solution, the solution yellow.Boiled 3 min,cooling.Add 20 mL of hexamethylenetetramine, then the solution should be yellow, red if the solution must also dropping (1 +3) HCl,to turn plement plus1drop of xylenol orange, Zn 2 +standard solution with flat to just drop into the purple to finish, recording the consumption of Zn 2 +standard solution volume.According to the experimental data of the content of aluminum in aluminum-containing samples (in percentage terms of quality).Five Data recording and processingTable1 EDTA standard solution for calibration(m ZnO = g, c ZnO = mol / L)Table2Determination of aluminum in aluminum-containing samples (G sample= g)The formula is:Six Thinking problems1.For complex alloy sample without replacement titration, while the use of back titration, the result is high or low?2.Back titration with the replacement of EDTA used in titration What is the difference?Experiment 7KMnO 4solution,H 2 O 2calibration and determinationA Purpose of the experiment1.Grasp the KMnO 4solution preparation and calibration process, understand the autocatalytic reaction.2.Master KMnO 4 H 2 O 2determination of the principles and methods.3.On the KMnO 4have experience of the characteristics of its own indicator.Two Experimental principleHydrogen peroxide in the industry, biology, medicine, have a wide range of applications, therefore, often required to determine its practical content.Determination by KMnO H 2 O 2content, often using KMnO 4in sulfuric acid solution standard solution direct 4titration.Titration reaction5H 2 O 2 +2 MnO 4-+ 6 H + =2Mn2+ + 5O2↑ + 8H2 OThe beginning of the slow reaction rate, reaction products to be generated after Mn 2 +, Mn 2 +as a catalyst to accelerate the reaction rate, it can be successfully titrated to a stable reddish presented to the end, so called auto-catalytic reaction.Slightly excessive titrant(2 × 10-6 mol / L)itself purple to display the end.KMnO 4standard solution prepared with the calibration method, often in dilute sulfuric acid solution, at75-85℃, using Na 2 C 2 O 4as the base material, calibration concentration.Calibration reaction is:5C 2 O 4 2-+2 MnO 4-+ 16 H + =2Mn2+ + 10CO2↑ + 8H2 OThe calibration response is autocatalytic reaction, the chemical reaction process should pay attention to acidity, temperature and titration rate.Three Main reagents and instruments1. H 2 SO 4solution of 3 mol / L.Na 2 C 2 O 4reference material Dried at105℃ for 2 h after the backup.2.3. KMnO 4solution of0.02 mol / L.Four Experimental procedure1. KMnO 4solution preparationWeigh KMnO 4solid1.6 g,dissolved in500 mL water, cover the surface of pan, heated to boiling and maintain micro-boiling state 1 h,after cooling, with a porous glass funnel (No.3or 4) filter.Filtrate stored in a brown reagent bottle.The solution at room temperature,2-3days after the filtration reserve.2. KMnO 4solution calibrationSubtraction Method in the weighing bottle to accurately weighed Na 2 C 2 O 4three, each of0.15-0.20 g,respectively, into250 mL conical flask, adding50-60 mL water and 15 mL H 2 SO 4, blowing a small amount of distilled water flask(Why?),heated to75-85℃, hot to be calibrated with a solution of KMnO 4titration.When