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睡眠剥夺后类比推理认知功能改变的功能性磁共振成像个体差异初步分析

睡眠剥夺后类比推理认知功能改变的功能性磁共振成像个

体差异初步分析

刘涛;余帮龙;母英文;何斌;陈华平;马果丰;邓皓冰;贺斌;蒲阳

【期刊名称】《西部医学》

【年(卷),期】2012(024)004

【摘要】Objective To investigate individual differences in cerebral hemodynamic response to analogy following sleep deprivation (SD). Methods 30 subjects were scanned twice with functional magnetic resonance imaging (fMRI) at a counter-balanced order after a normal night of sleep (rested state) , and 24 hours of SD state. Subjects performed analogy tasks alternated with a control tasks during the fMRI sean that lasted 12 minutes and 48 seconds. Based on individual behavioral performance after SD, subjects were separated into two subgroups-SD vulnerable (SDV) and SD resilient (SDR) groups. Subgroup data were reanalyzed with Statistical Parametric Mapping (SPM) and Analysis of Functional Neurolmages (AFNI). Results At the rested baseline, the brain activation induced by analogy in the SDR group was more than that in the SDV group. After SD,the brain became less responsive in the SDV group but more aetive in the SDR group, although similar patterns of brain activation were observed in both the rested and SD states. Conclusion Individuals respond to SD differently, fMRI at normal sleep baseline may be useful in predicting the