?606 ?现代中西医结合杂志Modern Journal of Integrated Traditional Chinese and Western Medic
皮下植入式化联合 抑瘤方治疗
结直肠癌的临床研究
孔利霞，孔军卫，赵天昌，王梅，王旭锋
(河北省武安市中医院，河北武安056300)
[摘要] 探讨微创皮下植入式化疗泵导向给药联合扶正抑瘤方
治疗中晚期结直肠癌的临床疗效。将60例中晚期结直肠癌患者随机
分为研究组和对照组各3 0例，研究组采用皮下植入式化疗泵导向给药联合扶
正抑瘤方治疗，对照组采用静脉化疗。21d为1个疗程，2组均治疗6个疗
程。统计2组近期疗效及不良反应发生情况，观察2组治疗前后肿瘤标志物
甲胎蛋白（A F P)、癌胚抗原（C E A)及白细胞计数情况。研究组近期总
有效率和控制率分别为63. 33%和80.00% ,对照组近期总有效率和控制率分 别为46.67%和60.00%,研究组近期疗效优于对照组（/><0.05)。2组治疗后入？？^瓦入水平均显 著降低均<0.05),且研究组均明显低于对照组均<0. 05)。2组治疗后白细胞计数检均较 治疗前有所下降均<0.05),但研究组下降幅度小于对照组<0.05)。研究组不良反应发生 率明显低于对照组（P< 0.0 5)。皮下动脉植入化疗泵导向给药联合扶正抑瘤方治疗结直肠
癌患者近期疗效明显优于静脉化疗，且可增强患者免疫力，减轻化疗反应。
[关键词]化疗泵导向给药；扶正抑瘤方；结直肠癌
doi:10.3969/j.issn. 1008 -8849.2019.06.010
[中图分类号]R75.3[文献标识码]A[文章编号]1008 -884(019) 06 -0606 -04 Clinical study of subcutaneous implantable chemottierapy pum p- guided medication com bined
witli Fuzheng Yilin decoction in the treatment of colorectal cancer
K O N G Lixia，K O N G Junw ei，ZH AO Tianchang，W AN G Mei，W AN G X ufen g
(Wu’a n H ospital〇0T raditional C hinese M edicine，Wu’a n056300，Hebei，China)
Abstract：Objective It is to investigate th e clinical efficacy of m in im ally invasiv th erap y pum p-guided m ed ication com bin ed w ith Fuzheng Yiliu decoction o n advanced colorectal cancer.M tien ts w ith advanced colorectal cancer w ere ran d o m ly divided in to stu d y gro u p ad con trol group，30 cases in each group.
T h e stu d y g ro u p w as treated w ith subcutan eous im plantable chem otherapy p u m p - directed m ed ication com bin ed w ith
F uzheng Yiliu decoction.The con trol gro u p w as treated w ith in traven ou s chem otherapy. 21 days a
b o th gro u p s w ere treated for6courses.The sh o rt-term efects an d occurrence of adverse r
statistically analyzed.The tu m o r m arkers alpha-fetoprotein (AFP)，carcinoem bry〇nic an tigen (CEA)a n d w h ite b lo od cell cou n t w ere observed before a n d after treatm en t.Results T h e recent to ta l effective ra te a n d con trol ra te of th e stu d y g ro u p
w ere63.33% a n d80.00%，respectively，th ose of th e con trol gro u p w ere46.67% an d60.00%，respectively.T he sh ort-te rm eficacy of th e stu d y gro u p w as better th an th at of th e con trol gro u p(P< 0.05). The levels of AFP an d CEA in th e
tw o gro u p s w ere significantly decreased after treatm en t(P<0. 05)，an d th e levels in th e s er th a n th at in th e con trol gro u p(P<0. 05) .T he w h ite b lo od cell cou n ts of th e tw o gro u p s w ere low er th a n th o se b efo re treatm en t(P< 0.05)，b u t th e decrease of th e stu d y gro u p w as less th an th at of th e con trol g ro u p(P< 0.05). The inci-dence of adverse reactions in th e stu d y g ro u p w as significantly low er th a n th a t in th e con trol gro u p(P< T h e sh o rt-term efect of su bcutaneous artery im p lan tation chem otherapy-guided m ed ication c coction is significantly b etter th a n in traven ou s chem otherapy in th e treatm en t of colorectal cancer patients,an d can en hance
th e patients im m u n ity a n d reduce th e chem otherapy response.
[作者简介]孔利霞，女，硕士，副主任医师，主要从事肛肠科临床工作。