the reaction began to slow titration, the solution had to be Mn 2 +,the titration speed may be faster, until the solution showed reddish and continued for half a minute does not fade shall end. Data record in Table 1, calculate the concentration of KMnO 4solution.3. H 2 O 2contentAccurate, pipet25.00 mL test solution in250 mL conical flask, three, by adding50 mL water and20 mL H 2 SO 4,KMnO 4standard solution with a titration solution and continued for half a minute showed reddish discoloration shall not end.When the reaction began to slow titration, the solution had to be Mn 2 +,the titration speed may be accelerated.Data recorded in Table 2,calculation of test solution in H 2 O 2content, results in g / L,said.Five Data ProcessingIn this study, the data recording and processing are shown in Table1and Table 2..Table 1 KMnO 4standard solution for calibrationTable2 H 2 O 2contentSix Thinking problems1. KMnO 4solution preparation process to use porous glass filter funnel, how can quantitative filter paper filter?Why?2.Prepared KMnO 4solution should pay attention to?With Na 2 C 2 O 4calibration KMnO 4solution, why start drops of KMnO 4purple disappear slowly?Then they disappear faster and faster, until the endpoint of stability of the purple?3.With KMnO 4 H 2 O 2determination, the ability to use HNO 3, HCl or HAc control of acidity?Why?4.Preparation of KMnO 4solution, the filtration after the filter on the adhesion of the material for that?What material should be used to clean?5. H 2 O 2What are the important properties, should pay attention to what use?Experiment 8CuSO 4 · 5H 2 O in the Cu contentA Purpose of the experiment1.Master Na 2 S 2 O 3solution preparation and calibration points.2.To understand the role of starch indicator principle.3.Indirect iodometric method for the determination to master the principle and operation of copper.4.To understand the decomposition of copper alloy samples.Two Experimental principleCopper alloy sample and CuSO 4 · 5H 2 O in the determination of copper, generally use the iodometric method.In weak acid solution,Cu 2 +and the role of excess KI to generate Cu I precipitation, while precipitation of I 2,titration reactionCu 2 + + 4 I-+ 6 H+= 2 Cu I↓+ I 22Precipitation of I 2,with starch as indicator, with Na 2 S 2 O 3standard solution titration:I 2 + 2 S 2 O 3 2-=2 I-+ S4O62-Cu 2 +and I- the reaction is reversible by adding excess KI, the reduction of Cu 2 + can become completely, but,CuI precipitate strongly adsorbed I 2,then the results will lower.The usual approach is to be incorporated in the near end of thiocyanate, the CuI (Ksp = 1.1 × 10-12)into the solubility of smaller CuSCN (Ksp = 4.8 × 10-15) precipitation, the adsorption of iodine released CuI to respond more fully.ThatCuI + SCN-= CuSCN + I-KSCN near the finish line should be added, or SCN- would restore the abundance of I 2,led to lower measured results.Solution pH should generally be controlled at3.0 -4.0between.Acidity is too low,Cu 2 +easily hydrolyzed, the reaction is not complete, the result is low, and slow reaction rate, the end extension; acidity is too high, then I- oxidation by oxygen in the air as I 2,so that the results high.Determination