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sTILLE羰基化偶联

Stille-Carbonylative cross-coupling

A common alteration to the Stille coupling is the incorporation of a group between R1 and R2, serving as an efficient method to form . This process is extremely similar to the initial exploration by Migita and (see History) of coupling organostannane to . However, these moieties are not always readily available and can be difficult to form, especially in the presence of sensitive . Furthermore, controlling their high reactiv
ity can be challenging. The Stille-carbonylative cross-coupling employs the same conditions as the Stille coupling, except with an atmosphere of (CO) being used. The CO can coordinate to the palladium catalyst (9) after initial oxidative addition, followed by into the Pd-R1 bond (10), resulting in subsequent to the ketone (12). The step is normally the .

A common alteration to the Stille coupling is the incorporation of a group between R1 and R2, serving as an efficient method to form . This process is extremely similar to the initial exploration by Migita and (see History) of coupling organostannane to . However, these moieties are not always readily available and can be difficult to form, especially in the presence of sensitive . Furthermore, controlling their high reactivity can be challenging. The Stille-carbonylative cross-coupling employs the same conditions as the Stille coupling, except with an atmosphere of (CO) being used. The CO can coordinate to the palladium catalyst (9) after initial oxidative addition, followed by into the Pd-R1 bond (10), resulting in subsequent to the ketone (12). The step is normally the .

sTILLE羰基化偶联

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