Product Name:
KB-R7943 mesylate CAS No.:
182004-65-5Product Data Sheet
Cat. No.:
HY-15415MWt:
427.50Formula:
C17H21N3O6S2Purity :
>98%
Solubility:Mechanisms:Biological Activity:
Pathways:Membrane Transporter/Ion Channel; Target:Na+/Ca2+
Exchanger DMSO
g y KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger
(IC50 = 0.7 mM).
IC50 value: 0.7 mM
Target: NCX KB-R7943 also inhibits the mitochondrial Ca2+ uniporter (MCU; IC50 = 5.5 μM). KB-R7943 does not affect Na+-dependent transport systems or ionotropic glutamate receptors.
References:
[1]. Cheng, Hongwei; Zhang, Yihong; Du, Chunyun et al. High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943. British Journal of Pharmacology
(2012), 165(7), 2260-2273.[2]. Talbot, Janet D.; David, Gavriel; Barrett, Ellen F.; Barrett, John N. Calcium dependence of []p
damage to mouse motor nerve terminals following oxygen/glucose deprivation. Experimental
Neurology (2012), 234(1), 95-104.[3]. Brustovetsky, Tatiana; Brittain, Matthew K.; Sheets, Patrick L. et al. KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl--aspartate receptor and inhibits mitochondrial
complex I. British Journal of Pharmacology (2010), Volume Date2011, 162(1), 255-270.[4]. Barrientos, Genaro; Bose, Diptiman D.; Feng, Wei The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulf...
Caution: Not fully tested. For research purposes only
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