of copper in copper alloys, the samples of Fe 3 +oxidation of I-,affects the determination, but may be masked by adding NH 4 HF 2.NH 4 HF 2is a good buffer solution, can control the solution pH 3.0- 4.0between.Na 2 S 2 O 3standard solution prepared with the calibration method, often using K 2 CrO 7as the base material, calibration concentration.Calibration reaction is:2Cr 2 O 7 2-+ 6 I-+ 14 H + = 2 Cr 3 + + 3I 2 + 7H 2 OI 2 + 2 S 2 O 3 2-=2 I-+ S4O62-Three Main reagents and instruments1. KI solution of 4%.。
实验名称：亲子英语互动实验实验目的：通过亲子英语互动，提高家长和孩子的英语水平，增进亲子关系，培养孩子的英语学习兴趣。
实验时间：2023年3月至2023年6月实验对象：5-8岁儿童及其家长实验方法：1. 设计一套适合亲子英语互动的教材和活动方案。
2. 定期组织亲子英语活动，包括家庭英语角、亲子阅读、英语游戏等。
3. 对实验对象进行定期评估，记录他们的英语学习进度和互动效果。
4. 通过问卷调查和家长访谈，了解家长和孩子的反馈。
实验过程：一、实验准备阶段1. 收集适合亲子英语互动的教材和资源，包括儿童英语绘本、英语歌曲、动画片等。
2. 设计亲子英语活动方案，包括家庭英语角、亲子阅读、英语游戏等。
3. 邀请家长参加实验前的培训，介绍实验目的、方法和注意事项。
二、实验实施阶段1. 家庭英语角：每周安排一次家庭英语角活动，家长和孩子一起参与。
活动内容包括唱英文歌曲、讲英文故事、玩英语游戏等。
2. 亲子阅读：家长每天陪孩子阅读英文绘本，共同讨论故事内容，学习新单词和短语。
3. 英语游戏：设计一些寓教于乐的英语游戏，如单词接龙、猜谜语、角色扮演等，提高孩子的英语运用能力。
4. 定期评估：每两个月对实验对象进行一次英语水平评估，包括听、说、读、写四个方面。
三、实验总结阶段1. 数据分析：对实验数据进行统计分析，比较实验前后家长和孩子的英语水平变化。
2. 问卷调查：对家长和孩子进行问卷调查，了解他们对实验的满意度和反馈意见。
3. 家长访谈：与部分家长进行访谈，深入了解他们对实验的看法和建议。
实验结果：一、家长和孩子的英语水平变化1. 家长：实验结束后，家长在英语听、说、读、写四个方面的能力均有显著提高。
特别是在口语交流方面，家长的英语表达能力得到了明显提升。
2. 孩子：实验结束后，孩子在英语听、说、读、写四个方面的能力均有明显提高。
特别是在口语交流方面，孩子的英语表达能力得到了显著提升。
二、亲子关系变化实验过程中，家长和孩子之间的互动明显增多，亲子关系得到进一步增进。
一、实验背景字母优先效应（Letter Priming Effect）是指当某个字母被呈现后，人们在识别该字母时比其他字母更快，这种现象在心理学中被称为“字母优先效应”。
本研究旨在探讨字母优先效应在不同情境下的表现，以及影响该效应的因素。
二、实验目的1. 验证字母优先效应的存在；2. 探讨字母优先效应在不同情境下的表现；3. 分析影响字母优先效应的因素。
三、实验方法1. 实验材料：随机选取26个英文字母作为实验材料，分为两组，每组13个字母。
其中一组作为实验组，另一组作为对照组。
2. 实验设计：采用2（字母类型：实验组、对照组）× 2（呈现方式：字母、字母组合）的混合实验设计。
3. 实验步骤：（1）首先，向实验参与者说明实验目的和操作方法，并请其进行熟悉；（2）实验开始，随机呈现字母或字母组合，要求参与者尽快识别并按键；（3）记录参与者在不同条件下识别字母所需的时间；（4）重复实验，确保实验结果的有效性。
四、实验结果1. 实验组在识别字母时比对照组更快；2. 在字母呈现条件下，参与者识别字母所需时间短于字母组合呈现条件下；3. 实验结果在不同情境下均表现出字母优先效应。
五、分析与讨论1. 实验结果验证了字母优先效应的存在，即当某个字母被呈现后，人们在识别该字母时比其他字母更快；2. 实验结果表明，字母优先效应在不同情境下均存在，表明该效应具有一定的普遍性；3. 实验结果还表明，字母优先效应受呈现方式的影响，即字母呈现比字母组合呈现更能激发字母优先效应。
六、结论本研究通过实验验证了字母优先效应的存在，并探讨了该效应在不同情境下的表现。
实验结果表明，字母优先效应具有普遍性，且受呈现方式的影响。
本研究为心理学领域的研究提供了有益的参考。
七、实验局限性1. 实验样本量较小，可能影响实验结果的普遍性；2. 实验材料仅限于英文字母，未涉及其他语言文字；3. 实验未考虑个体差异对字母优先效应的影响。
实验记录常用英文表达句型一、 加料过程常用表述1.添加试剂2.催化量的3.气体保护4.通入气体5.通过双针头导管加料6.通过注射器加料二、 反应过程常用表述1.反应检测2.放置过液3.甲苯/乙醇带水4.氢化反应5.分水器6.反应放热7.微波反应三、 后处理过程常用表述1.过滤2.淬火3.磨碎4.在两相中分开5.静止固化6.在冻干机冻干7.纯化过柱制备HPLC纯化制备TLC纯化重结晶8.调PH9.萃取10.浓缩11.干燥干燥真空干燥四、 部分常见反应现象描述1.加料放热2.反应过程中或者降温有固体析出3.加料不溶解4.反应变粘稠/变色五、 特殊结果叙述1.无进一步处理2.统一和其他批次一起后处理3.检测条件，不需要后处理一、加料过程常用表述1.添加试剂To a mixture (suspension / solution / slurry) of compound 12 (487 mg, 1 mmol) and o-plenylenediamine (948 mg, 6 mmol) in CH2Cl2 (15 ml) being coolen to 0℃ was added the DCC (226 mg, 1.1 mmol).Anhydrous lithium iodide (1.38 g, 10.3 mmol) was added the five portions (dropwise / in one portion / in portions) to a stirred solution of compound 12 (10.90 g, 51.5 mmol) in CH2Cl2 (120 ml).A round-bottom flask was changed with compound 3 (1.75 g, 5.27 mmol), LiCl (1.17 g, 26.3 mmol), DMSO (100 Ml) and H2O (378 ul)分批加入 in portions/portionwise一次性加入 in one portion滴加 dropwise2.催化量的Et3N (20 mL, 142 mmol) and a catalytic amount of DMAP were added the solution of compound 1 (4.549 g, 46.4 mmol) in CH2Cl2（120 ml） at 0℃3.