Product Name:
Hydrocortisone CAS No.:
50-23-7Cat. No.:
HY-N0583Product Data Sheet
MWt:
362.46Formula:
C21H30O5Purity :>98%
Solubility:
DMSO 73 mg/mL; Water <1 mg/mL
Mechanisms:
Biological Activity:
Hydrocortisone is a main glucocorticoid secreted by the adrenal cortex
Pathways:GPCR/G protein; Target:Glucocorticoid Receptor
Hydrocortisone is a main glucocorticoid secreted by the adrenal cortex.
Target: Glucocorticoid Receptor Hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of action. Hydrocortisone significantly reduced monocyte expression of hTLR4 in test group (P<0.01).In addition, it had a significant effect on reduction of serum concentrations of TNF-α and IL-1β in test group in a time-dependent manner (P<0.01). Conclusion: In this study, hydrocortisone was able to reduce the hTLR4/CD14 positive monocytes and its related pro-inflammatory cytokines, thus it can
decrease inflammatory responses following PCI [1]. Hydrocortisone dose was negatively associated with predicted AH, with each mg/m2/day increase in References:
[1]. Bagheri, B., et al., Hydrocortisone Reduces Toll-Like Receptor 4 Expression on Peripheral CD14+ Monocytes in Patients Undergoing Percutanoues Coronary Intervention. Iran Biomed J,2014. 18(2): p. 76-81. average growth period Hydrocortisone dose predicting a 0.37-cm decrease in AH (P < .004) [2]. ...
()p [2]. Sarafoglou, K., et al., Impact of Hydrocortisone on Adult Height in Congenital Adrenal
Hyperplasia-The Minnesota Cohort. J Pediatr, 2014.Caution: Not fully tested. For research purposes only
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