气体保护To a stirred -78 solution℃of trimethylsilyacetylene (4.44g, 45.5 mmol)in THF (10 ml) under argon was added dropwise n-butylithium (1.6M in hexane, 28.25 ml).4.通入气体An ozone-enrichen steam of oxygen was bubbled through a cold (-78) solution of℃compound 9 (128 mg, 1.409 mmol) in CH2Cl2 (5 ml) until it turned light blue. The℃3 . solution was purged with argon at -78 for 10 min to remove the excess O5.通过双针头导管加料The mixture was added to a sulotion of compound 2 (3.00 g, 12.8 mmol) in THF (48 ml) via cannula over a period of 30 min.A solution of compound 29 (100 mg, 0.19 mmol, 1.0 equiv) in dry DMSO (1.5 ml) was cannulated under argon to a vigorously stirred mixture of powered potassium superoxide (62 mg, 0.87 mmol, 4.5 equiv) and 18-crown-6-ether (23 mg, 0.087 mmol, 0.45 equiv) in dry DMSO （0.5 ml）.6.通过注射器加料To a stirred solution of compound 15 (8.61 g, 21.2 mmol) was added a solution of p-toluenesulfonic acid (6.0 g) in CH2Cl2 via syringe over 5 min.7. 反应控温A solution of compound 1 (10 g, 1 mol) in EtOAc (20 ml) was added dropwise (via addition funnel or syringe) to the above mixture at 10 ℃(while maintaining gentle reflux;℃.while keeping internal temperature between 10 ℃ - 30)二、反应过程常用表述1. 常温/回流搅拌℃a.The reaction mixture (solution or suspension) was stirred at 5 for 2 hrs andthen kept at room temperature (or ambient temperature) for another 2 hrs (or overnight)b.The reaction mixture (solution or suspension) was refluxed (or heated to reflux)for 2 hrs (or overnight)℃c.The reaction mixture (solution or suspension) was heated at 60 for 2 hrs (orovernight)d.The reaction mixture (solution or suspension) was allowed to reflux (or heat toreflux) for 2 hrs (or overnight)2. 反应检测a. After 1 h, TLC analysis (CH2Cl2 / hexane 3:1) showed the complete consumption of compound 15.b. The reaction was complete (incomplete or messy) detected by TLC (Petroleum ether/EtOAc = 4:1),LC-MS, HPLC or NMR.3. 放置/过夜The mixture was left standing overnight.The mixture was allowed to stand at room temperature for 1 day.℃The mixture was allowed to stand in a freezer at -15 .4. 甲苯/乙醇带水Compound A (1.97 g, 6.63 mmol) was coevaporated with toluene five times to remove the water. The residue was subjected to toluene azeotrope to give the corresponding acid choride as brown oil. The aqueous portion was concentrated under reduced pressure followed by azeotropic removal of water with absolute EtOH.5. 氢化反应A mixture of compound 1 (190 g, 0.88 mmol) and Raney Ni (20 g) in ethanol (1500 ml) and ethyl acetate (500 ml) was stirred under 1 atm at room temperature for an hour.6. 分水器A mixture of TsOH.H 2O (56.91 g. 0.3 mol) and toluene (400 mL) was heated to reflux to remove water by Dean-Stark trap.7. 反应放热 / 吸热The reaction was exothermic / endothermic .8. 微波反应The sealed vial was irradiated in the microwave on a Biotage Smith Synthesis at 150 for 10 min.℃9. 抽真空The mixture was degassed for 10 min and refilled with N .210. 吸收装置The device for absorbing the evolved hydrogen bromide was attched to the reaction flask. [care!! The reaction evolves HBr and is best connected to a HBr gas trap (bubber containing 1 M NaOH solution)].11.避光反应To the solution which is protected from light was added dropwise Br (3.45 g, 22 mmol) in CH 22Cl 2 (10 mL) over 5 min and the mixture was stirred for 1 h.A mixture of compound 8 (213 mg, 0.186 mmol) and compound 9 (220 mg, 0.279 mmol) was refluxed for 20h under dark in a nitrogen atmsophere.三、后处理过程常用表述1. 过滤The mixture was filtered through a Celite pad, and the filtrate was concentrated to give the crude product.2. 淬火The reaction mixture was quenched by the addition of the saturated aqueous NH4Cl. 3. 磨碎The residue was triturated with ether and filtered to afford a white solid.4. 分液After quenching the reaction, the reaction mixture was poured into separator funnel and separated.5. 在两相中分开The residue was partitioned between ethyl acetate (100 ml) and HCl (1N, 50 ml).The organic layer was washed with water, dried (MgSO4) and evaporated to dryness.Ethyl acetate (100 ml) and HCl（1 M aq, 50 mL）were added to the residue, and the layers were separated.6. 静止固化The crude product was purified by prep-HPLC to give compound 4 as colorless thick oil, which was solid i fied on standing.7. 在冻干机冻干The white solid was re-crystallized from water, dried by hyophilization to give a white solid.7.纯化7.1 过柱The crude produt was chromatographed on silica gel (CH2Cl2 / MeOH 20:1→10:1→5:1) to give the compond 8 (0.282 g, 51%) as a white solid.The crude product was purified by column chromatography on silica gel eluted with (CH2Cl2 / MeOH 20:1→10:1→5:1) to give the compound 8 (0.282 g, 51%) as a white solid.7.2 制备HPLC纯化Be purified by prep-HPLC to afford/give/yield7.3 制备TLC纯化Be purified by prepare TLC to afford/give/yield7.4 重结晶Recrystallized from8.调PHThe pH was adjusted to around 9 by progressively adding solid NaHCO3.The mixture was adjusted to pH 9 with solid NaHCO3.酸化: be acidified to 碱化: be basified to 中和: be neutralized9.萃取The aqueous layer was extracted with ethyl acetate (100 mL×4).10.浓缩The mixture was evaporated to afford the crude product.The mixture was concentrated afford the crude product.The solvent was removed to afford the crude product.11.干燥11.1 常规干燥The organic layer was dried over , and concentrated.MgSO411.2 真空干燥The precipitate was filtered and dried (in/under vacumm; under reduced pressure).四、部分常见反应现象表述1.加料加热A gentle reflux appeared throughout the addition.The temperature was increased from 25℃to 50 during the addition.℃2.反应过程中或者降温有固体析出Solid was precipitate out after 1h reaction.℃The reaction mixture was cooled to -10, and solid was precipitate out.3.加料不溶解XX was added to the mixture, and the resulting suspension was stirred for 2h.4.加热溶解℃The suspension was heated to 90 and stirred until all solid was dissolved.5.反应变粘稠/变色The reaction mixture became sticky after 2hrs reaction/stirring.After 2hrs stirring, the mixture turned into black/brown/gray/yellow/red color.五、特殊结果叙述1.无进一步处理No further operation2.统一和其他批次一起后处理The work-up of this batch was together with the other batches that recorded in the following pages.3.检测条件，不需要后处理IPC check showed this condition is better/bad for this reaction. No further operation / screen reaction.Processs 组关于实验记录本内容方面的规范1. 反应时间要明确，统一规定为：XX(时): XX(分) 投料XX(时): XX(分) 检测XX(时): XX(分) 后处理XX(时): XX(分) 纯化及结果2. 反应必须有重要的反应现象叙述，包括物理现象和化学现象，比如放热，产生气体，产生沉淀，变粘稠，颜色变化等等。
